Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

28S ribosomal protein S6, mitochondrial

Gene

MRPS6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • small ribosomal subunit rRNA binding Source: GO_Central
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  • mitochondrial translation Source: UniProtKB
  • mitochondrial translational elongation Source: Reactome
  • mitochondrial translational termination Source: Reactome
  • translation Source: UniProtKB

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S6, mitochondrial
Short name:
MRP-S6
Short name:
S6mt
Alternative name(s):
Mitochondrial small ribosomal subunit protein bS6m1 Publication
Gene namesi
Name:MRPS6
Synonyms:C21orf101, RPMS6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000243927.5.
HGNCiHGNC:14051. MRPS6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi64968.
OpenTargetsiENSG00000243927.
PharmGKBiPA31025.

Polymorphism and mutation databases

BioMutaiMRPS6.
DMDMi13959558.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001768921 – 12528S ribosomal protein S6, mitochondrialAdd BLAST125

Proteomic databases

EPDiP82932.
MaxQBiP82932.
PaxDbiP82932.
PeptideAtlasiP82932.
PRIDEiP82932.
TopDownProteomicsiP82932.

PTM databases

iPTMnetiP82932.
PhosphoSitePlusiP82932.

Expressioni

Gene expression databases

BgeeiENSG00000243927.
CleanExiHS_MRPS6.
GenevisibleiP82932. HS.

Organism-specific databases

HPAiHPA007861.
HPA008163.
HPA049676.

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi122361. 22 interactors.
CORUMiP82932.
IntActiP82932. 19 interactors.
MINTiMINT-1405592.
STRINGi9606.ENSP00000382250.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AE1-125[»]
ProteinModelPortaliP82932.
SMRiP82932.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4708. Eukaryota.
COG0360. LUCA.
GeneTreeiENSGT00390000014606.
HOGENOMiHOG000045806.
HOVERGENiHBG082699.
InParanoidiP82932.
KOiK02990.
OMAiPKSYPIA.
OrthoDBiEOG091G0W0U.
PhylomeDBiP82932.
TreeFamiTF314045.

Family and domain databases

Gene3Di3.30.70.60. 1 hit.
InterProiView protein in InterPro
IPR000529. Ribosomal_S6.
IPR014717. Transl_elong_EF1B/ribosomal_S6.
PANTHERiPTHR21011. PTHR21011. 1 hit.
PfamiView protein in Pfam
PF01250. Ribosomal_S6. 1 hit.
SUPFAMiSSF54995. SSF54995. 1 hit.
TIGRFAMsiTIGR00166. S6. 1 hit.

Sequencei

Sequence statusi: Complete.

P82932-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRYELALIL KAMQRPETAA TLKRTIEALM DRGAIVRDLE NLGERALPYR
60 70 80 90 100
ISAHSQQHNR GGYFLVDFYA PTAAVESMVE HLSRDIDVIR GNIVKHPLTQ
110 120
ELKECEGIVP VPLAEKLYST KKRKK
Length:125
Mass (Da):14,227
Last modified:January 23, 2007 - v3
Checksum:i65995BB83B76F127
GO

Sequence cautioni

The sequence BAB40995 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049942 mRNA. Translation: BAB40995.1. Different initiation.
AY061855 mRNA. Translation: AAL35739.1.
AK312084 mRNA. Translation: BAG35020.1.
AP001719 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09798.1.
BC000547 mRNA. Translation: AAH00547.2.
BC004976 mRNA. Translation: AAH04976.2.
BC010076 mRNA. Translation: AAH10076.1.
BC051302 mRNA. Translation: AAH51302.1.
AB051347 Genomic DNA. Translation: BAB54937.1.
CCDSiCCDS33548.1.
RefSeqiNP_115865.1. NM_032476.3.
UniGeneiHs.302742.

Genome annotation databases

EnsembliENST00000399312; ENSP00000382250; ENSG00000243927.
GeneIDi64968.
KEGGihsa:64968.
UCSCiuc002ytp.2. human.

Similar proteinsi

Entry informationi

Entry nameiRT06_HUMAN
AccessioniPrimary (citable) accession number: P82932
Secondary accession number(s): B2R573
, Q96Q64, Q9BSK8, Q9BW89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: January 23, 2007
Last modified: September 27, 2017
This is version 157 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families