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P82921

- RT21_HUMAN

UniProt

P82921 - RT21_HUMAN

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Protein
28S ribosomal protein S21, mitochondrial
Gene
MRPS21, RPMS21, MDS016
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  1. translation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S21, mitochondrial
Short name:
MRP-S21
Short name:
S21mt
Gene namesi
Name:MRPS21
Synonyms:RPMS21
ORF Names:MDS016
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:14046. MRPS21.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial small ribosomal subunit Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31009.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 878728S ribosomal protein S21, mitochondrialUniRule annotation
PRO_0000178413Add
BLAST

Proteomic databases

MaxQBiP82921.
PaxDbiP82921.
PRIDEiP82921.

PTM databases

PhosphoSiteiP82921.

Expressioni

Gene expression databases

BgeeiP82921.
CleanExiHS_MRPS21.
GenevestigatoriP82921.

Organism-specific databases

HPAiHPA059308.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

Protein-protein interaction databases

BioGridi119966. 15 interactions.
IntActiP82921. 5 interactions.
MINTiMINT-8052164.
STRINGi9606.ENSP00000312395.

Structurei

3D structure databases

ProteinModelPortaliP82921.
SMRiP82921. Positions 12-60.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG47836.
HOGENOMiHOG000007789.
HOVERGENiHBG047411.
InParanoidiP82921.
KOiK02970.
OMAiCAHTREY.
OrthoDBiEOG7W9RX2.
PhylomeDBiP82921.
TreeFamiTF313903.

Family and domain databases

HAMAPiMF_00358. Ribosomal_S21.
InterProiIPR001911. Ribosomal_S21.
[Graphical view]
PfamiPF01165. Ribosomal_S21. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00030. S21p. 1 hit.

Sequencei

Sequence statusi: Complete.

P82921-1 [UniParc]FASTAAdd to Basket

« Hide

MAKHLKFIAR TVMVQEGNVE SAYRTLNRIL TMDGLIEDIK HRRYYEKPCR   50
RRQRESYERC RRIYNMEMAR KINFLMRKNR ADPWQGC 87
Length:87
Mass (Da):10,742
Last modified:May 4, 2001 - v2
Checksum:i49FAEB58D9ECF61B
GO

Sequence cautioni

The sequence AAG14953.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti50 – 501R → C.
Corresponds to variant rs10480 [ dbSNP | Ensembl ].
VAR_051825
Natural varianti51 – 511R → Q.
Corresponds to variant rs4845 [ dbSNP | Ensembl ].
VAR_024610

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB049955 mRNA. Translation: BAB41008.1.
AF182417 mRNA. Translation: AAG14953.1. Different initiation.
AK289467 mRNA. Translation: BAF82156.1.
AL138795 Genomic DNA. Translation: CAI22820.1.
CH471121 Genomic DNA. Translation: EAW53558.1.
CH471121 Genomic DNA. Translation: EAW53559.1.
BC004566 mRNA. Translation: AAH04566.2.
BC006554 mRNA. Translation: AAH06554.1.
CCDSiCCDS950.1.
RefSeqiNP_061870.1. NM_018997.3.
NP_114107.1. NM_031901.5.
UniGeneiHs.405880.

Genome annotation databases

EnsembliENST00000309092; ENSP00000312395; ENSG00000187145.
ENST00000369084; ENSP00000358080; ENSG00000187145.
GeneIDi54460.
KEGGihsa:54460.
UCSCiuc001euk.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB049955 mRNA. Translation: BAB41008.1 .
AF182417 mRNA. Translation: AAG14953.1 . Different initiation.
AK289467 mRNA. Translation: BAF82156.1 .
AL138795 Genomic DNA. Translation: CAI22820.1 .
CH471121 Genomic DNA. Translation: EAW53558.1 .
CH471121 Genomic DNA. Translation: EAW53559.1 .
BC004566 mRNA. Translation: AAH04566.2 .
BC006554 mRNA. Translation: AAH06554.1 .
CCDSi CCDS950.1.
RefSeqi NP_061870.1. NM_018997.3.
NP_114107.1. NM_031901.5.
UniGenei Hs.405880.

3D structure databases

ProteinModelPortali P82921.
SMRi P82921. Positions 12-60.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119966. 15 interactions.
IntActi P82921. 5 interactions.
MINTi MINT-8052164.
STRINGi 9606.ENSP00000312395.

PTM databases

PhosphoSitei P82921.

Proteomic databases

MaxQBi P82921.
PaxDbi P82921.
PRIDEi P82921.

Protocols and materials databases

DNASUi 54460.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000309092 ; ENSP00000312395 ; ENSG00000187145 .
ENST00000369084 ; ENSP00000358080 ; ENSG00000187145 .
GeneIDi 54460.
KEGGi hsa:54460.
UCSCi uc001euk.3. human.

Organism-specific databases

CTDi 54460.
GeneCardsi GC01P150266.
HGNCi HGNC:14046. MRPS21.
HPAi HPA059308.
MIMi 611984. gene.
neXtProti NX_P82921.
PharmGKBi PA31009.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47836.
HOGENOMi HOG000007789.
HOVERGENi HBG047411.
InParanoidi P82921.
KOi K02970.
OMAi CAHTREY.
OrthoDBi EOG7W9RX2.
PhylomeDBi P82921.
TreeFami TF313903.

Miscellaneous databases

ChiTaRSi MRPS21. human.
GeneWikii MRPS21.
GenomeRNAii 54460.
NextBioi 56711.
PROi P82921.
SOURCEi Search...

Gene expression databases

Bgeei P82921.
CleanExi HS_MRPS21.
Genevestigatori P82921.

Family and domain databases

HAMAPi MF_00358. Ribosomal_S21.
InterProi IPR001911. Ribosomal_S21.
[Graphical view ]
Pfami PF01165. Ribosomal_S21. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00030. S21p. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit."
    Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
    J. Biol. Chem. 276:33181-33195(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Novel genes expressed in hematopoietic stem/progenitor cells from myelodysplastic syndrome patients."
    Huang C., Qian B., Tu Y., Gu W., Wang Y., Han Z., Chen Z.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hematopoietic stem cell.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Uterus.
  7. "The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present."
    Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L.
    J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRT21_HUMAN
AccessioniPrimary (citable) accession number: P82921
Secondary accession number(s): Q5TB11, Q9BST6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: May 4, 2001
Last modified: July 9, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Ribosomal proteins
    Ribosomal proteins families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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