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P83055

- BRK2_BOMMX

UniProt

P83055 - BRK2_BOMMX

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Protein

Kininogen-2

Gene
N/A
Organism
Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Potent vasodilator. Binds B1 (BDKRB1) and B2 (BDKRB2) bradykinin receptors.

GO - Biological processi

  1. defense response Source: UniProtKB-KW
  2. vasodilation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Amphibian defense peptide, Bradykinin receptor impairing toxin, G-protein coupled receptor impairing toxin, Toxin, Vasoactive, Vasodilator

Names & Taxonomyi

Protein namesi
Recommended name:
Kininogen-2
Alternative name(s):
BMK-2
Cleaved into the following 3 chains:
OrganismiBombina maxima (Giant fire-bellied toad) (Chinese red belly toad)
Taxonomic identifieri161274 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraBombinatoridaeBombina

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 11491Kininogen-2PRO_0000003425Add
BLAST
Peptidei77 – 9519MaximakininPRO_0000003426Add
BLAST
Peptidei87 – 959BradykininPRO_0000003427
Peptidei105 – 1139Maximakinin-associated peptidePRO_0000003428

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei105 – 1051Pyrrolidone carboxylic acid
Modified residuei113 – 1131Arginine amide1 Publication

Keywords - PTMi

Amidation, Pyrrolidone carboxylic acid

Expressioni

Tissue specificityi

Expressed by the skin glands.

Family & Domainsi

Sequence similaritiesi

Belongs to the bradykinin-related peptide family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOVERGENiHBG031664.

Family and domain databases

InterProiIPR009608. Bradykinin.
[Graphical view]
PfamiPF06753. Bradykinin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P83055-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLWFCLSFF IVLCLEHFPG TLADERNNRD YTIRTRLHGH HKPSRNNRYA
60 70 80 90 100
IKTSIHGHHI PRNVPESEEK TEQFLRDLPK INRKGPRPPG FSPFRGKFHS
110
QSLRQIPGLG PLRG
Length:114
Mass (Da):13,361
Last modified:October 19, 2002 - v2
Checksum:i51D4525AB970C853
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti74 – 741F → L.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ440236 mRNA. Translation: CAD29346.1.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ440236 mRNA. Translation: CAD29346.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG031664.

Family and domain databases

InterProi IPR009608. Bradykinin.
[Graphical view ]
Pfami PF06753. Bradykinin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of maximakinin precursor cDNAs from Chinese toad, Bombina maxima, venom."
    Chen T., Bjourson A.J., McClean S., Orr D.F., O'Kane E.J., Rao P., Shaw C.
    Peptides 24:853-861(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 77-95 AND 105-114, AMIDATION AT ARG-113, VARIANT LEU-74.
    Tissue: Skin secretion.

Entry informationi

Entry nameiBRK2_BOMMX
AccessioniPrimary (citable) accession number: P83055
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: October 19, 2002
Last modified: October 29, 2014
This is version 49 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3