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P83060 (BRK1_BOMOR) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kininogen-1
Alternative name(s):
BOK-1

Cleaved into the following chain:

  1. Bradykinin
OrganismBombina orientalis (Oriental fire-bellied toad)
Taxonomic identifier8346 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraBombinatoridaeBombina

Protein attributes

Sequence length167 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Vasodilator. Bradykinin produces in vitro relaxation of rat arterial smooth muscle and constriction of intestinal smooth muscle. May target bradykinin receptors (BDKRB).

Subcellular location

Secreted.

Tissue specificity

Expressed by the skin glands.

Sequence similarities

Belongs to the bradykinin-related peptide family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainRepeat
Signal
   Molecular functionAmphibian defense peptide
G-protein coupled receptor impairing toxin
Toxin
Vasoactive
Vasodilator
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processdefense response

Inferred from electronic annotation. Source: UniProtKB-KW

vasodilation

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 167144Kininogen-1
PRO_0000003429
Peptide51 – 599Bradykinin Ref.1
PRO_0000003430
Peptide79 – 879Bradykinin
PRO_0000003431
Peptide107 – 1159Bradykinin
PRO_0000003432
Peptide135 – 1439Bradykinin
PRO_0000003433

Sequences

Sequence LengthMass (Da)Tools
P83060 [UniParc].

Last modified October 19, 2002. Version 2.
Checksum: CBEB4CAF3F001A9F

FASTA16719,753
        10         20         30         40         50         60 
MRLWFCLSFF IILCLEHFPG TLADERNVPE SEEKTEQFLR DLSEISRLQR RPPGFSPFRG 

        70         80         90        100        110        120 
KFHSQSLRDL SEISRLQRRP PGFSPFRGKF HSQSMRDLSE ISRLQRRPPG FSPFRGKFHS 

       130        140        150        160 
QSMRDLSEIS RLQRRPPGFS PFRGKFHSQS LRGLSEIKRL KTTHKIH 

« Hide

References

[1]"Bradykinins and their precursor cDNAs from the skin of the fire-bellied toad (Bombina orientalis)."
Chen T., Orr D.F., Bjourson A.J., McClean S., O'Rourke M., Hirst D.G., Rao P., Shaw C.
Peptides 23:1547-1555(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 51-59; 79-87; 107-115 AND 135-143, CHARACTERIZATION.
Tissue: Skin and Skin secretion.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ316578 mRNA. Translation: CAC69834.1.
PIRA61361.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG031664.

Family and domain databases

InterProIPR009608. Bradykinin.
[Graphical view]
PfamPF06753. Bradykinin. 4 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBRK1_BOMOR
AccessionPrimary (citable) accession number: P83060
Secondary accession number(s): Q90W16
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: November 13, 2013
This is version 42 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families