Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Retinol-binding protein 5

Gene

RBP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Intracellular transport of retinol.1 Publication

GO - Molecular functioni

  • retinal binding Source: UniProtKB-KW
  • retinoid binding Source: UniProtKB
  • retinol binding Source: UniProtKB-KW
  • transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Retinol-binding, Vitamin A

Enzyme and pathway databases

BioCyciZFISH:ENSG00000139194-MONOMER.

Chemistry databases

SwissLipidsiSLP:000001526.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol-binding protein 5
Alternative name(s):
Cellular retinol-binding protein III
Short name:
CRBP-III
HRBPiso
Gene namesi
Name:RBP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:15847. RBP5.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000139194.
PharmGKBiPA164742366.

Chemistry databases

DrugBankiDB00162. Vitamin A.

Polymorphism and mutation databases

BioMutaiRBP5.
DMDMi14916691.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000674002 – 135Retinol-binding protein 5Add BLAST134

Proteomic databases

PaxDbiP82980.
PeptideAtlasiP82980.
PRIDEiP82980.
TopDownProteomicsiP82980.

Expressioni

Tissue specificityi

Higher expression in adult kidney and liver and to a lesser extent in adult and fetal spleen, adult lymph nodes and appendix, and fetal liver and kidney. Strongly decreased in hepatocellular carcinoma tissues (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000139194.
CleanExiHS_RBP5.
ExpressionAtlasiP82980. baseline and differential.
GenevisibleiP82980. HS.

Organism-specific databases

HPAiHPA038723.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCNDBP1O952733EBI-3941274,EBI-748961

Protein-protein interaction databases

BioGridi123759. 4 interactors.
IntActiP82980. 3 interactors.
STRINGi9606.ENSP00000266560.

Structurei

Secondary structure

1135
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 15Combined sources9
Helixi17 – 23Combined sources7
Turni28 – 33Combined sources6
Helixi34 – 36Combined sources3
Beta strandi40 – 45Combined sources6
Beta strandi47 – 55Combined sources9
Beta strandi61 – 66Combined sources6
Beta strandi71 – 74Combined sources4
Turni76 – 79Combined sources4
Beta strandi82 – 89Combined sources8
Beta strandi91 – 102Combined sources12
Beta strandi106 – 112Combined sources7
Beta strandi115 – 122Combined sources8
Beta strandi125 – 133Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GGLX-ray2.31A/B2-134[»]
ProteinModelPortaliP82980.
SMRiP82980.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP82980.

Family & Domainsi

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004831.
HOVERGENiHBG005633.
InParanoidiP82980.
OMAiKRNRGWR.
OrthoDBiEOG091G0QSV.
PhylomeDBiP82980.
TreeFamiTF316894.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR031270. CRBP-III.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PTHR11955:SF74. PTHR11955:SF74. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P82980-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPNLTGYYR FVSQKNMEDY LQALNISLAV RKIALLLKPD KEIEHQGNHM
60 70 80 90 100
TVRTLSTFRN YTVQFDVGVE FEEDLRSVDG RKCQTIVTWE EEHLVCVQKG
110 120 130
EVPNRGWRHW LEGEMLYLEL TARDAVCEQV FRKVR
Length:135
Mass (Da):15,931
Last modified:January 23, 2007 - v3
Checksum:iB9D059DCCC0A88ED
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04901319D → N.Corresponds to variant rs10963dbSNPEnsembl.1
Natural variantiVAR_03444570E → Q.Corresponds to variant rs7969705dbSNPEnsembl.1
Natural variantiVAR_034446115M → L.2 PublicationsCorresponds to variant rs2290237dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY007436 mRNA. Translation: AAG09617.1.
AF212239 mRNA. Translation: AAK14925.1.
AK311977 mRNA. Translation: BAG34916.1.
AK223378 mRNA. Translation: BAD97098.1.
BC029355 mRNA. Translation: AAH29355.1.
CCDSiCCDS8574.1.
RefSeqiNP_113679.1. NM_031491.3.
UniGeneiHs.246046.

Genome annotation databases

EnsembliENST00000266560; ENSP00000266560; ENSG00000139194.
GeneIDi83758.
KEGGihsa:83758.
UCSCiuc001qsq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY007436 mRNA. Translation: AAG09617.1.
AF212239 mRNA. Translation: AAK14925.1.
AK311977 mRNA. Translation: BAG34916.1.
AK223378 mRNA. Translation: BAD97098.1.
BC029355 mRNA. Translation: AAH29355.1.
CCDSiCCDS8574.1.
RefSeqiNP_113679.1. NM_031491.3.
UniGeneiHs.246046.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GGLX-ray2.31A/B2-134[»]
ProteinModelPortaliP82980.
SMRiP82980.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123759. 4 interactors.
IntActiP82980. 3 interactors.
STRINGi9606.ENSP00000266560.

Chemistry databases

DrugBankiDB00162. Vitamin A.
SwissLipidsiSLP:000001526.

Polymorphism and mutation databases

BioMutaiRBP5.
DMDMi14916691.

Proteomic databases

PaxDbiP82980.
PeptideAtlasiP82980.
PRIDEiP82980.
TopDownProteomicsiP82980.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266560; ENSP00000266560; ENSG00000139194.
GeneIDi83758.
KEGGihsa:83758.
UCSCiuc001qsq.4. human.

Organism-specific databases

CTDi83758.
GeneCardsiRBP5.
HGNCiHGNC:15847. RBP5.
HPAiHPA038723.
MIMi611866. gene.
neXtProtiNX_P82980.
OpenTargetsiENSG00000139194.
PharmGKBiPA164742366.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004831.
HOVERGENiHBG005633.
InParanoidiP82980.
OMAiKRNRGWR.
OrthoDBiEOG091G0QSV.
PhylomeDBiP82980.
TreeFamiTF316894.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000139194-MONOMER.

Miscellaneous databases

ChiTaRSiRBP5. human.
EvolutionaryTraceiP82980.
GenomeRNAii83758.
PROiP82980.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139194.
CleanExiHS_RBP5.
ExpressionAtlasiP82980. baseline and differential.
GenevisibleiP82980. HS.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR031270. CRBP-III.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PTHR11955:SF74. PTHR11955:SF74. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRET5_HUMAN
AccessioniPrimary (citable) accession number: P82980
Secondary accession number(s): Q53FB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 138 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.