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Protein

Putative protein kinase C delta type homolog

Gene

Pkcdelta

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei372ATPPROSITE-ProRule annotation1
Active sitei467Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri144 – 194Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri216 – 266Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST51
Nucleotide bindingi349 – 357ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • intracellular signal transduction Source: GO_Central
  • peptidyl-serine phosphorylation Source: GO_Central
  • protein phosphorylation Source: FlyBase

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DME-111465 Apoptotic cleavage of cellular proteins
R-DME-111933 Calmodulin induced events
R-DME-114508 Effects of PIP2 hydrolysis
R-DME-1489509 DAG and IP3 signaling
R-DME-202424 Downstream TCR signaling
R-DME-2029485 Role of phospholipids in phagocytosis
R-DME-2871837 FCERI mediated NF-kB activation
R-DME-373752 Netrin-1 signaling
R-DME-450520 HuR (ELAVL1) binds and stabilizes mRNA
R-DME-5218921 VEGFR2 mediated cell proliferation
R-DME-5607764 CLEC7A (Dectin-1) signaling
R-DME-6798695 Neutrophil degranulation
SignaLinkiP83099

Names & Taxonomyi

Protein namesi
Recommended name:
Putative protein kinase C delta type homolog (EC:2.7.11.13)
Gene namesi
ORF Names:CG10524
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0259680 Pkcdelta

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000557331 – 671Putative protein kinase C delta type homologAdd BLAST671

Proteomic databases

PaxDbiP83099
PRIDEiP83099

Expressioni

Gene expression databases

BgeeiFBgn0259680
ExpressionAtlasiP83099 baseline and differential
GenevisibleiP83099 DM

Interactioni

Protein-protein interaction databases

BioGridi58590, 3 interactors
DIPiDIP-18369N
IntActiP83099, 3 interactors
STRINGi7227.FBpp0289212

Structurei

3D structure databases

ProteinModelPortaliP83099
SMRiP83099
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini343 – 601Protein kinasePROSITE-ProRule annotationAdd BLAST259
Domaini602 – 671AGC-kinase C-terminalAdd BLAST70

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri144 – 194Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri216 – 266Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0694 Eukaryota
ENOG410XNPH LUCA
GeneTreeiENSGT00920000148938
InParanoidiP83099
KOiK06068
OrthoDBiEOG091G0QRS
PhylomeDBiP83099

Family and domain databases

CDDicd00029 C1, 2 hits
InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR020454 DAG/PE-bd
IPR011009 Kinase-like_dom_sf
IPR002219 PE/DAG-bd
IPR017892 Pkinase_C
IPR014376 Prot_kin_PKC_delta
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00130 C1_1, 2 hits
PF00069 Pkinase, 1 hit
PF00433 Pkinase_C, 1 hit
PIRSFiPIRSF000551 PKC_delta, 1 hit
PRINTSiPR00008 DAGPEDOMAIN
SMARTiView protein in SMART
SM00109 C1, 2 hits
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS00479 ZF_DAG_PE_1, 2 hits
PS50081 ZF_DAG_PE_2, 2 hits

Sequencei

Sequence statusi: Complete.

P83099-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMFTRAQVRK QKTSNSSSQR PRSSGGSTRH ETRYKQSSTS SSGAGSGLSG
60 70 80 90 100
ASGASGARRD QYRDRDHYGK HSFELPRQHS KEEAYHRDRE SSAGGVDRGE
110 120 130 140 150
RSGIGGNGGG VTGGGVYVDR RTRPRSITNR RGAIKHQKTH DINGHRFVAK
160 170 180 190 200
FFRQPTFCAF CNLFLWGFGK QGYQCIICQT VVHKKCHDKL LGKCSGSVFT
210 220 230 240 250
SASTILLRER FKIDMPHRFK PHTFMSPTFC DHCGSLMGGF FIQGLKCEEC
260 270 280 290 300
DVNCHKKCER LTANLCGVNQ KLIVEALNHV KRGAREARDS PSTPPSLNPA
310 320 330 340 350
YKIEASEEHD ETSYTYSQFQ KSGRFTAPAT VIPRFKNYSV DDFHFLAVLG
360 370 380 390 400
KGSFGKVLLA ELRDTTYYYA IKCLKKDVVL EDDDVDSTLI ERKVLALGTK
410 420 430 440 450
HPYLCHLFCT FQTESHLFFV MEYLNGGDLM FHIQESGRFS EERARFYGAE
460 470 480 490 500
IISGLKFLHK KGIIYRDLKL DNVLLDYEGH VRIADFGMCK LQIYLDKTAD
510 520 530 540 550
SFCGTPDYMA PEIIKGEKYN QNVDWWSFGV LLYEMLIGQS PFSGCDEDEL
560 570 580 590 600
FWSICNEIPW FPVYISAEAT GILKGLLEKD YTKRIGSQYS PAGDIADHIF
610 620 630 640 650
FRPIDWGLLE KRQIEPPFKP QVKHPLDTQY FDRVFTRERV RLTPIDKEIL
660 670
ASMDQKQFHG FTYTNPHITL D
Length:671
Mass (Da):76,333
Last modified:May 30, 2006 - v3
Checksum:i552783774078196C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF48160.3
BT021275 mRNA Translation: AAX33423.1
RefSeqiNP_001138191.1, NM_001144719.2
NP_511171.3, NM_078616.4
UniGeneiDm.23809

Genome annotation databases

EnsemblMetazoaiFBtr0299936; FBpp0289213; FBgn0259680
FBtr0299937; FBpp0289214; FBgn0259680
GeneIDi32191
KEGGidme:Dmel_CG42349

Similar proteinsi

Entry informationi

Entry nameiKPC4_DROME
AccessioniPrimary (citable) accession number: P83099
Secondary accession number(s): Q5BIE9, Q9VYN2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: May 30, 2006
Last modified: June 20, 2018
This is version 162 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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