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P83055 (BRK2_BOMMX) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kininogen-2
Alternative name(s):
BMK-2

Cleaved into the following 3 chains:

  1. Maximakinin
  2. Bradykinin
  3. Maximakinin-associated peptide
OrganismBombina maxima (Giant fire-bellied toad) (Chinese red belly toad)
Taxonomic identifier161274 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraBombinatoridaeBombina

Protein attributes

Sequence length114 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Potent vasodilator. Binds B1 (BDKRB1) and B2 (BDKRB2) bradykinin receptors.

Subcellular location

Secreted.

Tissue specificity

Expressed by the skin glands.

Sequence similarities

Belongs to the bradykinin-related peptide family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 11491Kininogen-2
PRO_0000003425
Peptide77 – 9519Maximakinin Ref.1
PRO_0000003426
Peptide87 – 959Bradykinin
PRO_0000003427
Peptide105 – 1139Maximakinin-associated peptide
PRO_0000003428

Amino acid modifications

Modified residue1051Pyrrolidone carboxylic acid
Modified residue1131Arginine amide Ref.1

Natural variations

Natural variant741F → L. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P83055 [UniParc].

Last modified October 19, 2002. Version 2.
Checksum: 51D4525AB970C853

FASTA11413,361
        10         20         30         40         50         60 
MRLWFCLSFF IVLCLEHFPG TLADERNNRD YTIRTRLHGH HKPSRNNRYA IKTSIHGHHI 

        70         80         90        100        110 
PRNVPESEEK TEQFLRDLPK INRKGPRPPG FSPFRGKFHS QSLRQIPGLG PLRG 

« Hide

References

[1]"Cloning of maximakinin precursor cDNAs from Chinese toad, Bombina maxima, venom."
Chen T., Bjourson A.J., McClean S., Orr D.F., O'Kane E.J., Rao P., Shaw C.
Peptides 24:853-861(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 77-95 AND 105-114, AMIDATION AT ARG-113, VARIANT LEU-74.
Tissue: Skin secretion.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ440236 mRNA. Translation: CAD29346.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG031664.

Family and domain databases

InterProIPR009608. Bradykinin.
[Graphical view]
PfamPF06753. Bradykinin. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBRK2_BOMMX
AccessionPrimary (citable) accession number: P83055
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: October 19, 2002
Last modified: November 13, 2013
This is version 47 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families