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Protein

High mobility group nucleosome-binding domain-containing protein 5

Gene

HMGN5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction.By similarity

GO - Molecular functioni

  • chromatin binding Source: GO_Central
  • nucleosomal DNA binding Source: InterPro
  • RNA binding Source: UniProtKB

GO - Biological processi

  • covalent chromatin modification Source: UniProtKB-KW
  • glutathione metabolic process Source: Ensembl
  • negative regulation of apoptotic process Source: CACAO
  • negative regulation of cell cycle arrest Source: CACAO
  • positive regulation of cell proliferation Source: CACAO
  • positive regulation of gene expression Source: CACAO
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB
  • regulation of transcription from RNA polymerase II promoter Source: GO_Central
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
High mobility group nucleosome-binding domain-containing protein 5
Alternative name(s):
Nucleosome-binding protein 1
Gene namesi
Name:HMGN5
Synonyms:NSBP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:8013. HMGN5.

Subcellular locationi

  • Nucleus 1 Publication

  • Note: Associates with nucleosomes in euchromatin and is largely excluded from constitutive heterochromatin.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi79366.
OpenTargetsiENSG00000198157.
PharmGKBiPA31789.

Polymorphism and mutation databases

BioMutaiHMGN5.
DMDMi23396771.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002067171 – 282High mobility group nucleosome-binding domain-containing protein 5Add BLAST282

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei31PhosphothreonineCombined sources1
Cross-linki67Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei76PhosphotyrosineCombined sources1
Modified residuei93PhosphoserineCombined sources1
Cross-linki101Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki101Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki124Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP82970.
MaxQBiP82970.
PaxDbiP82970.
PeptideAtlasiP82970.
PRIDEiP82970.
TopDownProteomicsiP82970.

PTM databases

iPTMnetiP82970.
PhosphoSitePlusiP82970.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000198157.
CleanExiHS_NSBP1.
ExpressionAtlasiP82970. baseline and differential.
GenevisibleiP82970. HS.

Organism-specific databases

HPAiHPA000511.

Interactioni

Protein-protein interaction databases

BioGridi122655. 15 interactors.
IntActiP82970. 1 interactor.
STRINGi9606.ENSP00000350848.

Structurei

3D structure databases

ProteinModelPortaliP82970.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Specifically targeted by its C-terminus to nucleosomes in euchromatin.By similarity

Sequence similaritiesi

Belongs to the HMGN family.Curated

Phylogenomic databases

eggNOGiENOG410JCH1. Eukaryota.
ENOG410XQBG. LUCA.
GeneTreeiENSGT00730000111570.
HOGENOMiHOG000113856.
HOVERGENiHBG094823.
InParanoidiP82970.
KOiK17045.
OMAiSAMLVPF.
OrthoDBiEOG091G12C3.
PhylomeDBiP82970.

Family and domain databases

InterProiView protein in InterPro
IPR000079. HMGN_fam.
PfamiView protein in Pfam
PF01101. HMG14_17. 1 hit.
PRINTSiPR00925. NONHISHMG17.
SMARTiView protein in SMART
SM00527. HMG17. 1 hit.
PROSITEiView protein in PROSITE
PS00355. HMG14_17. 1 hit.

Sequencei

Sequence statusi: Complete.

P82970-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKRKAAGQG DMRQEPKRRS ARLSAMLVPV TPEVKPKRTS SSRKMKTKSD
60 70 80 90 100
MMEENIDTSA QAVAETKQEA VVEEDYNENA KNGEAKITEA PASEKEIVEV
110 120 130 140 150
KEENIEDATE KGGEKKEAVA AEVKNEEEDQ KEDEEDQNEE KGEAGKEDKD
160 170 180 190 200
EKGEEDGKED KNGNEKGEDA KEKEDGKKGE DGKGNGEDGK EKGEDEKEEE
210 220 230 240 250
DRKETGDGKE NEDGKEKGDK KEGKDVKVKE DEKEREDGKE DEGGNEEEAG
260 270 280
KEKEDLKEEE EGKEEDEIKE DDGKKEEPQS IV
Length:282
Mass (Da):31,525
Last modified:June 1, 2001 - v1
Checksum:i257A2B22C795308F
GO

Sequence cautioni

The sequence AK094058 differs from that shown. Reason: Frameshift at position 132.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250329 mRNA. Translation: AAK14062.1.
AF250330 Genomic DNA. Translation: AAK14063.1.
AK094058 mRNA. No translation available.
AL391294 Genomic DNA. No translation available.
CH471104 Genomic DNA. Translation: EAW98582.1.
BC005342 mRNA. Translation: AAH05342.1.
CCDSiCCDS14448.1.
RefSeqiNP_110390.1. NM_030763.2.
UniGeneiHs.282204.

Genome annotation databases

EnsembliENST00000358130; ENSP00000350848; ENSG00000198157.
GeneIDi79366.
KEGGihsa:79366.
UCSCiuc004eee.1. human.

Similar proteinsi

Entry informationi

Entry nameiHMGN5_HUMAN
AccessioniPrimary (citable) accession number: P82970
Secondary accession number(s): Q5JSL1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 2001
Last modified: August 30, 2017
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families