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Protein

Phospholipase A2

Gene
N/A
Organism
Bombus terrestris (Buff-tailed bumblebee) (Apis terrestris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.

Catalytic activityi

Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.PROSITE-ProRule annotation

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi8Calcium; via carbonyl oxygenBy similarity1
Metal bindingi10Calcium; via carbonyl oxygenBy similarity1
Metal bindingi12Calcium; via carbonyl oxygenBy similarity1
Active sitei34PROSITE-ProRule annotation1
Metal bindingi35CalciumBy similarity1
Active sitei64PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase A2 (EC:3.1.1.4)
Short name:
PLA2
Alternative name(s):
Phosphatidylcholine 2-acylhydrolase
Allergen: Bom t 1
OrganismiBombus terrestris (Buff-tailed bumblebee) (Apis terrestris)
Taxonomic identifieri30195 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaHymenopteraApocritaAculeataApoideaApidaeBombusBombus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei155. Bom t 1.
3159. Bom t 1.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001617241 – 136Phospholipase A2Add BLAST136

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi9 ↔ 31By similarity
Glycosylationi16N-linked (GlcNAc...) asparagine1
Disulfide bondi30 ↔ 70By similarity
Disulfide bondi37 ↔ 63By similarity
Disulfide bondi61 ↔ 95By similarity
Disulfide bondi105 ↔ 117By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP82971.

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP82971.
SMRiP82971.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phospholipase A2 family.Curated

Family and domain databases

Gene3Di1.20.90.10. 1 hit.
InterProiView protein in InterPro
IPR016090. PLipase_A2_dom.
IPR033113. PLipase_A2_His_AS.
PfamiView protein in Pfam
PF05826. Phospholip_A2_2. 1 hit.
SMARTiView protein in SMART
SM00085. PA2c. 1 hit.
SUPFAMiSSF48619. SSF48619. 1 hit.
PROSITEiView protein in PROSITE
PS00118. PA2_HIS. 1 hit.

Sequencei

Sequence statusi: Complete.

P82971-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
IIFPGTLWCG NGNLANGTNQ LGSWKETDSC CRTHDMCPDL IEAHGSKHGL
60 70 80 90 100
TNAADYTRLS CECDEEFRRC LHNSGDTVSA GFVGRTYFTV LHTQCFRLDY
110 120 130
PIVKCKVKST ILHRSKCYDF ETFAPKKYQW FDVLQY
Length:136
Mass (Da):15,546
Last modified:June 20, 2001 - v1
Checksum:i07797BDDEC74F20E
GO

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPA2_BOMTE
AccessioniPrimary (citable) accession number: P82971
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: May 10, 2017
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families