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Protein

Regakine-1

Gene
N/A
Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Chemotactic activity for neutrophils and lymphocytes. Binds to heparin.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Regakine-1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Chaini22 – 9271Regakine-1PRO_0000005140Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 56By similarity
Disulfide bondi33 ↔ 72By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP82943.
PRIDEiP82943.

Expressioni

Tissue specificityi

Plasma serum.1 Publication

Gene expression databases

BgeeiENSBTAG00000010155.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013399.

Structurei

3D structure databases

ProteinModelPortaliP82943.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JQZ5. Eukaryota.
ENOG41116XA. LUCA.
GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiP82943.
OMAiICANPGQ.
OrthoDBiEOG091G14Y2.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P82943-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVSLAALAF LLTLAVLHSE ANEEPAGNMR VCCFSSVTRK IPLSLVKNYE
60 70 80 90
RTGDKCPQEA VIFQTRSGRS ICANPGQAWV QKYIEYLDQM SK
Length:92
Mass (Da):10,281
Last modified:April 13, 2004 - v2
Checksum:i797B53A5C0CA334A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ313203 Genomic DNA. Translation: CAC85743.1.
RefSeqiNP_001029392.1. NM_001034220.2.
UniGeneiBt.6556.

Genome annotation databases

EnsembliENSBTAT00000013399; ENSBTAP00000013399; ENSBTAG00000010155.
GeneIDi504773.
KEGGibta:504773.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ313203 Genomic DNA. Translation: CAC85743.1.
RefSeqiNP_001029392.1. NM_001034220.2.
UniGeneiBt.6556.

3D structure databases

ProteinModelPortaliP82943.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013399.

Proteomic databases

PaxDbiP82943.
PRIDEiP82943.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000013399; ENSBTAP00000013399; ENSBTAG00000010155.
GeneIDi504773.
KEGGibta:504773.

Phylogenomic databases

eggNOGiENOG410JQZ5. Eukaryota.
ENOG41116XA. LUCA.
GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiP82943.
OMAiICANPGQ.
OrthoDBiEOG091G14Y2.
TreeFamiTF334888.

Gene expression databases

BgeeiENSBTAG00000010155.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiREG1_BOVIN
AccessioniPrimary (citable) accession number: P82943
Secondary accession number(s): Q8MI76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: April 13, 2004
Last modified: September 7, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.