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P82943

- REG1_BOVIN

UniProt

P82943 - REG1_BOVIN

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Protein
Regakine-1
Gene
N/A
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Chemotactic activity for neutrophils and lymphocytes. Binds to heparin.1 Publication

GO - Molecular functioni

  1. heparin binding Source: UniProtKB-KW

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. immune response Source: InterPro
  3. inflammatory response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Regakine-1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 19

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 Publication
Add
BLAST
Chaini22 – 9271Regakine-1
PRO_0000005140Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 56 By similarity
Disulfide bondi33 ↔ 72 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP82943.

Expressioni

Tissue specificityi

Plasma serum.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP82943.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00730000110278.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiP82943.
OMAiCSTPGVI.
OrthoDBiEOG7CVQ1F.
TreeFamiTF334888.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P82943-1 [UniParc]FASTAAdd to Basket

« Hide

MRVSLAALAF LLTLAVLHSE ANEEPAGNMR VCCFSSVTRK IPLSLVKNYE   50
RTGDKCPQEA VIFQTRSGRS ICANPGQAWV QKYIEYLDQM SK 92
Length:92
Mass (Da):10,281
Last modified:April 13, 2004 - v2
Checksum:i797B53A5C0CA334A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ313203 Genomic DNA. Translation: CAC85743.1.
RefSeqiNP_001029392.1. NM_001034220.2.
UniGeneiBt.6556.

Genome annotation databases

EnsembliENSBTAT00000013399; ENSBTAP00000013399; ENSBTAG00000010155.
GeneIDi504773.
KEGGibta:504773.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ313203 Genomic DNA. Translation: CAC85743.1 .
RefSeqi NP_001029392.1. NM_001034220.2.
UniGenei Bt.6556.

3D structure databases

ProteinModelPortali P82943.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P82943.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000013399 ; ENSBTAP00000013399 ; ENSBTAG00000010155 .
GeneIDi 504773.
KEGGi bta:504773.

Phylogenomic databases

GeneTreei ENSGT00730000110278.
HOGENOMi HOG000036686.
HOVERGENi HBG017871.
InParanoidi P82943.
OMAi CSTPGVI.
OrthoDBi EOG7CVQ1F.
TreeFami TF334888.

Miscellaneous databases

NextBioi 20866823.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Gene cloning of a new plasma CC chemokine, activating and attracting myeloid cells in synergy with other chemoattractants."
    Struyf S., Stoops G., Van Coillie E., Gouwy M., Schutyser E., Lenaerts J.-P., Fiten P., Van Aelst I., Proost P., Opdenakker G., Van Damme J.
    Biochemistry 40:11715-11722(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Identification of a blood-derived chemoattractant for neutrophils and lymphocytes as a novel CC chemokine, Regakine-1."
    Struyf S., Proost P., Lenaerts J.-P., Stoops S., Wuyts A., Van Damme J.
    Blood 97:2197-2204(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-91, FUNCTION, TISSUE SPECIFICITY.
    Tissue: Serum.

Entry informationi

Entry nameiREG1_BOVIN
AccessioniPrimary (citable) accession number: P82943
Secondary accession number(s): Q8MI76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: April 13, 2004
Last modified: May 14, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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