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Protein

Kininogen-2

Gene
N/A
Organism
Bombina variegata (Yellow-bellied toad)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

[Val1,Thr3,Thr6]bradykinin: produces in vitro relaxation of rat arterial smooth muscle and constriction of intestinal smooth muscle. May target bradykinin receptors (BDKRB).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAmphibian defense peptide, G-protein coupled receptor impairing toxin, Toxin, Vasoactive, Vasodilator

Names & Taxonomyi

Protein namesi
Recommended name:
Kininogen-2
Alternative name(s):
BVK-2
Cleaved into the following 2 chains:
OrganismiBombina variegata (Yellow-bellied toad)Curated
Taxonomic identifieri8348 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraBombinatoridaeBombina

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000344024 – 96Kininogen-2Add BLAST73
PeptideiPRO_000000344151 – 59[Val1,Thr3,Thr6]-bradykinin9
PeptideiPRO_000000344276 – 92Kininogen-2-associated peptideAdd BLAST17

Keywords - PTMi

Cleavage on pair of basic residues

Expressioni

Tissue specificityi

Expressed by the skin glands.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiP83057.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the bradykinin-related peptide family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG031664.

Family and domain databases

InterProiView protein in InterPro
IPR009608. Bradykinin.
PfamiView protein in Pfam
PF06753. Bradykinin. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P83057-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILWFCLNFL IVLCLEHFPG TLAAERNVPQ SEEKTEQFLR DLSEISRLQR
60 70 80 90
VPTGFTPFRG KFHSQSLRGL SETKKFKAPY NIHWHCKPGL LCKNFN
Length:96
Mass (Da):11,237
Last modified:October 19, 2002 - v2
Checksum:iB78F54DE28E03B41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ318509 mRNA. Translation: CAC47938.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ318509 mRNA. Translation: CAC47938.1.

3D structure databases

SMRiP83057.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG031664.

Family and domain databases

InterProiView protein in InterPro
IPR009608. Bradykinin.
PfamiView protein in Pfam
PF06753. Bradykinin. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBRK2_BOMVA
AccessioniPrimary (citable) accession number: P83057
Secondary accession number(s): Q90W87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: May 10, 2017
This is version 46 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.