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P82943

- REG1_BOVIN

UniProt

P82943 - REG1_BOVIN

Protein

Regakine-1

Gene
N/A
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Chemotactic activity for neutrophils and lymphocytes. Binds to heparin.1 Publication

    GO - Molecular functioni

    1. heparin binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. immune response Source: InterPro
    3. inflammatory response Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Keywords - Ligandi

    Heparin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regakine-1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 19

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 21211 PublicationAdd
    BLAST
    Chaini22 – 9271Regakine-1PRO_0000005140Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi32 ↔ 56By similarity
    Disulfide bondi33 ↔ 72By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiP82943.

    Expressioni

    Tissue specificityi

    Plasma serum.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliP82943.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    GeneTreeiENSGT00730000110278.
    HOGENOMiHOG000036686.
    HOVERGENiHBG017871.
    InParanoidiP82943.
    OMAiCSTPGVI.
    OrthoDBiEOG7CVQ1F.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P82943-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRVSLAALAF LLTLAVLHSE ANEEPAGNMR VCCFSSVTRK IPLSLVKNYE   50
    RTGDKCPQEA VIFQTRSGRS ICANPGQAWV QKYIEYLDQM SK 92
    Length:92
    Mass (Da):10,281
    Last modified:April 13, 2004 - v2
    Checksum:i797B53A5C0CA334A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ313203 Genomic DNA. Translation: CAC85743.1.
    RefSeqiNP_001029392.1. NM_001034220.2.
    UniGeneiBt.6556.

    Genome annotation databases

    EnsembliENSBTAT00000013399; ENSBTAP00000013399; ENSBTAG00000010155.
    GeneIDi504773.
    KEGGibta:504773.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ313203 Genomic DNA. Translation: CAC85743.1 .
    RefSeqi NP_001029392.1. NM_001034220.2.
    UniGenei Bt.6556.

    3D structure databases

    ProteinModelPortali P82943.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P82943.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000013399 ; ENSBTAP00000013399 ; ENSBTAG00000010155 .
    GeneIDi 504773.
    KEGGi bta:504773.

    Phylogenomic databases

    GeneTreei ENSGT00730000110278.
    HOGENOMi HOG000036686.
    HOVERGENi HBG017871.
    InParanoidi P82943.
    OMAi CSTPGVI.
    OrthoDBi EOG7CVQ1F.
    TreeFami TF334888.

    Miscellaneous databases

    NextBioi 20866823.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Gene cloning of a new plasma CC chemokine, activating and attracting myeloid cells in synergy with other chemoattractants."
      Struyf S., Stoops G., Van Coillie E., Gouwy M., Schutyser E., Lenaerts J.-P., Fiten P., Van Aelst I., Proost P., Opdenakker G., Van Damme J.
      Biochemistry 40:11715-11722(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Identification of a blood-derived chemoattractant for neutrophils and lymphocytes as a novel CC chemokine, Regakine-1."
      Struyf S., Proost P., Lenaerts J.-P., Stoops S., Wuyts A., Van Damme J.
      Blood 97:2197-2204(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 22-91, FUNCTION, TISSUE SPECIFICITY.
      Tissue: Serum.

    Entry informationi

    Entry nameiREG1_BOVIN
    AccessioniPrimary (citable) accession number: P82943
    Secondary accession number(s): Q8MI76
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: April 13, 2004
    Last modified: October 1, 2014
    This is version 78 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3