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P83038 (HDAC4_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone deacetylase 4

Short name=HD4
EC=3.5.1.98
Gene names
Name:HDAC4
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length1080 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.

Catalytic activity

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the histone deacetylase family. HD type 2 subfamily.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandMetal-binding
Zinc
   Molecular functionChromatin regulator
Hydrolase
Repressor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processB cell activation

Traceable author statement PubMed 12711221. Source: UniProtKB

B cell differentiation

Traceable author statement PubMed 12711221. Source: UniProtKB

chromatin modification

Traceable author statement PubMed 12711221. Source: UniProtKB

chromatin organization

Traceable author statement PubMed 12711221. Source: UniProtKB

histone deacetylation

Traceable author statement PubMed 12711221. Source: GOC

inflammatory response

Traceable author statement PubMed 12711221. Source: UniProtKB

negative regulation of striated muscle tissue development

Traceable author statement PubMed 12711221. Source: UniProtKB

negative regulation of transcription, DNA-templated

Traceable author statement PubMed 12711221. Source: UniProtKB

nervous system development

Traceable author statement PubMed 12711221. Source: UniProtKB

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componenthistone deacetylase complex

Traceable author statement PubMed 12711221. Source: UniProtKB

   Molecular_functionNAD-dependent histone deacetylase activity (H3-K14 specific)

Inferred from electronic annotation. Source: UniProtKB-EC

NAD-dependent histone deacetylase activity (H3-K18 specific)

Inferred from electronic annotation. Source: UniProtKB-EC

NAD-dependent histone deacetylase activity (H3-K9 specific)

Inferred from electronic annotation. Source: UniProtKB-EC

NAD-dependent histone deacetylase activity (H4-K16 specific)

Inferred from electronic annotation. Source: UniProtKB-EC

histone deacetylase activity

Traceable author statement PubMed 12711221. Source: UniProtKB

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

transcription factor binding

Traceable author statement PubMed 12711221. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10801080Histone deacetylase 4
PRO_0000114700

Regions

Region651 – 1080430Histone deacetylase

Sites

Active site7991 By similarity
Metal binding6631Zinc By similarity
Metal binding6651Zinc By similarity
Metal binding6711Zinc By similarity
Metal binding7471Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
P83038 [UniParc].

Last modified August 14, 2001. Version 1.
Checksum: B6416E2C43F1428C

FASTA1,080119,468
        10         20         30         40         50         60 
MSSQSHPDGL SGRDQPVELL NPPRVNHMPS SVDVSTALPL QVAPTSVPMD LRLDHQFPMP 

        70         80         90        100        110        120 
VTEPTLREQQ LQQELLALKQ KQQIQRQILI AEFQRQHEQL SRQHEAQLHE HIKQQEMLAM 

       130        140        150        160        170        180 
KHQQELLEHQ RKLEQHRQEQ ELEKQHREQK LQQLKNKEKG KESAVASTEV KMKLQEFVLN 

       190        200        210        220        230        240 
KKKALAHRNL NHCISSDPRF WYGKTQHSSL DQSSPPQSGV SGTYNHPVLG MYDSKDDFPL 

       250        260        270        280        290        300 
RKTASEPNLK LRSRLKQKVA ERRSSPLLRR KDGPVVTALK KRPLDVTDSA CNSAPGSGPS 

       310        320        330        340        350        360 
SPNNSSNNIS AENGITGSVT SIQAETSLAH RLVNREGSVT QLPLYTSPSL PNITLGLPAT 

       370        380        390        400        410        420 
GPSSGGSAQQ DAERLAIPAL QQRISLFPGT HLTPYLSTTT LERDGGTAHN PLLQHMVLLE 

       430        440        450        460        470        480 
QPTAQTPLVT GLPLHAQSLV GGERVSPSIH KLRQHRPLGR TQSAPLPQNA QALQQLVIQQ 

       490        500        510        520        530        540 
QHQQFLEKHK QQFQQQQLHI NKIISKPNEP ARQHESHPEE TEEELREHQA LLEEPYSDRV 

       550        560        570        580        590        600 
SSQKEVPGLA NMVQVKQEPI ESDEEEAEPQ QELESGQRQA EQELLFRQQA LLLEQQRIHQ 

       610        620        630        640        650        660 
LRNYQASLEA AGMPVSFGGH RPLSRAQSSP ASATFPMSVQ EPPTKPRFTT GLVYDTLMLK 

       670        680        690        700        710        720 
HQCTCGNTNS HPEHAGRIQS IWSRLQETGL RGKCECIRGR KATLEELQTV HSEAHTLLYG 

       730        740        750        760        770        780 
TNPLNRQKLD SKKLLGSLTS MFVRLPCGGV GVDSDTIWNE VHSSGAARLA VGCVIELVFK 

       790        800        810        820        830        840 
VATGELKNGF AVVRPPGHHA EESTPMGFCY FNSVAIAAKL LQQRLNVSKI LIVDWDVHHG 

       850        860        870        880        890        900 
NGTQQAFYND PNVLYISLHR YDDGNFFPGS GAPDEVGTGA GVGFNVNMAF TGGLDPPMGD 

       910        920        930        940        950        960 
TEYLTAFRTV VMPIANEFAP DVVLVSSGFD AVEGHPTPLG GYNLSAKCFG YLTKQLMGLA 

       970        980        990       1000       1010       1020 
GGRVVLALEG GHDLTAICDA SEACVSALLG NELDPLPEKV LQQRANANAV HSMEKVIEIH 

      1030       1040       1050       1060       1070       1080 
SKYWHSLQRY ASTVGYSLVE AQKCENEEAE TVTAMASLSV GVKPAEKRPD DEPMEEEPPL 

« Hide

References

[1]Takechi S., Azuma R., Nakayama T.
Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB052839 mRNA. Translation: BAB60957.1.
RefSeqNP_989644.1. NM_204313.1.
UniGeneGga.3689.

3D structure databases

ProteinModelPortalP83038.
SMRP83038. Positions 62-128, 646-1047.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid675230. 1 interaction.
STRING9031.ENSGALP00000006811.

Chemistry

BindingDBP83038.

Proteomic databases

PaxDbP83038.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID374207.
KEGGgga:374207.

Organism-specific databases

CTD9759.

Phylogenomic databases

eggNOGCOG0123.
HOGENOMHOG000232065.
HOVERGENHBG057100.
InParanoidP83038.
KOK11406.
PhylomeDBP83038.

Family and domain databases

Gene3D3.40.800.20. 1 hit.
InterProIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR024643. Hist_deacetylase_Gln_rich_N.
IPR017320. Histone_deAcase_II_euk.
[Graphical view]
PANTHERPTHR10625. PTHR10625. 1 hit.
PfamPF12203. HDAC4_Gln. 1 hit.
PF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFPIRSF037911. HDAC_II_euk. 1 hit.
PRINTSPR01270. HDASUPER.
ProtoNetSearch...

Other

NextBio20813711.
PROP83038.

Entry information

Entry nameHDAC4_CHICK
AccessionPrimary (citable) accession number: P83038
Entry history
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: August 14, 2001
Last modified: April 16, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families