Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Histone deacetylase 4

Gene

HDAC4

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).By similarity

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi663ZincBy similarity1
Metal bindingi665ZincBy similarity1
Metal bindingi671ZincBy similarity1
Metal bindingi747ZincBy similarity1
Active sitei799By similarity1

GO - Molecular functioni

  • histone deacetylase activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  • transcription factor binding Source: UniProtKB

GO - Biological processi

  • B cell activation Source: UniProtKB
  • B cell differentiation Source: UniProtKB
  • chromatin organization Source: UniProtKB
  • inflammatory response Source: UniProtKB
  • negative regulation of striated muscle tissue development Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • nervous system development Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulator, Hydrolase, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-GGA-4551638 SUMOylation of chromatin organization proteins
R-GGA-8951936 RUNX3 regulates p14-ARF

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 4 (EC:3.5.1.98)
Short name:
HD4
Gene namesi
Name:HDAC4
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001147001 – 1080Histone deacetylase 4Add BLAST1080

Proteomic databases

PaxDbiP83038
PRIDEiP83038

Expressioni

Gene expression databases

ExpressionAtlasiP83038 baseline and differential

Interactioni

GO - Molecular functioni

  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi675230, 1 interactor
STRINGi9031.ENSGALP00000006811

Structurei

3D structure databases

ProteinModelPortaliP83038
SMRiP83038
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni651 – 1080Histone deacetylaseAdd BLAST430

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi348 – 353PxLPxI/LBy similarity6

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1343 Eukaryota
COG0123 LUCA
GeneTreeiENSGT00530000062809
HOGENOMiHOG000232065
HOVERGENiHBG057100
InParanoidiP83038
KOiK11406
PhylomeDBiP83038

Family and domain databases

Gene3Di3.40.800.20, 1 hit
InterProiView protein in InterPro
IPR033660 HDAC4
IPR000286 His_deacetylse
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR024643 Hist_deacetylase_Gln_rich_N
IPR017320 Histone_deAcase_II_euk
IPR023696 Ureohydrolase_dom_sf
PANTHERiPTHR10625 PTHR10625, 1 hit
PTHR10625:SF100 PTHR10625:SF100, 1 hit
PfamiView protein in Pfam
PF12203 HDAC4_Gln, 1 hit
PF00850 Hist_deacetyl, 1 hit
PIRSFiPIRSF037911 HDAC_II_euk, 1 hit
PRINTSiPR01270 HDASUPER
SUPFAMiSSF52768 SSF52768, 1 hit

Sequencei

Sequence statusi: Complete.

P83038-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSQSHPDGL SGRDQPVELL NPPRVNHMPS SVDVSTALPL QVAPTSVPMD
60 70 80 90 100
LRLDHQFPMP VTEPTLREQQ LQQELLALKQ KQQIQRQILI AEFQRQHEQL
110 120 130 140 150
SRQHEAQLHE HIKQQEMLAM KHQQELLEHQ RKLEQHRQEQ ELEKQHREQK
160 170 180 190 200
LQQLKNKEKG KESAVASTEV KMKLQEFVLN KKKALAHRNL NHCISSDPRF
210 220 230 240 250
WYGKTQHSSL DQSSPPQSGV SGTYNHPVLG MYDSKDDFPL RKTASEPNLK
260 270 280 290 300
LRSRLKQKVA ERRSSPLLRR KDGPVVTALK KRPLDVTDSA CNSAPGSGPS
310 320 330 340 350
SPNNSSNNIS AENGITGSVT SIQAETSLAH RLVNREGSVT QLPLYTSPSL
360 370 380 390 400
PNITLGLPAT GPSSGGSAQQ DAERLAIPAL QQRISLFPGT HLTPYLSTTT
410 420 430 440 450
LERDGGTAHN PLLQHMVLLE QPTAQTPLVT GLPLHAQSLV GGERVSPSIH
460 470 480 490 500
KLRQHRPLGR TQSAPLPQNA QALQQLVIQQ QHQQFLEKHK QQFQQQQLHI
510 520 530 540 550
NKIISKPNEP ARQHESHPEE TEEELREHQA LLEEPYSDRV SSQKEVPGLA
560 570 580 590 600
NMVQVKQEPI ESDEEEAEPQ QELESGQRQA EQELLFRQQA LLLEQQRIHQ
610 620 630 640 650
LRNYQASLEA AGMPVSFGGH RPLSRAQSSP ASATFPMSVQ EPPTKPRFTT
660 670 680 690 700
GLVYDTLMLK HQCTCGNTNS HPEHAGRIQS IWSRLQETGL RGKCECIRGR
710 720 730 740 750
KATLEELQTV HSEAHTLLYG TNPLNRQKLD SKKLLGSLTS MFVRLPCGGV
760 770 780 790 800
GVDSDTIWNE VHSSGAARLA VGCVIELVFK VATGELKNGF AVVRPPGHHA
810 820 830 840 850
EESTPMGFCY FNSVAIAAKL LQQRLNVSKI LIVDWDVHHG NGTQQAFYND
860 870 880 890 900
PNVLYISLHR YDDGNFFPGS GAPDEVGTGA GVGFNVNMAF TGGLDPPMGD
910 920 930 940 950
TEYLTAFRTV VMPIANEFAP DVVLVSSGFD AVEGHPTPLG GYNLSAKCFG
960 970 980 990 1000
YLTKQLMGLA GGRVVLALEG GHDLTAICDA SEACVSALLG NELDPLPEKV
1010 1020 1030 1040 1050
LQQRANANAV HSMEKVIEIH SKYWHSLQRY ASTVGYSLVE AQKCENEEAE
1060 1070 1080
TVTAMASLSV GVKPAEKRPD DEPMEEEPPL
Length:1,080
Mass (Da):119,468
Last modified:August 14, 2001 - v1
Checksum:iB6416E2C43F1428C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052839 mRNA Translation: BAB60957.1
RefSeqiNP_989644.1, NM_204313.1
XP_015144580.1, XM_015289094.1
UniGeneiGga.3689

Genome annotation databases

EnsembliENSGALT00000033739; ENSGALP00000033098; ENSGALG00000004288
GeneIDi374207
KEGGigga:374207

Similar proteinsi

Entry informationi

Entry nameiHDAC4_CHICK
AccessioniPrimary (citable) accession number: P83038
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: August 14, 2001
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health