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P83060

- BRK1_BOMOR

UniProt

P83060 - BRK1_BOMOR

Protein

Kininogen-1

Gene
N/A
Organism
Bombina orientalis (Oriental fire-bellied toad)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Vasodilator. Bradykinin produces in vitro relaxation of rat arterial smooth muscle and constriction of intestinal smooth muscle. May target bradykinin receptors (BDKRB).

    GO - Biological processi

    1. defense response Source: UniProtKB-KW
    2. vasodilation Source: UniProtKB-KW

    Keywords - Molecular functioni

    Amphibian defense peptide, G-protein coupled receptor impairing toxin, Toxin, Vasoactive, Vasodilator

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kininogen-1
    Alternative name(s):
    BOK-1
    Cleaved into the following chain:
    OrganismiBombina orientalis (Oriental fire-bellied toad)Curated
    Taxonomic identifieri8346 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraBombinatoridaeBombina

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 167144Kininogen-1PRO_0000003429Add
    BLAST
    Peptidei51 – 599BradykininPRO_0000003430
    Peptidei79 – 879BradykininPRO_0000003431
    Peptidei107 – 1159BradykininPRO_0000003432
    Peptidei135 – 1439BradykininPRO_0000003433

    Expressioni

    Tissue specificityi

    Expressed by the skin glands.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the bradykinin-related peptide family.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    HOVERGENiHBG031664.

    Family and domain databases

    InterProiIPR009608. Bradykinin.
    [Graphical view]
    PfamiPF06753. Bradykinin. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P83060-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLWFCLSFF IILCLEHFPG TLADERNVPE SEEKTEQFLR DLSEISRLQR    50
    RPPGFSPFRG KFHSQSLRDL SEISRLQRRP PGFSPFRGKF HSQSMRDLSE 100
    ISRLQRRPPG FSPFRGKFHS QSMRDLSEIS RLQRRPPGFS PFRGKFHSQS 150
    LRGLSEIKRL KTTHKIH 167
    Length:167
    Mass (Da):19,753
    Last modified:October 19, 2002 - v2
    Checksum:iCBEB4CAF3F001A9F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ316578 mRNA. Translation: CAC69834.1.
    PIRiA61361.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ316578 mRNA. Translation: CAC69834.1 .
    PIRi A61361.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG031664.

    Family and domain databases

    InterProi IPR009608. Bradykinin.
    [Graphical view ]
    Pfami PF06753. Bradykinin. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Bradykinins and their precursor cDNAs from the skin of the fire-bellied toad (Bombina orientalis)."
      Chen T., Orr D.F., Bjourson A.J., McClean S., O'Rourke M., Hirst D.G., Rao P., Shaw C.
      Peptides 23:1547-1555(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 51-59; 79-87; 107-115 AND 135-143, CHARACTERIZATION.
      Tissue: Skin and Skin secretion.

    Entry informationi

    Entry nameiBRK1_BOMOR
    AccessioniPrimary (citable) accession number: P83060
    Secondary accession number(s): Q90W16
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: October 19, 2002
    Last modified: October 1, 2014
    This is version 43 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3