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P82912

- RT11_HUMAN

UniProt

P82912 - RT11_HUMAN

Protein

28S ribosomal protein S11, mitochondrial

Gene

MRPS11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 2 (27 May 2002)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. DNA damage response, detection of DNA damage Source: UniProtKB
    2. translation Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    28S ribosomal protein S11, mitochondrial
    Short name:
    MRP-S11
    Short name:
    S11mt
    Alternative name(s):
    Cervical cancer proto-oncogene 2 protein
    Short name:
    HCC-2
    Gene namesi
    Name:MRPS11
    Synonyms:RPMS11
    ORF Names:HCC2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:14050. MRPS11.

    Subcellular locationi

    Mitochondrion 1 Publication

    GO - Cellular componenti

    1. mitochondrial small ribosomal subunit Source: UniProtKB
    2. mitochondrion Source: HPA

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30994.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 19428S ribosomal protein S11, mitochondrialPRO_0000030602
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Proteomic databases

    MaxQBiP82912.
    PaxDbiP82912.
    PRIDEiP82912.

    PTM databases

    PhosphoSiteiP82912.

    Expressioni

    Gene expression databases

    ArrayExpressiP82912.
    BgeeiP82912.
    CleanExiHS_MRPS11.
    GenevestigatoriP82912.

    Organism-specific databases

    HPAiHPA043752.
    HPA050345.

    Interactioni

    Subunit structurei

    Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

    Protein-protein interaction databases

    BioGridi122359. 11 interactions.
    IntActiP82912. 5 interactions.
    MINTiMINT-3023637.
    STRINGi9606.ENSP00000317376.

    Structurei

    3D structure databases

    ProteinModelPortaliP82912.
    SMRiP82912. Positions 85-193.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S11P family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0100.
    HOGENOMiHOG000111599.
    HOVERGENiHBG036124.
    InParanoidiP82912.
    KOiK02948.
    OMAiMIDEVQQ.
    PhylomeDBiP82912.
    TreeFamiTF354231.

    Family and domain databases

    Gene3Di3.30.420.80. 1 hit.
    HAMAPiMF_01310. Ribosomal_S11.
    InterProiIPR001971. Ribosomal_S11.
    IPR018102. Ribosomal_S11_CS.
    [Graphical view]
    PANTHERiPTHR11759. PTHR11759. 1 hit.
    PfamiPF00411. Ribosomal_S11. 1 hit.
    [Graphical view]
    PROSITEiPS00054. RIBOSOMAL_S11. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Note: Experimental confirmation may be lacking for some isoforms.

    Isoform 1 (identifier: P82912-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQAVRNAGSR FLRSWTWPQT AGRVVARTPA GTICTGARQL QDAAAKQKVE    50
    QNAAPSHTKF SIYPPIPGEE SSLRWAGKKF EEIPIAHIKA SHNNTQIQVV 100
    SASNEPLAFA SCGTEGFRNA KKGTGIAAQT AGIAAAARAK QKGVIHIRVV 150
    VKGLGPGRLS AMHGLIMGGL EVISITDNTP IPHNGCRPRK ARKL 194
    Length:194
    Mass (Da):20,616
    Last modified:May 27, 2002 - v2
    Checksum:i6DACB8FDDD0194BE
    GO
    Isoform 2 (identifier: P82912-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         23-23: Missing.

    Show »
    Length:193
    Mass (Da):20,460
    Checksum:iFF411F94C2D45B61
    GO
    Isoform 3 (identifier: P82912-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         62-94: Missing.

    Show »
    Length:161
    Mass (Da):16,904
    Checksum:i3324188DDC2D02BD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti52 – 521N → Y in BAB15381. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti10 – 101R → W.
    Corresponds to variant rs16941904 [ dbSNP | Ensembl ].
    VAR_052054
    Natural varianti51 – 511Q → H.
    Corresponds to variant rs16941907 [ dbSNP | Ensembl ].
    VAR_052055

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei23 – 231Missing in isoform 2. 1 PublicationVSP_005719
    Alternative sequencei62 – 9433Missing in isoform 3. 1 PublicationVSP_005720Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB049944 mRNA. Translation: BAB40997.1.
    AF320777 Genomic DNA. Translation: AAK97314.1.
    AK026165 mRNA. Translation: BAB15381.1.
    AK315407 mRNA. Translation: BAG37799.1.
    CH471101 Genomic DNA. Translation: EAX02000.1.
    BC009451 mRNA. Translation: AAH09451.1.
    BC012489 mRNA. Translation: AAH12489.1.
    BC032378 mRNA. Translation: AAH32378.1.
    CCDSiCCDS10342.1. [P82912-1]
    CCDS10343.1. [P82912-3]
    RefSeqiNP_073750.2. NM_022839.3. [P82912-1]
    NP_789775.1. NM_176805.2. [P82912-3]
    XP_005255034.1. XM_005254977.1. [P82912-2]
    UniGeneiHs.111286.

    Genome annotation databases

    EnsembliENST00000325844; ENSP00000317376; ENSG00000181991. [P82912-1]
    ENST00000353598; ENSP00000318054; ENSG00000181991. [P82912-3]
    GeneIDi64963.
    KEGGihsa:64963.
    UCSCiuc002bml.3. human. [P82912-1]
    uc002bmm.3. human. [P82912-3]
    uc002bmn.3. human. [P82912-2]

    Polymorphism databases

    DMDMi21263985.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB049944 mRNA. Translation: BAB40997.1 .
    AF320777 Genomic DNA. Translation: AAK97314.1 .
    AK026165 mRNA. Translation: BAB15381.1 .
    AK315407 mRNA. Translation: BAG37799.1 .
    CH471101 Genomic DNA. Translation: EAX02000.1 .
    BC009451 mRNA. Translation: AAH09451.1 .
    BC012489 mRNA. Translation: AAH12489.1 .
    BC032378 mRNA. Translation: AAH32378.1 .
    CCDSi CCDS10342.1. [P82912-1 ]
    CCDS10343.1. [P82912-3 ]
    RefSeqi NP_073750.2. NM_022839.3. [P82912-1 ]
    NP_789775.1. NM_176805.2. [P82912-3 ]
    XP_005255034.1. XM_005254977.1. [P82912-2 ]
    UniGenei Hs.111286.

    3D structure databases

    ProteinModelPortali P82912.
    SMRi P82912. Positions 85-193.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122359. 11 interactions.
    IntActi P82912. 5 interactions.
    MINTi MINT-3023637.
    STRINGi 9606.ENSP00000317376.

    PTM databases

    PhosphoSitei P82912.

    Polymorphism databases

    DMDMi 21263985.

    Proteomic databases

    MaxQBi P82912.
    PaxDbi P82912.
    PRIDEi P82912.

    Protocols and materials databases

    DNASUi 64963.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000325844 ; ENSP00000317376 ; ENSG00000181991 . [P82912-1 ]
    ENST00000353598 ; ENSP00000318054 ; ENSG00000181991 . [P82912-3 ]
    GeneIDi 64963.
    KEGGi hsa:64963.
    UCSCi uc002bml.3. human. [P82912-1 ]
    uc002bmm.3. human. [P82912-3 ]
    uc002bmn.3. human. [P82912-2 ]

    Organism-specific databases

    CTDi 64963.
    GeneCardsi GC15P089010.
    HGNCi HGNC:14050. MRPS11.
    HPAi HPA043752.
    HPA050345.
    MIMi 611977. gene.
    neXtProti NX_P82912.
    PharmGKBi PA30994.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0100.
    HOGENOMi HOG000111599.
    HOVERGENi HBG036124.
    InParanoidi P82912.
    KOi K02948.
    OMAi MIDEVQQ.
    PhylomeDBi P82912.
    TreeFami TF354231.

    Miscellaneous databases

    GeneWikii MRPS11.
    GenomeRNAii 64963.
    NextBioi 67138.
    PROi P82912.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P82912.
    Bgeei P82912.
    CleanExi HS_MRPS11.
    Genevestigatori P82912.

    Family and domain databases

    Gene3Di 3.30.420.80. 1 hit.
    HAMAPi MF_01310. Ribosomal_S11.
    InterProi IPR001971. Ribosomal_S11.
    IPR018102. Ribosomal_S11_CS.
    [Graphical view ]
    PANTHERi PTHR11759. PTHR11759. 1 hit.
    Pfami PF00411. Ribosomal_S11. 1 hit.
    [Graphical view ]
    PROSITEi PS00054. RIBOSOMAL_S11. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit."
      Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
      J. Biol. Chem. 276:33181-33195(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
    2. "Identification of a new proto-oncogene in human cervical cancer."
      Kim J.W.
      Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Colon.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
      Tissue: Cervix, Kidney and Muscle.
    6. "The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present."
      Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L.
      J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRT11_HUMAN
    AccessioniPrimary (citable) accession number: P82912
    Secondary accession number(s): B2RD52
    , Q969D7, Q96GI3, Q9BYC3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 27, 2002
    Last sequence update: May 27, 2002
    Last modified: October 1, 2014
    This is version 113 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Ribosomal proteins
      Ribosomal proteins families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3