Reviewed,
UniProtKB/Swiss-Prot P82979 (SARNP_HUMAN)
Last modified
January 19, 2010.
Version 83.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: SAP domain-containing ribonucleoprotein Alternative name(s): Nuclear protein Hcc-1 Proliferation-associated cytokine-inducible protein CIP29 Cytokine-induced protein of 29 kDa | ||||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||||
| Taxonomic identifier | 9606 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 210 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Ref.8 Ref.9 |
| Subunit structure | Interacts with DDX39. Interacts with FUS. Ref.9 |
| Subcellular location | |
| Tissue specificity | Low expression in spleen, liver, pancreas, testis, thymus, heart, and kidney. Increased levels are seen in hepatocellular carcinoma and pancreatic adenocarcinoma. Ref.1 |
| Induction | By erythropoietin. |
| Sequence similarities | Contains 1 SAP domain. |
| Sequence caution | The sequence AAF28994.1 differs from that shown. Reason: Frameshift at positions 134 and 149. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation Translation regulation |
| Cellular component | Nucleus |
| Ligand | DNA-binding RNA-binding |
| PTM | Acetylation Phosphoprotein |
| Technical term | 3D-structure Complete proteome Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | regulation of transcription, DNA-dependent Non-traceable author statement. Source: UniProtKB regulation of translationInferred from electronic annotation. Source: UniProtKB-KW transcriptionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | nucleus Ref.1 Non-traceable author statement. Source: UniProtKB |
| Molecular function | DNA binding Inferred from electronic annotation. Source: UniProtKB-KW RNA bindingInferred from electronic annotation. Source: UniProtKB-KW protein bindingInferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||
Molecule processing | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed Ref.7 | ||||||||||||
| Chain | 2 – 210 | 209 | SAP domain-containing ribonucleoprotein | PRO_0000083916 | |||||||||||
Regions | |||||||||||||||
| Domain | 8 – 42 | 35 | SAP | ||||||||||||
Amino acid modifications | |||||||||||||||
| Modified residue | 2 | 1 | N-acetylalanine Ref.7 Ref.12 | ||||||||||||
| Modified residue | 142 | 1 | N6-acetyllysine Ref.13 | ||||||||||||
| Modified residue | 163 | 1 | Phosphoserine Ref.10 | ||||||||||||
Experimental info | |||||||||||||||
| Sequence conflict | 127 | 1 | F → V in AAF28994. Ref.3 | ||||||||||||
| Sequence conflict | 153 – 157 | 5 | RAQRF → ELKDL in AAF28994. Ref.3 | ||||||||||||
| Sequence conflict | 199 – 210 | 12 | KKRKR…RFGIA → RRGKEQSALGLP in AAF28994. Ref.3 | ||||||||||||
Secondary structure | |||||||||||||||
Helix Strand Turn | |||||||||||||||
| Turn | 8 – 10 | 3 | |||||||||||||
| Helix | 13 – 23 | 11 | |||||||||||||
| Helix | 31 – 44 | 14 | |||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "An integrated approach in the discovery and characterization of a novel nuclear protein over-expressed in liver and pancreatic tumors." Choong M.L., Tan L.K., Lo S.L., Ren E.-C., Ou K.L., Ong S.-E., Liang R.C.M.Y., Seow T.K., Chung M.C.M. FEBS Lett. 496:109-116(2001) [PubMed: 11356193] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 110-119; 157-167 AND 181-199, TISSUE SPECIFICITY, SUBCELLULAR LOCATION. Tissue: Liver. |
| [2] | "Cloning and characterization of a proliferation-associated cytokine-inducible protein, CIP29." Fukuda S., Wu D.W., Stark K., Pelus L.M. Biochem. Biophys. Res. Commun. 292:593-600(2002) [PubMed: 11922608] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Mammary cancer. |
| [3] | "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. Chen Z.Genome Res. 10:1546-1560(2000) [PubMed: 11042152] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Umbilical cord blood. |
| [4] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Fetal brain. |
| [5] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate. |
| [7] | Bienvenut W.V., Potts A., Brablan J., Quadroni M. Submitted (JUL-2004) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-10 AND 127-135, ACETYLATION AT ALA-2, MASS SPECTROMETRY. Tissue: B-cell lymphoma. |
| [8] | "Hcc-1 is a novel component of the nuclear matrix with growth inhibitory function." Leaw C.L., Ren E.C., Choong M.L. Cell. Mol. Life Sci. 61:2264-2273(2004) [PubMed: 15338056] [Abstract] Cited for: FUNCTION. |
| [9] | "Intracellular characterization of DDX39, a novel growth-associated RNA helicase." Sugiura T., Sakurai K., Nagano Y. Exp. Cell Res. 313:782-790(2007) [PubMed: 17196963] [Abstract] Cited for: FUNCTION, INTERACTION WITH DDX39 AND FUS. |
| [10] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-163, MASS SPECTROMETRY. |
| [11] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| [12] | "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, MASS SPECTROMETRY. |
| [13] | "Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-142, MASS SPECTROMETRY. |
| [14] | "Solution structure of the SAP domain of human nuclear protein HCC-1." RIKEN structural genomics initiative (RSGI) Submitted (OCT-2006) to the PDB data bank Cited for: STRUCTURE BY NMR OF 6-47. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | AJ409089 Genomic DNA. Translation: CAC37950.1. AF486281 mRNA. Translation: AAM09686.1. AF161434 mRNA. Translation: AAF28994.1. Sequence problems. AK290508 mRNA. Translation: BAF83197.1. CH471054 Genomic DNA. Translation: EAW96838.1. BC007099 mRNA. Translation: AAH07099.1. | ||||||||||||
| IPI | IPI00014938. | ||||||||||||
| PIR | JC7830. | ||||||||||||
| RefSeq | NP_149073.1. | ||||||||||||
| UniGene | Hs.505676 | ||||||||||||
3D structure databases | |||||||||||||
| PDBe RCSB PDB PDBj |
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| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| IntAct | P82979. 2 interactions. | ||||||||||||
| STRING | P82979. | ||||||||||||
PTM databases | |||||||||||||
| PhosphoSite | P82979. | ||||||||||||
Proteomic databases | |||||||||||||
| PRIDE | P82979. | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENST00000336133; ENSP00000337632; ENSG00000205323; Homo sapiens. [Genome view] ENST00000444631; ENSP00000392892; ENSG00000205323; Homo sapiens. [Genome view] | ||||||||||||
| GeneID | 84324. | ||||||||||||
| KEGG | hsa:84324. | ||||||||||||
| UCSC | uc001sht.1. human. | ||||||||||||
Organism-specific databases | |||||||||||||
| CTD | 84324. | ||||||||||||
| GeneCards | GC12M054437. | ||||||||||||
| H-InvDB | HIX0010705. | ||||||||||||
| HGNC | HGNC:24432. SARNP. | ||||||||||||
| MIM | 610049. gene. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| eggNOG | prNOG20287. | ||||||||||||
| HOGENOM | HBG280797. | ||||||||||||
| HOVERGEN | P82979. | ||||||||||||
| InParanoid | P82979. | ||||||||||||
| OMA | XEEEANE. | ||||||||||||
| OrthoDB | EOG9STVR1. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | P82979. | ||||||||||||
| Bgee | P82979. | ||||||||||||
| Genevestigator | P82979. | ||||||||||||
| GermOnline | ENSG00000205323. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR003034. SAP_DNA_bd. [Graphical view] | ||||||||||||
| Pfam | PF02037. SAP. 1 hit. [Graphical view] | ||||||||||||
| SMART | SM00513. SAP. 1 hit. [Graphical view] | ||||||||||||
| PROSITE | PS50800. SAP. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other Resources | |||||||||||||
| NextBio | 74056. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | SARNP_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P82979 Secondary accession number(s): A8K393, Q9P066 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 12 Human chromosome 12: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


