P82987 (ATL3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ADAMTS-like protein 3
Short name=ADAMTSL-3

Alternative name(s):
Punctin-2

Gene names

Name:	ADAMTSL3
Synonyms:	KIAA1233

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1691 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Secreted › extracellular space › extracellular matrix Ref.3.
Tissue specificity	Expressed in epithelial cells of the colon, fallopian tube, skin, breast, prostate, epididymis, liver, pancreatic islets and bile ducts, as well as by vascular endothelial cells, smooth muscle cells, fibroblasts, cortical and ganglionic neurons and cardiac myocytes. Also expressed by malignant epithelial cells in colon cancer, as well as breast, prostate, renal and skin tumors. Expression is significantly reduced in colon cancer compared to normal colon. Ref.3 Ref.5
Post-translational modification	Glycosylated By similarity. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion By similarity.
Sequence similarities	Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 PLAC domain. Contains 10 TSP type-1 domains.
Caution	Although strongly similar to members of the ADAMTS family it lacks the metalloprotease and disintegrin-like domains which are typical of that family.

Ontologies

Keywords
Cellular component	Extracellular matrix Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metallopeptidase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P82987-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P82987-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1657-1691: RDCTDTTHYCMFVKHLNLCSLDRYKQRCCQSCQEG → STYTSQTATNKGAASHVKRDKPLEGS

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Potential
	Chain	27 – 1691	1665	ADAMTS-like protein 3		PRO_0000249684
Regions
	Domain	75 – 124	50	TSP type-1 1
	Domain	418 – 468	51	TSP type-1 2
	Domain	478 – 535	58	TSP type-1 3
	Domain	564 – 626	63	TSP type-1 4
	Domain	703 – 760	58	TSP type-1 5
	Domain	763 – 818	56	TSP type-1 6
	Domain	819 – 881	63	TSP type-1 7
	Domain	896 – 992	97	Ig-like C2-type 1
	Domain	1185 – 1279	95	Ig-like C2-type 2
	Domain	1296 – 1378	83	Ig-like C2-type 3
	Domain	1424 – 1482	59	TSP type-1 8
	Domain	1483 – 1545	63	TSP type-1 9
	Domain	1597 – 1644	48	TSP type-1 10
	Domain	1655 – 1691	37	PLAC
Amino acid modifications
	Glycosylation	293	1	N-linked (GlcNAc...) Potential
	Glycosylation	681	1	N-linked (GlcNAc...) Potential
	Glycosylation	797	1	N-linked (GlcNAc...) Potential
	Glycosylation	915	1	N-linked (GlcNAc...) Potential
	Glycosylation	927	1	N-linked (GlcNAc...) Potential
	Glycosylation	1102	1	N-linked (GlcNAc...) Potential
	Glycosylation	1191	1	N-linked (GlcNAc...) Potential
	Glycosylation	1292	1	N-linked (GlcNAc...) Potential
	Glycosylation	1316	1	N-linked (GlcNAc...) Potential
	Glycosylation	1330	1	N-linked (GlcNAc...) Potential
	Glycosylation	1343	1	N-linked (GlcNAc...) Potential
	Glycosylation	1349	1	N-linked (GlcNAc...) Potential
	Glycosylation	1356	1	N-linked (GlcNAc...) Potential
	Glycosylation	1432	1	N-linked (GlcNAc...) Potential
	Glycosylation	1516	1	N-linked (GlcNAc...) Potential
	Glycosylation	1574	1	N-linked (GlcNAc...) Potential
	Glycosylation	1591	1	N-linked (GlcNAc...) Potential
	Disulfide bond	87 ↔ 118		By similarity
	Disulfide bond	91 ↔ 123		By similarity
	Disulfide bond	102 ↔ 108		By similarity
	Disulfide bond	576 ↔ 620		By similarity
	Disulfide bond	580 ↔ 625		By similarity
	Disulfide bond	591 ↔ 609		By similarity
	Disulfide bond	831 ↔ 875		By similarity
	Disulfide bond	835 ↔ 880		By similarity
	Disulfide bond	846 ↔ 863		By similarity
	Disulfide bond	934 ↔ 982		By similarity
	Disulfide bond	1215 ↔ 1263		By similarity
	Disulfide bond	1321 ↔ 1367		By similarity
Natural variations
	Alternative sequence	1657 – 1691	35	RDCTD…SCQEG → STYTSQTATNKGAASHVKRD KPLEGS in isoform 2.		VSP_037810
	Natural variant	146	1	H → R. Ref.2 Corresponds to variant rs4483821 [ dbSNP | Ensembl ].		VAR_027478
	Natural variant	290	1	L → V. Ref.3 Corresponds to variant rs4144691 [ dbSNP | Ensembl ].		VAR_027479
	Natural variant	330	1	V → M in a colorectal cancer sample; somatic mutation. Ref.6		VAR_035809
	Natural variant	587	1	R → H in a colorectal cancer sample; somatic mutation. Ref.6		VAR_035810
	Natural variant	661	1	V → L. Ref.3 Corresponds to variant rs4842838 [ dbSNP | Ensembl ].		VAR_027480
	Natural variant	713	1	G → R. Corresponds to variant rs34047645 [ dbSNP | Ensembl ].		VAR_057365
	Natural variant	855	1	R → C in a colorectal cancer sample; somatic mutation. Ref.6		VAR_035811
	Natural variant	855	1	R → H. Corresponds to variant rs2277848 [ dbSNP | Ensembl ].		VAR_027481
	Natural variant	869	1	L → F. Ref.2 Corresponds to variant rs2277849 [ dbSNP | Ensembl ].		VAR_027482
	Natural variant	1315	1	A → E in a colorectal cancer sample; somatic mutation. Ref.6		VAR_035812
	Natural variant	1370	1	T → A. Corresponds to variant rs17158450 [ dbSNP | Ensembl ].		VAR_027483
	Natural variant	1558	1	M → T. Corresponds to variant rs7175910 [ dbSNP | Ensembl ].		VAR_027484
	Natural variant	1660	1	T → I. Corresponds to variant rs950169 [ dbSNP | Ensembl ].		VAR_027485
	Natural variant	1679	1	R → H. Corresponds to variant rs11857906 [ dbSNP | Ensembl ].		VAR_027486
Experimental info
	Sequence conflict	265	1	A → V in AAK15041. Ref.3
	Sequence conflict	986	1	S → F in AAI28390. Ref.2
	Sequence conflict	1526	1	A → S in AAI28390. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 5, 2010. Version 4. Checksum: 48C7281C737EA56E	FASTA	1,691	188,692
	10 20 30 40 50 60 MASWTSPWWV LIGMVFMHSP LPQTTAEKSP GAYFLPEFAL SPQGSFLEDT TGEQFLTYRY 70 80 90 100 110 120 DDQTSRNTRS DEDKDGNWDA WGDWSDCSRT CGGGASYSLR RCLTGRNCEG QNIRYKTCSN 130 140 150 160 170 180 HDCPPDAEDF RAQQCSAYND VQYQGHYYEW LPRYNDPAAP CALKCHAQGQ NLVVELAPKV 190 200 210 220 230 240 LDGTRCNTDS LDMCISGICQ AVGCDRQLGS NAKEDNCGVC AGDGSTCRLV RGQSKSHVSP 250 260 270 280 290 300 EKREENVIAV PLGSRSVRIT VKGPAHLFIE SKTLQGSKGE HSFNSPGVFL VENTTVEFQR 310 320 330 340 350 360 GSERQTFKIP GPLMADFIFK TRYTAAKDSV VQFFFYQPIS HQWRQTDFFP CTVTCGGGYQ 370 380 390 400 410 420 LNSAECVDIR LKRVVPDHYC HYYPENVKPK PKLKECSMDP CPSSDGFKEI MPYDHFQPLP 430 440 450 460 470 480 RWEHNPWTAC SVSCGGGIQR RSFVCVEESM HGEILQVEEW KCMYAPKPKV MQTCNLFDCP 490 500 510 520 530 540 KWIAMEWSQC TVTCGRGLRY RVVLCINHRG EHVGGCNPQL KLHIKEECVI PIPCYKPKEK 550 560 570 580 590 600 SPVEAKLPWL KQAQELEETR IATEEPTFIP EPWSACSTTC GPGVQVREVK CRVLLTFTQT 610 620 630 640 650 660 ETELPEEECE GPKLPTERPC LLEACDESPA SRELDIPLPE DSETTYDWEY AGFTPCTATC 670 680 690 700 710 720 VGGHQEAIAV CLHIQTQQTV NDSLCDMVHR PPAMSQACNT EPCPPRWHVG SWGPCSATCG 730 740 750 760 770 780 VGIQTRDVYC LHPGETPAPP EECRDEKPHA LQACNQFDCP PGWHIEEWQQ CSRTCGGGTQ 790 800 810 820 830 840 NRRVTCRQLL TDGSFLNLSD ELCQGPKASS HKSCARTDCP PHLAVGDWSK CSVSCGVGIQ 850 860 870 880 890 900 RRKQVCQRLA AKGRRIPLSE MMCRDLPGLP LVRSCQMPEC SKIKSEMKTK LGEQGPQILS 910 920 930 940 950 960 VQRVYIQTRE EKRINLTIGS RAYLLPNTSV IIKCPVRRFQ KSLIQWEKDG RCLQNSKRLG 970 980 990 1000 1010 1020 ITKSGSLKIH GLAAPDIGVY RCIAGSAQET VVLKLIGTDN RLIARPALRE PMREYPGMDH 1030 1040 1050 1060 1070 1080 SEANSLGVTW HKMRQMWNNK NDLYLDDDHI SNQPFLRALL GHCSNSAGST NSWELKNKQF 1090 1100 1110 1120 1130 1140 EAAVKQGAYS MDTAQFDELI RNMSQLMETG EVSDDLASQL IYQLVAELAK AQPTHMQWRG 1150 1160 1170 1180 1190 1200 IQEETPPAAQ LRGETGSVSQ SSHAKNSGKL TFKPKGPVLM RQSQPPSISF NKTINSRIGN 1210 1220 1230 1240 1250 1260 TVYITKRTEV INILCDLITP SEATYTWTKD GTLLQPSVKI ILDGTGKIQI QNPTRKEQGI 1270 1280 1290 1300 1310 1320 YECSVANHLG SDVESSSVLY AEAPVILSVE RNITKPEHNH LSVVVGGIVE AALGANVTIR 1330 1340 1350 1360 1370 1380 CPVKGVPQPN ITWLKRGGSL SGNVSLLFNG SLLLQNVSLE NEGTYVCIAT NALGKAVATS 1390 1400 1410 1420 1430 1440 VLHLLERRWP ESRIVFLQGH KKYILQATNT RTNSNDPTGE PPPQEPFWEP GNWSHCSATC 1450 1460 1470 1480 1490 1500 GHLGARIQRP QCVMANGQEV SEALCDHLQK PLAGFEPCNI RDCPARWFTS VWSQCSVSCG 1510 1520 1530 1540 1550 1560 EGYHSRQVTC KRTKANGTVQ VVSPRACAPK DRPLGRKPCF GHPCVQWEPG NRCPGRCMGR 1570 1580 1590 1600 1610 1620 AVRMQQRHTA CQHNSSDSNC DDRKRPTLRR NCTSGACDVC WHTGPWKPCT AACGRGFQSR 1630 1640 1650 1660 1670 1680 KVDCIHTRSC KPVAKRHCVQ KKKPISWRHC LGPSCDRDCT DTTHYCMFVK HLNLCSLDRY 1690 KQRCCQSCQE G
	Isoform 2 [UniParc]. Checksum: EED57C7F66CA0CC6	FASTA	1,682	187,240
	10 20 30 40 50 60 MASWTSPWWV LIGMVFMHSP LPQTTAEKSP GAYFLPEFAL SPQGSFLEDT TGEQFLTYRY 70 80 90 100 110 120 DDQTSRNTRS DEDKDGNWDA WGDWSDCSRT CGGGASYSLR RCLTGRNCEG QNIRYKTCSN 130 140 150 160 170 180 HDCPPDAEDF RAQQCSAYND VQYQGHYYEW LPRYNDPAAP CALKCHAQGQ NLVVELAPKV 190 200 210 220 230 240 LDGTRCNTDS LDMCISGICQ AVGCDRQLGS NAKEDNCGVC AGDGSTCRLV RGQSKSHVSP 250 260 270 280 290 300 EKREENVIAV PLGSRSVRIT VKGPAHLFIE SKTLQGSKGE HSFNSPGVFL VENTTVEFQR 310 320 330 340 350 360 GSERQTFKIP GPLMADFIFK TRYTAAKDSV VQFFFYQPIS HQWRQTDFFP CTVTCGGGYQ 370 380 390 400 410 420 LNSAECVDIR LKRVVPDHYC HYYPENVKPK PKLKECSMDP CPSSDGFKEI MPYDHFQPLP 430 440 450 460 470 480 RWEHNPWTAC SVSCGGGIQR RSFVCVEESM HGEILQVEEW KCMYAPKPKV MQTCNLFDCP 490 500 510 520 530 540 KWIAMEWSQC TVTCGRGLRY RVVLCINHRG EHVGGCNPQL KLHIKEECVI PIPCYKPKEK 550 560 570 580 590 600 SPVEAKLPWL KQAQELEETR IATEEPTFIP EPWSACSTTC GPGVQVREVK CRVLLTFTQT 610 620 630 640 650 660 ETELPEEECE GPKLPTERPC LLEACDESPA SRELDIPLPE DSETTYDWEY AGFTPCTATC 670 680 690 700 710 720 VGGHQEAIAV CLHIQTQQTV NDSLCDMVHR PPAMSQACNT EPCPPRWHVG SWGPCSATCG 730 740 750 760 770 780 VGIQTRDVYC LHPGETPAPP EECRDEKPHA LQACNQFDCP PGWHIEEWQQ CSRTCGGGTQ 790 800 810 820 830 840 NRRVTCRQLL TDGSFLNLSD ELCQGPKASS HKSCARTDCP PHLAVGDWSK CSVSCGVGIQ 850 860 870 880 890 900 RRKQVCQRLA AKGRRIPLSE MMCRDLPGLP LVRSCQMPEC SKIKSEMKTK LGEQGPQILS 910 920 930 940 950 960 VQRVYIQTRE EKRINLTIGS RAYLLPNTSV IIKCPVRRFQ KSLIQWEKDG RCLQNSKRLG 970 980 990 1000 1010 1020 ITKSGSLKIH GLAAPDIGVY RCIAGSAQET VVLKLIGTDN RLIARPALRE PMREYPGMDH 1030 1040 1050 1060 1070 1080 SEANSLGVTW HKMRQMWNNK NDLYLDDDHI SNQPFLRALL GHCSNSAGST NSWELKNKQF 1090 1100 1110 1120 1130 1140 EAAVKQGAYS MDTAQFDELI RNMSQLMETG EVSDDLASQL IYQLVAELAK AQPTHMQWRG 1150 1160 1170 1180 1190 1200 IQEETPPAAQ LRGETGSVSQ SSHAKNSGKL TFKPKGPVLM RQSQPPSISF NKTINSRIGN 1210 1220 1230 1240 1250 1260 TVYITKRTEV INILCDLITP SEATYTWTKD GTLLQPSVKI ILDGTGKIQI QNPTRKEQGI 1270 1280 1290 1300 1310 1320 YECSVANHLG SDVESSSVLY AEAPVILSVE RNITKPEHNH LSVVVGGIVE AALGANVTIR 1330 1340 1350 1360 1370 1380 CPVKGVPQPN ITWLKRGGSL SGNVSLLFNG SLLLQNVSLE NEGTYVCIAT NALGKAVATS 1390 1400 1410 1420 1430 1440 VLHLLERRWP ESRIVFLQGH KKYILQATNT RTNSNDPTGE PPPQEPFWEP GNWSHCSATC 1450 1460 1470 1480 1490 1500 GHLGARIQRP QCVMANGQEV SEALCDHLQK PLAGFEPCNI RDCPARWFTS VWSQCSVSCG 1510 1520 1530 1540 1550 1560 EGYHSRQVTC KRTKANGTVQ VVSPRACAPK DRPLGRKPCF GHPCVQWEPG NRCPGRCMGR 1570 1580 1590 1600 1610 1620 AVRMQQRHTA CQHNSSDSNC DDRKRPTLRR NCTSGACDVC WHTGPWKPCT AACGRGFQSR 1630 1640 1650 1660 1670 1680 KVDCIHTRSC KPVAKRHCVQ KKKPISWRHC LGPSCDSTYT SQTATNKGAA SHVKRDKPLE GS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-146 AND PHE-869.
[3]	"ADAMTSL-3/punctin-2, a novel glycoprotein in extracellular matrix related to the ADAMTS family of metalloproteases." Hall N.G., Klenotic P., Anand-Apte B., Apte S.S. Matrix Biol. 22:501-510(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-766, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANTS VAL-290 AND LEU-661.
[4]	"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O. DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 669-1691. Tissue: Brain.
[5]	"ADAMTSL3/punctin-2, a gene frequently mutated in colorectal tumors, is widely expressed in normal and malignant epithelial cells, vascular endothelial cells and other cell types, and its mRNA is reduced in colon cancer." Koo B.H., Hurskainen T., Mielke K., Aung P.P., Casey G., Autio-Harmainen H., Apte S.S. Int. J. Cancer 121:1710-1716(2007) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[6]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] MET-330; HIS-587; CYS-855 AND GLU-1315.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC087738 Genomic DNA. No translation available. AC116157 Genomic DNA. No translation available. AC027807 Genomic DNA. No translation available. BC128389 mRNA. Translation: AAI28390.1. BC128390 mRNA. Translation: AAI28391.1. AF237652 mRNA. Translation: AAK15041.1. AB033059 mRNA. Translation: BAA86547.1.
IPI	IPI00410588. IPI00788778.
RefSeq	NP_997400.2. NM_207517.2.
UniGene	Hs.459162.
3D structure databases
HSSP	HSSP built from PDB template 1LSL based on UniProtKB P07996.
ProteinModelPortal	P82987.
SMR	P82987. Positions 71-339, 421-509, 564-627, 705-761, 824-882, 923-994, 1164-1424, 1429-1454.
ModBase	Search...
PTM databases
PhosphoSite	P82987.
Polymorphism databases
DMDM	308153648.
Proteomic databases
PaxDb	P82987.
PRIDE	P82987.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000286744; ENSP00000286744; ENSG00000156218. ENST00000567476; ENSP00000456313; ENSG00000156218.
GeneID	57188.
KEGG	hsa:57188.
UCSC	uc002bjz.4. human.
Organism-specific databases
CTD	57188.
GeneCards	GC15P084322.
H-InvDB	HIX0017599.
HGNC	HGNC:14633. ADAMTSL3.
HPA	HPA034773.
MIM	609199. gene.
neXtProt	NX_P82987.
PharmGKB	PA134934525.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG272362.
HOGENOM	HOG000230906.
HOVERGEN	HBG079989.
InParanoid	P82987.
OMA	ANGQEVS.
OrthoDB	EOG483D40.
PhylomeDB	P82987.
Gene expression databases
Bgee	P82987.
CleanEx	HS_ADAMTSL3.
Genevestigator	P82987.
Family and domain databases
Gene3D	2.60.40.10. 3 hits.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003599. Ig_sub. IPR003598. Ig_sub2. IPR013273. Peptidase_M12B_ADAM-TS. IPR010909. PLAC. IPR000884. Thrombospondin_1_rpt. [Graphical view]
Pfam	PF07679. I-set. 1 hit. PF08686. PLAC. 1 hit. PF00090. TSP_1. 9 hits. [Graphical view]
PRINTS	PR01857. ADAMTSFAMILY.
SMART	SM00409. IG. 1 hit. SM00408. IGc2. 2 hits. SM00209. TSP1. 12 hits. [Graphical view]
SUPFAM	SSF82895. TSP1. 12 hits.
PROSITE	PS50835. IG_LIKE. 3 hits. PS50900. PLAC. 1 hit. PS50092. TSP1. 10 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	57188.
NextBio	63254.
SOURCE	Search...

Entry information

Entry name

ATL3_HUMAN

Accession

Primary (citable) accession number: P82987
Secondary accession number(s): A1A566, A1A567, Q9ULI7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2006
Last sequence update:	October 5, 2010
Last modified:	May 1, 2013
This is version 74 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.