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Protein

Stromal interaction molecule 2

Gene

Stim2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in mediating store-operated Ca2+ entry (SOCE), a Ca2+ influx following depletion of intracellular Ca2+ stores. Functions as a highly sensitive Ca2+ sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca2+-influx. Regulates basal cytosolic and endoplasmic reticulum Ca2+ concentrations. Upon mild variations of the endoplasmic reticulum Ca2+ concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca2+ release-activated Ca2+ (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca2+ influx (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi80 – 91By similarityAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Stromal interaction molecule 2
Gene namesi
Name:Stim2
Synonyms:Kiaa1482
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2151156. Stim2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini15 – 218ExtracellularSequence analysisAdd BLAST204
Transmembranei219 – 235HelicalSequence analysisAdd BLAST17
Topological domaini236 – 746CytoplasmicSequence analysisAdd BLAST511

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 14Sequence analysisAdd BLAST14
ChainiPRO_000021828215 – 746Stromal interaction molecule 2Add BLAST732

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei28PhosphoserineCombined sources1
Glycosylationi135N-linked (GlcNAc...)Sequence analysis1
Modified residuei523PhosphoserineCombined sources1
Modified residuei609PhosphoserineBy similarity1
Modified residuei621PhosphoserineBy similarity1
Modified residuei640PhosphoserineCombined sources1
Modified residuei650PhosphoserineCombined sources1
Modified residuei661PhosphoserineBy similarity1
Modified residuei665PhosphoserineBy similarity1
Modified residuei680PhosphoserineBy similarity1
Modified residuei697PhosphoserineBy similarity1

Post-translational modificationi

Glycosylated.By similarity
Phosphorylated predominantly on Ser residues.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP83093.
MaxQBiP83093.
PaxDbiP83093.
PRIDEiP83093.

PTM databases

iPTMnetiP83093.
PhosphoSitePlusiP83093.

Expressioni

Gene expression databases

BgeeiENSMUSG00000039156.
CleanExiMM_STIM2.
ExpressionAtlasiP83093. baseline and differential.
GenevisibleiP83093. MM.

Interactioni

Subunit structurei

Oligomer with STIM1. Interacts with ORAI1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113174.

Structurei

3D structure databases

ProteinModelPortaliP83093.
SMRiP83093.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 102EF-handAdd BLAST36
Domaini136 – 204SAMPROSITE-ProRule annotationAdd BLAST69

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili247 – 394Sequence analysisAdd BLAST148

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi534 – 552His-richAdd BLAST19

Sequence similaritiesi

Contains 1 EF-hand domain.Curated
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4403. Eukaryota.
ENOG410XRM6. LUCA.
GeneTreeiENSGT00390000000214.
HOGENOMiHOG000261647.
HOVERGENiHBG079219.
InParanoidiP83093.
KOiK18196.
OrthoDBiEOG091G0CO0.
PhylomeDBiP83093.
TreeFamiTF313487.

Family and domain databases

CDDicd11722. SOAR. 1 hit.
Gene3Di1.10.150.50. 1 hit.
InterProiIPR001660. SAM.
IPR013761. SAM/pointed.
IPR032393. SOAR.
[Graphical view]
PfamiPF07647. SAM_2. 1 hit.
PF16533. SOAR. 1 hit.
[Graphical view]
SMARTiSM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P83093-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLFGLLVAG VADGCDLVPR HLRGRRASGS AGAAASPSAA AAGERQALLT
60 70 80 90 100
DPCMSLSPPC FTEEDRFSLE ALQTIHKQMD DDKDGGIEVD ESDEFIREDM
110 120 130 140 150
KYKDATNKHS HLHREDKHIT VEDLWKQWKT SEVHNWTLED TLQWLIEFVE
160 170 180 190 200
LPQYEKNFRD NNVKGTTLPR IAVHETSFMI SQLKISDRSH RQKLQLKALD
210 220 230 240 250
VVLFGPLTRP PHNWMKDFIL TISIVIGVGG CWFAYTQNKT SKEHVAKMMK
260 270 280 290 300
DLESLQTAEQ SLMDLQERLE KAQEENRTVA VEKQNLERKM MDEINYAKEE
310 320 330 340 350
ACRLRELREG AECELSRRQY AEQELEQVRM ALKKAEKEFE LRSSWSVPDA
360 370 380 390 400
LQKWLQLTHE VEVQYYNIKR QNAEMQLAIA KDEAEKIKKK RSTVFGTLHV
410 420 430 440 450
AHSSSLDEVD HKILEAKKAL SELTTCLRER LFRWQQIEKI CGFQIAHNSG
460 470 480 490 500
LPSLTSSLYS DHSWVVMPRV SIPPYPIAGG VDDLDEDTPP IVPQFPGTVA
510 520 530 540 550
KPAGSLARSS SLCRSRRSIV PSSPQSQRAQ LPAHAPLAAH PRHPHHPQHP
560 570 580 590 600
QHSLPSPDPD ILSVSSCPAL YRNEEEEEAI YFTAEKQWEV PDTASECDSL
610 620 630 640 650
NSSSGRKPSP PSSLEMYQTL SSRKISRDEL SLEDSSRGES PVTADVSRGS
660 670 680 690 700
PECVGLTETK SMIFSPASRV YNGILEKSCS MHQLSSGIPV PHPRHTSCSS
710 720 730 740
AGNDSKPVQE ASNVSRVSSI PHDLCHNGEK SKKPSKIKSL FKKKSK
Length:746
Mass (Da):83,925
Last modified:October 17, 2006 - v2
Checksum:iEE48455117B4E0BD
GO

Sequence cautioni

The sequence BAD32461 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173183 mRNA. Translation: BAD32461.1. Different initiation.
AF328907 mRNA. Translation: AAK82339.1.
BC043455 mRNA. Translation: AAH43455.1.
CCDSiCCDS39089.2.
RefSeqiNP_001074572.2. NM_001081103.2.
UniGeneiMm.265985.

Genome annotation databases

EnsembliENSMUST00000117661; ENSMUSP00000113174; ENSMUSG00000039156.
GeneIDi116873.
KEGGimmu:116873.
UCSCiuc008xlq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173183 mRNA. Translation: BAD32461.1. Different initiation.
AF328907 mRNA. Translation: AAK82339.1.
BC043455 mRNA. Translation: AAH43455.1.
CCDSiCCDS39089.2.
RefSeqiNP_001074572.2. NM_001081103.2.
UniGeneiMm.265985.

3D structure databases

ProteinModelPortaliP83093.
SMRiP83093.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113174.

PTM databases

iPTMnetiP83093.
PhosphoSitePlusiP83093.

Proteomic databases

EPDiP83093.
MaxQBiP83093.
PaxDbiP83093.
PRIDEiP83093.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000117661; ENSMUSP00000113174; ENSMUSG00000039156.
GeneIDi116873.
KEGGimmu:116873.
UCSCiuc008xlq.2. mouse.

Organism-specific databases

CTDi57620.
MGIiMGI:2151156. Stim2.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG4403. Eukaryota.
ENOG410XRM6. LUCA.
GeneTreeiENSGT00390000000214.
HOGENOMiHOG000261647.
HOVERGENiHBG079219.
InParanoidiP83093.
KOiK18196.
OrthoDBiEOG091G0CO0.
PhylomeDBiP83093.
TreeFamiTF313487.

Miscellaneous databases

ChiTaRSiStim2. mouse.
PROiP83093.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039156.
CleanExiMM_STIM2.
ExpressionAtlasiP83093. baseline and differential.
GenevisibleiP83093. MM.

Family and domain databases

CDDicd11722. SOAR. 1 hit.
Gene3Di1.10.150.50. 1 hit.
InterProiIPR001660. SAM.
IPR013761. SAM/pointed.
IPR032393. SOAR.
[Graphical view]
PfamiPF07647. SAM_2. 1 hit.
PF16533. SOAR. 1 hit.
[Graphical view]
SMARTiSM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTIM2_MOUSE
AccessioniPrimary (citable) accession number: P83093
Secondary accession number(s): Q69ZI3, Q80VF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: October 17, 2006
Last modified: November 2, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.