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Protein

Potassium channel toxin kappa-KTx 1.2

Gene
N/A
Organism
Heterometrus fulvipes (Indian black scorpion)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Voltage-gated potassium channel blocker.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei5Aromatic residue of the functional dyadBy similarity1
Sitei19Basic residue of the functional dyadBy similarity1

GO - Biological processi

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin kappa-KTx 1.21 Publication
Alternative name(s):
Kappa-hefutoxin-21 Publication
Short name:
Kappa-HfTx21 Publication
OrganismiHeterometrus fulvipes (Indian black scorpion)
Taxonomic identifieri141248 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesIuridaScorpionoideaScorpionidaeScorpioninaeHeterometrus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000445451 – 23Potassium channel toxin kappa-KTx 1.21 PublicationAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi4 ↔ 22By similarity
Disulfide bondi8 ↔ 18By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Family & Domainsi

Domaini

Has the structural arrangement of two alpha-helices stabilized by two disulfide bonds (CSalpha/alpha 2(S-S)).By similarity

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR012630. Toxin_25.
PfamiView protein in Pfam
PF08095. Toxin_25. 1 hit.

Sequencei

Sequence statusi: Complete.

P82851-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
GHACYRNCWR EGNDEETCKE RCG
Length:23
Mass (Da):2,717
Last modified:March 1, 2001 - v1
Checksum:iA61FB555EB877C6E
GO

Mass spectrometryi

Molecular mass is 2713.3±0.5 Da from positions 1 - 23. Determined by ESI. 1 Publication

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKKX12_HETFU
AccessioniPrimary (citable) accession number: P82851
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: March 1, 2001
Last modified: July 5, 2017
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families