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P82912 (RT11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
28S ribosomal protein S11, mitochondrial

Short name=MRP-S11
Short name=S11mt
Alternative name(s):
Cervical cancer proto-oncogene 2 protein
Short name=HCC-2
Gene names
Name:MRPS11
Synonyms:RPMS11
ORF Names:HCC2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length194 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

Subcellular location

Mitochondrion Ref.1.

Sequence similarities

Belongs to the ribosomal protein S11P family.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Note: Experimental confirmation may be lacking for some isoforms.
Isoform 1 (identifier: P82912-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P82912-2)

The sequence of this isoform differs from the canonical sequence as follows:
     23-23: Missing.
Isoform 3 (identifier: P82912-3)

The sequence of this isoform differs from the canonical sequence as follows:
     62-94: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 19428S ribosomal protein S11, mitochondrial HAMAP-Rule MF_01310PRO_0000030602

Natural variations

Alternative sequence231Missing in isoform 2.
VSP_005719
Alternative sequence62 – 9433Missing in isoform 3.
VSP_005720
Natural variant101R → W.
Corresponds to variant rs16941904 [ dbSNP | Ensembl ].
VAR_052054
Natural variant511Q → H.
Corresponds to variant rs16941907 [ dbSNP | Ensembl ].
VAR_052055

Experimental info

Sequence conflict521N → Y in BAB15381. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 27, 2002. Version 2.
Checksum: 6DACB8FDDD0194BE

FASTA19420,616
        10         20         30         40         50         60 
MQAVRNAGSR FLRSWTWPQT AGRVVARTPA GTICTGARQL QDAAAKQKVE QNAAPSHTKF 

        70         80         90        100        110        120 
SIYPPIPGEE SSLRWAGKKF EEIPIAHIKA SHNNTQIQVV SASNEPLAFA SCGTEGFRNA 

       130        140        150        160        170        180 
KKGTGIAAQT AGIAAAARAK QKGVIHIRVV VKGLGPGRLS AMHGLIMGGL EVISITDNTP 

       190 
IPHNGCRPRK ARKL 

« Hide

Isoform 2 [UniParc].

Checksum: FF411F94C2D45B61
Show »

FASTA19320,460
Isoform 3 [UniParc].

Checksum: 3324188DDC2D02BD
Show »

FASTA16116,904

References

« Hide 'large scale' references
[1]"Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit."
Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
J. Biol. Chem. 276:33181-33195(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
[2]"Identification of a new proto-oncogene in human cervical cancer."
Kim J.W.
Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2).
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Colon.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
Tissue: Cervix, Kidney and Muscle.
[6]"The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present."
Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L.
J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB049944 mRNA. Translation: BAB40997.1.
AF320777 Genomic DNA. Translation: AAK97314.1.
AK026165 mRNA. Translation: BAB15381.1.
AK315407 mRNA. Translation: BAG37799.1.
CH471101 Genomic DNA. Translation: EAX02000.1.
BC009451 mRNA. Translation: AAH09451.1.
BC012489 mRNA. Translation: AAH12489.1.
BC032378 mRNA. Translation: AAH32378.1.
RefSeqNP_073750.2. NM_022839.3.
NP_789775.1. NM_176805.2.
XP_005255034.1. XM_005254977.1.
UniGeneHs.111286.

3D structure databases

ProteinModelPortalP82912.
SMRP82912. Positions 85-193.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122359. 11 interactions.
IntActP82912. 5 interactions.
MINTMINT-3023637.
STRING9606.ENSP00000317376.

PTM databases

PhosphoSiteP82912.

Polymorphism databases

DMDM21263985.

Proteomic databases

PaxDbP82912.
PRIDEP82912.

Protocols and materials databases

DNASU64963.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000325844; ENSP00000317376; ENSG00000181991. [P82912-1]
ENST00000353598; ENSP00000318054; ENSG00000181991. [P82912-3]
GeneID64963.
KEGGhsa:64963.
UCSCuc002bml.3. human. [P82912-1]
uc002bmm.3. human. [P82912-3]
uc002bmn.3. human. [P82912-2]

Organism-specific databases

CTD64963.
GeneCardsGC15P089010.
HGNCHGNC:14050. MRPS11.
HPAHPA043752.
HPA050345.
MIM611977. gene.
neXtProtNX_P82912.
PharmGKBPA30994.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0100.
HOGENOMHOG000111599.
HOVERGENHBG036124.
InParanoidP82912.
KOK02948.
OMAPLRWAGK.
PhylomeDBP82912.
TreeFamTF354231.

Gene expression databases

ArrayExpressP82912.
BgeeP82912.
CleanExHS_MRPS11.
GenevestigatorP82912.

Family and domain databases

Gene3D3.30.420.80. 1 hit.
HAMAPMF_01310. Ribosomal_S11.
InterProIPR001971. Ribosomal_S11.
IPR018102. Ribosomal_S11_CS.
[Graphical view]
PANTHERPTHR11759. PTHR11759. 1 hit.
PfamPF00411. Ribosomal_S11. 1 hit.
[Graphical view]
PROSITEPS00054. RIBOSOMAL_S11. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiMRPS11.
GenomeRNAi64963.
NextBio67138.
PROP82912.
SOURCESearch...

Entry information

Entry nameRT11_HUMAN
AccessionPrimary (citable) accession number: P82912
Secondary accession number(s): B2RD52 expand/collapse secondary AC list , Q969D7, Q96GI3, Q9BYC3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 27, 2002
Last modified: April 16, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM