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Protein

Low molecular weight phosphotyrosine protein phosphatase 1

Gene

primo-1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei9NucleophileBy similarity1
Active sitei15By similarity1
Active sitei124Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Low molecular weight phosphotyrosine protein phosphatase 1 (EC:3.1.3.48)
Alternative name(s):
Low molecular weight cytosolic acid phosphatase 1 (EC:3.1.3.2)
PTPase 1
Gene namesi
Name:primo-1
ORF Names:CG31311
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0040077. primo-1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000465621 – 155Low molecular weight phosphotyrosine protein phosphatase 1Add BLAST155

Proteomic databases

PaxDbiP82890.
PRIDEiP82890.

Expressioni

Tissue specificityi

Cone cells and primary pigment cells in developing pupal retina.1 Publication

Developmental stagei

Larvae, pupae and adults.1 Publication

Gene expression databases

BgeeiFBgn0040077.
GenevisibleiP82890. DM.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0099893.

Structurei

3D structure databases

ProteinModelPortaliP82890.
SMRiP82890.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3217. Eukaryota.
COG0394. LUCA.
GeneTreeiENSGT00500000044891.
KOiK14394.
OMAiAGTGSWH.
OrthoDBiEOG091G0P0O.
PhylomeDBiP82890.

Family and domain databases

InterProiView protein in InterPro
IPR023485. Ptyr_pPase_SF.
IPR002115. Tyr_Pase_low_mol_wt_mml.
IPR017867. Tyr_phospatase_low_mol_wt.
PfamiView protein in Pfam
PF01451. LMWPc. 1 hit.
PRINTSiPR00719. LMWPTPASE.
PR00720. MAMMALPTPASE.
SMARTiView protein in SMART
SM00226. LMWPc. 1 hit.
SUPFAMiSSF52788. SSF52788. 1 hit.

Sequencei

Sequence statusi: Complete.

P82890-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRKVLMICL GNICRSPIAE VVMVDTLEKA NVKDVEVDSA AIGGWHVGNR
60 70 80 90 100
ADPRAISTLQ KHGLKCTHIV RQIRKQDFSE FDYIFGMDED NMSELRRLAP
110 120 130 140 150
KGSKAELLML GDFGLEKKNR IIEDPYYERG AEGFETAYQQ CVVACAAFMK

ERLQK
Length:155
Mass (Da):17,556
Last modified:March 1, 2001 - v1
Checksum:i26C05D1EC3B1A07C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAN13591.2.
AE014297 Genomic DNA. Translation: AAO41564.1.
RefSeqiNP_001027186.1. NM_001032015.2.
NP_001027187.1. NM_001032016.2.
UniGeneiDm.4988.

Genome annotation databases

EnsemblMetazoaiFBtr0091747; FBpp0099893; FBgn0040077.
FBtr0091748; FBpp0099895; FBgn0040077.
GeneIDi3772179.
KEGGidme:Dmel_CG33748.
UCSCiCG33748-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiPPAC1_DROME
AccessioniPrimary (citable) accession number: P82890
Secondary accession number(s): A4V2V3, Q9VFR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: March 1, 2001
Last modified: August 30, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families