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Protein

High mobility group nucleosome-binding domain-containing protein 5

Gene

HMGN5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction.By similarity

GO - Molecular functioni

  • chromatin binding Source: UniProtKB
  • nucleosomal DNA binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  • chromatin modification Source: UniProtKB-KW
  • glutathione metabolic process Source: Ensembl
  • negative regulation of apoptotic process Source: CACAO
  • negative regulation of cell cycle arrest Source: CACAO
  • positive regulation of cell proliferation Source: CACAO
  • positive regulation of gene expression Source: CACAO
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB
  • regulation of transcription from RNA polymerase II promoter Source: GO_Central
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:G66-31786-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
High mobility group nucleosome-binding domain-containing protein 5
Alternative name(s):
Nucleosome-binding protein 1
Gene namesi
Name:HMGN5
Synonyms:NSBP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:8013. HMGN5.

Subcellular locationi

  • Nucleus 1 Publication

  • Note: Associates with nucleosomes in euchromatin and is largely excluded from constitutive heterochromatin.By similarity

GO - Cellular componenti

  • chromatin Source: InterPro
  • intracellular membrane-bounded organelle Source: HPA
  • nucleolus Source: HPA
  • nucleoplasm Source: Ensembl
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi79366.
OpenTargetsiENSG00000198157.
PharmGKBiPA31789.

Polymorphism and mutation databases

BioMutaiHMGN5.
DMDMi23396771.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002067171 – 282High mobility group nucleosome-binding domain-containing protein 5Add BLAST282

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei31PhosphothreonineCombined sources1
Cross-linki67Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei76PhosphotyrosineCombined sources1
Modified residuei93PhosphoserineCombined sources1
Cross-linki101Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki101Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki124Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP82970.
MaxQBiP82970.
PaxDbiP82970.
PeptideAtlasiP82970.
PRIDEiP82970.
TopDownProteomicsiP82970.

PTM databases

iPTMnetiP82970.
PhosphoSitePlusiP82970.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000198157.
CleanExiHS_NSBP1.
ExpressionAtlasiP82970. baseline and differential.
GenevisibleiP82970. HS.

Organism-specific databases

HPAiHPA000511.

Interactioni

Protein-protein interaction databases

BioGridi122655. 9 interactors.
IntActiP82970. 1 interactor.
STRINGi9606.ENSP00000350848.

Structurei

3D structure databases

ProteinModelPortaliP82970.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Specifically targeted by its C-terminus to nucleosomes in euchromatin.By similarity

Sequence similaritiesi

Belongs to the HMGN family.Curated

Phylogenomic databases

eggNOGiENOG410JCH1. Eukaryota.
ENOG410XQBG. LUCA.
GeneTreeiENSGT00730000111570.
HOGENOMiHOG000113856.
HOVERGENiHBG094823.
InParanoidiP82970.
KOiK17045.
OMAiAERNTEN.
OrthoDBiEOG091G12C3.
PhylomeDBiP82970.

Family and domain databases

InterProiIPR000079. HMGN_fam.
[Graphical view]
PfamiPF01101. HMG14_17. 1 hit.
[Graphical view]
PRINTSiPR00925. NONHISHMG17.
SMARTiSM00527. HMG17. 1 hit.
[Graphical view]
PROSITEiPS00355. HMG14_17. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P82970-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKRKAAGQG DMRQEPKRRS ARLSAMLVPV TPEVKPKRTS SSRKMKTKSD
60 70 80 90 100
MMEENIDTSA QAVAETKQEA VVEEDYNENA KNGEAKITEA PASEKEIVEV
110 120 130 140 150
KEENIEDATE KGGEKKEAVA AEVKNEEEDQ KEDEEDQNEE KGEAGKEDKD
160 170 180 190 200
EKGEEDGKED KNGNEKGEDA KEKEDGKKGE DGKGNGEDGK EKGEDEKEEE
210 220 230 240 250
DRKETGDGKE NEDGKEKGDK KEGKDVKVKE DEKEREDGKE DEGGNEEEAG
260 270 280
KEKEDLKEEE EGKEEDEIKE DDGKKEEPQS IV
Length:282
Mass (Da):31,525
Last modified:June 1, 2001 - v1
Checksum:i257A2B22C795308F
GO

Sequence cautioni

The sequence AK094058 differs from that shown. Reason: Frameshift at position 132.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250329 mRNA. Translation: AAK14062.1.
AF250330 Genomic DNA. Translation: AAK14063.1.
AK094058 mRNA. No translation available.
AL391294 Genomic DNA. Translation: CAI39708.1.
CH471104 Genomic DNA. Translation: EAW98582.1.
BC005342 mRNA. Translation: AAH05342.1.
CCDSiCCDS14448.1.
RefSeqiNP_110390.1. NM_030763.2.
UniGeneiHs.282204.

Genome annotation databases

EnsembliENST00000358130; ENSP00000350848; ENSG00000198157.
GeneIDi79366.
KEGGihsa:79366.
UCSCiuc004eee.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250329 mRNA. Translation: AAK14062.1.
AF250330 Genomic DNA. Translation: AAK14063.1.
AK094058 mRNA. No translation available.
AL391294 Genomic DNA. Translation: CAI39708.1.
CH471104 Genomic DNA. Translation: EAW98582.1.
BC005342 mRNA. Translation: AAH05342.1.
CCDSiCCDS14448.1.
RefSeqiNP_110390.1. NM_030763.2.
UniGeneiHs.282204.

3D structure databases

ProteinModelPortaliP82970.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122655. 9 interactors.
IntActiP82970. 1 interactor.
STRINGi9606.ENSP00000350848.

PTM databases

iPTMnetiP82970.
PhosphoSitePlusiP82970.

Polymorphism and mutation databases

BioMutaiHMGN5.
DMDMi23396771.

Proteomic databases

EPDiP82970.
MaxQBiP82970.
PaxDbiP82970.
PeptideAtlasiP82970.
PRIDEiP82970.
TopDownProteomicsiP82970.

Protocols and materials databases

DNASUi79366.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358130; ENSP00000350848; ENSG00000198157.
GeneIDi79366.
KEGGihsa:79366.
UCSCiuc004eee.1. human.

Organism-specific databases

CTDi79366.
DisGeNETi79366.
GeneCardsiHMGN5.
HGNCiHGNC:8013. HMGN5.
HPAiHPA000511.
MIMi300385. gene.
neXtProtiNX_P82970.
OpenTargetsiENSG00000198157.
PharmGKBiPA31789.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JCH1. Eukaryota.
ENOG410XQBG. LUCA.
GeneTreeiENSGT00730000111570.
HOGENOMiHOG000113856.
HOVERGENiHBG094823.
InParanoidiP82970.
KOiK17045.
OMAiAERNTEN.
OrthoDBiEOG091G12C3.
PhylomeDBiP82970.

Enzyme and pathway databases

BioCyciZFISH:G66-31786-MONOMER.

Miscellaneous databases

ChiTaRSiHMGN5. human.
GenomeRNAii79366.
PROiP82970.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198157.
CleanExiHS_NSBP1.
ExpressionAtlasiP82970. baseline and differential.
GenevisibleiP82970. HS.

Family and domain databases

InterProiIPR000079. HMGN_fam.
[Graphical view]
PfamiPF01101. HMG14_17. 1 hit.
[Graphical view]
PRINTSiPR00925. NONHISHMG17.
SMARTiSM00527. HMG17. 1 hit.
[Graphical view]
PROSITEiPS00355. HMG14_17. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHMGN5_HUMAN
AccessioniPrimary (citable) accession number: P82970
Secondary accession number(s): Q5JSL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.