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Protein

Histone deacetylase 4

Gene

HDAC4

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).By similarity

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi663 – 6631ZincBy similarity
Metal bindingi665 – 6651ZincBy similarity
Metal bindingi671 – 6711ZincBy similarity
Metal bindingi747 – 7471ZincBy similarity
Active sitei799 – 7991By similarity

GO - Molecular functioni

  • histone deacetylase activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  • transcription factor binding Source: UniProtKB

GO - Biological processi

  • B cell activation Source: UniProtKB
  • B cell differentiation Source: UniProtKB
  • chromatin modification Source: UniProtKB
  • chromatin organization Source: UniProtKB
  • histone deacetylation Source: GOC
  • inflammatory response Source: UniProtKB
  • negative regulation of striated muscle tissue development Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • nervous system development Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 4 (EC:3.5.1.98)
Short name:
HD4
Gene namesi
Name:HDAC4
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • histone deacetylase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10801080Histone deacetylase 4PRO_0000114700Add
BLAST

Proteomic databases

PaxDbiP83038.

Interactioni

Protein-protein interaction databases

BioGridi675230. 1 interaction.
STRINGi9031.ENSGALP00000006811.

Structurei

3D structure databases

ProteinModelPortaliP83038.
SMRiP83038. Positions 62-128, 646-1047.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni651 – 1080430Histone deacetylaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0123.
HOGENOMiHOG000232065.
HOVERGENiHBG057100.
InParanoidiP83038.
KOiK11406.
PhylomeDBiP83038.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR024643. Hist_deacetylase_Gln_rich_N.
IPR017320. Histone_deAcase_II_euk.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF12203. HDAC4_Gln. 1 hit.
PF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037911. HDAC_II_euk. 1 hit.
PRINTSiPR01270. HDASUPER.

Sequencei

Sequence statusi: Complete.

P83038-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSQSHPDGL SGRDQPVELL NPPRVNHMPS SVDVSTALPL QVAPTSVPMD
60 70 80 90 100
LRLDHQFPMP VTEPTLREQQ LQQELLALKQ KQQIQRQILI AEFQRQHEQL
110 120 130 140 150
SRQHEAQLHE HIKQQEMLAM KHQQELLEHQ RKLEQHRQEQ ELEKQHREQK
160 170 180 190 200
LQQLKNKEKG KESAVASTEV KMKLQEFVLN KKKALAHRNL NHCISSDPRF
210 220 230 240 250
WYGKTQHSSL DQSSPPQSGV SGTYNHPVLG MYDSKDDFPL RKTASEPNLK
260 270 280 290 300
LRSRLKQKVA ERRSSPLLRR KDGPVVTALK KRPLDVTDSA CNSAPGSGPS
310 320 330 340 350
SPNNSSNNIS AENGITGSVT SIQAETSLAH RLVNREGSVT QLPLYTSPSL
360 370 380 390 400
PNITLGLPAT GPSSGGSAQQ DAERLAIPAL QQRISLFPGT HLTPYLSTTT
410 420 430 440 450
LERDGGTAHN PLLQHMVLLE QPTAQTPLVT GLPLHAQSLV GGERVSPSIH
460 470 480 490 500
KLRQHRPLGR TQSAPLPQNA QALQQLVIQQ QHQQFLEKHK QQFQQQQLHI
510 520 530 540 550
NKIISKPNEP ARQHESHPEE TEEELREHQA LLEEPYSDRV SSQKEVPGLA
560 570 580 590 600
NMVQVKQEPI ESDEEEAEPQ QELESGQRQA EQELLFRQQA LLLEQQRIHQ
610 620 630 640 650
LRNYQASLEA AGMPVSFGGH RPLSRAQSSP ASATFPMSVQ EPPTKPRFTT
660 670 680 690 700
GLVYDTLMLK HQCTCGNTNS HPEHAGRIQS IWSRLQETGL RGKCECIRGR
710 720 730 740 750
KATLEELQTV HSEAHTLLYG TNPLNRQKLD SKKLLGSLTS MFVRLPCGGV
760 770 780 790 800
GVDSDTIWNE VHSSGAARLA VGCVIELVFK VATGELKNGF AVVRPPGHHA
810 820 830 840 850
EESTPMGFCY FNSVAIAAKL LQQRLNVSKI LIVDWDVHHG NGTQQAFYND
860 870 880 890 900
PNVLYISLHR YDDGNFFPGS GAPDEVGTGA GVGFNVNMAF TGGLDPPMGD
910 920 930 940 950
TEYLTAFRTV VMPIANEFAP DVVLVSSGFD AVEGHPTPLG GYNLSAKCFG
960 970 980 990 1000
YLTKQLMGLA GGRVVLALEG GHDLTAICDA SEACVSALLG NELDPLPEKV
1010 1020 1030 1040 1050
LQQRANANAV HSMEKVIEIH SKYWHSLQRY ASTVGYSLVE AQKCENEEAE
1060 1070 1080
TVTAMASLSV GVKPAEKRPD DEPMEEEPPL
Length:1,080
Mass (Da):119,468
Last modified:August 14, 2001 - v1
Checksum:iB6416E2C43F1428C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052839 mRNA. Translation: BAB60957.1.
RefSeqiNP_989644.1. NM_204313.1.
UniGeneiGga.3689.

Genome annotation databases

GeneIDi374207.
KEGGigga:374207.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052839 mRNA. Translation: BAB60957.1.
RefSeqiNP_989644.1. NM_204313.1.
UniGeneiGga.3689.

3D structure databases

ProteinModelPortaliP83038.
SMRiP83038. Positions 62-128, 646-1047.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi675230. 1 interaction.
STRINGi9031.ENSGALP00000006811.

Proteomic databases

PaxDbiP83038.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi374207.
KEGGigga:374207.

Organism-specific databases

CTDi9759.

Phylogenomic databases

eggNOGiCOG0123.
HOGENOMiHOG000232065.
HOVERGENiHBG057100.
InParanoidiP83038.
KOiK11406.
PhylomeDBiP83038.

Miscellaneous databases

NextBioi20813711.
PROiP83038.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR024643. Hist_deacetylase_Gln_rich_N.
IPR017320. Histone_deAcase_II_euk.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF12203. HDAC4_Gln. 1 hit.
PF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037911. HDAC_II_euk. 1 hit.
PRINTSiPR01270. HDASUPER.
ProtoNetiSearch...

Publicationsi

  1. Takechi S., Azuma R., Nakayama T.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiHDAC4_CHICK
AccessioniPrimary (citable) accession number: P83038
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: August 14, 2001
Last modified: July 22, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.