Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P82890

- PPAC1_DROME

UniProt

P82890 - PPAC1_DROME

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Low molecular weight phosphotyrosine protein phosphatase 1

Gene

primo-1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei9 – 91NucleophileBy similarity
Active sitei15 – 151By similarity
Active sitei124 – 1241Proton donorBy similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC
  2. non-membrane spanning protein tyrosine phosphatase activity Source: InterPro
  3. protein tyrosine phosphatase activity Source: FlyBase

GO - Biological processi

  1. peptidyl-tyrosine dephosphorylation Source: GOC
  2. protein dephosphorylation Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Low molecular weight phosphotyrosine protein phosphatase 1 (EC:3.1.3.48)
Alternative name(s):
Low molecular weight cytosolic acid phosphatase 1 (EC:3.1.3.2)
PTPase 1
Gene namesi
Name:primo-1
ORF Names:CG31311
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0040077. primo-1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 155155Low molecular weight phosphotyrosine protein phosphatase 1PRO_0000046562Add
BLAST

Proteomic databases

PaxDbiP82890.
PRIDEiP82890.

Expressioni

Tissue specificityi

Cone cells and primary pigment cells in developing pupal retina.1 Publication

Developmental stagei

Larvae, pupae and adults.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0099895.

Structurei

3D structure databases

ProteinModelPortaliP82890.
SMRiP82890. Positions 3-151.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0394.
GeneTreeiENSGT00500000044891.
KOiK14394.
OMAiEIMSADL.
OrthoDBiEOG7QZGCG.
PhylomeDBiP82890.

Family and domain databases

InterProiIPR023485. Ptyr_pPase_SF.
IPR002115. Tyr_Pase_low_mol_wt_mml.
IPR000106. Tyr_phospatase/Ars_reductase.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERiPTHR11717:SF7. PTHR11717:SF7. 1 hit.
PfamiPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSiPR00719. LMWPTPASE.
PR00720. MAMMALPTPASE.
SMARTiSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform A (identifier: P82890-1) [UniParc]FASTAAdd to Basket

Also known as: B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVRKVLMICL GNICRSPIAE VVMVDTLEKA NVKDVEVDSA AIGGWHVGNR
60 70 80 90 100
ADPRAISTLQ KHGLKCTHIV RQIRKQDFSE FDYIFGMDED NMSELRRLAP
110 120 130 140 150
KGSKAELLML GDFGLEKKNR IIEDPYYERG AEGFETAYQQ CVVACAAFMK

ERLQK
Length:155
Mass (Da):17,556
Last modified:March 1, 2001 - v1
Checksum:i26C05D1EC3B1A07C
GO
Isoform C (identifier: P82890-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     128-131: ERGA → VRYF
     132-155: Missing.

Note: No experimental confirmation available.

Show »
Length:131
Mass (Da):14,975
Checksum:i19DBF93C31A19250
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei128 – 1314ERGA → VRYF in isoform C. CuratedVSP_007676
Alternative sequencei132 – 15524Missing in isoform C. CuratedVSP_007677Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAN13591.2.
AE014297 Genomic DNA. Translation: AAO41564.1.
AE014297 Genomic DNA. Translation: AAO41565.1.
RefSeqiNP_001027186.1. NM_001032015.2. [P82890-1]
NP_001027187.1. NM_001032016.2. [P82890-1]
UniGeneiDm.4988.

Genome annotation databases

EnsemblMetazoaiFBtr0091747; FBpp0099893; FBgn0040077. [P82890-1]
FBtr0091748; FBpp0099895; FBgn0040077. [P82890-1]
GeneIDi3772179.
KEGGidme:Dmel_CG33748.
UCSCiCG33748-RA. d. melanogaster. [P82890-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA. Translation: AAN13591.2 .
AE014297 Genomic DNA. Translation: AAO41564.1 .
AE014297 Genomic DNA. Translation: AAO41565.1 .
RefSeqi NP_001027186.1. NM_001032015.2. [P82890-1 ]
NP_001027187.1. NM_001032016.2. [P82890-1 ]
UniGenei Dm.4988.

3D structure databases

ProteinModelPortali P82890.
SMRi P82890. Positions 3-151.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7227.FBpp0099895.

Proteomic databases

PaxDbi P82890.
PRIDEi P82890.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0091747 ; FBpp0099893 ; FBgn0040077 . [P82890-1 ]
FBtr0091748 ; FBpp0099895 ; FBgn0040077 . [P82890-1 ]
GeneIDi 3772179.
KEGGi dme:Dmel_CG33748.
UCSCi CG33748-RA. d. melanogaster. [P82890-1 ]

Organism-specific databases

CTDi 3772179.
FlyBasei FBgn0040077. primo-1.

Phylogenomic databases

eggNOGi COG0394.
GeneTreei ENSGT00500000044891.
KOi K14394.
OMAi EIMSADL.
OrthoDBi EOG7QZGCG.
PhylomeDBi P82890.

Miscellaneous databases

GenomeRNAii 3772179.
NextBioi 852731.
PROi P82890.

Family and domain databases

InterProi IPR023485. Ptyr_pPase_SF.
IPR002115. Tyr_Pase_low_mol_wt_mml.
IPR000106. Tyr_phospatase/Ars_reductase.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view ]
PANTHERi PTHR11717:SF7. PTHR11717:SF7. 1 hit.
Pfami PF01451. LMWPc. 1 hit.
[Graphical view ]
PRINTSi PR00719. LMWPTPASE.
PR00720. MAMMALPTPASE.
SMARTi SM00226. LMWPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52788. SSF52788. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Drosophila primo locus encodes two low-molecular-weight tyrosine phosphatases."
    Miller D.T., Read R., Rusconi J., Cagan R.L.
    Gene 243:1-9(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Embryo and Pupae.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.

Entry informationi

Entry nameiPPAC1_DROME
AccessioniPrimary (citable) accession number: P82890
Secondary accession number(s): A4V2V3, Q9VFR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3