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P83055

- BRK2_BOMMX

UniProt

P83055 - BRK2_BOMMX

Protein

Kininogen-2

Gene
N/A
Organism
Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Potent vasodilator. Binds B1 (BDKRB1) and B2 (BDKRB2) bradykinin receptors.

    GO - Biological processi

    1. defense response Source: UniProtKB-KW
    2. vasodilation Source: UniProtKB-KW

    Keywords - Molecular functioni

    Amphibian defense peptide, Bradykinin receptor impairing toxin, G-protein coupled receptor impairing toxin, Toxin, Vasoactive, Vasodilator

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kininogen-2
    Alternative name(s):
    BMK-2
    Cleaved into the following 3 chains:
    OrganismiBombina maxima (Giant fire-bellied toad) (Chinese red belly toad)
    Taxonomic identifieri161274 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraBombinatoridaeBombina

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 11491Kininogen-2PRO_0000003425Add
    BLAST
    Peptidei77 – 9519MaximakininPRO_0000003426Add
    BLAST
    Peptidei87 – 959BradykininPRO_0000003427
    Peptidei105 – 1139Maximakinin-associated peptidePRO_0000003428

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei105 – 1051Pyrrolidone carboxylic acid
    Modified residuei113 – 1131Arginine amide1 Publication

    Keywords - PTMi

    Amidation, Pyrrolidone carboxylic acid

    Expressioni

    Tissue specificityi

    Expressed by the skin glands.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the bradykinin-related peptide family.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    HOVERGENiHBG031664.

    Family and domain databases

    InterProiIPR009608. Bradykinin.
    [Graphical view]
    PfamiPF06753. Bradykinin. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P83055-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLWFCLSFF IVLCLEHFPG TLADERNNRD YTIRTRLHGH HKPSRNNRYA    50
    IKTSIHGHHI PRNVPESEEK TEQFLRDLPK INRKGPRPPG FSPFRGKFHS 100
    QSLRQIPGLG PLRG 114
    Length:114
    Mass (Da):13,361
    Last modified:October 19, 2002 - v2
    Checksum:i51D4525AB970C853
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti74 – 741F → L.1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ440236 mRNA. Translation: CAD29346.1.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ440236 mRNA. Translation: CAD29346.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG031664.

    Family and domain databases

    InterProi IPR009608. Bradykinin.
    [Graphical view ]
    Pfami PF06753. Bradykinin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of maximakinin precursor cDNAs from Chinese toad, Bombina maxima, venom."
      Chen T., Bjourson A.J., McClean S., Orr D.F., O'Kane E.J., Rao P., Shaw C.
      Peptides 24:853-861(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 77-95 AND 105-114, AMIDATION AT ARG-113, VARIANT LEU-74.
      Tissue: Skin secretion.

    Entry informationi

    Entry nameiBRK2_BOMMX
    AccessioniPrimary (citable) accession number: P83055
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2001
    Last sequence update: October 19, 2002
    Last modified: October 1, 2014
    This is version 48 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3