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P82914

- RT15_HUMAN

UniProt

P82914 - RT15_HUMAN

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Protein
28S ribosomal protein S15, mitochondrial
Gene
MRPS15, RPMS15, DC37
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  1. translation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S15, mitochondrial
Short name:
MRP-S15
Short name:
S15mt
Gene namesi
Name:MRPS15
Synonyms:RPMS15
ORF Names:DC37
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:14504. MRPS15.

Subcellular locationi

Mitochondrion 1 Publication

GO - Cellular componenti

  1. mitochondrial small ribosomal subunit Source: UniProtKB
  2. mitochondrion Source: HPA
  3. nuclear membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30999.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 5757Mitochondrion Reviewed prediction
Add
BLAST
Chaini58 – 25720028S ribosomal protein S15, mitochondrialUniRule annotation
PRO_0000030614Add
BLAST

Proteomic databases

MaxQBiP82914.
PaxDbiP82914.
PRIDEiP82914.

PTM databases

PhosphoSiteiP82914.

Expressioni

Gene expression databases

ArrayExpressiP82914.
BgeeiP82914.
CleanExiHS_MRPS15.
GenevestigatoriP82914.

Organism-specific databases

HPAiHPA028100.
HPA028134.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

Protein-protein interaction databases

BioGridi122358. 9 interactions.
IntActiP82914. 6 interactions.
STRINGi9606.ENSP00000362208.

Structurei

3D structure databases

ProteinModelPortaliP82914.
SMRiP82914. Positions 105-187.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG298367.
HOGENOMiHOG000231143.
HOVERGENiHBG017757.
InParanoidiP82914.
KOiK02956.
OMAiEKTCREL.
OrthoDBiEOG74XS86.
PhylomeDBiP82914.
TreeFamiTF319038.

Family and domain databases

Gene3Di1.10.287.10. 1 hit.
HAMAPiMF_01343_B. Ribosomal_S15_B.
InterProiIPR000589. Ribosomal_S15.
IPR005290. Ribosomal_S15_bac-type.
IPR009068. S15_NS1_RNA-bd.
[Graphical view]
PfamiPF00312. Ribosomal_S15. 1 hit.
[Graphical view]
SUPFAMiSSF47060. SSF47060. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P82914-1 [UniParc]FASTAAdd to Basket

« Hide

MLRVAWRTLS LIRTRAVTQV LVPGLPGGGS AKFPFNQWGL QPRSLLLQAA    50
RGYVVRKPAQ SRLDDDPPPS TLLKDYQNVP GIEKVDDVVK RLLSLEMANK 100
KEMLKIKQEQ FMKKIVANPE DTRSLEARII ALSVKIRSYE EHLEKHRKDK 150
AHKRYLLMSI DQRKKMLKNL RNTNYDVFEK ICWGLGIEYT FPPLYYRRAH 200
RRFVTKKALC IRVFQETQKL KKRRRALKAA AAAQKQAKRR NPDSPAKAIP 250
KTLKDSQ 257
Length:257
Mass (Da):29,842
Last modified:March 1, 2001 - v1
Checksum:iB2D951BC47B8FFEB
GO

Sequence cautioni

The sequence AAG44697.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 7953GGGSA…DYQNV → AVGAPSFLSTSGACSLEVSS SRPRADMSSGNQPSLGWMMT HLLLRCSKTTRMS in AAG44697. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB049946 mRNA. Translation: BAB40999.1.
AF265439 mRNA. Translation: AAG44697.1. Different initiation.
AK315441 mRNA. Translation: BAG37829.1.
CH471059 Genomic DNA. Translation: EAX07359.1.
BC031336 mRNA. Translation: AAH31336.1.
CCDSiCCDS411.1.
RefSeqiNP_112570.2. NM_031280.3.
UniGeneiHs.352839.

Genome annotation databases

EnsembliENST00000373116; ENSP00000362208; ENSG00000116898.
GeneIDi64960.
KEGGihsa:64960.
UCSCiuc001cas.2. human.

Polymorphism databases

DMDMi13633907.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB049946 mRNA. Translation: BAB40999.1 .
AF265439 mRNA. Translation: AAG44697.1 . Different initiation.
AK315441 mRNA. Translation: BAG37829.1 .
CH471059 Genomic DNA. Translation: EAX07359.1 .
BC031336 mRNA. Translation: AAH31336.1 .
CCDSi CCDS411.1.
RefSeqi NP_112570.2. NM_031280.3.
UniGenei Hs.352839.

3D structure databases

ProteinModelPortali P82914.
SMRi P82914. Positions 105-187.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122358. 9 interactions.
IntActi P82914. 6 interactions.
STRINGi 9606.ENSP00000362208.

PTM databases

PhosphoSitei P82914.

Polymorphism databases

DMDMi 13633907.

Proteomic databases

MaxQBi P82914.
PaxDbi P82914.
PRIDEi P82914.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000373116 ; ENSP00000362208 ; ENSG00000116898 .
GeneIDi 64960.
KEGGi hsa:64960.
UCSCi uc001cas.2. human.

Organism-specific databases

CTDi 64960.
GeneCardsi GC01M036921.
HGNCi HGNC:14504. MRPS15.
HPAi HPA028100.
HPA028134.
MIMi 611979. gene.
neXtProti NX_P82914.
PharmGKBi PA30999.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG298367.
HOGENOMi HOG000231143.
HOVERGENi HBG017757.
InParanoidi P82914.
KOi K02956.
OMAi EKTCREL.
OrthoDBi EOG74XS86.
PhylomeDBi P82914.
TreeFami TF319038.

Miscellaneous databases

ChiTaRSi MRPS15. human.
GenomeRNAii 64960.
NextBioi 67134.
PROi P82914.
SOURCEi Search...

Gene expression databases

ArrayExpressi P82914.
Bgeei P82914.
CleanExi HS_MRPS15.
Genevestigatori P82914.

Family and domain databases

Gene3Di 1.10.287.10. 1 hit.
HAMAPi MF_01343_B. Ribosomal_S15_B.
InterProi IPR000589. Ribosomal_S15.
IPR005290. Ribosomal_S15_bac-type.
IPR009068. S15_NS1_RNA-bd.
[Graphical view ]
Pfami PF00312. Ribosomal_S15. 1 hit.
[Graphical view ]
SUPFAMi SSF47060. SSF47060. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit."
    Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
    J. Biol. Chem. 276:33181-33195(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
  2. "Novel genes expressed in human dendritic cell."
    Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Dendritic cell.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  6. "The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present."
    Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L.
    J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRT15_HUMAN
AccessioniPrimary (citable) accession number: P82914
Secondary accession number(s): B2RD82, Q9H2K1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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