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Protein

Kininogen-1

Gene
N/A
Organism
Bombina orientalis (Oriental fire-bellied toad)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Vasodilator. Bradykinin produces in vitro relaxation of rat arterial smooth muscle and constriction of intestinal smooth muscle. May target bradykinin receptors (BDKRB).

GO - Biological processi

  1. defense response Source: UniProtKB-KW
  2. vasodilation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Amphibian defense peptide, G-protein coupled receptor impairing toxin, Toxin, Vasoactive, Vasodilator

Names & Taxonomyi

Protein namesi
Recommended name:
Kininogen-1
Alternative name(s):
BOK-1
Cleaved into the following chain:
OrganismiBombina orientalis (Oriental fire-bellied toad)Curated
Taxonomic identifieri8346 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraBombinatoridaeBombina

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 167144Kininogen-1PRO_0000003429Add
BLAST
Peptidei51 – 599BradykininPRO_0000003430
Peptidei79 – 879BradykininPRO_0000003431
Peptidei107 – 1159BradykininPRO_0000003432
Peptidei135 – 1439BradykininPRO_0000003433

Expressioni

Tissue specificityi

Expressed by the skin glands.

Family & Domainsi

Sequence similaritiesi

Belongs to the bradykinin-related peptide family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOVERGENiHBG031664.

Family and domain databases

InterProiIPR009608. Bradykinin.
[Graphical view]
PfamiPF06753. Bradykinin. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P83060-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLWFCLSFF IILCLEHFPG TLADERNVPE SEEKTEQFLR DLSEISRLQR
60 70 80 90 100
RPPGFSPFRG KFHSQSLRDL SEISRLQRRP PGFSPFRGKF HSQSMRDLSE
110 120 130 140 150
ISRLQRRPPG FSPFRGKFHS QSMRDLSEIS RLQRRPPGFS PFRGKFHSQS
160
LRGLSEIKRL KTTHKIH
Length:167
Mass (Da):19,753
Last modified:October 19, 2002 - v2
Checksum:iCBEB4CAF3F001A9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ316578 mRNA. Translation: CAC69834.1.
PIRiA61361.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ316578 mRNA. Translation: CAC69834.1.
PIRiA61361.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG031664.

Family and domain databases

InterProiIPR009608. Bradykinin.
[Graphical view]
PfamiPF06753. Bradykinin. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Bradykinins and their precursor cDNAs from the skin of the fire-bellied toad (Bombina orientalis)."
    Chen T., Orr D.F., Bjourson A.J., McClean S., O'Rourke M., Hirst D.G., Rao P., Shaw C.
    Peptides 23:1547-1555(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 51-59; 79-87; 107-115 AND 135-143, CHARACTERIZATION.
    Tissue: Skin and Skin secretion.

Entry informationi

Entry nameiBRK1_BOMOR
AccessioniPrimary (citable) accession number: P83060
Secondary accession number(s): Q90W16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: January 7, 2015
This is version 45 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.