Reviewed,
UniProtKB/Swiss-Prot P83038 (HDAC4_CHICK)
Last modified
September 1, 2009.
Version 46.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Histone deacetylase 4 Short name=HD4 EC=3.5.1.98 | ||
| Gene names |
| ||
| Organism | Gallus gallus (Chicken) | ||
| Taxonomic identifier | 9031 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus |
Protein attributes
| Sequence length | 1080 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity. |
| Catalytic activity | Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone. |
| Subcellular location | Nucleus By similarity. |
| Sequence similarities | Belongs to the histone deacetylase family. Type 2 subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Nucleus |
| Molecular function | Chromatin regulator Hydrolase Repressor |
| Gene Ontology (GO) | |
| Biological process | B cell differentiation Traceable author statement. Source: UniProtKB chromatin modificationTraceable author statement. Source: UniProtKB inflammatory responseTraceable author statement. Source: UniProtKB negative regulation of striated muscle tissue developmentTraceable author statement. Source: UniProtKB nervous system developmentTraceable author statement. Source: UniProtKB transcriptionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | histone deacetylase complex Traceable author statement. Source: UniProtKB |
| Molecular function | histone deacetylase activity Traceable author statement. Source: UniProtKB specific transcriptional repressor activityTraceable author statement. Source: UniProtKB transcription factor bindingTraceable author statement. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1080 | 1080 | Histone deacetylase 4 | PRO_0000114700 | |||||
Regions | |||||||||
| Region | 651 – 1080 | 430 | Histone deacetylase | ||||||
Sites | |||||||||
| Active site | 799 | 1 | By similarity | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | Takechi S., Azuma R., Nakayama T. Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
Cross-references
Sequence databases | |
|---|---|
| AB052839 mRNA. Translation: BAB60957.1. | |
| IPI | IPI00597373. |
| RefSeq | NP_989644.1. |
| UniGene | Gga.3689 |
3D structure databases | |
| SMR | P83038. Positions 648-1029. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P83038. |
Genome annotation databases | |
| Ensembl | ENSGALT00000006822; ENSGALP00000006811; ENSGALG00000004288; Gallus gallus. [Genome view] |
| GeneID | 374207. |
| KEGG | gga:374207. |
Organism-specific databases | |
| CTD | 374207. |
Phylogenomic databases | |
| HOGENOM | P83038. |
| HOVERGEN | P83038. |
Family and domain databases | |
| InterPro | IPR000286. His_deacetylse. IPR017320. Histone_deAcase_II_euk. [Graphical view] |
| Gene3D | G3DSA:3.40.800.20. His_deacetylse. 1 hit. |
| PANTHER | PTHR10625. His_deacetylse. 1 hit. |
| Pfam | PF00850. Hist_deacetyl. 1 hit. [Graphical view] |
| PIRSF | PIRSF037911. HDAC_II_euk. 1 hit. |
| PRINTS | PR01270. HDASUPER. |
| ProtoNet | Search... |
Entry information
| Entry name | HDAC4_CHICK | ||||||||
| Accession | Primary (citable) accession number: P83038 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||

Clusters with


