P82933 (RT09_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
28S ribosomal protein S9, mitochondrial
Short name=MRP-S9
Short name=S9mt

Gene names

Name:	MRPS9
Synonyms:	RPMS9

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	396 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins By similarity.
Subcellular location	Mitochondrion.
Sequence similarities	Belongs to the ribosomal protein S9P family.

Ontologies

Keywords
Cellular component	Mitochondrion
Coding sequence diversity	Polymorphism
Domain	Transit peptide
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA damage response, detection of DNA damage Non-traceable author statement PubMed 15300802. Source: UniProtKB peptide biosynthetic process Inferred by curator Ref.4. Source: UniProtKB translation Inferred from electronic annotation. Source: InterPro
Cellular_component	mitochondrial small ribosomal subunit Non-traceable author statement Ref.4. Source: UniProtKB
Molecular_function	structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
rev	P04618	2	EBI-721385,EBI-6164309	From a different organism.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 396		28S ribosomal protein S9, mitochondrial		PRO_0000030655
Amino acid modifications
	Modified residue	174	1	N6-acetyllysine By similarity
	Modified residue	287	1	N6-acetyllysine Ref.5
Natural variations
	Natural variant	13	1	S → L. Corresponds to variant rs13399067 [ dbSNP | Ensembl ].		VAR_047902

Sequences

	Sequence		Length	Mass (Da)
	P82933 [UniParc]. Last modified December 16, 2008. Version 2. Checksum: 74412E34F0926360	FASTA	396	45,835
	10 20 30 40 50 60 MAAPCVSYGG AVSYRLLLWG RGSLARKQGL WKTAAPELQT NVRSQILRLR HTAFVIPKKN 70 80 90 100 110 120 VPTSKRETYT EDFIKKQIEE FNIGKRHLAN MMGEDPETFT QEDIDRAIAY LFPSGLFEKR 130 140 150 160 170 180 ARPVMKHPEQ IFPRQRAIQW GEDGRPFHYL FYTGKQSYYS LMHDVYGMLL NLEKHQSHLQ 190 200 210 220 230 240 AKSLLPEKTV TRDVIGSRWL IKEELEEMLV EKLSDLDYMQ FIRLLEKLLT SQCGAAEEEF 250 260 270 280 290 300 VQRFRRSVTL ESKKQLIEPV QYDEQGMAFS KSEGKRKTAK AEAIVYKHGS GRIKVNGIDY 310 320 330 340 350 360 QLYFPITQDR EQLMFPFHFV DRLGKHDVTC TVSGGGRSAQ AGAIRLAMAK ALCSFVTEDE 370 380 390 VEWMRQAGLL TTDPRVRERK KPGQEGARRK FTWKKR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present." Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L. J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[5]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-287, MASS SPECTROMETRY.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC010884 Genomic DNA. No translation available. AC107080 Genomic DNA. No translation available. AC104655 Genomic DNA. No translation available. CH471127 Genomic DNA. Translation: EAX01767.1. BC057240 mRNA. Translation: AAH57240.1.
IPI	IPI00641924.
RefSeq	NP_872578.1. NM_182640.2.
UniGene	Hs.590900.
3D structure databases
ProteinModelPortal	P82933.
ModBase	Search...
Protein-protein interaction databases
IntAct	P82933. 8 interactions.
MINT	MINT-1379488.
STRING	9606.ENSP00000258455.
PTM databases
PhosphoSite	P82933.
Polymorphism databases
DMDM	218511769.
Proteomic databases
PaxDb	P82933.
PRIDE	P82933.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000258455; ENSP00000258455; ENSG00000135972.
GeneID	64965.
KEGG	hsa:64965.
UCSC	uc002tcn.4. human.
Organism-specific databases
CTD	64965.
GeneCards	GC02P105654.
HGNC	HGNC:14501. MRPS9.
HPA	HPA043476. HPA048479.
MIM	611975. gene.
neXtProt	NX_P82933.
PharmGKB	PA31028.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0103.
HOGENOM	HOG000020877.
HOVERGEN	HBG023132.
InParanoid	P82933.
KO	K02996.
OMA	ARPVMKH.
OrthoDB	EOG4WWRJR.
PhylomeDB	P82933.
Gene expression databases
ArrayExpress	P82933.
Bgee	P82933.
CleanEx	HS_MRPS9.
Genevestigator	P82933.
GermOnline	ENSG00000135972. Homo sapiens.
Family and domain databases
Gene3D	3.30.230.10. 1 hit.
InterPro	IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. IPR000754. Ribosomal_S9. IPR020574. Ribosomal_S9_CS. [Graphical view]
PANTHER	PTHR21569. PTHR21569. 1 hit.
Pfam	PF00380. Ribosomal_S9. 1 hit. [Graphical view]
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
PROSITE	PS00360. RIBOSOMAL_S9. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	64965.
NextBio	67144.
SOURCE	Search...

Entry information

Entry name

RT09_HUMAN

Accession

Primary (citable) accession number: P82933
Secondary accession number(s): Q6PG40

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	December 16, 2008
Last modified:	May 1, 2013
This is version 98 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.