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P82921

- RT21_HUMAN

UniProt

P82921 - RT21_HUMAN

Protein

28S ribosomal protein S21, mitochondrial

Gene

MRPS21

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. structural constituent of ribosome Source: UniProtKB

    GO - Biological processi

    1. translation Source: UniProtKB

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    28S ribosomal protein S21, mitochondrial
    Short name:
    MRP-S21
    Short name:
    S21mt
    Gene namesi
    Name:MRPS21
    Synonyms:RPMS21
    ORF Names:MDS016
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:14046. MRPS21.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial small ribosomal subunit Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31009.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 878728S ribosomal protein S21, mitochondrialPRO_0000178413Add
    BLAST

    Proteomic databases

    MaxQBiP82921.
    PaxDbiP82921.
    PRIDEiP82921.

    PTM databases

    PhosphoSiteiP82921.

    Expressioni

    Gene expression databases

    BgeeiP82921.
    CleanExiHS_MRPS21.
    GenevestigatoriP82921.

    Organism-specific databases

    HPAiHPA059308.

    Interactioni

    Subunit structurei

    Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

    Protein-protein interaction databases

    BioGridi119966. 15 interactions.
    IntActiP82921. 5 interactions.
    MINTiMINT-8052164.
    STRINGi9606.ENSP00000312395.

    Structurei

    3D structure databases

    ProteinModelPortaliP82921.
    SMRiP82921. Positions 12-60.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S21P family.Curated

    Phylogenomic databases

    eggNOGiNOG47836.
    HOGENOMiHOG000007789.
    HOVERGENiHBG047411.
    InParanoidiP82921.
    KOiK02970.
    OMAiCAHTREY.
    OrthoDBiEOG7W9RX2.
    PhylomeDBiP82921.
    TreeFamiTF313903.

    Family and domain databases

    HAMAPiMF_00358. Ribosomal_S21.
    InterProiIPR001911. Ribosomal_S21.
    [Graphical view]
    PfamiPF01165. Ribosomal_S21. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00030. S21p. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P82921-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKHLKFIAR TVMVQEGNVE SAYRTLNRIL TMDGLIEDIK HRRYYEKPCR   50
    RRQRESYERC RRIYNMEMAR KINFLMRKNR ADPWQGC 87
    Length:87
    Mass (Da):10,742
    Last modified:May 4, 2001 - v2
    Checksum:i49FAEB58D9ECF61B
    GO

    Sequence cautioni

    The sequence AAG14953.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti50 – 501R → C.
    Corresponds to variant rs10480 [ dbSNP | Ensembl ].
    VAR_051825
    Natural varianti51 – 511R → Q.
    Corresponds to variant rs4845 [ dbSNP | Ensembl ].
    VAR_024610

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB049955 mRNA. Translation: BAB41008.1.
    AF182417 mRNA. Translation: AAG14953.1. Different initiation.
    AK289467 mRNA. Translation: BAF82156.1.
    AL138795 Genomic DNA. Translation: CAI22820.1.
    CH471121 Genomic DNA. Translation: EAW53558.1.
    CH471121 Genomic DNA. Translation: EAW53559.1.
    BC004566 mRNA. Translation: AAH04566.2.
    BC006554 mRNA. Translation: AAH06554.1.
    CCDSiCCDS950.1.
    RefSeqiNP_061870.1. NM_018997.3.
    NP_114107.1. NM_031901.5.
    UniGeneiHs.405880.

    Genome annotation databases

    GeneIDi54460.
    KEGGihsa:54460.
    UCSCiuc001euk.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB049955 mRNA. Translation: BAB41008.1 .
    AF182417 mRNA. Translation: AAG14953.1 . Different initiation.
    AK289467 mRNA. Translation: BAF82156.1 .
    AL138795 Genomic DNA. Translation: CAI22820.1 .
    CH471121 Genomic DNA. Translation: EAW53558.1 .
    CH471121 Genomic DNA. Translation: EAW53559.1 .
    BC004566 mRNA. Translation: AAH04566.2 .
    BC006554 mRNA. Translation: AAH06554.1 .
    CCDSi CCDS950.1.
    RefSeqi NP_061870.1. NM_018997.3.
    NP_114107.1. NM_031901.5.
    UniGenei Hs.405880.

    3D structure databases

    ProteinModelPortali P82921.
    SMRi P82921. Positions 12-60.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119966. 15 interactions.
    IntActi P82921. 5 interactions.
    MINTi MINT-8052164.
    STRINGi 9606.ENSP00000312395.

    PTM databases

    PhosphoSitei P82921.

    Proteomic databases

    MaxQBi P82921.
    PaxDbi P82921.
    PRIDEi P82921.

    Protocols and materials databases

    DNASUi 54460.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 54460.
    KEGGi hsa:54460.
    UCSCi uc001euk.3. human.

    Organism-specific databases

    CTDi 54460.
    GeneCardsi GC01P150266.
    HGNCi HGNC:14046. MRPS21.
    HPAi HPA059308.
    MIMi 611984. gene.
    neXtProti NX_P82921.
    PharmGKBi PA31009.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47836.
    HOGENOMi HOG000007789.
    HOVERGENi HBG047411.
    InParanoidi P82921.
    KOi K02970.
    OMAi CAHTREY.
    OrthoDBi EOG7W9RX2.
    PhylomeDBi P82921.
    TreeFami TF313903.

    Miscellaneous databases

    ChiTaRSi MRPS21. human.
    GeneWikii MRPS21.
    GenomeRNAii 54460.
    NextBioi 56711.
    PROi P82921.
    SOURCEi Search...

    Gene expression databases

    Bgeei P82921.
    CleanExi HS_MRPS21.
    Genevestigatori P82921.

    Family and domain databases

    HAMAPi MF_00358. Ribosomal_S21.
    InterProi IPR001911. Ribosomal_S21.
    [Graphical view ]
    Pfami PF01165. Ribosomal_S21. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00030. S21p. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit."
      Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
      J. Biol. Chem. 276:33181-33195(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Novel genes expressed in hematopoietic stem/progenitor cells from myelodysplastic syndrome patients."
      Huang C., Qian B., Tu Y., Gu W., Wang Y., Han Z., Chen Z.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Hematopoietic stem cell.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cerebellum.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung and Uterus.
    7. "The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present."
      Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L.
      J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRT21_HUMAN
    AccessioniPrimary (citable) accession number: P82921
    Secondary accession number(s): Q5TB11, Q9BST6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 4, 2001
    Last sequence update: May 4, 2001
    Last modified: October 1, 2014
    This is version 113 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Ribosomal proteins
      Ribosomal proteins families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3