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Reviewed, UniProtKB/Swiss-Prot P82987 (ATL3_HUMAN)

Last modified June 16, 2009. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    ADAMTS-like protein 3
      Short name=ADAMTSL-3
Alternative name(s):
    Punctin-2
Gene names
Name: ADAMTSL3
Synonyms: KIAA1233
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length1691 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Subcellular location

Secreted › extracellular space › extracellular matrix. Ref.2

Tissue specificity

Widely expressed, with highest in liver, kidney, heart and skeletal muscle. Ref.2

Sequence similarities

Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Contains 1 PLAC domain.

Contains 10 TSP type-1 domains.

Caution

Although strongly similar to members of the ADAMTS family it lacks the metalloprotease and disintegrin-like domains which are typical of that family.

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Ontologies

Keywords
   Cellular componentExtracellular matrix
Secreted
   Coding sequence diversityPolymorphism
   DomainRepeat
Signal
   PTMDisulfide bond
Glycoprotein
Gene Ontology (GO)
   Cellular componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-SubCell

proteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionmetallopeptidase activity

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 16911665ADAMTS-like protein 3
PRO_0000249684

Regions

Domain75 – 12450TSP type-1 1
Domain418 – 46851TSP type-1 2
Domain478 – 53558TSP type-1 3
Domain564 – 62663TSP type-1 4
Domain703 – 76058TSP type-1 5
Domain763 – 81856TSP type-1 6
Domain819 – 88163TSP type-1 7
Domain896 – 99297Ig-like C2-type 1
Domain1185 – 127995Ig-like C2-type 2
Domain1296 – 137883Ig-like C2-type 3
Domain1424 – 148259TSP type-1 8
Domain1483 – 154563TSP type-1 9
Domain1597 – 164448TSP type-1 10
Domain1655 – 169137PLAC

Amino acid modifications

Glycosylation2931N-linked (GlcNAc...) Potential
Glycosylation6811N-linked (GlcNAc...) Potential
Glycosylation7971N-linked (GlcNAc...) Potential
Glycosylation9151N-linked (GlcNAc...) Potential
Glycosylation9271N-linked (GlcNAc...) Potential
Glycosylation11021N-linked (GlcNAc...) Potential
Glycosylation11911N-linked (GlcNAc...) Potential
Glycosylation12921N-linked (GlcNAc...) Potential
Glycosylation13161N-linked (GlcNAc...) Potential
Glycosylation13301N-linked (GlcNAc...) Potential
Glycosylation13431N-linked (GlcNAc...) Potential
Glycosylation13491N-linked (GlcNAc...) Potential
Glycosylation13561N-linked (GlcNAc...) Potential
Glycosylation14321N-linked (GlcNAc...) Potential
Glycosylation15161N-linked (GlcNAc...) Potential
Glycosylation15741N-linked (GlcNAc...) Potential
Glycosylation15911N-linked (GlcNAc...) Potential
Disulfide bond87 ↔ 118 By similarity
Disulfide bond91 ↔ 123 By similarity
Disulfide bond102 ↔ 108 By similarity
Disulfide bond576 ↔ 620 By similarity
Disulfide bond580 ↔ 625 By similarity
Disulfide bond591 ↔ 609 By similarity
Disulfide bond831 ↔ 875 By similarity
Disulfide bond835 ↔ 880 By similarity
Disulfide bond846 ↔ 863 By similarity
Disulfide bond934 ↔ 982 By similarity
Disulfide bond1215 ↔ 1263 By similarity
Disulfide bond1321 ↔ 1367 By similarity

Natural variations

Natural variant1461H → R: dbSNP rs4483821.
VAR_027478
Natural variant2901V → L: dbSNP rs4144691.
VAR_027479
Natural variant3301V → M in a colorectal cancer sample; somatic mutation. Ref.4
VAR_035809
Natural variant5871R → H in a colorectal cancer sample; somatic mutation. Ref.4
VAR_035810
Natural variant6611L → V: dbSNP rs4842838.
VAR_027480
Natural variant7131G → R: dbSNP rs34047645.
VAR_057365
Natural variant8551R → C in a colorectal cancer sample; somatic mutation. Ref.4
VAR_035811
Natural variant8551R → H: dbSNP rs2277848. Ref.4
VAR_027481
Natural variant8691L → F: dbSNP rs2277849.
VAR_027482
Natural variant13151A → E in a colorectal cancer sample; somatic mutation. Ref.4
VAR_035812
Natural variant13701T → A: dbSNP rs17158450.
VAR_027483
Natural variant15581M → T: dbSNP rs7175910.
VAR_027484
Natural variant16601T → I: dbSNP rs950169.
VAR_027485
Natural variant16791R → H: dbSNP rs11857906.
VAR_027486

Experimental info

Sequence conflict2651A → V in AAK15041. Ref.2
Sequence conflict2681V → F in AAK15041. Ref.2

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Sequences

Sequence LengthMass (Da)Tools
P82987-1 [UniParc].

Last modified September 19, 2006. Version 2.
Checksum: E6AAF7C742116933

FASTA1,691188,644
        10         20         30         40         50         60 
MASWTSPWWV LIGMVFMHSP LPQTTAEKSP GAYFLPEFAL SPQGSFLEDT TGEQFLTYRY 

        70         80         90        100        110        120 
DDQTSRNTRS DEDKDGNWDA WGDWSDCSRT CGGGASYSLR RCLTGRNCEG QNIRYKTCSN 

       130        140        150        160        170        180 
HDCPPDAEDF RAQQCSAYND VQYQGHYYEW LPRYNDPAAP CALKCHAQGQ NLVVELAPKV 

       190        200        210        220        230        240 
LDGTRCNTDS LDMCISGICQ AVGCDRQLGS NAKEDNCGVC AGDGSTCRLV RGQSKSHVSP 

       250        260        270        280        290        300 
EKREENVIAV PLGSRSVRIT VKGPAHLVIE SKTLQGSKGE HSFNSPGVFV VENTTVEFQR 

       310        320        330        340        350        360 
GSERQTFKIP GPLMADFIFK TRYTAAKDSV VQFFFYQPIS HQWRQTDFFP CTVTCGGGYQ 

       370        380        390        400        410        420 
LNSAECVDIR LKRVVPDHYC HYYPENVKPK PKLKECSMDP CPSSDGFKEI MPYDHFQPLP 

       430        440        450        460        470        480 
RWEHNPWTAC SVSCGGGIQR RSFVCVEESM HGEILQVEEW KCMYAPKPKV MQTCNLFDCP 

       490        500        510        520        530        540 
KWIAMEWSQC TVTCGRGLRY RVVLCINHRG EHVGGCNPQL KLHIKEECVI PIPCYKPKEK 

       550        560        570        580        590        600 
SPVEAKLPWL KQAQELEETR IATEEPTFIP EPWSACSTTC GPGVQVREVK CRVLLTFTQT 

       610        620        630        640        650        660 
ETELPEEECE GPKLPTERPC LLEACDESPA SRELDIPLPE DSETTYDWEY AGFTPCTATC 

       670        680        690        700        710        720 
LGGHQEAIAV CLHIQTQQTV NDSLCDMVHR PPAMSQACNT EPCPPRWHVG SWGPCSATCG 

       730        740        750        760        770        780 
VGIQTRDVYC LHPGETPAPP EECRDEKPHA LQACNQFDCP PGWHIEEWQQ CSRTCGGGTQ 

       790        800        810        820        830        840 
NRRVTCRQLL TDGSFLNLSD ELCQGPKASS HKSCARTDCP PHLAVGDWSK CSVSCGVGIQ 

       850        860        870        880        890        900 
RRKQVCQRLA AKGRRIPLSE MMCRDLPGLP LVRSCQMPEC SKIKSEMKTK LGEQGPQILS 

       910        920        930        940        950        960 
VQRVYIQTRE EKRINLTIGS RAYLLPNTSV IIKCPVRRFQ KSLIQWEKDG RCLQNSKRLG 

       970        980        990       1000       1010       1020 
ITKSGSLKIH GLAAPDIGVY RCIAGSAQET VVLKLIGTDN RLIARPALRE PMREYPGMDH 

      1030       1040       1050       1060       1070       1080 
SEANSLGVTW HKMRQMWNNK NDLYLDDDHI SNQPFLRALL GHCSNSAGST NSWELKNKQF 

      1090       1100       1110       1120       1130       1140 
EAAVKQGAYS MDTAQFDELI RNMSQLMETG EVSDDLASQL IYQLVAELAK AQPTHMQWRG 

      1150       1160       1170       1180       1190       1200 
IQEETPPAAQ LRGETGSVSQ SSHAKNSGKL TFKPKGPVLM RQSQPPSISF NKTINSRIGN 

      1210       1220       1230       1240       1250       1260 
TVYITKRTEV INILCDLITP SEATYTWTKD GTLLQPSVKI ILDGTGKIQI QNPTRKEQGI 

      1270       1280       1290       1300       1310       1320 
YECSVANHLG SDVESSSVLY AEAPVILSVE RNITKPEHNH LSVVVGGIVE AALGANVTIR 

      1330       1340       1350       1360       1370       1380 
CPVKGVPQPN ITWLKRGGSL SGNVSLLFNG SLLLQNVSLE NEGTYVCIAT NALGKAVATS 

      1390       1400       1410       1420       1430       1440 
VLHLLERRWP ESRIVFLQGH KKYILQATNT RTNSNDPTGE PPPQEPFWEP GNWSHCSATC 

      1450       1460       1470       1480       1490       1500 
GHLGARIQRP QCVMANGQEV SEALCDHLQK PLAGFEPCNI RDCPARWFTS VWSQCSVSCG 

      1510       1520       1530       1540       1550       1560 
EGYHSRQVTC KRTKANGTVQ VVSPRACAPK DRPLGRKPCF GHPCVQWEPG NRCPGRCMGR 

      1570       1580       1590       1600       1610       1620 
AVRMQQRHTA CQHNSSDSNC DDRKRPTLRR NCTSGACDVC WHTGPWKPCT AACGRGFQSR 

      1630       1640       1650       1660       1670       1680 
KVDCIHTRSC KPVAKRHCVQ KKKPISWRHC LGPSCDRDCT DTTHYCMFVK HLNLCSLDRY 

      1690 
KQRCCQSCQE G

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References

« Hide 'large scale' references
[1]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed: 12508121] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"ADAMTSL-3/punctin-2, a novel glycoprotein in extracellular matrix related to the ADAMTS family of metalloproteases."
Hall N.G., Klenotic P., Anand-Apte B., Apte S.S.
Matrix Biol. 22:501-510(2003) [PubMed: 14667842] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-766, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANTS 290-LEU AND 661-VAL.
[3]"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
DNA Res. 6:337-345(1999) [PubMed: 10574462] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 669-1691.
Tissue: Brain.
[4]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed: 16959974] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] MET-330; HIS-587; CYS-855 AND GLU-1315.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AC087738 Genomic DNA. No translation available.
AC116157 Genomic DNA. No translation available.
AC027807 Genomic DNA. No translation available.
AF237652 mRNA. Translation: AAK15041.1.
AB033059 mRNA. Translation: BAA86547.1.
IPIIPI00410588.
RefSeqNP_997400.2.
UniGeneHs.459162

3D structure databases

ModBaseSearch...

PTM databases

PhosphoSiteP82987.

Proteomic databases

PRIDEP82987.

Genome annotation databases

EnsemblENSG00000156218. Homo sapiens. [Contig view]
GeneID57188.
KEGGhsa:57188.

Organism-specific databases

GeneCardsGC15P082113.
HGNCHGNC:14633. ADAMTSL3.
MIM609199. gene.
PharmGKBPA134934525.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

HOVERGENP82987.

Gene expression databases

ArrayExpressP82987.
BgeeP82987.
CleanExHS_ADAMTSL3.

Family and domain databases

InterProIPR013151. Ig.
IPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR010909. PLAC.
IPR000884. Thrombospondin_1_rpt.
[Graphical view]
Gene3DG3DSA:2.60.40.10. Ig-like_fold. 3 hits.
PfamPF07679. I-set. 2 hits.
PF00047. ig. 1 hit.
PF08686. PLAC. 1 hit.
PF00090. TSP_1. 10 hits.
[Graphical view]
PRINTSPR01857. ADAMTSFAMILY.
SMARTSM00409. IG. 1 hit.
SM00408. IGc2. 2 hits.
SM00209. TSP1. 12 hits.
[Graphical view]
PROSITEPS50835. IG_LIKE. 3 hits.
PS50900. PLAC. 1 hit.
PS50092. TSP1. 10 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio63254.
SOURCESearch...

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Entry information

Entry nameATL3_HUMAN
AccessionPrimary (citable) accession number: P82987
Secondary accession number(s): Q9ULI7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: September 19, 2006
Last modified: June 16, 2009
This is version 40 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents