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P82914

- RT15_HUMAN

UniProt

P82914 - RT15_HUMAN

Protein

28S ribosomal protein S15, mitochondrial

Gene

MRPS15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. structural constituent of ribosome Source: UniProtKB

    GO - Biological processi

    1. translation Source: UniProtKB

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    28S ribosomal protein S15, mitochondrial
    Short name:
    MRP-S15
    Short name:
    S15mt
    Gene namesi
    Name:MRPS15
    Synonyms:RPMS15
    ORF Names:DC37
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:14504. MRPS15.

    Subcellular locationi

    Mitochondrion 1 Publication

    GO - Cellular componenti

    1. mitochondrial small ribosomal subunit Source: UniProtKB
    2. mitochondrion Source: HPA
    3. nuclear membrane Source: HPA

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30999.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 5757MitochondrionSequence AnalysisAdd
    BLAST
    Chaini58 – 25720028S ribosomal protein S15, mitochondrialPRO_0000030614Add
    BLAST

    Proteomic databases

    MaxQBiP82914.
    PaxDbiP82914.
    PRIDEiP82914.

    PTM databases

    PhosphoSiteiP82914.

    Expressioni

    Gene expression databases

    ArrayExpressiP82914.
    BgeeiP82914.
    CleanExiHS_MRPS15.
    GenevestigatoriP82914.

    Organism-specific databases

    HPAiHPA028100.
    HPA028134.

    Interactioni

    Subunit structurei

    Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

    Protein-protein interaction databases

    BioGridi122358. 9 interactions.
    IntActiP82914. 6 interactions.
    STRINGi9606.ENSP00000362208.

    Structurei

    3D structure databases

    ProteinModelPortaliP82914.
    SMRiP82914. Positions 105-187.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S15P family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG298367.
    HOGENOMiHOG000231143.
    HOVERGENiHBG017757.
    InParanoidiP82914.
    KOiK02956.
    OMAiEKTCREL.
    OrthoDBiEOG74XS86.
    PhylomeDBiP82914.
    TreeFamiTF319038.

    Family and domain databases

    Gene3Di1.10.287.10. 1 hit.
    HAMAPiMF_01343_B. Ribosomal_S15_B.
    InterProiIPR000589. Ribosomal_S15.
    IPR005290. Ribosomal_S15_bac-type.
    IPR009068. S15_NS1_RNA-bd.
    [Graphical view]
    PfamiPF00312. Ribosomal_S15. 1 hit.
    [Graphical view]
    SUPFAMiSSF47060. SSF47060. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P82914-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRVAWRTLS LIRTRAVTQV LVPGLPGGGS AKFPFNQWGL QPRSLLLQAA    50
    RGYVVRKPAQ SRLDDDPPPS TLLKDYQNVP GIEKVDDVVK RLLSLEMANK 100
    KEMLKIKQEQ FMKKIVANPE DTRSLEARII ALSVKIRSYE EHLEKHRKDK 150
    AHKRYLLMSI DQRKKMLKNL RNTNYDVFEK ICWGLGIEYT FPPLYYRRAH 200
    RRFVTKKALC IRVFQETQKL KKRRRALKAA AAAQKQAKRR NPDSPAKAIP 250
    KTLKDSQ 257
    Length:257
    Mass (Da):29,842
    Last modified:March 1, 2001 - v1
    Checksum:iB2D951BC47B8FFEB
    GO

    Sequence cautioni

    The sequence AAG44697.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti27 – 7953GGGSA…DYQNV → AVGAPSFLSTSGACSLEVSS SRPRADMSSGNQPSLGWMMT HLLLRCSKTTRMS in AAG44697. 1 PublicationCuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB049946 mRNA. Translation: BAB40999.1.
    AF265439 mRNA. Translation: AAG44697.1. Different initiation.
    AK315441 mRNA. Translation: BAG37829.1.
    CH471059 Genomic DNA. Translation: EAX07359.1.
    BC031336 mRNA. Translation: AAH31336.1.
    CCDSiCCDS411.1.
    RefSeqiNP_112570.2. NM_031280.3.
    UniGeneiHs.352839.

    Genome annotation databases

    EnsembliENST00000373116; ENSP00000362208; ENSG00000116898.
    GeneIDi64960.
    KEGGihsa:64960.
    UCSCiuc001cas.2. human.

    Polymorphism databases

    DMDMi13633907.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB049946 mRNA. Translation: BAB40999.1 .
    AF265439 mRNA. Translation: AAG44697.1 . Different initiation.
    AK315441 mRNA. Translation: BAG37829.1 .
    CH471059 Genomic DNA. Translation: EAX07359.1 .
    BC031336 mRNA. Translation: AAH31336.1 .
    CCDSi CCDS411.1.
    RefSeqi NP_112570.2. NM_031280.3.
    UniGenei Hs.352839.

    3D structure databases

    ProteinModelPortali P82914.
    SMRi P82914. Positions 105-187.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122358. 9 interactions.
    IntActi P82914. 6 interactions.
    STRINGi 9606.ENSP00000362208.

    PTM databases

    PhosphoSitei P82914.

    Polymorphism databases

    DMDMi 13633907.

    Proteomic databases

    MaxQBi P82914.
    PaxDbi P82914.
    PRIDEi P82914.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000373116 ; ENSP00000362208 ; ENSG00000116898 .
    GeneIDi 64960.
    KEGGi hsa:64960.
    UCSCi uc001cas.2. human.

    Organism-specific databases

    CTDi 64960.
    GeneCardsi GC01M036921.
    HGNCi HGNC:14504. MRPS15.
    HPAi HPA028100.
    HPA028134.
    MIMi 611979. gene.
    neXtProti NX_P82914.
    PharmGKBi PA30999.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG298367.
    HOGENOMi HOG000231143.
    HOVERGENi HBG017757.
    InParanoidi P82914.
    KOi K02956.
    OMAi EKTCREL.
    OrthoDBi EOG74XS86.
    PhylomeDBi P82914.
    TreeFami TF319038.

    Miscellaneous databases

    ChiTaRSi MRPS15. human.
    GenomeRNAii 64960.
    NextBioi 67134.
    PROi P82914.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P82914.
    Bgeei P82914.
    CleanExi HS_MRPS15.
    Genevestigatori P82914.

    Family and domain databases

    Gene3Di 1.10.287.10. 1 hit.
    HAMAPi MF_01343_B. Ribosomal_S15_B.
    InterProi IPR000589. Ribosomal_S15.
    IPR005290. Ribosomal_S15_bac-type.
    IPR009068. S15_NS1_RNA-bd.
    [Graphical view ]
    Pfami PF00312. Ribosomal_S15. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47060. SSF47060. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit."
      Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
      J. Biol. Chem. 276:33181-33195(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
    2. "Novel genes expressed in human dendritic cell."
      Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Dendritic cell.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin.
    6. "The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present."
      Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L.
      J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRT15_HUMAN
    AccessioniPrimary (citable) accession number: P82914
    Secondary accession number(s): B2RD82, Q9H2K1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. Ribosomal proteins
      Ribosomal proteins families and list of entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3