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P83099 (KPC4_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative protein kinase C delta type homolog
EC=2.7.11.13
Gene names
Name:Pkcdelta
ORF Names:CG10524
OrganismDrosophila melanogaster (Fruit fly)
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length671 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Sequence similarities

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.

Contains 1 AGC-kinase C-terminal domain.

Contains 2 phorbol-ester/DAG-type zinc fingers.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 671671Putative protein kinase C delta type homolog
PRO_0000055733

Regions

Domain343 – 601259Protein kinase
Domain602 – 67170AGC-kinase C-terminal
Zinc finger144 – 19451Phorbol-ester/DAG-type 1
Zinc finger216 – 26651Phorbol-ester/DAG-type 2
Nucleotide binding349 – 3579ATP By similarity

Sites

Active site4671Proton acceptor By similarity
Binding site3721ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P83099 [UniParc].

Last modified May 30, 2006. Version 3.
Checksum: 552783774078196C

FASTA67176,333
        10         20         30         40         50         60 
MMFTRAQVRK QKTSNSSSQR PRSSGGSTRH ETRYKQSSTS SSGAGSGLSG ASGASGARRD 

        70         80         90        100        110        120 
QYRDRDHYGK HSFELPRQHS KEEAYHRDRE SSAGGVDRGE RSGIGGNGGG VTGGGVYVDR 

       130        140        150        160        170        180 
RTRPRSITNR RGAIKHQKTH DINGHRFVAK FFRQPTFCAF CNLFLWGFGK QGYQCIICQT 

       190        200        210        220        230        240 
VVHKKCHDKL LGKCSGSVFT SASTILLRER FKIDMPHRFK PHTFMSPTFC DHCGSLMGGF 

       250        260        270        280        290        300 
FIQGLKCEEC DVNCHKKCER LTANLCGVNQ KLIVEALNHV KRGAREARDS PSTPPSLNPA 

       310        320        330        340        350        360 
YKIEASEEHD ETSYTYSQFQ KSGRFTAPAT VIPRFKNYSV DDFHFLAVLG KGSFGKVLLA 

       370        380        390        400        410        420 
ELRDTTYYYA IKCLKKDVVL EDDDVDSTLI ERKVLALGTK HPYLCHLFCT FQTESHLFFV 

       430        440        450        460        470        480 
MEYLNGGDLM FHIQESGRFS EERARFYGAE IISGLKFLHK KGIIYRDLKL DNVLLDYEGH 

       490        500        510        520        530        540 
VRIADFGMCK LQIYLDKTAD SFCGTPDYMA PEIIKGEKYN QNVDWWSFGV LLYEMLIGQS 

       550        560        570        580        590        600 
PFSGCDEDEL FWSICNEIPW FPVYISAEAT GILKGLLEKD YTKRIGSQYS PAGDIADHIF 

       610        620        630        640        650        660 
FRPIDWGLLE KRQIEPPFKP QVKHPLDTQY FDRVFTRERV RLTPIDKEIL ASMDQKQFHG 

       670 
FTYTNPHITL D

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[3]Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE014298 Genomic DNA. Translation: AAF48160.3.
BT021275 mRNA. Translation: AAX33423.1.
RefSeqNP_001138191.1. NM_001144719.1.
NP_511171.3. NM_078616.3.
UniGeneDm.23809.

3D structure databases

ProteinModelPortalP83099.
SMRP83099. Positions 134-669.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-18369N.
IntActP83099. 2 interactions.
MINTMINT-803131.
STRINGP83099.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0299936; FBpp0289213; FBgn0259680.
FBtr0299937; FBpp0289214; FBgn0259680.
GeneID32191.
KEGGdme:Dmel_CG42349.

Organism-specific databases

CTD32191.
FlyBaseFBgn0259680. Pkcdelta.

Phylogenomic databases

eggNOGinNOG09283.
GeneTreeEMGT00050000001097.
OMAHDINGHR.
OrthoDBEOG49S4NM.
PhylomeDBP83099.

Gene expression databases

BgeeP83099.

Family and domain databases

InterProIPR000961. AGC-kinase_C.
IPR020454. DAG/PE-bd.
IPR011009. Kinase-like_dom.
IPR017892. Pkinase_C.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR017442. Se/Thr_kinase-like_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR002290. Ser/Thr_kinase_dom.
[Graphical view]
KOK06068.
PfamPF00130. C1_1. 2 hits.
PF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
PRINTSPR00008. DAGPEDOMAIN.
SMARTSM00109. C1. 2 hits.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. Kinase_like. 1 hit.
PROSITEPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio777316.

Entry information

Entry nameKPC4_DROME
AccessionPrimary (citable) accession number: P83099
Secondary accession number(s): Q5BIE9, Q9VYN2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: May 30, 2006
Last modified: January 25, 2012
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents