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Protein

28S ribosomal protein S6, mitochondrial

Gene

MRPS6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • small ribosomal subunit rRNA binding Source: GO_Central
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  • mitochondrial translation Source: UniProtKB
  • mitochondrial translational elongation Source: Reactome
  • mitochondrial translational termination Source: Reactome
  • translation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S6, mitochondrial
Short name:
MRP-S6
Short name:
S6mt
Gene namesi
Name:MRPS6
Synonyms:C21orf101, RPMS6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:14051. MRPS6.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: Reactome
  • mitochondrial small ribosomal subunit Source: UniProtKB
  • small ribosomal subunit Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31025.

Polymorphism and mutation databases

BioMutaiMRPS6.
DMDMi13959558.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 12512428S ribosomal protein S6, mitochondrialPRO_0000176892Add
BLAST

Proteomic databases

EPDiP82932.
MaxQBiP82932.
PaxDbiP82932.
PRIDEiP82932.
TopDownProteomicsiP82932.

PTM databases

iPTMnetiP82932.
PhosphoSiteiP82932.

Expressioni

Gene expression databases

BgeeiP82932.
CleanExiHS_MRPS6.
GenevisibleiP82932. HS.

Organism-specific databases

HPAiHPA007861.
HPA049676.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

Binary interactionsi

WithEntry#Exp.IntActNotes
MKRN3Q130643EBI-716172,EBI-2340269
taxP034103EBI-716172,EBI-9676218From a different organism.
taxP140793EBI-716172,EBI-9675698From a different organism.

Protein-protein interaction databases

BioGridi122361. 17 interactions.
IntActiP82932. 13 interactions.
MINTiMINT-1405592.
STRINGi9606.ENSP00000382250.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AE1-125[»]
ProteinModelPortaliP82932.
SMRiP82932. Positions 2-124.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S6P family.Curated

Phylogenomic databases

eggNOGiKOG4708. Eukaryota.
COG0360. LUCA.
GeneTreeiENSGT00390000014606.
HOGENOMiHOG000045806.
HOVERGENiHBG082699.
InParanoidiP82932.
KOiK02990.
OMAiGTYFLVD.
OrthoDBiEOG7HTHK5.
PhylomeDBiP82932.
TreeFamiTF314045.

Family and domain databases

Gene3Di3.30.70.60. 1 hit.
InterProiIPR000529. Ribosomal_S6.
IPR014717. Transl_elong_EF1B/ribosomal_S6.
[Graphical view]
PfamiPF01250. Ribosomal_S6. 1 hit.
[Graphical view]
SUPFAMiSSF54995. SSF54995. 1 hit.
TIGRFAMsiTIGR00166. S6. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P82932-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRYELALIL KAMQRPETAA TLKRTIEALM DRGAIVRDLE NLGERALPYR
60 70 80 90 100
ISAHSQQHNR GGYFLVDFYA PTAAVESMVE HLSRDIDVIR GNIVKHPLTQ
110 120
ELKECEGIVP VPLAEKLYST KKRKK
Length:125
Mass (Da):14,227
Last modified:January 23, 2007 - v3
Checksum:i65995BB83B76F127
GO

Sequence cautioni

The sequence BAB40995.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049942 mRNA. Translation: BAB40995.1. Different initiation.
AY061855 mRNA. Translation: AAL35739.1.
AK312084 mRNA. Translation: BAG35020.1.
AP001719 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09798.1.
BC000547 mRNA. Translation: AAH00547.2.
BC004976 mRNA. Translation: AAH04976.2.
BC010076 mRNA. Translation: AAH10076.1.
BC051302 mRNA. Translation: AAH51302.1.
AB051347 Genomic DNA. Translation: BAB54937.1.
CCDSiCCDS33548.1.
RefSeqiNP_115865.1. NM_032476.3.
UniGeneiHs.302742.

Genome annotation databases

EnsembliENST00000399312; ENSP00000382250; ENSG00000243927.
GeneIDi64968.
KEGGihsa:64968.
UCSCiuc002ytp.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049942 mRNA. Translation: BAB40995.1. Different initiation.
AY061855 mRNA. Translation: AAL35739.1.
AK312084 mRNA. Translation: BAG35020.1.
AP001719 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09798.1.
BC000547 mRNA. Translation: AAH00547.2.
BC004976 mRNA. Translation: AAH04976.2.
BC010076 mRNA. Translation: AAH10076.1.
BC051302 mRNA. Translation: AAH51302.1.
AB051347 Genomic DNA. Translation: BAB54937.1.
CCDSiCCDS33548.1.
RefSeqiNP_115865.1. NM_032476.3.
UniGeneiHs.302742.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AE1-125[»]
ProteinModelPortaliP82932.
SMRiP82932. Positions 2-124.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122361. 17 interactions.
IntActiP82932. 13 interactions.
MINTiMINT-1405592.
STRINGi9606.ENSP00000382250.

PTM databases

iPTMnetiP82932.
PhosphoSiteiP82932.

Polymorphism and mutation databases

BioMutaiMRPS6.
DMDMi13959558.

Proteomic databases

EPDiP82932.
MaxQBiP82932.
PaxDbiP82932.
PRIDEiP82932.
TopDownProteomicsiP82932.

Protocols and materials databases

DNASUi64968.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399312; ENSP00000382250; ENSG00000243927.
GeneIDi64968.
KEGGihsa:64968.
UCSCiuc002ytp.2. human.

Organism-specific databases

CTDi64968.
GeneCardsiMRPS6.
HGNCiHGNC:14051. MRPS6.
HPAiHPA007861.
HPA049676.
MIMi611973. gene.
neXtProtiNX_P82932.
PharmGKBiPA31025.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4708. Eukaryota.
COG0360. LUCA.
GeneTreeiENSGT00390000014606.
HOGENOMiHOG000045806.
HOVERGENiHBG082699.
InParanoidiP82932.
KOiK02990.
OMAiGTYFLVD.
OrthoDBiEOG7HTHK5.
PhylomeDBiP82932.
TreeFamiTF314045.

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiMRPS6. human.
GeneWikiiMRPS6.
GenomeRNAii64968.
PROiP82932.
SOURCEiSearch...

Gene expression databases

BgeeiP82932.
CleanExiHS_MRPS6.
GenevisibleiP82932. HS.

Family and domain databases

Gene3Di3.30.70.60. 1 hit.
InterProiIPR000529. Ribosomal_S6.
IPR014717. Transl_elong_EF1B/ribosomal_S6.
[Graphical view]
PfamiPF01250. Ribosomal_S6. 1 hit.
[Graphical view]
SUPFAMiSSF54995. SSF54995. 1 hit.
TIGRFAMsiTIGR00166. S6. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit."
    Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
    J. Biol. Chem. 276:33181-33195(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: B-cell, Brain, Kidney and Uterus.
  7. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
    Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
    Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 28-62.
  8. "The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present."
    Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L.
    J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRT06_HUMAN
AccessioniPrimary (citable) accession number: P82932
Secondary accession number(s): B2R573
, Q96Q64, Q9BSK8, Q9BW89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 146 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.