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P83038

- HDAC4_CHICK

UniProt

P83038 - HDAC4_CHICK

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Protein

Histone deacetylase 4

Gene
HDAC4
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi663 – 6631Zinc By similarity
Metal bindingi665 – 6651Zinc By similarity
Metal bindingi671 – 6711Zinc By similarity
Metal bindingi747 – 7471Zinc By similarity
Active sitei799 – 7991 By similarity

GO - Molecular functioni

  1. histone deacetylase activity Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW
  3. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  5. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  6. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
  7. transcription factor binding Source: UniProtKB

GO - Biological processi

  1. B cell activation Source: UniProtKB
  2. B cell differentiation Source: UniProtKB
  3. chromatin modification Source: UniProtKB
  4. chromatin organization Source: UniProtKB
  5. histone deacetylation Source: GOC
  6. inflammatory response Source: UniProtKB
  7. negative regulation of striated muscle tissue development Source: UniProtKB
  8. negative regulation of transcription, DNA-templated Source: UniProtKB
  9. nervous system development Source: UniProtKB
  10. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 4 (EC:3.5.1.98)
Short name:
HD4
Gene namesi
Name:HDAC4
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. histone deacetylase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10801080Histone deacetylase 4PRO_0000114700Add
BLAST

Proteomic databases

PaxDbiP83038.

Interactioni

Protein-protein interaction databases

BioGridi675230. 1 interaction.
STRINGi9031.ENSGALP00000006811.

Structurei

3D structure databases

ProteinModelPortaliP83038.
SMRiP83038. Positions 62-128, 646-1047.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni651 – 1080430Histone deacetylaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0123.
HOGENOMiHOG000232065.
HOVERGENiHBG057100.
InParanoidiP83038.
KOiK11406.
PhylomeDBiP83038.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR024643. Hist_deacetylase_Gln_rich_N.
IPR017320. Histone_deAcase_II_euk.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF12203. HDAC4_Gln. 1 hit.
PF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037911. HDAC_II_euk. 1 hit.
PRINTSiPR01270. HDASUPER.

Sequencei

Sequence statusi: Complete.

P83038-1 [UniParc]FASTAAdd to Basket

« Hide

MSSQSHPDGL SGRDQPVELL NPPRVNHMPS SVDVSTALPL QVAPTSVPMD     50
LRLDHQFPMP VTEPTLREQQ LQQELLALKQ KQQIQRQILI AEFQRQHEQL 100
SRQHEAQLHE HIKQQEMLAM KHQQELLEHQ RKLEQHRQEQ ELEKQHREQK 150
LQQLKNKEKG KESAVASTEV KMKLQEFVLN KKKALAHRNL NHCISSDPRF 200
WYGKTQHSSL DQSSPPQSGV SGTYNHPVLG MYDSKDDFPL RKTASEPNLK 250
LRSRLKQKVA ERRSSPLLRR KDGPVVTALK KRPLDVTDSA CNSAPGSGPS 300
SPNNSSNNIS AENGITGSVT SIQAETSLAH RLVNREGSVT QLPLYTSPSL 350
PNITLGLPAT GPSSGGSAQQ DAERLAIPAL QQRISLFPGT HLTPYLSTTT 400
LERDGGTAHN PLLQHMVLLE QPTAQTPLVT GLPLHAQSLV GGERVSPSIH 450
KLRQHRPLGR TQSAPLPQNA QALQQLVIQQ QHQQFLEKHK QQFQQQQLHI 500
NKIISKPNEP ARQHESHPEE TEEELREHQA LLEEPYSDRV SSQKEVPGLA 550
NMVQVKQEPI ESDEEEAEPQ QELESGQRQA EQELLFRQQA LLLEQQRIHQ 600
LRNYQASLEA AGMPVSFGGH RPLSRAQSSP ASATFPMSVQ EPPTKPRFTT 650
GLVYDTLMLK HQCTCGNTNS HPEHAGRIQS IWSRLQETGL RGKCECIRGR 700
KATLEELQTV HSEAHTLLYG TNPLNRQKLD SKKLLGSLTS MFVRLPCGGV 750
GVDSDTIWNE VHSSGAARLA VGCVIELVFK VATGELKNGF AVVRPPGHHA 800
EESTPMGFCY FNSVAIAAKL LQQRLNVSKI LIVDWDVHHG NGTQQAFYND 850
PNVLYISLHR YDDGNFFPGS GAPDEVGTGA GVGFNVNMAF TGGLDPPMGD 900
TEYLTAFRTV VMPIANEFAP DVVLVSSGFD AVEGHPTPLG GYNLSAKCFG 950
YLTKQLMGLA GGRVVLALEG GHDLTAICDA SEACVSALLG NELDPLPEKV 1000
LQQRANANAV HSMEKVIEIH SKYWHSLQRY ASTVGYSLVE AQKCENEEAE 1050
TVTAMASLSV GVKPAEKRPD DEPMEEEPPL 1080
Length:1,080
Mass (Da):119,468
Last modified:August 14, 2001 - v1
Checksum:iB6416E2C43F1428C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB052839 mRNA. Translation: BAB60957.1.
RefSeqiNP_989644.1. NM_204313.1.
UniGeneiGga.3689.

Genome annotation databases

GeneIDi374207.
KEGGigga:374207.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB052839 mRNA. Translation: BAB60957.1 .
RefSeqi NP_989644.1. NM_204313.1.
UniGenei Gga.3689.

3D structure databases

ProteinModelPortali P83038.
SMRi P83038. Positions 62-128, 646-1047.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 675230. 1 interaction.
STRINGi 9031.ENSGALP00000006811.

Chemistry

BindingDBi P83038.

Proteomic databases

PaxDbi P83038.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 374207.
KEGGi gga:374207.

Organism-specific databases

CTDi 9759.

Phylogenomic databases

eggNOGi COG0123.
HOGENOMi HOG000232065.
HOVERGENi HBG057100.
InParanoidi P83038.
KOi K11406.
PhylomeDBi P83038.

Miscellaneous databases

NextBioi 20813711.
PROi P83038.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR024643. Hist_deacetylase_Gln_rich_N.
IPR017320. Histone_deAcase_II_euk.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF12203. HDAC4_Gln. 1 hit.
PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PIRSFi PIRSF037911. HDAC_II_euk. 1 hit.
PRINTSi PR01270. HDASUPER.
ProtoNeti Search...

Publicationsi

  1. Takechi S., Azuma R., Nakayama T.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiHDAC4_CHICK
AccessioniPrimary (citable) accession number: P83038
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: August 14, 2001
Last modified: April 16, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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