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Protein

28S ribosomal protein S11, mitochondrial

Gene

MRPS11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • mRNA 5'-UTR binding Source: GO_Central
  • RNA binding Source: UniProtKB
  • small ribosomal subunit rRNA binding Source: GO_Central
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S11, mitochondrial
Short name:
MRP-S11
Short name:
S11mt
Alternative name(s):
Cervical cancer proto-oncogene 2 protein
Short name:
HCC-2
Mitochondrial small ribosomal subunit protein uS11m1 Publication
Gene namesi
Name:MRPS11
Synonyms:RPMS11
ORF Names:HCC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:14050. MRPS11.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi64963.
OpenTargetsiENSG00000181991.
PharmGKBiPA30994.

Polymorphism and mutation databases

BioMutaiMRPS11.
DMDMi21263985.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000030602? – 19428S ribosomal protein S11, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

EPDiP82912.
MaxQBiP82912.
PaxDbiP82912.
PeptideAtlasiP82912.
PRIDEiP82912.

PTM databases

iPTMnetiP82912.
PhosphoSitePlusiP82912.

Expressioni

Gene expression databases

BgeeiENSG00000181991.
CleanExiHS_MRPS11.
ExpressionAtlasiP82912. baseline and differential.
GenevisibleiP82912. HS.

Organism-specific databases

HPAiHPA043752.
HPA050345.

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.1 Publication

Protein-protein interaction databases

BioGridi122359. 84 interactors.
IntActiP82912. 12 interactors.
MINTiMINT-3023637.
STRINGi9606.ENSP00000317376.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AI1-194[»]
ProteinModelPortaliP82912.
SMRiP82912.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0408. Eukaryota.
COG0100. LUCA.
GeneTreeiENSGT00390000016068.
HOGENOMiHOG000111599.
HOVERGENiHBG036124.
InParanoidiP82912.
KOiK02948.
OMAiSWFLRSW.
OrthoDBiEOG091G0MCM.
PhylomeDBiP82912.
TreeFamiTF354231.

Family and domain databases

Gene3Di3.30.420.80. 1 hit.
HAMAPiMF_01310. Ribosomal_S11. 1 hit.
InterProiView protein in InterPro
IPR001971. Ribosomal_S11.
IPR018102. Ribosomal_S11_CS.
PANTHERiPTHR11759. PTHR11759. 1 hit.
PfamiView protein in Pfam
PF00411. Ribosomal_S11. 1 hit.
PROSITEiView protein in PROSITE
PS00054. RIBOSOMAL_S11. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Experimental confirmation may be lacking for some isoforms.
Isoform 1 (identifier: P82912-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQAVRNAGSR FLRSWTWPQT AGRVVARTPA GTICTGARQL QDAAAKQKVE
60 70 80 90 100
QNAAPSHTKF SIYPPIPGEE SSLRWAGKKF EEIPIAHIKA SHNNTQIQVV
110 120 130 140 150
SASNEPLAFA SCGTEGFRNA KKGTGIAAQT AGIAAAARAK QKGVIHIRVV
160 170 180 190
VKGLGPGRLS AMHGLIMGGL EVISITDNTP IPHNGCRPRK ARKL
Length:194
Mass (Da):20,616
Last modified:May 27, 2002 - v2
Checksum:i6DACB8FDDD0194BE
GO
Isoform 2 (identifier: P82912-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-23: Missing.

Show »
Length:193
Mass (Da):20,460
Checksum:iFF411F94C2D45B61
GO
Isoform 3 (identifier: P82912-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     62-94: Missing.

Show »
Length:161
Mass (Da):16,904
Checksum:i3324188DDC2D02BD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52N → Y in BAB15381 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05205410R → W. Corresponds to variant dbSNP:rs16941904Ensembl.1
Natural variantiVAR_05205551Q → H. Corresponds to variant dbSNP:rs16941907Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00571923Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_00572062 – 94Missing in isoform 3. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049944 mRNA. Translation: BAB40997.1.
AF320777 Genomic DNA. Translation: AAK97314.1.
AK026165 mRNA. Translation: BAB15381.1.
AK315407 mRNA. Translation: BAG37799.1.
CH471101 Genomic DNA. Translation: EAX02000.1.
BC009451 mRNA. Translation: AAH09451.1.
BC012489 mRNA. Translation: AAH12489.1.
BC032378 mRNA. Translation: AAH32378.1.
CCDSiCCDS10342.1. [P82912-1]
CCDS10343.1. [P82912-3]
RefSeqiNP_001308899.1. NM_001321970.1. [P82912-2]
NP_001308901.1. NM_001321972.1.
NP_001308902.1. NM_001321973.1.
NP_001308903.1. NM_001321974.1.
NP_001308905.1. NM_001321976.1.
NP_073750.2. NM_022839.4. [P82912-1]
NP_789775.1. NM_176805.3. [P82912-3]
UniGeneiHs.111286.

Genome annotation databases

EnsembliENST00000325844; ENSP00000317376; ENSG00000181991. [P82912-1]
ENST00000353598; ENSP00000318054; ENSG00000181991. [P82912-3]
GeneIDi64963.
KEGGihsa:64963.
UCSCiuc002bml.4. human. [P82912-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRT11_HUMAN
AccessioniPrimary (citable) accession number: P82912
Secondary accession number(s): B2RD52
, Q969D7, Q96GI3, Q9BYC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 27, 2002
Last modified: April 12, 2017
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families