Reviewed, UniProtKB/Swiss-Prot P83049 (XYL2_PIG)

Names and origin

Protein names	Recommended name:     D-xylulose reductase     EC=1.1.1.9 Alternative name(s):     Xylitol dehydrogenase       Short name=XDH
Organism	Sus scrofa (Pig)
Taxonomic identifier	9823 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	134 AA.
Sequence status	Fragments.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	Xylitol + NAD(+) = D-xylulose + NADH.
Enzyme regulation	Activated by calcium and inhibited by zinc.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Xylose metabolism
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	D-xylose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	D-xylulose reductase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›134	›134	D-xylulose reductase		PRO_0000160882
Experimental info
	Non-adjacent residues	21 – 22	2
	Non-adjacent residues	37 – 38	2
	Non-adjacent residues	44 – 45	2
	Non-adjacent residues	55 – 56	2
	Non-adjacent residues	68 – 69	2
	Non-adjacent residues	76 – 77	2
	Non-adjacent residues	80 – 81	2
	Non-adjacent residues	92 – 93	2
	Non-adjacent residues	110 – 111	2
	Non-adjacent residues	128 – 129	2
	Non-terminal residue	134	1

Sequences

	Sequence		Length	Mass (Da)
	P83049-1 [UniParc]. Last modified October 1, 2001. Version 1. Checksum: 540FC39ADDBFB5DA	FASTA	134	14,858
	10 20 30 40 50 60 XXKLVESGXX LVQPGGSLRL SKXYTENVNH PATTTXYKXQ PMTPDFTEXQ THEGTHQDVF 70 80 90 100 110 120 DQPNLXXWKG NTLPEGYEPA KXGEXGTQDA NPKXXQDGDE XTXTGXXQXD KIGRYNLXPT 130 IFFEATPPKA NENQ

References

[1]	"Xylitol:NAD 2-oxidoreductase (D-xylulose reductase EC 1.1.1.9) from porcine kidney. Purification and properties." Schweiger M., Wissler J.H., Amselgruber W.M. Submitted (JUL-2001) to UniProtKB Cited for: PROTEIN SEQUENCE, COFACTOR, ENZYME REGULATION. Tissue: Kidney.

Cross-references

3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	P83049.
Family and domain databases
InterPro	IPR002328. AlcDHase_Zn_CS. [Graphical view]
PROSITE	PS00059. ADH_ZINC. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

XYL2_PIG

Accession

Primary (citable) accession number: P83049

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	October 1, 2001
Last modified:	November 4, 2008
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)