P82980 (RET5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Retinol-binding protein 5

Alternative name(s):
Cellular retinol-binding protein III
Short name=CRBP-III
HRBPiso

Gene names

Name:

RBP5

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	135 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Intracellular transport of retinol. Ref.1
Subcellular location	Cytoplasm By similarity.
Tissue specificity	Higher expression in adult kidney and liver and to a lesser extent in adult and fetal spleen, adult lymph nodes and appendix, and fetal liver and kidney. Strongly decreased in hepatocellular carcinoma tissues (at protein level). Ref.1 Ref.6
Domain	Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
Sequence similarities	Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Ligand	Retinol-binding Vitamin A
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Non-traceable author statement. Source: UniProtKB
Molecular function	retinal binding Inferred from electronic annotation. Source: UniProtKB-KW retinol binding Inferred from electronic annotation. Source: UniProtKB-KW transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

1

Removed

Chain

2 – 135

134

Retinol-binding protein 5

PRO_0000067400

Natural variations

Natural variant

19

1

D → N.
Corresponds to variant rs10963 [ dbSNP | Ensembl ].

VAR_049013

Natural variant

70

1

E → Q.
Corresponds to variant rs7969705 [ dbSNP | Ensembl ].

VAR_034445

Natural variant

115

1

M → L. Ref.3 Ref.4
Corresponds to variant rs2290237 [ dbSNP | Ensembl ].

VAR_034446

Secondary structure

1

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135

Helix Strand Turn

Details...

Beta strand

7 – 15

9

Helix

17 – 23

7

Turn

28 – 33

6

Helix

34 – 36

3

Beta strand

40 – 45

6

Beta strand

47 – 55

9

Beta strand

61 – 66

6

Beta strand

71 – 74

4

Turn

76 – 79

4

Beta strand

82 – 89

8

Beta strand

91 – 102

12

Beta strand

106 – 112

7

Beta strand

115 – 122

8

Beta strand

125 – 133

9

Sequences

	Sequence		Length	Mass (Da)
	P82980 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: B9D059DCCC0A88ED	FASTA	135	15,931
	10 20 30 40 50 60 MPPNLTGYYR FVSQKNMEDY LQALNISLAV RKIALLLKPD KEIEHQGNHM TVRTLSTFRN 70 80 90 100 110 120 YTVQFDVGVE FEEDLRSVDG RKCQTIVTWE EEHLVCVQKG EVPNRGWRHW LEGEMLYLEL 130 TARDAVCEQV FRKVR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification, retinoid binding and X-ray analysis of a human retinol-binding protein." Folli C., Calderone V., Ottonello S., Bolchi A., Zanotti G., Stoppini M., Berni R. Proc. Natl. Acad. Sci. U.S.A. 98:3710-3715(2001) [PubMed: 11274389] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS), FUNCTION, TISSUE SPECIFICITY.
[2]	"A novel gene expressed in human liver non-tumor tissues." Li Y., Wu T., Xu S., Ren S., Chen Z., Han Z. Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-115. Tissue: Small intestine.
[4]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-115. Tissue: Spleen.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[6]	"Down-regulation of retinol binding protein 5 is associated with aggressive tumor features in hepatocellular carcinoma." Ho J.C.Y., Cheung S.T., Poon W.S., Lee Y.T., Ng I.O.L., Fan S.T. J. Cancer Res. Clin. Oncol. 133:929-936(2007) [PubMed: 17497168] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY007436 mRNA. Translation: AAG09617.1.
AF212239 mRNA. Translation: AAK14925.1.
AK311977 mRNA. Translation: BAG34916.1.
AK223378 mRNA. Translation: BAD97098.1.
BC029355 mRNA. Translation: AAH29355.1.

IPI

IPI00219782.

RefSeq

NP_113679.1. NM_031491.2.

UniGene

Hs.729110.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1GGL	X-ray	2.31	A/B	2-134	[»]

ProteinModelPortal

P82980.

SMR

P82980. Positions 2-134.

ModBase

Search...

Protein-protein interaction databases

IntAct

P82980. 2 interactions.

STRING

P82980.

Polymorphism databases

DMDM

14916691.

Proteomic databases

PRIDE

P82980.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000266560; ENSP00000266560; ENSG00000139194.

GeneID

83758.

KEGG

hsa:83758.

UCSC

uc001qsq.1. human.

Organism-specific databases

CTD

83758.

GeneCards

GC12M007276.

H-InvDB

HIX0010395.

HGNC

HGNC:15847. RBP5.

MIM

611866. gene.

neXtProt

NX_P82980.

PharmGKB

PA164742366.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG06207.

GeneTree

ENSGT00560000076799.

HOGENOM

HBG714759.

HOVERGEN

HBG005633.

InParanoid

P82980.

OMA

CQTIVTW.

OrthoDB

EOG4G4GRR.

PhylomeDB

P82980.

Gene expression databases

ArrayExpress

P82980.

Bgee

P82980.

CleanEx

HS_RBP5.

Genevestigator

P82980.

GermOnline

ENSG00000139194. Homo sapiens.

Family and domain databases

InterPro

IPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]

Gene3D

G3DSA:2.40.128.20. Calycin. 1 hit.

Pfam

PF00061. Lipocalin. 1 hit.
[Graphical view]

PRINTS

PR00178. FATTYACIDBP.

SUPFAM

SSF50814. Calycin. 1 hit.

PROSITE

PS00214. FABP. False negative.
[Graphical view]

ProtoNet

Search...

Other

DrugBank

DB00162. Vitamin A.

NextBio

72791.

SOURCE

Search...

Entry information

Entry name

RET5_HUMAN

Accession

Primary (citable) accession number: P82980
Secondary accession number(s): Q53FB1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2001
Last sequence update:	January 23, 2007
Last modified:	January 25, 2012
This is version 98 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.