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Protein

28S ribosomal protein S34, mitochondrial

Gene

MRPS34

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for mitoribosome formation.1 Publication

GO - Molecular functioni

  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  • mitochondrial translation Source: UniProtKB
  • mitochondrial translational elongation Source: Reactome
  • mitochondrial translational termination Source: Reactome

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S34, mitochondrial
Short name:
MRP-S34
Short name:
S34mt
Alternative name(s):
Mitochondrial small ribosomal subunit protein mS341 Publication
Gene namesi
Name:MRPS34
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000074071.13
HGNCiHGNC:16618 MRPS34
MIMi611994 gene
neXtProtiNX_P82930

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Involvement in diseasei

Combined oxidative phosphorylation deficiency 32 (COXPD32)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder due to deficiency of mitochondrial respiratory chain complexes, I, III and IV, and characterized by delayed psychomotor development and neurodevelopmental regression. Additional variable symptoms include poor or absent speech, inability to walk, and abnormal movements.
See also OMIM:617664
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08021813E → K in COXPD32; significant decrease in protein levels; destabilizes the small ribosomal subunit resulting in impaired mitochondrial translation. 1 Publication1
Natural variantiVAR_08021932 – 218Missing in COXPD32; significant decrease in protein levels; destabilizes the small ribosomal subunit resulting in impaired mitochondrial translation. 1 PublicationAdd BLAST187
Natural variantiVAR_080220100 – 107Missing in COXPD32. 1 Publication8

Keywords - Diseasei

Disease mutation, Primary mitochondrial disease

Organism-specific databases

DisGeNETi65993
MalaCardsiMRPS34
MIMi617664 phenotype
OpenTargetsiENSG00000074071
PharmGKBiPA31021

Polymorphism and mutation databases

BioMutaiMRPS34
DMDMi24212369

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000877301 – 21828S ribosomal protein S34, mitochondrialAdd BLAST218

Proteomic databases

EPDiP82930
MaxQBiP82930
PaxDbiP82930
PeptideAtlasiP82930
PRIDEiP82930
TopDownProteomicsiP82930

PTM databases

iPTMnetiP82930
PhosphoSitePlusiP82930
SwissPalmiP82930

Expressioni

Gene expression databases

BgeeiENSG00000074071
CleanExiHS_MRPS34
ExpressionAtlasiP82930 baseline and differential
GenevisibleiP82930 HS

Organism-specific databases

HPAiHPA042112

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.1 Publication

Protein-protein interaction databases

BioGridi122442, 91 interactors
CORUMiP82930
IntActiP82930, 23 interactors
MINTiP82930
STRINGi9606.ENSP00000380531

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50A01-218[»]
ProteinModelPortaliP82930
SMRiP82930
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IGV1 Eukaryota
ENOG4111FKH LUCA
GeneTreeiENSGT00390000008964
HOGENOMiHOG000154216
HOVERGENiHBG036130
InParanoidiP82930
KOiK17412
PhylomeDBiP82930
TreeFamiTF320386

Family and domain databases

InterProiView protein in InterPro
IPR032053 MRP-S34
PfamiView protein in Pfam
PF16053 MRP-S34, 1 hit

Sequencei

Sequence statusi: Complete.

P82930-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARKKVRPRL IAELARRVRA LREQLNRPRD SQLYAVDYET LTRPFSGRRL
60 70 80 90 100
PVRAWADVRR ESRLLQLLGR LPLFGLGRLV TRKSWLWQHD EPCYWRLTRV
110 120 130 140 150
RPDYTAQNLD HGKAWGILTF KGKTESEARE IEHVMYHDWR LVPKHEEEAF
160 170 180 190 200
TAFTPAPEDS LASVPYPPLL RAMIIAERQK NGDTSTEEPM LNVQRIRMEP
210
WDYPAKQEDK GRAKGTPV
Length:218
Mass (Da):25,650
Last modified:October 19, 2002 - v2
Checksum:i58DC48FF63276060
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08021813E → K in COXPD32; significant decrease in protein levels; destabilizes the small ribosomal subunit resulting in impaired mitochondrial translation. 1 Publication1
Natural variantiVAR_08021932 – 218Missing in COXPD32; significant decrease in protein levels; destabilizes the small ribosomal subunit resulting in impaired mitochondrial translation. 1 PublicationAdd BLAST187
Natural variantiVAR_05205033L → I. Corresponds to variant dbSNP:rs11552431Ensembl.1
Natural variantiVAR_080220100 – 107Missing in COXPD32. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC001182 mRNA Translation: AAH01182.1
CCDSiCCDS10444.1
RefSeqiNP_001287829.1, NM_001300900.1
NP_076425.1, NM_023936.1
UniGeneiHs.720388

Genome annotation databases

EnsembliENST00000397375; ENSP00000380531; ENSG00000074071
GeneIDi65993
KEGGihsa:65993
UCSCiuc002cmo.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRT34_HUMAN
AccessioniPrimary (citable) accession number: P82930
Secondary accession number(s): Q9BVI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: May 23, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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