P82869 (CYP37_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidyl-prolyl cis-trans isomerase CYP37, chloroplastic
Short name=PPIase CYP37
EC=5.2.1.8

Alternative name(s):
Rotamase CYP37
Thylakoid lumen PPIase of 38 kDa
Short name=TLP38
Short name=p38

Gene names

Name:	CYP37
Ordered Locus Names:	At3g15520
ORF Names:	MJK13.18

Organism

Arabidopsis thaliana (Mouse-ear cress)

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	466 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides By similarity.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Subcellular location	Plastid › chloroplast thylakoid lumen Ref.5 Ref.6 Ref.7.
Tissue specificity	Aerial parts. Ref.9
Induction	By light. Ref.8
Sequence similarities	Contains 1 PPIase cyclophilin-type domain.
Caution	Both gene predictions and some EST data suggest that there may be an additional exon at the C-terminus, adding another 10 kDa to the protein.
Sequence caution	The sequence AAF35418.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence BAB02381.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Chloroplast Plastid Thylakoid
Domain	Transit peptide
Molecular function	Isomerase Rotamase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	chloroplast thylakoid lumen Inferred from electronic annotation. Source: UniProtKB-SubCell chloroplast thylakoid membrane Inferred from direct assay Ref.7Ref.6. Source: TAIR
Molecular function	peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 65	65	Chloroplast Potential
	Transit peptide	66 – 114	49	Thylakoid Ref.5
	Chain	115 – 466	352	Peptidyl-prolyl cis-trans isomerase CYP37, chloroplastic		PRO_0000025504
Regions
	Domain	278 – 466	189	PPIase cyclophilin-type

Sequences

	Sequence		Length	Mass (Da)
	P82869 [UniParc]. Last modified June 12, 2007. Version 3. Checksum: F160CC1CF95D89E5	FASTA	466	50,483
	10 20 30 40 50 60 MASPLSSSTV VSHRLFFLHP SPLNRKFLFV KPKLPFNRTN SGDFRMRLHS TSSKTGTKEL 70 80 90 100 110 120 IHSCNSSIDS KLNTFEAGSK NLEKLVATIL IFVQVWSPLP LFGLDSAYIS PAEAVLYSPD 130 140 150 160 170 180 TKVPRTGELA LRRAIPANPS MKIIQASLED ISYLLRIPQR KPYGTMESNV KKALKVAIDD 190 200 210 220 230 240 KDKILASIPV DLKDKGSELY TTLIDGKGGL QALITSIKKQ DPDKVSLGLA ASLDTVADLE 250 260 270 280 290 300 LLQASGLSFL LPQQYLNYPR LAGRGTVEIT IEKADGSTFS AEAGGDQRKS ATVQIVIDGY 310 320 330 340 350 360 SAPLTAGNFA KLVTSGAYDG AKLNTVNQAV ITEDGSGKVE SVSVPLEVMP SGQFEPLYRT 370 380 390 400 410 420 PLSVQDGELP VLPLSVYGAV AMAHSENSEE YSSPYQFFFY LYDKRNSGLG GLSFDEGQFS 430 440 450 460 VFGYTIAGKD ILGQIKTGDI IKSAKLIEGQ DRLSLPVQNN NINEST

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones." Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S. DNA Res. 7:131-135(2000) [PubMed: 10819329] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	"Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana." Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F. , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. Nature 408:820-822(2000) [PubMed: 11130713] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[3]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[4]	"Arabidopsis ORF clones." Shinn P., Chen H., Kim C.J., Quinitio C., Ecker J.R. Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[5]	"Proteome map of the chloroplast lumen of Arabidopsis thaliana." Schubert M., Petersson U.A., Haas B.J., Funk C., Schroeder W.P., Kieselbach T. J. Biol. Chem. 277:8354-8365(2002) [PubMed: 11719511] [Abstract] Cited for: PROTEIN SEQUENCE OF 115-138; 179-188; 191-214; 260-317; 334-354 AND 441-447, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
[6]	"New functions of the thylakoid membrane proteome of Arabidopsis thaliana revealed by a simple, fast, and versatile fractionation strategy." Peltier J.-B., Ytterberg A.J., Sun Q., van Wijk K.J. J. Biol. Chem. 279:49367-49383(2004) [PubMed: 15322131] [Abstract] Cited for: SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
[7]	"In-depth analysis of the thylakoid membrane proteome of Arabidopsis thaliana chloroplasts: new proteins, new functions, and a plastid proteome database." Friso G., Giacomelli L., Ytterberg A.J., Peltier J.-B., Rudella A., Sun Q., van Wijk K.J. Plant Cell 16:478-499(2004) [PubMed: 14729914] [Abstract] Cited for: SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
[8]	"Immunophilins and parvulins. Superfamily of peptidyl prolyl isomerases in Arabidopsis." He Z., Li L., Luan S. Plant Physiol. 134:1248-1267(2004) [PubMed: 15047905] [Abstract] Cited for: INDUCTION.
[9]	"The Arabidopsis cyclophilin gene family." Romano P.G.N., Horton P., Gray J.E. Plant Physiol. 134:1268-1282(2004) [PubMed: 15051864] [Abstract] Cited for: TISSUE SPECIFICITY, GENE FAMILY, NOMENCLATURE.
[10]	"Sorting signals, N-terminal modifications and abundance of the chloroplast proteome." Zybailov B., Rutschow H., Friso G., Rudella A., Emanuelsson O., Sun Q., van Wijk K.J. PLoS ONE 3:E1994-E1994(2008) [PubMed: 18431481] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB022218 Genomic DNA. Translation: BAB02381.1. Sequence problems. AC024081 Genomic DNA. Translation: AAF35418.1. Sequence problems. CP002686 Genomic DNA. Translation: AEE75686.1. BT025317 mRNA. Translation: ABF57273.1.
IPI	IPI00521211.
RefSeq	NP_188171.2. NM_112420.4.
UniGene	At.25187. At.48665. At.72746.
3D structure databases
ProteinModelPortal	P82869.
ModBase	Search...
Protein-protein interaction databases
STRING	P82869.
Proteomic databases
PRIDE	P82869.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT3G15520.1; AT3G15520.1; AT3G15520.
GeneID	820791.
GenomeReviews	Gene locus AT3G15520 in contig BA000014_GR.
KEGG	ath:AT3G15520.
NMPDR	fig|3702.1.peg.13715.
Organism-specific databases
TAIR	At3g15520.
Phylogenomic databases
eggNOG	COG0652.
GeneTree	EPGT00070000030603.
HOGENOM	HBG317495.
InParanoid	P82869.
OMA	YLLRIPQ.
PhylomeDB	P82869.
ProtClustDB	CLSN2680841.
Gene expression databases
ArrayExpress	P82869.
Genevestigator	P82869.
GermOnline	AT3G15520. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR002130. Cyclophilin-like_PPIase_dom. [Graphical view]
Gene3D	G3DSA:2.40.100.10. PPIase_cyclophilin. 1 hit.
Pfam	PF00160. Pro_isomerase. 1 hit. [Graphical view]
SUPFAM	SSF50891. CSA_PPIase. 1 hit.
PROSITE	PS00170. CSA_PPIASE_1. False negative. PS50072. CSA_PPIASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYP37_ARATH

Accession

Primary (citable) accession number: P82869
Secondary accession number(s): Q1JPN6, Q9LDZ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 14, 2001
Last sequence update:	June 12, 2007
Last modified:	January 25, 2012
This is version 76 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program