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P83057 (BRK2_BOMVA) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kininogen-2
Alternative name(s):
BVK-2
OrganismBombina variegata (Yellow-bellied toad)
Taxonomic identifier8348 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraBombinatoridaeBombina

Protein attributes

Sequence length96 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

[Val1,Thr3,Thr6]bradykinin: produces in vitro relaxation of rat arterial smooth muscle and constriction of intestinal smooth muscle. May target bradykinin receptors (BDKRB).

Subcellular location

Secreted.

Tissue specificity

Expressed by the skin glands.

Sequence similarities

Belongs to the bradykinin-related peptide family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionAmphibian defense peptide
G-protein coupled receptor impairing toxin
Toxin
Vasoactive
Vasodilator
   PTMCleavage on pair of basic residues
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processdefense response

Inferred from electronic annotation. Source: UniProtKB-KW

vasodilation

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 9673Kininogen-2
PRO_0000003440
Peptide51 – 599[Val1,Thr3,Thr6]-bradykinin Ref.1
PRO_0000003441
Peptide76 – 9217Kininogen-2-associated peptide
PRO_0000003442

Sequences

Sequence LengthMass (Da)Tools
P83057 [UniParc].

Last modified October 19, 2002. Version 2.
Checksum: B78F54DE28E03B41

FASTA9611,237
        10         20         30         40         50         60 
MILWFCLNFL IVLCLEHFPG TLAAERNVPQ SEEKTEQFLR DLSEISRLQR VPTGFTPFRG 

        70         80         90 
KFHSQSLRGL SETKKFKAPY NIHWHCKPGL LCKNFN 

« Hide

References

[1]"Novel bradykinins and their precursor cDNAs from European yellow-bellied toad (Bombina variegata) skin."
Chen T., Orr D.F., Bjourson A.J., McClean S., O'Rourke M., Hirst D.G., Rao P., Shaw C.
Eur. J. Biochem. 269:4693-4700(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 51-59, CHARACTERIZATION.
Tissue: Skin and Skin secretion.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ318509 mRNA. Translation: CAC47938.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG031664.

Family and domain databases

InterProIPR009608. Bradykinin.
[Graphical view]
PfamPF06753. Bradykinin. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBRK2_BOMVA
AccessionPrimary (citable) accession number: P83057
Secondary accession number(s): Q90W87
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: November 13, 2013
This is version 41 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families