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Protein

28S ribosomal protein S11, mitochondrial

Gene

MRPS11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_267634. Mitochondrial translation initiation.
REACT_268133. Mitochondrial translation elongation.
REACT_268261. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S11, mitochondrial
Short name:
MRP-S11
Short name:
S11mt
Alternative name(s):
Cervical cancer proto-oncogene 2 protein
Short name:
HCC-2
Gene namesi
Name:MRPS11
Synonyms:RPMS11
ORF Names:HCC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:14050. MRPS11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30994.

Polymorphism and mutation databases

BioMutaiMRPS11.
DMDMi21263985.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 19428S ribosomal protein S11, mitochondrialPRO_0000030602
Transit peptidei1 – ?MitochondrionSequence Analysis

Proteomic databases

MaxQBiP82912.
PaxDbiP82912.
PRIDEiP82912.

PTM databases

PhosphoSiteiP82912.

Expressioni

Gene expression databases

BgeeiP82912.
CleanExiHS_MRPS11.
ExpressionAtlasiP82912. baseline and differential.
GenevisibleiP82912. HS.

Organism-specific databases

HPAiHPA043752.
HPA050345.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

Protein-protein interaction databases

BioGridi122359. 37 interactions.
IntActiP82912. 5 interactions.
MINTiMINT-3023637.
STRINGi9606.ENSP00000317376.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AI1-194[»]
ProteinModelPortaliP82912.
SMRiP82912. Positions 26-194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S11P family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0100.
GeneTreeiENSGT00390000016068.
HOGENOMiHOG000111599.
HOVERGENiHBG036124.
InParanoidiP82912.
KOiK02948.
OMAiPLRWAGK.
PhylomeDBiP82912.
TreeFamiTF354231.

Family and domain databases

Gene3Di3.30.420.80. 1 hit.
HAMAPiMF_01310. Ribosomal_S11.
InterProiIPR001971. Ribosomal_S11.
IPR018102. Ribosomal_S11_CS.
[Graphical view]
PANTHERiPTHR11759. PTHR11759. 1 hit.
PfamiPF00411. Ribosomal_S11. 1 hit.
[Graphical view]
PROSITEiPS00054. RIBOSOMAL_S11. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: P82912-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQAVRNAGSR FLRSWTWPQT AGRVVARTPA GTICTGARQL QDAAAKQKVE
60 70 80 90 100
QNAAPSHTKF SIYPPIPGEE SSLRWAGKKF EEIPIAHIKA SHNNTQIQVV
110 120 130 140 150
SASNEPLAFA SCGTEGFRNA KKGTGIAAQT AGIAAAARAK QKGVIHIRVV
160 170 180 190
VKGLGPGRLS AMHGLIMGGL EVISITDNTP IPHNGCRPRK ARKL
Length:194
Mass (Da):20,616
Last modified:May 27, 2002 - v2
Checksum:i6DACB8FDDD0194BE
GO
Isoform 2 (identifier: P82912-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-23: Missing.

Show »
Length:193
Mass (Da):20,460
Checksum:iFF411F94C2D45B61
GO
Isoform 3 (identifier: P82912-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     62-94: Missing.

Show »
Length:161
Mass (Da):16,904
Checksum:i3324188DDC2D02BD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti52 – 521N → Y in BAB15381 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101R → W.
Corresponds to variant rs16941904 [ dbSNP | Ensembl ].
VAR_052054
Natural varianti51 – 511Q → H.
Corresponds to variant rs16941907 [ dbSNP | Ensembl ].
VAR_052055

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei23 – 231Missing in isoform 2. 1 PublicationVSP_005719
Alternative sequencei62 – 9433Missing in isoform 3. 1 PublicationVSP_005720Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049944 mRNA. Translation: BAB40997.1.
AF320777 Genomic DNA. Translation: AAK97314.1.
AK026165 mRNA. Translation: BAB15381.1.
AK315407 mRNA. Translation: BAG37799.1.
CH471101 Genomic DNA. Translation: EAX02000.1.
BC009451 mRNA. Translation: AAH09451.1.
BC012489 mRNA. Translation: AAH12489.1.
BC032378 mRNA. Translation: AAH32378.1.
CCDSiCCDS10342.1. [P82912-1]
CCDS10343.1. [P82912-3]
RefSeqiNP_073750.2. NM_022839.3. [P82912-1]
NP_789775.1. NM_176805.2. [P82912-3]
XP_005255034.1. XM_005254977.2. [P82912-2]
UniGeneiHs.111286.

Genome annotation databases

EnsembliENST00000325844; ENSP00000317376; ENSG00000181991. [P82912-1]
ENST00000353598; ENSP00000318054; ENSG00000181991. [P82912-3]
GeneIDi64963.
KEGGihsa:64963.
UCSCiuc002bml.3. human. [P82912-1]
uc002bmm.3. human. [P82912-3]
uc002bmn.3. human. [P82912-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049944 mRNA. Translation: BAB40997.1.
AF320777 Genomic DNA. Translation: AAK97314.1.
AK026165 mRNA. Translation: BAB15381.1.
AK315407 mRNA. Translation: BAG37799.1.
CH471101 Genomic DNA. Translation: EAX02000.1.
BC009451 mRNA. Translation: AAH09451.1.
BC012489 mRNA. Translation: AAH12489.1.
BC032378 mRNA. Translation: AAH32378.1.
CCDSiCCDS10342.1. [P82912-1]
CCDS10343.1. [P82912-3]
RefSeqiNP_073750.2. NM_022839.3. [P82912-1]
NP_789775.1. NM_176805.2. [P82912-3]
XP_005255034.1. XM_005254977.2. [P82912-2]
UniGeneiHs.111286.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AI1-194[»]
ProteinModelPortaliP82912.
SMRiP82912. Positions 26-194.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122359. 37 interactions.
IntActiP82912. 5 interactions.
MINTiMINT-3023637.
STRINGi9606.ENSP00000317376.

PTM databases

PhosphoSiteiP82912.

Polymorphism and mutation databases

BioMutaiMRPS11.
DMDMi21263985.

Proteomic databases

MaxQBiP82912.
PaxDbiP82912.
PRIDEiP82912.

Protocols and materials databases

DNASUi64963.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325844; ENSP00000317376; ENSG00000181991. [P82912-1]
ENST00000353598; ENSP00000318054; ENSG00000181991. [P82912-3]
GeneIDi64963.
KEGGihsa:64963.
UCSCiuc002bml.3. human. [P82912-1]
uc002bmm.3. human. [P82912-3]
uc002bmn.3. human. [P82912-2]

Organism-specific databases

CTDi64963.
GeneCardsiGC15P089010.
HGNCiHGNC:14050. MRPS11.
HPAiHPA043752.
HPA050345.
MIMi611977. gene.
neXtProtiNX_P82912.
PharmGKBiPA30994.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0100.
GeneTreeiENSGT00390000016068.
HOGENOMiHOG000111599.
HOVERGENiHBG036124.
InParanoidiP82912.
KOiK02948.
OMAiPLRWAGK.
PhylomeDBiP82912.
TreeFamiTF354231.

Enzyme and pathway databases

ReactomeiREACT_267634. Mitochondrial translation initiation.
REACT_268133. Mitochondrial translation elongation.
REACT_268261. Mitochondrial translation termination.

Miscellaneous databases

GeneWikiiMRPS11.
GenomeRNAii64963.
NextBioi67138.
PROiP82912.
SOURCEiSearch...

Gene expression databases

BgeeiP82912.
CleanExiHS_MRPS11.
ExpressionAtlasiP82912. baseline and differential.
GenevisibleiP82912. HS.

Family and domain databases

Gene3Di3.30.420.80. 1 hit.
HAMAPiMF_01310. Ribosomal_S11.
InterProiIPR001971. Ribosomal_S11.
IPR018102. Ribosomal_S11_CS.
[Graphical view]
PANTHERiPTHR11759. PTHR11759. 1 hit.
PfamiPF00411. Ribosomal_S11. 1 hit.
[Graphical view]
PROSITEiPS00054. RIBOSOMAL_S11. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit."
    Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
    J. Biol. Chem. 276:33181-33195(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
  2. "Identification of a new proto-oncogene in human cervical cancer."
    Kim J.W.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Cervix, Kidney and Muscle.
  6. "The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present."
    Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L.
    J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRT11_HUMAN
AccessioniPrimary (citable) accession number: P82912
Secondary accession number(s): B2RD52
, Q969D7, Q96GI3, Q9BYC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 27, 2002
Last modified: June 24, 2015
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.