P83041 (DISI5_CERCE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Disintegrin CC5 Cleaved into the following chain: Disintegrin CC5B
Organism	Cerastes cerastes (Horned desert viper)
Taxonomic identifier	8697 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Scleroglossa › Serpentes › Colubroidea › Viperidae › Viperinae › Cerastes

Protein attributes

Sequence length	65 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds and inhibits integrins alpha-IIb/beta-3, alpha-V/beta-3 and alpha-5/beta-1.
Subunit structure	Homodimer; disulfide-linked.
Subcellular location	Secreted.
Tissue specificity	Expressed by the venom gland.
Sequence similarities	Belongs to the disintegrin family. Contains 1 disintegrin domain.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Secreted
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 65	65	Disintegrin CC5		PRO_0000045876
	Chain	2 – 65	64	Disintegrin CC5B		PRO_0000045877
Regions
	Domain	1 – 65	65	Disintegrin
	Motif	43 – 45	3	Cell attachment site By similarity
Amino acid modifications
	Disulfide bond	7 ↔ 30		By similarity
	Disulfide bond	8		Interchain By similarity
	Disulfide bond	13		Interchain By similarity
	Disulfide bond	21 ↔ 27		By similarity
	Disulfide bond	26 ↔ 51		By similarity
	Disulfide bond	39 ↔ 58		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P83041 [UniParc]. Last modified August 29, 2001. Version 1. Checksum: 558BDF91EDA596E8	FASTA	65	7,158
	10 20 30 40 50 60 MNSAHPCCDP VTCKPKRGEH CISGPCCRNC KFLSPGTICK KARGDDMNDY CTGISSDCPR NRYKS

References

[1]	"The presence of the WGD motif in CC8 heterodimeric disintegrin increases its inhibitory effect on alphaII(b)beta3, alpha(v)beta3, and alpha5beta1 integrins." Calvete J.J., Fox J.W., Agelan A., Niewiarowski S., Marcinkiewicz C. Biochemistry 41:2014-2021(2002) [PubMed: 11827548] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Venom.
+	Additional computationally mapped references.

Cross-references

3D structure databases
ProteinModelPortal	P83041.
SMR	P83041. Positions 2-63.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG005487.
Family and domain databases
InterPro	IPR001762. Blood-coag_inhib_Disintegrin. IPR018358. Disintegrin_CS. [Graphical view]
Gene3D	G3DSA:4.10.70.10. Blood-coag_inhib_Disintegrin. 1 hit.
Pfam	PF00200. Disintegrin. 1 hit. [Graphical view]
PRINTS	PR00289. DISINTEGRIN.
SMART	SM00050. DISIN. 1 hit. [Graphical view]
SUPFAM	SSF57552. Disintegrin. 1 hit.
PROSITE	PS00427. DISINTEGRIN_1. 1 hit. PS50214. DISINTEGRIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DISI5_CERCE

Accession

Primary (citable) accession number: P83041
Secondary accession number(s): P83042

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2001
Last sequence update:	August 29, 2001
Last modified:	August 10, 2010
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program