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P83100 (MK14C_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative mitogen-activated protein kinase 14C

Short name=MAP kinase 14C
Short name=MAPK 14C
EC=2.7.11.24
Alternative name(s):
MAP kinase p38c
Gene names
Name:p38c
ORF Names:CG33338
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length356 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Kinase involved in a signal transduction pathway.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Cofactor

Magnesium By similarity.

Post-translational modification

The phosphorylation on Thr-177 activates the enzyme By similarity. A conserved Tyr, which must also be phosphorylated to activate the enzyme in closely related sequences, is replaced by His-179 in this sequence.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

Contains 1 protein kinase domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 356356Putative mitogen-activated protein kinase 14C
PRO_0000186302

Regions

Domain20 – 305286Protein kinase
Nucleotide binding26 – 349ATP By similarity

Sites

Active site1471Proton acceptor By similarity
Binding site491ATP By similarity

Amino acid modifications

Modified residue1771Phosphothreonine By similarity

Sequences

Sequence LengthMass (Da)Tools
P83100 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: F90340860375BAF9

FASTA35641,969
        10         20         30         40         50         60 
MPEFVRVAIN ESLWEFPDIY EFVRFLGGGS FGQVAKVRLR GTENYFAMKR LMRPFEREED 

        70         80         90        100        110        120 
AKGTYREIRL LKHMNHRNVI SLLNVFHPPA HNMMEFQQVY LVTHLMDADL HRYSRSKRMS 

       130        140        150        160        170        180 
DQEIRIILYQ ILRGLKYIHS AGVVHRDLKP CNIAVNGNSE VRILDFGLSR MCADKMTDHV 

       190        200        210        220        230        240 
GTMWYLAPEI IFLRGQYTKA IDVWSVGCIL AELITDRVLF RGENYVSQIR CLINIMGTPT 

       250        260        270        280        290        300 
REFITGISME RSRNYLEGYP LRQRCDFHHL FMGYDVQAID LMEKMLEMVP EKRITAAEAM 

       310        320        330        340        350 
LHPYLRDLIE PHHHAEDTAP VYDQNFENMV LPVKCWKELV SHEIRNFRPD QLDLHF 

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[3]Stapleton M., Carlson J.W., Booth B., Frise E., Kapadia B., Park S., Wan K.H., Yu C., Celniker S.E.
Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014297 Genomic DNA. Translation: AAS65203.1.
BT030917 mRNA. Translation: ABV82299.1.
BT030937 mRNA. Translation: ABV82319.1.
BT030954 mRNA. Translation: ABV82336.1.
BT032708 mRNA. Translation: ACD81722.1.
RefSeqNP_996277.1. NM_206554.2.
UniGeneDm.31337.

3D structure databases

ProteinModelPortalP83100.
SMRP83100. Positions 2-353.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbP83100.
PRIDEP83100.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0084582; FBpp0083967; FBgn0046322.
GeneID2768679.
KEGGdme:Dmel_CG33338.
UCSCCG33338-RA. d. melanogaster.

Organism-specific databases

CTD2768679.
FlyBaseFBgn0046322. p38c.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00550000074271.
InParanoidP83100.
KOK04441.
OMAPSHERRY.
OrthoDBEOG75MVW7.
PhylomeDBP83100.

Enzyme and pathway databases

SignaLinkP83100.

Gene expression databases

BgeeP83100.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi2768679.
NextBio848055.

Entry information

Entry nameMK14C_DROME
AccessionPrimary (citable) accession number: P83100
Secondary accession number(s): A8E6X5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: October 1, 2001
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase