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P83060

- BRK1_BOMOR

UniProt

P83060 - BRK1_BOMOR

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Protein

Kininogen-1

Gene
N/A
Organism
Bombina orientalis (Oriental fire-bellied toad)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Vasodilator. Bradykinin produces in vitro relaxation of rat arterial smooth muscle and constriction of intestinal smooth muscle. May target bradykinin receptors (BDKRB).

GO - Biological processi

  1. defense response Source: UniProtKB-KW
  2. vasodilation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Amphibian defense peptide, G-protein coupled receptor impairing toxin, Toxin, Vasoactive, Vasodilator

Names & Taxonomyi

Protein namesi
Recommended name:
Kininogen-1
Alternative name(s):
BOK-1
Cleaved into the following chain:
OrganismiBombina orientalis (Oriental fire-bellied toad)
Taxonomic identifieri8346 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraBombinatoridaeBombina

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed predictionAdd
BLAST
Chaini24 – 167144Kininogen-1PRO_0000003429Add
BLAST
Peptidei51 – 599Bradykinin1 PublicationPRO_0000003430
Peptidei79 – 879BradykininPRO_0000003431
Peptidei107 – 1159BradykininPRO_0000003432
Peptidei135 – 1439BradykininPRO_0000003433

Expressioni

Tissue specificityi

Expressed by the skin glands.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOVERGENiHBG031664.

Family and domain databases

InterProiIPR009608. Bradykinin.
[Graphical view]
PfamiPF06753. Bradykinin. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P83060-1 [UniParc]FASTAAdd to Basket

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MRLWFCLSFF IILCLEHFPG TLADERNVPE SEEKTEQFLR DLSEISRLQR    50
RPPGFSPFRG KFHSQSLRDL SEISRLQRRP PGFSPFRGKF HSQSMRDLSE 100
ISRLQRRPPG FSPFRGKFHS QSMRDLSEIS RLQRRPPGFS PFRGKFHSQS 150
LRGLSEIKRL KTTHKIH 167
Length:167
Mass (Da):19,753
Last modified:October 19, 2002 - v2
Checksum:iCBEB4CAF3F001A9F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ316578 mRNA. Translation: CAC69834.1.
PIRiA61361.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ316578 mRNA. Translation: CAC69834.1 .
PIRi A61361.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG031664.

Family and domain databases

InterProi IPR009608. Bradykinin.
[Graphical view ]
Pfami PF06753. Bradykinin. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Bradykinins and their precursor cDNAs from the skin of the fire-bellied toad (Bombina orientalis)."
    Chen T., Orr D.F., Bjourson A.J., McClean S., O'Rourke M., Hirst D.G., Rao P., Shaw C.
    Peptides 23:1547-1555(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 51-59; 79-87; 107-115 AND 135-143, CHARACTERIZATION.
    Tissue: Skin and Skin secretion.

Entry informationi

Entry nameiBRK1_BOMOR
AccessioniPrimary (citable) accession number: P83060
Secondary accession number(s): Q90W16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: November 13, 2013
This is version 42 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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