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Protein

Regakine-1

Gene
N/A
Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Chemotactic activity for neutrophils and lymphocytes. Binds to heparin.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Heparin-binding
Biological processChemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-BTA-416476. G alpha (q) signalling events.
R-BTA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Regakine-1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000000514022 – 92Regakine-1Add BLAST71

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 56By similarity
Disulfide bondi33 ↔ 72By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP82943.
PRIDEiP82943.

Expressioni

Tissue specificityi

Plasma serum.1 Publication

Gene expression databases

BgeeiENSBTAG00000010155.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013399.

Structurei

3D structure databases

ProteinModelPortaliP82943.
SMRiP82943.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JQZ5. Eukaryota.
ENOG41116XA. LUCA.
GeneTreeiENSGT00860000133690.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiP82943.
OMAiICANPGQ.
OrthoDBiEOG091G14Y2.
TreeFamiTF334888.

Family and domain databases

InterProiView protein in InterPro
IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
PfamiView protein in Pfam
PF00048. IL8. 1 hit.
SMARTiView protein in SMART
SM00199. SCY. 1 hit.
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiView protein in PROSITE
PS00472. SMALL_CYTOKINES_CC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P82943-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVSLAALAF LLTLAVLHSE ANEEPAGNMR VCCFSSVTRK IPLSLVKNYE
60 70 80 90
RTGDKCPQEA VIFQTRSGRS ICANPGQAWV QKYIEYLDQM SK
Length:92
Mass (Da):10,281
Last modified:April 13, 2004 - v2
Checksum:i797B53A5C0CA334A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ313203 Genomic DNA. Translation: CAC85743.1.
RefSeqiNP_001029392.1. NM_001034220.2.
UniGeneiBt.6556.

Genome annotation databases

EnsembliENSBTAT00000013399; ENSBTAP00000013399; ENSBTAG00000010155.
GeneIDi504773.
KEGGibta:504773.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiREG1_BOVIN
AccessioniPrimary (citable) accession number: P82943
Secondary accession number(s): Q8MI76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: April 13, 2004
Last modified: June 7, 2017
This is version 91 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families