Reviewed, UniProtKB/Swiss-Prot P82980 (RET5_HUMAN)

Names and origin

Protein names

Recommended name:
    Retinol-binding protein 5
Alternative name(s):
    Cellular retinol-binding protein III
      Short name=CRBP-III
    HRBPiso

Gene names

Name:

RBP5

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	135 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Intracellular transport of retinol.
Subcellular location	CytoplasmBy similarity.
Tissue specificity	Higher expression in adult kidney and liver and to a lesser extent in adult and fetal spleen, adult lymph nodes and appendix, and fetal liver and kidney. Strongly decreased in hepatocellular carcinoma tissues (at protein level).
Domain	Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
Sequence similarities	Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Ligand	Retinol-binding Vitamin A
Technical term	3D-structure
Gene Ontology (GO)
Biological process	transport Non-traceable author statement. Source: UniProtKB
Cellular component	cytoplasm Non-traceable author statement. Source: UniProtKB
Molecular function	lipid binding Inferred from electronic annotation. Source: InterPro retinal binding Inferred from electronic annotation. Source: UniProtKB-KW retinol binding Inferred from electronic annotation. Source: UniProtKB-KW transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

1

Removed

Chain

2 – 135

134

Retinol-binding protein 5

PRO_0000067400

Natural variations

Natural variant

70

1

E → Q: dbSNP rs7969705.

VAR_034445

Natural variant

115

1

M → L: dbSNP rs2290237.

VAR_034446

Secondary structure

1

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135

Helix Strand Turn

Details...

Beta strand

7 – 15

9

Helix

17 – 23

7

Turn

28 – 33

6

Helix

34 – 36

3

Beta strand

40 – 45

6

Beta strand

47 – 55

9

Beta strand

61 – 66

6

Beta strand

71 – 74

4

Turn

76 – 79

4

Beta strand

82 – 89

8

Beta strand

91 – 102

12

Beta strand

106 – 112

7

Beta strand

115 – 122

8

Beta strand

125 – 133

9

Sequences

	Sequence		Length	Mass (Da)
	P82980-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: B9D059DCCC0A88ED	FASTA	135	15,931
	10 20 30 40 50 60 MPPNLTGYYR FVSQKNMEDY LQALNISLAV RKIALLLKPD KEIEHQGNHM TVRTLSTFRN 70 80 90 100 110 120 YTVQFDVGVE FEEDLRSVDG RKCQTIVTWE EEHLVCVQKG EVPNRGWRHW LEGEMLYLEL 130 TARDAVCEQV FRKVR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification, retinoid binding and X-ray analysis of a human retinol-binding protein." Folli C., Calderone V., Ottonello S., Bolchi A., Zanotti G., Stoppini M., Berni R. Proc. Natl. Acad. Sci. U.S.A. 98:3710-3715(2001) [PubMed: 11274389] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS), FUNCTION, TISSUE SPECIFICITY.
[2]	"A novel gene expressed in human liver non-tumor tissue." Li Y., Wu T., Xu S., Ren S., Chen Z., Han Z. Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-115. Tissue: Small intestine.
[4]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-115. Tissue: Spleen.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[6]	"Down-regulation of retinol binding protein 5 is associated with aggressive tumor features in hepatocellular carcinoma." Ho J.C.Y., Cheung S.T., Poon W.S., Lee Y.T., Ng I.O.L., Fan S.T. J. Cancer Res. Clin. Oncol. 133:929-936(2007) [PubMed: 17497168] [Abstract] Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBLGenBankDDBJ

AY007436 mRNA. Translation: AAG09617.1.
AF212239 mRNA. Translation: AAK14925.1.
AK311977 mRNA. Translation: BAG34916.1.
AK223378 mRNA. Translation: BAD97098.1.
BC029355 mRNA. Translation: AAH29355.1.

RefSeq

NP_113679.1.

UniGene

Hs.246046

3D structure databases

PDBMSD

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1GGL	X-ray	2.31	A/B	1-134	[»]

ModBase

Search...

Genome annotation databases

Ensembl

ENSG00000139194. Homo sapiens. [Contig view]

GeneID

83758.

KEGG

hsa:83758.

Organism-specific databases

H-InvDB

HIX0010395.

HGNC

HGNC:15847. RBP5.

MIM

611866. gene.

PharmGKB

PA34290.

GenAtlas

Search...

GeneCards

Search...

Phylogenomic databases

HOGENOM

P82980.

HOVERGEN

P82980.

Gene expression databases

ArrayExpress

P82980.

CleanEx

HS_RBP5.

GermOnline

ENSG00000139194. Homo sapiens.

Family and domain databases

InterPro

IPR012674. Calycin.
IPR000463. Fatty_acid_bd.
IPR000566. Lipocln_cytFABP.
[Graphical view]

Gene3D

G3DSA:2.40.128.20. Calycin. 1 hit.

PANTHER

PTHR11955. Fatty_acid_bd. 1 hit.

Pfam

PF00061. Lipocalin. 1 hit.
[Graphical view]

PROSITE

PS00214. FABP. False negative.
[Graphical view]

ProtoNet

Search...

Other Resources

DrugBank

DB00162. Vitamin A.

NextBio

72791.

SOURCE

Search...

Entry information

Entry name

RET5_HUMAN

Accession

Primary (citable) accession number: P82980
Secondary accession number(s): Q53FB1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2001
Last sequence update:	January 23, 2007
Last modified:	November 25, 2008
This is version 68 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)