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Protein

Low molecular weight phosphotyrosine protein phosphatase 2

Gene

primo-2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei14NucleophileBy similarity1
Active sitei20By similarity1
Active sitei130Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

  • protein dephosphorylation Source: FlyBase

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Low molecular weight phosphotyrosine protein phosphatase 2 (EC:3.1.3.48)
Alternative name(s):
Low molecular weight cytosolic acid phosphatase 2 (EC:3.1.3.2)
PTPase 2
Gene namesi
Name:primo-2
ORF Names:CG31311
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0040076. primo-2.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi14C → S: Complete loss of activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000465631 – 164Low molecular weight phosphotyrosine protein phosphatase 2Add BLAST164

Proteomic databases

PaxDbiP82891.
PRIDEiP82891.

Expressioni

Tissue specificityi

Cone cells and primary pigment cells in developing pupal retina.1 Publication

Developmental stagei

Embryo and adult.1 Publication

Gene expression databases

BgeeiFBgn0040076.
GenevisibleiP82891. DM.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0100064.

Structurei

3D structure databases

ProteinModelPortaliP82891.
SMRiP82891.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3217. Eukaryota.
COG0394. LUCA.
InParanoidiP82891.
KOiK14394.
OMAiGLQGEWH.
OrthoDBiEOG091G0P0O.
PhylomeDBiP82891.

Family and domain databases

CDDicd00115. LMWPc. 1 hit.
InterProiView protein in InterPro
IPR023485. Ptyr_pPase_SF.
IPR002115. Tyr_Pase_low_mol_wt_mml.
IPR017867. Tyr_phospatase_low_mol_wt.
PfamiView protein in Pfam
PF01451. LMWPc. 1 hit.
PRINTSiPR00719. LMWPTPASE.
PR00720. MAMMALPTPASE.
SMARTiView protein in SMART
SM00226. LMWPc. 1 hit.
SUPFAMiSSF52788. SSF52788. 1 hit.

Sequencei

Sequence statusi: Complete.

P82891-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKRSQKSSV LMVCVGNLCR SPIAEAVMRD LVARAGLQGE WHVESAGIED
60 70 80 90 100
WHSGHQPDER ALNVLARHNI EYNGKARVLA PEDFLEFDYI FAMDLSNLAA
110 120 130 140 150
LRRMAPKGTT AKLLILGNFG LKPDERIIED PYYDIGEASF EEIYRQCSIA
160
CRNFLKQARL KQIM
Length:164
Mass (Da):18,541
Last modified:March 1, 2001 - v1
Checksum:i320485DF557E4CCD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31L → V (PubMed:10675607).Curated1
Sequence conflicti111A → V (PubMed:10675607).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAF54981.3.
AY089477 mRNA. Translation: AAL90215.1.
RefSeqiNP_001027188.1. NM_001032017.2.
UniGeneiDm.4988.

Genome annotation databases

EnsemblMetazoaiFBtr0091746; FBpp0100064; FBgn0040076.
GeneIDi3772427.
KEGGidme:Dmel_CG33747.
UCSCiCG33747-RB. d. melanogaster.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPPAC2_DROME
AccessioniPrimary (citable) accession number: P82891
Secondary accession number(s): Q0KI75, Q9VFR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: March 1, 2001
Last modified: July 5, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families