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Protein

Putative protein kinase C delta type homolog

Gene

Pkcdelta

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei372ATPPROSITE-ProRule annotation1
Active sitei467Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri144 – 194Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri216 – 266Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST51
Nucleotide bindingi349 – 357ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • intracellular signal transduction Source: GO_Central
  • peptidyl-serine phosphorylation Source: GO_Central
  • protein phosphorylation Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DME-111465. Apoptotic cleavage of cellular proteins.
R-DME-111933. Calmodulin induced events.
R-DME-114508. Effects of PIP2 hydrolysis.
R-DME-1489509. DAG and IP3 signaling.
R-DME-202424. Downstream TCR signaling.
R-DME-2029485. Role of phospholipids in phagocytosis.
R-DME-2871837. FCERI mediated NF-kB activation.
R-DME-450520. HuR (ELAVL1) binds and stabilizes mRNA.
R-DME-5218921. VEGFR2 mediated cell proliferation.
R-DME-5607764. CLEC7A (Dectin-1) signaling.
R-DME-6798695. Neutrophil degranulation.
SignaLinkiP83099.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative protein kinase C delta type homolog (EC:2.7.11.13)
Gene namesi
ORF Names:CG10524
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0259680. Pkcdelta.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000557331 – 671Putative protein kinase C delta type homologAdd BLAST671

Proteomic databases

PaxDbiP83099.
PRIDEiP83099.

Expressioni

Gene expression databases

BgeeiFBgn0259680.
ExpressionAtlasiP83099. baseline.
GenevisibleiP83099. DM.

Interactioni

Protein-protein interaction databases

BioGridi58590. 3 interactors.
DIPiDIP-18369N.
IntActiP83099. 3 interactors.
MINTiMINT-803131.
STRINGi7227.FBpp0289212.

Structurei

3D structure databases

ProteinModelPortaliP83099.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini343 – 601Protein kinasePROSITE-ProRule annotationAdd BLAST259
Domaini602 – 671AGC-kinase C-terminalAdd BLAST70

Sequence similaritiesi

Contains 1 AGC-kinase C-terminal domain.Curated
Contains 2 phorbol-ester/DAG-type zinc fingers.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri144 – 194Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri216 – 266Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0694. Eukaryota.
ENOG410XNPH. LUCA.
GeneTreeiENSGT00820000126964.
InParanoidiP83099.
KOiK06068.
OrthoDBiEOG091G0QRS.
PhylomeDBiP83099.

Family and domain databases

CDDicd00029. C1. 2 hits.
InterProiIPR000961. AGC-kinase_C.
IPR020454. DAG/PE-bd.
IPR011009. Kinase-like_dom.
IPR002219. PE/DAG-bd.
IPR017892. Pkinase_C.
IPR014376. Prot_kin_PKC_delta.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00130. C1_1. 2 hits.
PF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000551. PKC_delta. 1 hit.
PRINTSiPR00008. DAGPEDOMAIN.
SMARTiSM00109. C1. 2 hits.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P83099-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMFTRAQVRK QKTSNSSSQR PRSSGGSTRH ETRYKQSSTS SSGAGSGLSG
60 70 80 90 100
ASGASGARRD QYRDRDHYGK HSFELPRQHS KEEAYHRDRE SSAGGVDRGE
110 120 130 140 150
RSGIGGNGGG VTGGGVYVDR RTRPRSITNR RGAIKHQKTH DINGHRFVAK
160 170 180 190 200
FFRQPTFCAF CNLFLWGFGK QGYQCIICQT VVHKKCHDKL LGKCSGSVFT
210 220 230 240 250
SASTILLRER FKIDMPHRFK PHTFMSPTFC DHCGSLMGGF FIQGLKCEEC
260 270 280 290 300
DVNCHKKCER LTANLCGVNQ KLIVEALNHV KRGAREARDS PSTPPSLNPA
310 320 330 340 350
YKIEASEEHD ETSYTYSQFQ KSGRFTAPAT VIPRFKNYSV DDFHFLAVLG
360 370 380 390 400
KGSFGKVLLA ELRDTTYYYA IKCLKKDVVL EDDDVDSTLI ERKVLALGTK
410 420 430 440 450
HPYLCHLFCT FQTESHLFFV MEYLNGGDLM FHIQESGRFS EERARFYGAE
460 470 480 490 500
IISGLKFLHK KGIIYRDLKL DNVLLDYEGH VRIADFGMCK LQIYLDKTAD
510 520 530 540 550
SFCGTPDYMA PEIIKGEKYN QNVDWWSFGV LLYEMLIGQS PFSGCDEDEL
560 570 580 590 600
FWSICNEIPW FPVYISAEAT GILKGLLEKD YTKRIGSQYS PAGDIADHIF
610 620 630 640 650
FRPIDWGLLE KRQIEPPFKP QVKHPLDTQY FDRVFTRERV RLTPIDKEIL
660 670
ASMDQKQFHG FTYTNPHITL D
Length:671
Mass (Da):76,333
Last modified:May 30, 2006 - v3
Checksum:i552783774078196C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF48160.3.
BT021275 mRNA. Translation: AAX33423.1.
RefSeqiNP_001138191.1. NM_001144719.2.
NP_511171.3. NM_078616.4.
UniGeneiDm.23809.

Genome annotation databases

EnsemblMetazoaiFBtr0299936; FBpp0289213; FBgn0259680.
FBtr0299937; FBpp0289214; FBgn0259680.
GeneIDi32191.
KEGGidme:Dmel_CG42349.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF48160.3.
BT021275 mRNA. Translation: AAX33423.1.
RefSeqiNP_001138191.1. NM_001144719.2.
NP_511171.3. NM_078616.4.
UniGeneiDm.23809.

3D structure databases

ProteinModelPortaliP83099.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi58590. 3 interactors.
DIPiDIP-18369N.
IntActiP83099. 3 interactors.
MINTiMINT-803131.
STRINGi7227.FBpp0289212.

Proteomic databases

PaxDbiP83099.
PRIDEiP83099.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0299936; FBpp0289213; FBgn0259680.
FBtr0299937; FBpp0289214; FBgn0259680.
GeneIDi32191.
KEGGidme:Dmel_CG42349.

Organism-specific databases

CTDi32191.
FlyBaseiFBgn0259680. Pkcdelta.

Phylogenomic databases

eggNOGiKOG0694. Eukaryota.
ENOG410XNPH. LUCA.
GeneTreeiENSGT00820000126964.
InParanoidiP83099.
KOiK06068.
OrthoDBiEOG091G0QRS.
PhylomeDBiP83099.

Enzyme and pathway databases

ReactomeiR-DME-111465. Apoptotic cleavage of cellular proteins.
R-DME-111933. Calmodulin induced events.
R-DME-114508. Effects of PIP2 hydrolysis.
R-DME-1489509. DAG and IP3 signaling.
R-DME-202424. Downstream TCR signaling.
R-DME-2029485. Role of phospholipids in phagocytosis.
R-DME-2871837. FCERI mediated NF-kB activation.
R-DME-450520. HuR (ELAVL1) binds and stabilizes mRNA.
R-DME-5218921. VEGFR2 mediated cell proliferation.
R-DME-5607764. CLEC7A (Dectin-1) signaling.
R-DME-6798695. Neutrophil degranulation.
SignaLinkiP83099.

Miscellaneous databases

ChiTaRSiPkcdelta. fly.
GenomeRNAii32191.
PROiP83099.

Gene expression databases

BgeeiFBgn0259680.
ExpressionAtlasiP83099. baseline.
GenevisibleiP83099. DM.

Family and domain databases

CDDicd00029. C1. 2 hits.
InterProiIPR000961. AGC-kinase_C.
IPR020454. DAG/PE-bd.
IPR011009. Kinase-like_dom.
IPR002219. PE/DAG-bd.
IPR017892. Pkinase_C.
IPR014376. Prot_kin_PKC_delta.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00130. C1_1. 2 hits.
PF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000551. PKC_delta. 1 hit.
PRINTSiPR00008. DAGPEDOMAIN.
SMARTiSM00109. C1. 2 hits.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKPC4_DROME
AccessioniPrimary (citable) accession number: P83099
Secondary accession number(s): Q5BIE9, Q9VYN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: May 30, 2006
Last modified: November 30, 2016
This is version 150 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.