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Protein

Serine protease HTRA4

Gene

HTRA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Serine protease.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei218Charge relay systemSequence analysis1
Active sitei248Charge relay systemSequence analysis1
Active sitei326Charge relay systemSequence analysis1

GO - Molecular functioni

  • endopeptidase activity Source: BHF-UCL
  • serine-type endopeptidase activity Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169495-MONOMER.

Protein family/group databases

MEROPSiS01.285.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease HTRA4 (EC:3.4.21.-)
Alternative name(s):
High-temperature requirement factor A4
Gene namesi
Name:HTRA4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:26909. HTRA4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi203100.
OpenTargetsiENSG00000169495.
PharmGKBiPA134862039.

Polymorphism and mutation databases

BioMutaiHTRA4.
DMDMi17366421.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000002695132 – 476Serine protease HTRA4Add BLAST445

Proteomic databases

PaxDbiP83105.
PeptideAtlasiP83105.
PRIDEiP83105.

PTM databases

iPTMnetiP83105.
PhosphoSitePlusiP83105.

Expressioni

Gene expression databases

BgeeiENSG00000169495.
CleanExiHS_HTRA4.
GenevisibleiP83105. HS.

Organism-specific databases

HPAiHPA045402.

Interactioni

Protein-protein interaction databases

BioGridi128450. 9 interactors.
STRINGi9606.ENSP00000305919.

Structurei

3D structure databases

ProteinModelPortaliP83105.
SMRiP83105.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 99IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST64
Domaini88 – 154Kazal-likePROSITE-ProRule annotationAdd BLAST67
Domaini383 – 474PDZPROSITE-ProRule annotationAdd BLAST92

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni202 – 362Serine proteaseAdd BLAST161

Sequence similaritiesi

Belongs to the peptidase S1C family.Curated
Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 1 Kazal-like domain.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1320. Eukaryota.
COG0265. LUCA.
GeneTreeiENSGT00510000046315.
HOGENOMiHOG000223641.
HOVERGENiHBG052044.
InParanoidiP83105.
KOiK08786.
OMAiCCRVCPA.
OrthoDBiEOG091G0LXR.
PhylomeDBiP83105.
TreeFamiTF323480.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_.
IPR000867. IGFBP-like.
IPR002350. Kazal_dom.
IPR001478. PDZ.
IPR009003. Peptidase_S1_PA.
IPR001940. Peptidase_S1C.
[Graphical view]
PfamiPF00219. IGFBP. 1 hit.
PF07648. Kazal_2. 1 hit.
PF13180. PDZ_2. 1 hit.
[Graphical view]
PRINTSiPR00834. PROTEASES2C.
SMARTiSM00280. KAZAL. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF50494. SSF50494. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS51323. IGFBP_N_2. 1 hit.
PS51465. KAZAL_2. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P83105-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRPQLRTAG LGRCLLPGLL LLLVPVLWAG AEKLHTQPSC PAVCQPTRCP
60 70 80 90 100
ALPTCALGTT PVFDLCRCCR VCPAAEREVC GGAQGQPCAP GLQCLQPLRP
110 120 130 140 150
GFPSTCGCPT LGGAVCGSDR RTYPSMCALR AENRAARRLG KVPAVPVQWG
160 170 180 190 200
NCGDTGTRSA GPLRRNYNFI AAVVEKVAPS VVHVQLWGRL LHGSRLVPVY
210 220 230 240 250
SGSGFIVSED GLIITNAHVV RNQQWIEVVL QNGARYEAVV KDIDLKLDLA
260 270 280 290 300
VIKIESNAEL PVLMLGRSSD LRAGEFVVAL GSPFSLQNTA TAGIVSTKQR
310 320 330 340 350
GGKELGMKDS DMDYVQIDAT INYGNSGGPL VNLDGDVIGV NSLRVTDGIS
360 370 380 390 400
FAIPSDRVRQ FLAEYHEHQM KGKAFSNKKY LGLQMLSLTV PLSEELKMHY
410 420 430 440 450
PDFPDVSSGV YVCKVVEGTA AQSSGLRDHD VIVNINGKPI TTTTDVVKAL
460 470
DSDSLSMAVL RGKDNLLLTV IPETIN
Length:476
Mass (Da):50,979
Last modified:October 1, 2001 - v1
Checksum:iD458FFFAB4AF4328
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti416V → F in AAH57765 (PubMed:16421571).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075205 mRNA. Translation: BAC11470.1.
AC108863 Genomic DNA. No translation available.
BC057765 mRNA. Translation: AAH57765.1.
CCDSiCCDS6110.1.
RefSeqiNP_710159.1. NM_153692.3.
UniGeneiHs.661014.

Genome annotation databases

EnsembliENST00000302495; ENSP00000305919; ENSG00000169495.
GeneIDi203100.
KEGGihsa:203100.
UCSCiuc003xmj.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075205 mRNA. Translation: BAC11470.1.
AC108863 Genomic DNA. No translation available.
BC057765 mRNA. Translation: AAH57765.1.
CCDSiCCDS6110.1.
RefSeqiNP_710159.1. NM_153692.3.
UniGeneiHs.661014.

3D structure databases

ProteinModelPortaliP83105.
SMRiP83105.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128450. 9 interactors.
STRINGi9606.ENSP00000305919.

Protein family/group databases

MEROPSiS01.285.

PTM databases

iPTMnetiP83105.
PhosphoSitePlusiP83105.

Polymorphism and mutation databases

BioMutaiHTRA4.
DMDMi17366421.

Proteomic databases

PaxDbiP83105.
PeptideAtlasiP83105.
PRIDEiP83105.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302495; ENSP00000305919; ENSG00000169495.
GeneIDi203100.
KEGGihsa:203100.
UCSCiuc003xmj.4. human.

Organism-specific databases

CTDi203100.
DisGeNETi203100.
GeneCardsiHTRA4.
HGNCiHGNC:26909. HTRA4.
HPAiHPA045402.
MIMi610700. gene.
neXtProtiNX_P83105.
OpenTargetsiENSG00000169495.
PharmGKBiPA134862039.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1320. Eukaryota.
COG0265. LUCA.
GeneTreeiENSGT00510000046315.
HOGENOMiHOG000223641.
HOVERGENiHBG052044.
InParanoidiP83105.
KOiK08786.
OMAiCCRVCPA.
OrthoDBiEOG091G0LXR.
PhylomeDBiP83105.
TreeFamiTF323480.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169495-MONOMER.

Miscellaneous databases

GenomeRNAii203100.
PROiP83105.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169495.
CleanExiHS_HTRA4.
GenevisibleiP83105. HS.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_.
IPR000867. IGFBP-like.
IPR002350. Kazal_dom.
IPR001478. PDZ.
IPR009003. Peptidase_S1_PA.
IPR001940. Peptidase_S1C.
[Graphical view]
PfamiPF00219. IGFBP. 1 hit.
PF07648. Kazal_2. 1 hit.
PF13180. PDZ_2. 1 hit.
[Graphical view]
PRINTSiPR00834. PROTEASES2C.
SMARTiSM00280. KAZAL. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF50494. SSF50494. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS51323. IGFBP_N_2. 1 hit.
PS51465. KAZAL_2. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHTRA4_HUMAN
AccessioniPrimary (citable) accession number: P83105
Secondary accession number(s): Q542Z4, Q6PF13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 1, 2001
Last modified: November 2, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.