Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Kininogen-2

Gene
N/A
Organism
Bombina variegata (Yellow-bellied toad)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

[Val1,Thr3,Thr6]bradykinin: produces in vitro relaxation of rat arterial smooth muscle and constriction of intestinal smooth muscle. May target bradykinin receptors (BDKRB).

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Amphibian defense peptide, G-protein coupled receptor impairing toxin, Toxin, Vasoactive, Vasodilator

Names & Taxonomyi

Protein namesi
Recommended name:
Kininogen-2
Alternative name(s):
BVK-2
Cleaved into the following 2 chains:
OrganismiBombina variegata (Yellow-bellied toad)Curated
Taxonomic identifieri8348 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraBombinatoridaeBombina

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 9673Kininogen-2PRO_0000003440Add
BLAST
Peptidei51 – 599[Val1,Thr3,Thr6]-bradykininPRO_0000003441
Peptidei76 – 9217Kininogen-2-associated peptidePRO_0000003442Add
BLAST

Keywords - PTMi

Cleavage on pair of basic residues

Expressioni

Tissue specificityi

Expressed by the skin glands.

Family & Domainsi

Sequence similaritiesi

Belongs to the bradykinin-related peptide family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG031664.

Family and domain databases

InterProiIPR009608. Bradykinin.
[Graphical view]
PfamiPF06753. Bradykinin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P83057-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILWFCLNFL IVLCLEHFPG TLAAERNVPQ SEEKTEQFLR DLSEISRLQR
60 70 80 90
VPTGFTPFRG KFHSQSLRGL SETKKFKAPY NIHWHCKPGL LCKNFN
Length:96
Mass (Da):11,237
Last modified:October 19, 2002 - v2
Checksum:iB78F54DE28E03B41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ318509 mRNA. Translation: CAC47938.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ318509 mRNA. Translation: CAC47938.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG031664.

Family and domain databases

InterProiIPR009608. Bradykinin.
[Graphical view]
PfamiPF06753. Bradykinin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Novel bradykinins and their precursor cDNAs from European yellow-bellied toad (Bombina variegata) skin."
    Chen T., Orr D.F., Bjourson A.J., McClean S., O'Rourke M., Hirst D.G., Rao P., Shaw C.
    Eur. J. Biochem. 269:4693-4700(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 51-59, CHARACTERIZATION.
    Tissue: Skin and Skin secretion.

Entry informationi

Entry nameiBRK2_BOMVA
AccessioniPrimary (citable) accession number: P83057
Secondary accession number(s): Q90W87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: January 7, 2015
This is version 44 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.