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P82943 (REG1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Regakine-1
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length92 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Chemotactic activity for neutrophils and lymphocytes. Binds to heparin. Ref.2

Subcellular location

Secreted.

Tissue specificity

Plasma serum. Ref.2

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
   Biological processChemotaxis
Inflammatory response
   Cellular componentSecreted
   DomainSignal
   LigandHeparin-binding
   Molecular functionCytokine
   PTMDisulfide bond
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processcell chemotaxis

Inferred from electronic annotation. Source: GOC

immune response

Inferred from electronic annotation. Source: InterPro

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionheparin binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Ref.2
Chain22 – 9271Regakine-1
PRO_0000005140

Amino acid modifications

Disulfide bond32 ↔ 56 By similarity
Disulfide bond33 ↔ 72 By similarity

Sequences

Sequence LengthMass (Da)Tools
P82943 [UniParc].

Last modified April 13, 2004. Version 2.
Checksum: 797B53A5C0CA334A

FASTA9210,281
        10         20         30         40         50         60 
MRVSLAALAF LLTLAVLHSE ANEEPAGNMR VCCFSSVTRK IPLSLVKNYE RTGDKCPQEA 

        70         80         90 
VIFQTRSGRS ICANPGQAWV QKYIEYLDQM SK 

« Hide

References

[1]"Gene cloning of a new plasma CC chemokine, activating and attracting myeloid cells in synergy with other chemoattractants."
Struyf S., Stoops G., Van Coillie E., Gouwy M., Schutyser E., Lenaerts J.-P., Fiten P., Van Aelst I., Proost P., Opdenakker G., Van Damme J.
Biochemistry 40:11715-11722(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Identification of a blood-derived chemoattractant for neutrophils and lymphocytes as a novel CC chemokine, Regakine-1."
Struyf S., Proost P., Lenaerts J.-P., Stoops S., Wuyts A., Van Damme J.
Blood 97:2197-2204(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 22-91, FUNCTION, TISSUE SPECIFICITY.
Tissue: Serum.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ313203 Genomic DNA. Translation: CAC85743.1.
RefSeqNP_001029392.1. NM_001034220.2.
UniGeneBt.6556.

3D structure databases

ProteinModelPortalP82943.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP82943.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000013399; ENSBTAP00000013399; ENSBTAG00000010155.
GeneID504773.
KEGGbta:504773.

Phylogenomic databases

GeneTreeENSGT00730000110278.
HOGENOMHOG000036686.
HOVERGENHBG017871.
InParanoidP82943.
OMASICANPG.
OrthoDBEOG7CVQ1F.
TreeFamTF334888.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20866823.

Entry information

Entry nameREG1_BOVIN
AccessionPrimary (citable) accession number: P82943
Secondary accession number(s): Q8MI76
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: April 13, 2004
Last modified: March 19, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families