P82914 (RT15_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
28S ribosomal protein S15, mitochondrial
Short name=MRP-S15
Short name=S15mt

Gene names

Name:	MRPS15
Synonyms:	RPMS15
ORF Names:	DC37

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
Subcellular location	Mitochondrion Ref.1.
Sequence similarities	Belongs to the ribosomal protein S15P family.
Sequence caution	The sequence AAG44697.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	translation Non-traceable author statement Ref.6. Source: UniProtKB
Cellular_component	mitochondrial small ribosomal subunit Inferred from direct assay Ref.6. Source: UniProtKB nuclear membrane Inferred from direct assay. Source: HPA
Molecular_function	structural constituent of ribosome Non-traceable author statement Ref.6. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 57	57	Mitochondrion Potential
	Chain	58 – 257	200	28S ribosomal protein S15, mitochondrial HAMAP-Rule MF_01343_B		PRO_0000030614
Experimental info
	Sequence conflict	27 – 79	53	GGGSA…DYQNV → AVGAPSFLSTSGACSLEVSS SRPRADMSSGNQPSLGWMMT HLLLRCSKTTRMS in AAG44697. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P82914 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: B2D951BC47B8FFEB	FASTA	257	29,842
	10 20 30 40 50 60 MLRVAWRTLS LIRTRAVTQV LVPGLPGGGS AKFPFNQWGL QPRSLLLQAA RGYVVRKPAQ 70 80 90 100 110 120 SRLDDDPPPS TLLKDYQNVP GIEKVDDVVK RLLSLEMANK KEMLKIKQEQ FMKKIVANPE 130 140 150 160 170 180 DTRSLEARII ALSVKIRSYE EHLEKHRKDK AHKRYLLMSI DQRKKMLKNL RNTNYDVFEK 190 200 210 220 230 240 ICWGLGIEYT FPPLYYRRAH RRFVTKKALC IRVFQETQKL KKRRRALKAA AAAQKQAKRR 250 NPDSPAKAIP KTLKDSQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit." Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K. J. Biol. Chem. 276:33181-33195(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
[2]	"Novel genes expressed in human dendritic cell." Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z. Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Dendritic cell.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
[6]	"The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present." Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L. J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB049946 mRNA. Translation: BAB40999.1. AF265439 mRNA. Translation: AAG44697.1. Different initiation. AK315441 mRNA. Translation: BAG37829.1. CH471059 Genomic DNA. Translation: EAX07359.1. BC031336 mRNA. Translation: AAH31336.1.
IPI	IPI00550037.
RefSeq	NP_112570.2. NM_031280.3.
UniGene	Hs.352839.
3D structure databases
ProteinModelPortal	P82914.
ModBase	Search...
Protein-protein interaction databases
IntAct	P82914. 2 interactions.
STRING	9606.ENSP00000362208.
PTM databases
PhosphoSite	P82914.
Polymorphism databases
DMDM	13633907.
Proteomic databases
PaxDb	P82914.
PRIDE	P82914.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000373116; ENSP00000362208; ENSG00000116898.
GeneID	64960.
KEGG	hsa:64960.
UCSC	uc001cas.2. human.
Organism-specific databases
CTD	64960.
GeneCards	GC01M036921.
HGNC	HGNC:14504. MRPS15.
HPA	HPA028100. HPA028134.
MIM	611979. gene.
neXtProt	NX_P82914.
PharmGKB	PA30999.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG298367.
HOGENOM	HOG000231143.
HOVERGEN	HBG017757.
InParanoid	P82914.
KO	K02956.
OMA	EKTCREL.
OrthoDB	EOG40K815.
PhylomeDB	P82914.
Gene expression databases
ArrayExpress	P82914.
Bgee	P82914.
CleanEx	HS_MRPS15.
Genevestigator	P82914.
GermOnline	ENSG00000116898. Homo sapiens.
Family and domain databases
Gene3D	1.10.287.10. 1 hit.
HAMAP	MF_01343_B. Ribosomal_S15_S13e_B.
InterPro	IPR000589. Ribosomal_S15. IPR009068. S15_NS1_RNA-bd. [Graphical view]
Pfam	PF00312. Ribosomal_S15. 1 hit. [Graphical view]
SUPFAM	SSF47060. S15/NS1_bind. 1 hit.
PROSITE	PS00362. RIBOSOMAL_S15. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	MRPS15. human.
GenomeRNAi	64960.
NextBio	67134.
SOURCE	Search...

Entry information

Entry name

RT15_HUMAN

Accession

Primary (citable) accession number: P82914
Secondary accession number(s): B2RD82, Q9H2K1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 109 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.