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P83056

- BRK1_BOMVA

UniProt

P83056 - BRK1_BOMVA

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Protein

Kininogen-1

Gene
N/A
Organism
Bombina variegata (Yellow-bellied toad)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

[Ala3,Thr6]bradykinin: produces in vitro relaxation of rat arterial smooth muscle and constriction of intestinal smooth muscle. Possesses insulin-releasing activity. May target bradykinin receptors (BDKRB).2 Publications

GO - Molecular functioni

  1. hormone activity Source: UniProtKB

GO - Biological processi

  1. defense response Source: UniProtKB
  2. negative regulation of smooth muscle contraction Source: UniProtKB
  3. positive regulation of smooth muscle contraction Source: UniProtKB
  4. regulation of insulin secretion Source: UniProtKB
  5. vasodilation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Amphibian defense peptide, G-protein coupled receptor impairing toxin, Toxin, Vasoactive, Vasodilator

Names & Taxonomyi

Protein namesi
Recommended name:
Kininogen-1
Alternative name(s):
BVK-1
Cleaved into the following 2 chains:
OrganismiBombina variegata (Yellow-bellied toad)
Taxonomic identifieri8348 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraBombinatoridaeBombina

Subcellular locationi

Secreted 2 Publications

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 9774Kininogen-1Sequence AnalysisPRO_0000003437Add
BLAST
Peptidei51 – 599[Ala3,Thr6]-bradykininPRO_0000003438
Peptidei76 – 9722Kininogen-1-associated peptidePRO_0000003439Add
BLAST

Keywords - PTMi

Cleavage on pair of basic residues

Expressioni

Tissue specificityi

Expressed by the skin glands.2 Publications

Family & Domainsi

Sequence similaritiesi

Belongs to the bradykinin-related peptide family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOVERGENiHBG031664.

Family and domain databases

InterProiIPR009608. Bradykinin.
[Graphical view]
PfamiPF06753. Bradykinin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P83056-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLWFCLSFL IILCVEHFPG TLAVERNVPE SEEKTEQFLR DLFEISRLQR
60 70 80 90
RPAGFTPFRG KFHSQSLRGL SETKRIYNAI WPCKHCNKCK PGLLCKK
Length:97
Mass (Da):11,427
Last modified:October 19, 2002 - v2
Checksum:i1F038BEFFF0C0908
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti95 – 973CKK → AN AA sequence (PubMed:15134346)Curated

Mass spectrometryi

Molecular mass is 1049.31±0.08 Da from positions 51 - 59. Determined by ESI. 1 Publication
Molecular mass is 2300.0 Da from positions 76 - 97. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ320269 mRNA. Translation: CAC44903.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ320269 mRNA. Translation: CAC44903.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG031664.

Family and domain databases

InterProi IPR009608. Bradykinin.
[Graphical view ]
Pfami PF06753. Bradykinin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Novel bradykinins and their precursor cDNAs from European yellow-bellied toad (Bombina variegata) skin."
    Chen T., Orr D.F., Bjourson A.J., McClean S., O'Rourke M., Hirst D.G., Rao P., Shaw C.
    Eur. J. Biochem. 269:4693-4700(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 51-59, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS SPECTROMETRY.
    Tissue: Skin1 Publication and Skin secretion1 Publication.
  2. "Skin secretion of the toad Bombina variegata contains multiple insulin-releasing peptides including bombesin and entirely novel insulinotropic structures."
    Marenah L., Flatt P.R., Orr D.F., McClean S., Shaw C., Abdel-Wahab Y.H.
    Biol. Chem. 385:315-321(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 76-97, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS SPECTROMETRY.
    Tissue: Skin secretion1 Publication.

Entry informationi

Entry nameiBRK1_BOMVA
AccessioniPrimary (citable) accession number: P83056
Secondary accession number(s): Q90W86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: October 1, 2014
This is version 48 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3