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P82933

- RT09_HUMAN

UniProt

P82933 - RT09_HUMAN

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Protein
28S ribosomal protein S9, mitochondrial
Gene
MRPS9, RPMS9
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. protein binding Source: IntAct
  3. structural constituent of ribosome Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. DNA damage response, detection of DNA damage Source: UniProtKB
  2. peptide biosynthetic process Source: UniProtKB
  3. translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S9, mitochondrial
Short name:
MRP-S9
Short name:
S9mt
Gene namesi
Name:MRPS9
Synonyms:RPMS9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:14501. MRPS9.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial small ribosomal subunit Source: UniProtKB
  2. mitochondrion Source: HPA
  3. nucleolus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31028.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 39628S ribosomal protein S9, mitochondrialPRO_0000030655
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei287 – 2871N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP82933.
PaxDbiP82933.
PRIDEiP82933.

PTM databases

PhosphoSiteiP82933.

Expressioni

Gene expression databases

ArrayExpressiP82933.
BgeeiP82933.
CleanExiHS_MRPS9.
GenevestigatoriP82933.

Organism-specific databases

HPAiHPA043476.
HPA048479.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
revP046182EBI-721385,EBI-6164309From a different organism.

Protein-protein interaction databases

BioGridi122360. 42 interactions.
IntActiP82933. 9 interactions.
MINTiMINT-1379488.
STRINGi9606.ENSP00000258455.

Structurei

3D structure databases

ProteinModelPortaliP82933.
SMRiP82933. Positions 274-389.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0103.
HOGENOMiHOG000020877.
HOVERGENiHBG023132.
InParanoidiP82933.
KOiK02996.
OMAiARPVMKH.
OrthoDBiEOG79PJPF.
PhylomeDBiP82933.
TreeFamiTF106154.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
InterProiIPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR000754. Ribosomal_S9.
IPR020574. Ribosomal_S9_CS.
[Graphical view]
PANTHERiPTHR21569. PTHR21569. 1 hit.
PfamiPF00380. Ribosomal_S9. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
PROSITEiPS00360. RIBOSOMAL_S9. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P82933-1 [UniParc]FASTAAdd to Basket

« Hide

MAAPCVSYGG AVSYRLLLWG RGSLARKQGL WKTAAPELQT NVRSQILRLR    50
HTAFVIPKKN VPTSKRETYT EDFIKKQIEE FNIGKRHLAN MMGEDPETFT 100
QEDIDRAIAY LFPSGLFEKR ARPVMKHPEQ IFPRQRAIQW GEDGRPFHYL 150
FYTGKQSYYS LMHDVYGMLL NLEKHQSHLQ AKSLLPEKTV TRDVIGSRWL 200
IKEELEEMLV EKLSDLDYMQ FIRLLEKLLT SQCGAAEEEF VQRFRRSVTL 250
ESKKQLIEPV QYDEQGMAFS KSEGKRKTAK AEAIVYKHGS GRIKVNGIDY 300
QLYFPITQDR EQLMFPFHFV DRLGKHDVTC TVSGGGRSAQ AGAIRLAMAK 350
ALCSFVTEDE VEWMRQAGLL TTDPRVRERK KPGQEGARRK FTWKKR 396
Length:396
Mass (Da):45,835
Last modified:December 16, 2008 - v2
Checksum:i74412E34F0926360
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti13 – 131S → L.
Corresponds to variant rs13399067 [ dbSNP | Ensembl ].
VAR_047902

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC010884 Genomic DNA. No translation available.
AC107080 Genomic DNA. No translation available.
AC104655 Genomic DNA. No translation available.
CH471127 Genomic DNA. Translation: EAX01767.1.
BC057240 mRNA. Translation: AAH57240.1.
CCDSiCCDS2065.1.
RefSeqiNP_872578.1. NM_182640.2.
UniGeneiHs.590900.

Genome annotation databases

EnsembliENST00000258455; ENSP00000258455; ENSG00000135972.
GeneIDi64965.
KEGGihsa:64965.
UCSCiuc002tcn.4. human.

Polymorphism databases

DMDMi218511769.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC010884 Genomic DNA. No translation available.
AC107080 Genomic DNA. No translation available.
AC104655 Genomic DNA. No translation available.
CH471127 Genomic DNA. Translation: EAX01767.1 .
BC057240 mRNA. Translation: AAH57240.1 .
CCDSi CCDS2065.1.
RefSeqi NP_872578.1. NM_182640.2.
UniGenei Hs.590900.

3D structure databases

ProteinModelPortali P82933.
SMRi P82933. Positions 274-389.
ModBasei Search...

Protein-protein interaction databases

BioGridi 122360. 42 interactions.
IntActi P82933. 9 interactions.
MINTi MINT-1379488.
STRINGi 9606.ENSP00000258455.

PTM databases

PhosphoSitei P82933.

Polymorphism databases

DMDMi 218511769.

Proteomic databases

MaxQBi P82933.
PaxDbi P82933.
PRIDEi P82933.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000258455 ; ENSP00000258455 ; ENSG00000135972 .
GeneIDi 64965.
KEGGi hsa:64965.
UCSCi uc002tcn.4. human.

Organism-specific databases

CTDi 64965.
GeneCardsi GC02P105654.
HGNCi HGNC:14501. MRPS9.
HPAi HPA043476.
HPA048479.
MIMi 611975. gene.
neXtProti NX_P82933.
PharmGKBi PA31028.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0103.
HOGENOMi HOG000020877.
HOVERGENi HBG023132.
InParanoidi P82933.
KOi K02996.
OMAi ARPVMKH.
OrthoDBi EOG79PJPF.
PhylomeDBi P82933.
TreeFami TF106154.

Miscellaneous databases

GenomeRNAii 64965.
NextBioi 67144.
PROi P82933.
SOURCEi Search...

Gene expression databases

ArrayExpressi P82933.
Bgeei P82933.
CleanExi HS_MRPS9.
Genevestigatori P82933.

Family and domain databases

Gene3Di 3.30.230.10. 1 hit.
InterProi IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR000754. Ribosomal_S9.
IPR020574. Ribosomal_S9_CS.
[Graphical view ]
PANTHERi PTHR21569. PTHR21569. 1 hit.
Pfami PF00380. Ribosomal_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF54211. SSF54211. 1 hit.
PROSITEi PS00360. RIBOSOMAL_S9. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present."
    Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L.
    J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  5. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-287, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRT09_HUMAN
AccessioniPrimary (citable) accession number: P82933
Secondary accession number(s): Q6PG40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: December 16, 2008
Last modified: September 3, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Ribosomal proteins
    Ribosomal proteins families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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