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P83056 (BRK1_BOMVA) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kininogen-1
Alternative name(s):
BVK-1

Cleaved into the following 2 chains:

  1. [Ala3,Thr6]-bradykinin
  2. Kininogen-1-associated peptide
OrganismBombina variegata (Yellow-bellied toad)
Taxonomic identifier8348 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraBombinatoridaeBombina

Protein attributes

Sequence length97 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

[Ala3,Thr6]bradykinin: produces in vitro relaxation of rat arterial smooth muscle and constriction of intestinal smooth muscle. Possesses insulin-releasing activity. May target bradykinin receptors (BDKRB). Ref.1 Ref.2

Subcellular location

Secreted Ref.1 Ref.2.

Tissue specificity

Expressed by the skin glands. Ref.1 Ref.2

Sequence similarities

Belongs to the bradykinin-related peptide family.

Mass spectrometry

Molecular mass is 1049.31±0.08 Da from positions 51 - 59. Determined by ESI. Ref.1

Molecular mass is 2300.0 Da from positions 76 - 97. Determined by ESI. Ref.2

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 9774Kininogen-1
PRO_0000003437
Peptide51 – 599[Ala3,Thr6]-bradykinin Ref.1
PRO_0000003438
Peptide76 – 9722Kininogen-1-associated peptide Ref.2
PRO_0000003439

Experimental info

Sequence conflict95 – 973CKK → AN AA sequence Ref.2

Sequences

Sequence LengthMass (Da)Tools
P83056 [UniParc].

Last modified October 19, 2002. Version 2.
Checksum: 1F038BEFFF0C0908

FASTA9711,427
        10         20         30         40         50         60 
MRLWFCLSFL IILCVEHFPG TLAVERNVPE SEEKTEQFLR DLFEISRLQR RPAGFTPFRG 

        70         80         90 
KFHSQSLRGL SETKRIYNAI WPCKHCNKCK PGLLCKK 

« Hide

References

[1]"Novel bradykinins and their precursor cDNAs from European yellow-bellied toad (Bombina variegata) skin."
Chen T., Orr D.F., Bjourson A.J., McClean S., O'Rourke M., Hirst D.G., Rao P., Shaw C.
Eur. J. Biochem. 269:4693-4700(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 51-59, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS SPECTROMETRY.
Tissue: Skin and Skin secretion.
[2]"Skin secretion of the toad Bombina variegata contains multiple insulin-releasing peptides including bombesin and entirely novel insulinotropic structures."
Marenah L., Flatt P.R., Orr D.F., McClean S., Shaw C., Abdel-Wahab Y.H.
Biol. Chem. 385:315-321(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 76-97, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS SPECTROMETRY.
Tissue: Skin secretion.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ320269 mRNA. Translation: CAC44903.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG031664.

Family and domain databases

InterProIPR009608. Bradykinin.
[Graphical view]
PfamPF06753. Bradykinin. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBRK1_BOMVA
AccessionPrimary (citable) accession number: P83056
Secondary accession number(s): Q90W86
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: November 13, 2013
This is version 47 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families