P82861 (ADRO_SALFO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NADPH:adrenodoxin oxidoreductase, mitochondrial
Short name=AR
Short name=Adrenodoxin reductase
EC=1.18.1.2

Alternative name(s):
Ferredoxin--NADP(+) reductase
Short name=Ferredoxin reductase

Gene names

Name:

fdxr

Organism

Salvelinus fontinalis (Brook trout) (Salmo fontinalis)

Taxonomic identifier

8038 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Protacanthopterygii › Salmoniformes › Salmonidae › Salmoninae › Salvelinus

Protein attributes

Sequence length	498 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	2 reduced ferredoxin + NADP+ + H+ = 2 oxidized ferredoxin + NADPH.
Cofactor	FAD By similarity.
Pathway	Steroid metabolism; cholesterol metabolism.
Subcellular location	Mitochondrion matrix By similarity.
Sequence similarities	Belongs to the ferredoxin--NADP reductase type 1 family.

Ontologies

Keywords
Biological process	Cholesterol metabolism Electron transport Lipid metabolism Steroid metabolism Transport
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	FAD Flavoprotein NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	cholesterol metabolic process Inferred from electronic annotation. Source: UniProtKB-KW electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ferredoxin-NADP+ reductase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 37	37	Mitochondrion By similarity
	Chain	38 – 498	461	NADPH:adrenodoxin oxidoreductase, mitochondrial		PRO_0000019423
Regions
	Nucleotide binding	190 – 193	4	NADP By similarity
	Nucleotide binding	234 – 235	2	NADP By similarity
	Nucleotide binding	411 – 413	3	FAD By similarity
Sites
	Binding site	54	1	FAD; via amide nitrogen By similarity
	Binding site	75	1	FAD By similarity
	Binding site	83	1	FAD; via amide nitrogen By similarity
	Binding site	119	1	FAD; via amide nitrogen and carbonyl oxygen By similarity
	Binding site	246	1	NADP By similarity
	Binding site	404	1	FAD; via amide nitrogen By similarity
	Binding site	411	1	NADP; via amide nitrogen By similarity

Sequences

	Sequence		Length	Mass (Da)
	P82861 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: B472004DF7BC4AA7	FASTA	498	54,342
	10 20 30 40 50 60 MSTHKAALCK VQILKLFLIS ARCVRITRFY GVCGLSTSTP ASSPKVCIVG GGPAGFYTAQ 70 80 90 100 110 120 HLVKTRTDVQ VDIYERLPVP FGLVRFGVAP DHPEVKNVIN TFTQTARHAR CSFHGNVRVG 130 140 150 160 170 180 KDVTVEELQE AYHAVVLSYG AEGNRTMGVP GEDLAGVYSA KDFVGWYNGL PRNRELRPDL 190 200 210 220 230 240 SCETAVILGQ GNVALDVARM LLSPVDILKK TDITQHALDA LAESSVRRVL IVGRRGPLQV 250 260 270 280 290 300 ACTIKELREM VNLPGTRPEM EASEFEGIAE TLKSLARPRK RLTELLLKAA IETPGEEELE 310 320 330 340 350 360 KRNKAERAWG FRFLRRPLEV LPSTDLIRAA GIRLAVNRLE GDGEGVRAVA TGEVEDVECG 370 380 390 400 410 420 LVISSIGYKS LPIDPAVPFD GRKAIIPNTM GRVQQTAGLY CSGWVKRGPT GVIATTMNDS 430 440 450 460 470 480 FDTARTLLQD IGKGTLDVSS VKPGSQGVSA LLEKRGVKPV SFSDWEKIDS EETRRGETRG 490 KPREKMLDVG EMLQVARA

References

[1]	"Molecular cloning of adrenodoxin reductase from brook trout." Bobe J., Goetz F.W., Langenau D. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Ovary.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF283287 mRNA. Translation: AAG13948.1.
3D structure databases
ProteinModelPortal	P82861.
SMR	P82861. Positions 43-495.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG002132.
Family and domain databases
InterPro	IPR021163. Adrenodoxin_Rdtase. IPR016040. NAD(P)-bd_dom. IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 2 hits.
Pfam	PF07992. Pyr_redox_2. 1 hit. [Graphical view]
PIRSF	PIRSF000362. FNR. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ADRO_SALFO

Accession

Primary (citable) accession number: P82861

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	March 1, 2001
Last modified:	January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program