P82912 (RT11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
28S ribosomal protein S11, mitochondrial
Short name=MRP-S11
Short name=S11mt

Alternative name(s):
Cervical cancer proto-oncogene 2 protein
Short name=HCC-2

Gene names

Name:	MRPS11
Synonyms:	RPMS11
ORF Names:	HCC2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	194 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
Subcellular location	Mitochondrion Ref.1.
Sequence similarities	Belongs to the ribosomal protein S11P family.

Ontologies

Keywords
Cellular component	Mitochondrion
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transit peptide
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA damage response, detection of DNA damage Non-traceable author statement PubMed 15300802. Source: UniProtKB translation Inferred from electronic annotation. Source: InterPro
Cellular_component	mitochondrial small ribosomal subunit Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Note: Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: P82912-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P82912-2)

The sequence of this isoform differs from the canonical sequence as follows:
     23-23: Missing.

Isoform 3 (identifier: P82912-3)

The sequence of this isoform differs from the canonical sequence as follows:
     62-94: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 194		28S ribosomal protein S11, mitochondrial HAMAP-Rule MF_01310		PRO_0000030602
Natural variations
	Alternative sequence	23	1	Missing in isoform 2.		VSP_005719
	Alternative sequence	62 – 94	33	Missing in isoform 3.		VSP_005720
	Natural variant	10	1	R → W. Corresponds to variant rs16941904 [ dbSNP | Ensembl ].		VAR_052054
	Natural variant	51	1	Q → H. Corresponds to variant rs16941907 [ dbSNP | Ensembl ].		VAR_052055
Experimental info
	Sequence conflict	52	1	N → Y in BAB15381. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 27, 2002. Version 2. Checksum: 6DACB8FDDD0194BE	FASTA	194	20,616
	10 20 30 40 50 60 MQAVRNAGSR FLRSWTWPQT AGRVVARTPA GTICTGARQL QDAAAKQKVE QNAAPSHTKF 70 80 90 100 110 120 SIYPPIPGEE SSLRWAGKKF EEIPIAHIKA SHNNTQIQVV SASNEPLAFA SCGTEGFRNA 130 140 150 160 170 180 KKGTGIAAQT AGIAAAARAK QKGVIHIRVV VKGLGPGRLS AMHGLIMGGL EVISITDNTP 190 IPHNGCRPRK ARKL
	Isoform 2 [UniParc]. Checksum: FF411F94C2D45B61	FASTA	193	20,460
	10 20 30 40 50 60 MQAVRNAGSR FLRSWTWPQT AGVVARTPAG TICTGARQLQ DAAAKQKVEQ NAAPSHTKFS 70 80 90 100 110 120 IYPPIPGEES SLRWAGKKFE EIPIAHIKAS HNNTQIQVVS ASNEPLAFAS CGTEGFRNAK 130 140 150 160 170 180 KGTGIAAQTA GIAAAARAKQ KGVIHIRVVV KGLGPGRLSA MHGLIMGGLE VISITDNTPI 190 PHNGCRPRKA RKL
	Isoform 3 [UniParc]. Checksum: 3324188DDC2D02BD	FASTA	161	16,904
	10 20 30 40 50 60 MQAVRNAGSR FLRSWTWPQT AGRVVARTPA GTICTGARQL QDAAAKQKVE QNAAPSHTKF 70 80 90 100 110 120 STQIQVVSAS NEPLAFASCG TEGFRNAKKG TGIAAQTAGI AAAARAKQKG VIHIRVVVKG 130 140 150 160 LGPGRLSAMH GLIMGGLEVI SITDNTPIPH NGCRPRKARK L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit." Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K. J. Biol. Chem. 276:33181-33195(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
[2]	"Identification of a new proto-oncogene in human cervical cancer." Kim J.W. Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Colon.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3). Tissue: Cervix, Kidney and Muscle.
[6]	"The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present." Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L. J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB049944 mRNA. Translation: BAB40997.1. AF320777 Genomic DNA. Translation: AAK97314.1. AK026165 mRNA. Translation: BAB15381.1. AK315407 mRNA. Translation: BAG37799.1. CH471101 Genomic DNA. Translation: EAX02000.1. BC009451 mRNA. Translation: AAH09451.1. BC012489 mRNA. Translation: AAH12489.1. BC032378 mRNA. Translation: AAH32378.1.
IPI	IPI00010244. IPI00219350. IPI00219351.
RefSeq	NP_073750.2. NM_022839.3. NP_789775.1. NM_176805.2.
UniGene	Hs.111286.
3D structure databases
ProteinModelPortal	P82912.
ModBase	Search...
Protein-protein interaction databases
IntAct	P82912. 2 interactions.
STRING	9606.ENSP00000317376.
PTM databases
PhosphoSite	P82912.
Polymorphism databases
DMDM	21263985.
Proteomic databases
PaxDb	P82912.
PRIDE	P82912.
Protocols and materials databases
DNASU	64963.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000325844; ENSP00000317376; ENSG00000181991. ENST00000353598; ENSP00000318054; ENSG00000181991.
GeneID	64963.
KEGG	hsa:64963.
UCSC	uc002bml.3. human. uc002bmm.3. human. uc002bmn.3. human.
Organism-specific databases
CTD	64963.
GeneCards	GC15P089010.
HGNC	HGNC:14050. MRPS11.
HPA	HPA043752. HPA050345.
MIM	611977. gene.
neXtProt	NX_P82912.
PharmGKB	PA30994.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0100.
HOGENOM	HOG000111599.
HOVERGEN	HBG036124.
InParanoid	P82912.
KO	K02948.
OMA	HIKASHN.
OrthoDB	EOG4CZBHG.
PhylomeDB	P82912.
Gene expression databases
ArrayExpress	P82912.
Bgee	P82912.
CleanEx	HS_MRPS11.
Genevestigator	P82912.
GermOnline	ENSG00000181991. Homo sapiens.
Family and domain databases
Gene3D	3.30.420.80. 1 hit.
HAMAP	MF_01310. Ribosomal_S11.
InterPro	IPR001971. Ribosomal_S11. IPR018102. Ribosomal_S11_CS. [Graphical view]
PANTHER	PTHR11759. PTHR11759. 1 hit.
Pfam	PF00411. Ribosomal_S11. 1 hit. [Graphical view]
PROSITE	PS00054. RIBOSOMAL_S11. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	64963.
NextBio	67138.
SOURCE	Search...

Entry information

Entry name

RT11_HUMAN

Accession

Primary (citable) accession number: P82912
Secondary accession number(s): B2RD52 , Q969D7, Q96GI3, Q9BYC3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
Last sequence update:	May 27, 2002
Last modified:	May 1, 2013
This is version 99 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.