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Protein

28S ribosomal protein S21, mitochondrial

Gene

MRPS21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  • mitochondrial translation Source: UniProtKB
  • mitochondrial translational elongation Source: Reactome
  • mitochondrial translational termination Source: Reactome
  • translation Source: UniProtKB

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S21, mitochondrial
Short name:
MRP-S21
Short name:
S21mt
Alternative name(s):
Mitochondrial small ribosomal subunit protein bS21m1 Publication
Gene namesi
Name:MRPS21
Synonyms:RPMS21
ORF Names:MDS016
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:14046. MRPS21.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: Reactome
  • mitochondrial small ribosomal subunit Source: UniProtKB

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31009.

Polymorphism and mutation databases

BioMutaiMRPS21.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001784131 – 8728S ribosomal protein S21, mitochondrialAdd BLAST87

Proteomic databases

EPDiP82921.
MaxQBiP82921.
PaxDbiP82921.
PeptideAtlasiP82921.
PRIDEiP82921.

PTM databases

iPTMnetiP82921.
PhosphoSitePlusiP82921.
SwissPalmiP82921.

Expressioni

Gene expression databases

BgeeiENSG00000187145.
CleanExiHS_MRPS21.

Organism-specific databases

HPAiHPA078289.

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.1 Publication

Protein-protein interaction databases

BioGridi119966. 31 interactors.
IntActiP82921. 10 interactors.
MINTiMINT-8052164.
STRINGi9606.ENSP00000312395.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AQ1-87[»]
ProteinModelPortaliP82921.
SMRiP82921.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410J1MD. Eukaryota.
ENOG4111YFB. LUCA.
HOGENOMiHOG000007789.
HOVERGENiHBG047411.
InParanoidiP82921.
KOiK02970.
PhylomeDBiP82921.
TreeFamiTF313903.

Family and domain databases

InterProiView protein in InterPro
IPR001911. Ribosomal_S21.
PANTHERiPTHR21109. PTHR21109. 1 hit.
PfamiView protein in Pfam
PF01165. Ribosomal_S21. 1 hit.
TIGRFAMsiTIGR00030. S21p. 1 hit.

Sequencei

Sequence statusi: Complete.

P82921-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKHLKFIAR TVMVQEGNVE SAYRTLNRIL TMDGLIEDIK HRRYYEKPCR
60 70 80
RRQRESYERC RRIYNMEMAR KINFLMRKNR ADPWQGC
Length:87
Mass (Da):10,742
Last modified:May 4, 2001 - v2
Checksum:i49FAEB58D9ECF61B
GO

Sequence cautioni

The sequence AAG14953 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05182550R → C. Corresponds to variant dbSNP:rs10480Ensembl.1
Natural variantiVAR_02461051R → Q. Corresponds to variant dbSNP:rs4845Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049955 mRNA. Translation: BAB41008.1.
AF182417 mRNA. Translation: AAG14953.1. Different initiation.
AK289467 mRNA. Translation: BAF82156.1.
AL138795 Genomic DNA. Translation: CAI22820.1.
CH471121 Genomic DNA. Translation: EAW53558.1.
CH471121 Genomic DNA. Translation: EAW53559.1.
BC004566 mRNA. Translation: AAH04566.2.
BC006554 mRNA. Translation: AAH06554.1.
CCDSiCCDS950.1.
RefSeqiNP_061870.1. NM_018997.3.
NP_114107.1. NM_031901.5.
UniGeneiHs.405880.

Genome annotation databases

GeneIDi54460.
KEGGihsa:54460.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRT21_HUMAN
AccessioniPrimary (citable) accession number: P82921
Secondary accession number(s): Q5TB11, Q9BST6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: May 4, 2001
Last modified: April 12, 2017
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families