Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Kininogen-2

Gene
N/A
Organism
Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Potent vasodilator. Binds B1 (BDKRB1) and B2 (BDKRB2) bradykinin receptors.

GO - Biological processi

  1. defense response Source: UniProtKB-KW
  2. vasodilation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Amphibian defense peptide, Bradykinin receptor impairing toxin, G-protein coupled receptor impairing toxin, Toxin, Vasoactive, Vasodilator

Names & Taxonomyi

Protein namesi
Recommended name:
Kininogen-2
Alternative name(s):
BMK-2
Cleaved into the following 3 chains:
OrganismiBombina maxima (Giant fire-bellied toad) (Chinese red belly toad)
Taxonomic identifieri161274 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraBombinatoridaeBombina

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 11491Kininogen-2PRO_0000003425Add
BLAST
Peptidei77 – 9519MaximakininPRO_0000003426Add
BLAST
Peptidei87 – 959BradykininPRO_0000003427
Peptidei105 – 1139Maximakinin-associated peptidePRO_0000003428

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei105 – 1051Pyrrolidone carboxylic acid
Modified residuei113 – 1131Arginine amide1 Publication

Keywords - PTMi

Amidation, Pyrrolidone carboxylic acid

Expressioni

Tissue specificityi

Expressed by the skin glands.

Family & Domainsi

Sequence similaritiesi

Belongs to the bradykinin-related peptide family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOVERGENiHBG031664.

Family and domain databases

InterProiIPR009608. Bradykinin.
[Graphical view]
PfamiPF06753. Bradykinin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P83055-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLWFCLSFF IVLCLEHFPG TLADERNNRD YTIRTRLHGH HKPSRNNRYA
60 70 80 90 100
IKTSIHGHHI PRNVPESEEK TEQFLRDLPK INRKGPRPPG FSPFRGKFHS
110
QSLRQIPGLG PLRG
Length:114
Mass (Da):13,361
Last modified:October 19, 2002 - v2
Checksum:i51D4525AB970C853
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti74 – 741F → L.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ440236 mRNA. Translation: CAD29346.1.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ440236 mRNA. Translation: CAD29346.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG031664.

Family and domain databases

InterProiIPR009608. Bradykinin.
[Graphical view]
PfamiPF06753. Bradykinin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of maximakinin precursor cDNAs from Chinese toad, Bombina maxima, venom."
    Chen T., Bjourson A.J., McClean S., Orr D.F., O'Kane E.J., Rao P., Shaw C.
    Peptides 24:853-861(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 77-95 AND 105-114, AMIDATION AT ARG-113, VARIANT LEU-74.
    Tissue: Skin secretion.

Entry informationi

Entry nameiBRK2_BOMMX
AccessioniPrimary (citable) accession number: P83055
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: October 19, 2002
Last modified: January 7, 2015
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.