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P83100

- MK14C_DROME

UniProt

P83100 - MK14C_DROME

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Protein

Putative mitogen-activated protein kinase 14C

Gene

p38c

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Kinase involved in a signal transduction pathway.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Magnesium.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei49 – 491ATPPROSITE-ProRule annotation
Active sitei147 – 1471Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi26 – 349ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiP83100.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative mitogen-activated protein kinase 14C (EC:2.7.11.24)
Short name:
MAP kinase 14C
Short name:
MAPK 14C
Alternative name(s):
MAP kinase p38c
Gene namesi
Name:p38c
ORF Names:CG33338
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0267339. p38c.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356Putative mitogen-activated protein kinase 14CPRO_0000186302Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei177 – 1771PhosphothreonineBy similarity

Post-translational modificationi

The phosphorylation on Thr-177 activates the enzyme (By similarity). A conserved Tyr, which must also be phosphorylated to activate the enzyme in closely related sequences, is replaced by His-179 in this sequence.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP83100.
PRIDEiP83100.

Expressioni

Gene expression databases

BgeeiP83100.

Structurei

3D structure databases

ProteinModelPortaliP83100.
SMRiP83100. Positions 2-353.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 305286Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00550000074271.
InParanoidiP83100.
KOiK04441.
OMAiPSHERRY.
OrthoDBiEOG75MVW7.
PhylomeDBiP83100.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P83100-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPEFVRVAIN ESLWEFPDIY EFVRFLGGGS FGQVAKVRLR GTENYFAMKR
60 70 80 90 100
LMRPFEREED AKGTYREIRL LKHMNHRNVI SLLNVFHPPA HNMMEFQQVY
110 120 130 140 150
LVTHLMDADL HRYSRSKRMS DQEIRIILYQ ILRGLKYIHS AGVVHRDLKP
160 170 180 190 200
CNIAVNGNSE VRILDFGLSR MCADKMTDHV GTMWYLAPEI IFLRGQYTKA
210 220 230 240 250
IDVWSVGCIL AELITDRVLF RGENYVSQIR CLINIMGTPT REFITGISME
260 270 280 290 300
RSRNYLEGYP LRQRCDFHHL FMGYDVQAID LMEKMLEMVP EKRITAAEAM
310 320 330 340 350
LHPYLRDLIE PHHHAEDTAP VYDQNFENMV LPVKCWKELV SHEIRNFRPD

QLDLHF
Length:356
Mass (Da):41,969
Last modified:October 1, 2001 - v1
Checksum:iF90340860375BAF9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014297 Genomic DNA. Translation: AAS65203.1.
BT030917 mRNA. Translation: ABV82299.1.
BT030937 mRNA. Translation: ABV82319.1.
BT030954 mRNA. Translation: ABV82336.1.
BT032708 mRNA. Translation: ACD81722.1.
RefSeqiNP_996277.1. NM_206554.2.
UniGeneiDm.31337.

Genome annotation databases

EnsemblMetazoaiFBtr0084582; FBpp0083967; FBgn0046322.
GeneIDi2768679.
KEGGidme:Dmel_CG33338.
UCSCiCG33338-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014297 Genomic DNA. Translation: AAS65203.1 .
BT030917 mRNA. Translation: ABV82299.1 .
BT030937 mRNA. Translation: ABV82319.1 .
BT030954 mRNA. Translation: ABV82336.1 .
BT032708 mRNA. Translation: ACD81722.1 .
RefSeqi NP_996277.1. NM_206554.2.
UniGenei Dm.31337.

3D structure databases

ProteinModelPortali P83100.
SMRi P83100. Positions 2-353.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi P83100.
PRIDEi P83100.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0084582 ; FBpp0083967 ; FBgn0046322 .
GeneIDi 2768679.
KEGGi dme:Dmel_CG33338.
UCSCi CG33338-RA. d. melanogaster.

Organism-specific databases

CTDi 2768679.
FlyBasei FBgn0267339. p38c.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00550000074271.
InParanoidi P83100.
KOi K04441.
OMAi PSHERRY.
OrthoDBi EOG75MVW7.
PhylomeDBi P83100.

Enzyme and pathway databases

SignaLinki P83100.

Miscellaneous databases

GenomeRNAii 2768679.
NextBioi 848055.

Gene expression databases

Bgeei P83100.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  3. Stapleton M., Carlson J.W., Booth B., Frise E., Kapadia B., Park S., Wan K.H., Yu C., Celniker S.E.
    Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.

Entry informationi

Entry nameiMK14C_DROME
AccessioniPrimary (citable) accession number: P83100
Secondary accession number(s): A8E6X5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: October 1, 2001
Last modified: October 29, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3