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Protein

Hepcidin

Gene

hamp

Organism
Morone chrysops x Morone saxatilis (White bass x Striped bass)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity).By similarity
Antimicrobial activity against Gram-negative bacteria such as E.coli.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Hepcidin
Gene namesi
Name:hamp
OrganismiMorone chrysops x Morone saxatilis (White bass x Striped bass)
Taxonomic identifieri45352 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaMoronidaeMorone

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Propeptidei25 – 64401 PublicationPRO_0000013391Add
BLAST
Peptidei65 – 8521HepcidinPRO_0000013392Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi66 ↔ 831 Publication
Disulfide bondi69 ↔ 721 Publication
Disulfide bondi70 ↔ 791 Publication
Disulfide bondi73 ↔ 821 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Predominantly expressed in liver.1 Publication

Inductioni

By bacterial challenge.

Structurei

Secondary structure

1
85
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi67 – 704Combined sources
Beta strandi80 – 823Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1S6WNMR-A65-85[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP82951.

Family & Domainsi

Sequence similaritiesi

Belongs to the hepcidin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG024013.

Family and domain databases

InterProiIPR010500. Hepcidin.
[Graphical view]
PfamiPF06446. Hepcidin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P82951-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTFSVAVAV AVVLAFICLQ ESSAVPVTEV QELEEPMSNE YQEMPVESWK
60 70 80
MPYNNRHKRH SSPGGCRFCC NCCPNMSGCG VCCRF
Length:85
Mass (Da):9,484
Last modified:June 20, 2002 - v1
Checksum:i0FEA55CF0A522C84
GO

Mass spectrometryi

Molecular mass is 2255.97 Da from positions 65 - 85. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF394245 Genomic DNA. Translation: AAM28439.1.
AF394246 mRNA. Translation: AAM28440.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF394245 Genomic DNA. Translation: AAM28439.1.
AF394246 mRNA. Translation: AAM28440.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1S6WNMR-A65-85[»]
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG024013.

Miscellaneous databases

EvolutionaryTraceiP82951.

Family and domain databases

InterProiIPR010500. Hepcidin.
[Graphical view]
PfamiPF06446. Hepcidin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Bass hepcidin is a novel antimicrobial peptide induced by bacterial challenge."
    Shike H., Lauth X., Westerman M.E., Ostland V.E., Carlberg J.M., Van Olst J.C., Shimizu C., Bulet P., Burns J.C.
    Eur. J. Biochem. 269:2232-2237(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], PROTEIN SEQUENCE OF 65-85, TISSUE SPECIFICITY, ANTIBACTERIAL ACTIVITY, MASS SPECTROMETRY.
    Tissue: Gill and Skin.
  2. "Bass hepcidin synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections."
    Lauth X., Babon J.J., Stannard J.A., Singh S., Nizet V., Carlberg J.M., Ostland V.E., Pennington M.W., Norton R.S., Westerman M.E.
    J. Biol. Chem. 280:9272-9282(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 65-85, DISULFIDE BONDS.

Entry informationi

Entry nameiHEPC_MORCS
AccessioniPrimary (citable) accession number: P82951
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: June 20, 2002
Last modified: June 24, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.