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Protein

Putative glycogen synthase kinase-3 homolog

Gene

gskt

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + [tau protein] = ADP + [tau protein] phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei62ATPPROSITE-ProRule annotation1
Active sitei158Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi39 – 47ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • male gamete generation Source: FlyBase
  • protein phosphorylation Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiP83101.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative glycogen synthase kinase-3 homolog (EC:2.7.11.26)
Short name:
GSK-3
Alternative name(s):
Protein gasket
Gene namesi
Name:gskt
ORF Names:CG31003
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0046332. gskt.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000859841 – 501Putative glycogen synthase kinase-3 homologAdd BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei193PhosphotyrosineBy similarity1

Post-translational modificationi

Phosphorylation on Tyr-193 is necessary for the activity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP83101.
PRIDEiP83101.

Expressioni

Gene expression databases

BgeeiFBgn0046332.
GenevisibleiP83101. DM.

Interactioni

Protein-protein interaction databases

BioGridi76872. 1 interactor.
IntActiP83101. 2 interactors.
STRINGi7227.FBpp0085145.

Structurei

3D structure databases

ProteinModelPortaliP83101.
SMRiP83101.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 317Protein kinasePROSITE-ProRule annotationAdd BLAST285

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi452 – 499Asp-richAdd BLAST48

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0658. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00520000055635.
InParanoidiP83101.
KOiK03083.
OMAiDMNPHYK.
OrthoDBiEOG091G099S.
PhylomeDBiP83101.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P83101-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASQSKNSGL TNKVTTVVAT NAFGADVMSE ISYTDAKVVG NGSFGVVFQA
60 70 80 90 100
KMVPSNEMVA IKKVLQDRRF KNRELQIMRK LRHDNIITLK WFFFSSGEKR
110 120 130 140 150
DEVYLNLVME FLPETLYKVE RQYARAKQTL PVNFVRLYMY QLLRSMGYLH
160 170 180 190 200
SLGFCHRDIK PQNMLLDSET GVLKLCDFGS AKQLISGEPN VSYICSRYYR
210 220 230 240 250
APELIFGSTD YTTKIDMWSA GCVMSELLLG QLIFPGDSGV DQIVEIVKVM
260 270 280 290 300
GTPTSEQLHD MNPHYKQFKL PELKPHPWSK VFRIRTPAEA IDLVSKMLIY
310 320 330 340 350
SPNARVSPLM GCAHPFFDEL RQDPHQQLPN GRSLPPLFNF TDYEKTIEPD
360 370 380 390 400
TMPLLLPRAQ GSSTTKEPSA AHRNRNTAGE ESPRKTEDSQ KPATAALSKS
410 420 430 440 450
PGPSGKALES PPGFLQHDLG NGDHVAVGTM PMEPLTLEQN HFAAESYAVG
460 470 480 490 500
EDAEDNLEED VGDENDYDYD DGGQCNSTYI SDDMDEASES DDDDFEEEDE

N
Length:501
Mass (Da):56,237
Last modified:October 1, 2001 - v1
Checksum:i949DBCADBD72A2C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAN14270.1.
BT001338 mRNA. Translation: AAN71093.1.
RefSeqiNP_733426.1. NM_170547.3.
UniGeneiDm.14965.

Genome annotation databases

EnsemblMetazoaiFBtr0085784; FBpp0085145; FBgn0046332.
GeneIDi318552.
KEGGidme:Dmel_CG31003.
UCSCiCG31003-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAN14270.1.
BT001338 mRNA. Translation: AAN71093.1.
RefSeqiNP_733426.1. NM_170547.3.
UniGeneiDm.14965.

3D structure databases

ProteinModelPortaliP83101.
SMRiP83101.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi76872. 1 interactor.
IntActiP83101. 2 interactors.
STRINGi7227.FBpp0085145.

Proteomic databases

PaxDbiP83101.
PRIDEiP83101.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0085784; FBpp0085145; FBgn0046332.
GeneIDi318552.
KEGGidme:Dmel_CG31003.
UCSCiCG31003-RA. d. melanogaster.

Organism-specific databases

CTDi318552.
FlyBaseiFBgn0046332. gskt.

Phylogenomic databases

eggNOGiKOG0658. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00520000055635.
InParanoidiP83101.
KOiK03083.
OMAiDMNPHYK.
OrthoDBiEOG091G099S.
PhylomeDBiP83101.

Enzyme and pathway databases

SignaLinkiP83101.

Miscellaneous databases

GenomeRNAii318552.
PROiP83101.

Gene expression databases

BgeeiFBgn0046332.
GenevisibleiP83101. DM.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGSK3H_DROME
AccessioniPrimary (citable) accession number: P83101
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: October 1, 2001
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.