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Protein

28S ribosomal protein S34, mitochondrial

Gene

MRPS34

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for mitoribosome formation.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S34, mitochondrial
Short name:
MRP-S34
Short name:
S34mt
Alternative name(s):
Mitochondrial small ribosomal subunit protein mS341 Publication
Gene namesi
Name:MRPS34
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:16618. MRPS34.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000074071.
PharmGKBiPA31021.

Polymorphism and mutation databases

BioMutaiMRPS34.
DMDMi24212369.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000877302 – 21828S ribosomal protein S34, mitochondrialAdd BLAST217

Proteomic databases

EPDiP82930.
MaxQBiP82930.
PaxDbiP82930.
PeptideAtlasiP82930.
PRIDEiP82930.
TopDownProteomicsiP82930.

PTM databases

iPTMnetiP82930.
PhosphoSitePlusiP82930.
SwissPalmiP82930.

Expressioni

Gene expression databases

BgeeiENSG00000074071.
CleanExiHS_MRPS34.
ExpressionAtlasiP82930. baseline and differential.
GenevisibleiP82930. HS.

Organism-specific databases

HPAiHPA042112.

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.1 Publication

Protein-protein interaction databases

BioGridi122442. 78 interactors.
IntActiP82930. 14 interactors.
STRINGi9606.ENSP00000380531.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50A01-218[»]
ProteinModelPortaliP82930.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IGV1. Eukaryota.
ENOG4111FKH. LUCA.
GeneTreeiENSGT00390000008964.
HOGENOMiHOG000154216.
HOVERGENiHBG036130.
InParanoidiP82930.
KOiK17412.
PhylomeDBiP82930.
TreeFamiTF320386.

Family and domain databases

InterProiView protein in InterPro
IPR032053. MRP-S34.
PfamiView protein in Pfam
PF16053. MRP-S34. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P82930-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARKKVRPRL IAELARRVRA LREQLNRPRD SQLYAVDYET LTRPFSGRRL
60 70 80 90 100
PVRAWADVRR ESRLLQLLGR LPLFGLGRLV TRKSWLWQHD EPCYWRLTRV
110 120 130 140 150
RPDYTAQNLD HGKAWGILTF KGKTESEARE IEHVMYHDWR LVPKHEEEAF
160 170 180 190 200
TAFTPAPEDS LASVPYPPLL RAMIIAERQK NGDTSTEEPM LNVQRIRMEP
210
WDYPAKQEDK GRAKGTPV
Length:218
Mass (Da):25,650
Last modified:October 19, 2002 - v2
Checksum:i58DC48FF63276060
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05205033L → I. Corresponds to variant dbSNP:rs11552431Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC001182 mRNA. Translation: AAH01182.1.
CCDSiCCDS10444.1.
RefSeqiNP_001287829.1. NM_001300900.1.
NP_076425.1. NM_023936.1.
UniGeneiHs.720388.

Genome annotation databases

EnsembliENST00000397375; ENSP00000380531; ENSG00000074071.
GeneIDi65993.
KEGGihsa:65993.
UCSCiuc002cmo.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC001182 mRNA. Translation: AAH01182.1.
CCDSiCCDS10444.1.
RefSeqiNP_001287829.1. NM_001300900.1.
NP_076425.1. NM_023936.1.
UniGeneiHs.720388.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50A01-218[»]
ProteinModelPortaliP82930.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122442. 78 interactors.
IntActiP82930. 14 interactors.
STRINGi9606.ENSP00000380531.

PTM databases

iPTMnetiP82930.
PhosphoSitePlusiP82930.
SwissPalmiP82930.

Polymorphism and mutation databases

BioMutaiMRPS34.
DMDMi24212369.

Proteomic databases

EPDiP82930.
MaxQBiP82930.
PaxDbiP82930.
PeptideAtlasiP82930.
PRIDEiP82930.
TopDownProteomicsiP82930.

Protocols and materials databases

DNASUi65993.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397375; ENSP00000380531; ENSG00000074071.
GeneIDi65993.
KEGGihsa:65993.
UCSCiuc002cmo.4. human.

Organism-specific databases

CTDi65993.
GeneCardsiMRPS34.
HGNCiHGNC:16618. MRPS34.
HPAiHPA042112.
MIMi611994. gene.
neXtProtiNX_P82930.
OpenTargetsiENSG00000074071.
PharmGKBiPA31021.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGV1. Eukaryota.
ENOG4111FKH. LUCA.
GeneTreeiENSGT00390000008964.
HOGENOMiHOG000154216.
HOVERGENiHBG036130.
InParanoidiP82930.
KOiK17412.
PhylomeDBiP82930.
TreeFamiTF320386.

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiMRPS34. human.
GenomeRNAii65993.
PROiPR:P82930.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000074071.
CleanExiHS_MRPS34.
ExpressionAtlasiP82930. baseline and differential.
GenevisibleiP82930. HS.

Family and domain databases

InterProiView protein in InterPro
IPR032053. MRP-S34.
PfamiView protein in Pfam
PF16053. MRP-S34. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRT34_HUMAN
AccessioniPrimary (citable) accession number: P82930
Secondary accession number(s): Q9BVI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: April 12, 2017
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.