Reviewed, UniProtKB/Swiss-Prot P83038 (HDAC4_CHICK)

Names and origin

Protein names

Recommended name:
    Histone deacetylase 4
      Short name=HD4
    EC=3.5.1.98

Gene names

Name:

HDAC4

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	1080 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.
Catalytic activity	Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the histone deacetylase family. Type 2 subfamily.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Molecular function	Chromatin regulator Hydrolase Repressor
Gene Ontology (GO)
Biological process	B cell differentiation Traceable author statement. Source: UniProtKB chromatin modification Traceable author statement. Source: UniProtKB inflammatory response Traceable author statement. Source: UniProtKB negative regulation of striated muscle tissue development Traceable author statement. Source: UniProtKB nervous system development Traceable author statement. Source: UniProtKB transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	histone deacetylase complex Traceable author statement. Source: UniProtKB
Molecular function	histone deacetylase activity Traceable author statement. Source: UniProtKB specific transcriptional repressor activity Traceable author statement. Source: UniProtKB transcription factor binding Traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1080	1080	Histone deacetylase 4		PRO_0000114700
Regions
	Region	651 – 1080	430	Histone deacetylase
Sites
	Active site	799	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P83038-1 [UniParc]. Last modified August 14, 2001. Version 1. Checksum: B6416E2C43F1428C	FASTA	1,080	119,468
	10 20 30 40 50 60 MSSQSHPDGL SGRDQPVELL NPPRVNHMPS SVDVSTALPL QVAPTSVPMD LRLDHQFPMP 70 80 90 100 110 120 VTEPTLREQQ LQQELLALKQ KQQIQRQILI AEFQRQHEQL SRQHEAQLHE HIKQQEMLAM 130 140 150 160 170 180 KHQQELLEHQ RKLEQHRQEQ ELEKQHREQK LQQLKNKEKG KESAVASTEV KMKLQEFVLN 190 200 210 220 230 240 KKKALAHRNL NHCISSDPRF WYGKTQHSSL DQSSPPQSGV SGTYNHPVLG MYDSKDDFPL 250 260 270 280 290 300 RKTASEPNLK LRSRLKQKVA ERRSSPLLRR KDGPVVTALK KRPLDVTDSA CNSAPGSGPS 310 320 330 340 350 360 SPNNSSNNIS AENGITGSVT SIQAETSLAH RLVNREGSVT QLPLYTSPSL PNITLGLPAT 370 380 390 400 410 420 GPSSGGSAQQ DAERLAIPAL QQRISLFPGT HLTPYLSTTT LERDGGTAHN PLLQHMVLLE 430 440 450 460 470 480 QPTAQTPLVT GLPLHAQSLV GGERVSPSIH KLRQHRPLGR TQSAPLPQNA QALQQLVIQQ 490 500 510 520 530 540 QHQQFLEKHK QQFQQQQLHI NKIISKPNEP ARQHESHPEE TEEELREHQA LLEEPYSDRV 550 560 570 580 590 600 SSQKEVPGLA NMVQVKQEPI ESDEEEAEPQ QELESGQRQA EQELLFRQQA LLLEQQRIHQ 610 620 630 640 650 660 LRNYQASLEA AGMPVSFGGH RPLSRAQSSP ASATFPMSVQ EPPTKPRFTT GLVYDTLMLK 670 680 690 700 710 720 HQCTCGNTNS HPEHAGRIQS IWSRLQETGL RGKCECIRGR KATLEELQTV HSEAHTLLYG 730 740 750 760 770 780 TNPLNRQKLD SKKLLGSLTS MFVRLPCGGV GVDSDTIWNE VHSSGAARLA VGCVIELVFK 790 800 810 820 830 840 VATGELKNGF AVVRPPGHHA EESTPMGFCY FNSVAIAAKL LQQRLNVSKI LIVDWDVHHG 850 860 870 880 890 900 NGTQQAFYND PNVLYISLHR YDDGNFFPGS GAPDEVGTGA GVGFNVNMAF TGGLDPPMGD 910 920 930 940 950 960 TEYLTAFRTV VMPIANEFAP DVVLVSSGFD AVEGHPTPLG GYNLSAKCFG YLTKQLMGLA 970 980 990 1000 1010 1020 GGRVVLALEG GHDLTAICDA SEACVSALLG NELDPLPEKV LQQRANANAV HSMEKVIEIH 1030 1040 1050 1060 1070 1080 SKYWHSLQRY ASTVGYSLVE AQKCENEEAE TVTAMASLSV GVKPAEKRPD DEPMEEEPPL

References

[1]	Takechi S., Azuma R., Nakayama T. Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB052839 mRNA. Translation: BAB60957.1.
IPI	IPI00597373.
RefSeq	NP_989644.1.
UniGene	Gga.3689
3D structure databases
SMR	P83038. Positions 648-1029.
ModBase	Search...
Protein-protein interaction databases
STRING	P83038.
Genome annotation databases
Ensembl	ENSGALT00000006822; ENSGALP00000006811; ENSGALG00000004288; Gallus gallus. [Genome view]
GeneID	374207.
KEGG	gga:374207.
Organism-specific databases
CTD	374207.
Phylogenomic databases
HOGENOM	P83038.
HOVERGEN	P83038.
Family and domain databases
InterPro	IPR000286. His_deacetylse. IPR017320. Histone_deAcase_II_euk. [Graphical view]
Gene3D	G3DSA:3.40.800.20. His_deacetylse. 1 hit.
PANTHER	PTHR10625. His_deacetylse. 1 hit.
Pfam	PF00850. Hist_deacetyl. 1 hit. [Graphical view]
PIRSF	PIRSF037911. HDAC_II_euk. 1 hit.
PRINTS	PR01270. HDASUPER.
ProtoNet	Search...

Entry information

Entry name

HDAC4_CHICK

Accession

Primary (citable) accession number: P83038

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 14, 2001
Last sequence update:	August 14, 2001
Last modified:	September 1, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)