UniProtKB - P82851 (KKX12_HETFU)
(max 400 entries)x
Your basket is currently empty.
Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)
Protein
Potassium channel toxin kappa-KTx 1.2
Gene
N/A
Organism
Heterometrus fulvipes (Indian black scorpion)
Status
Functioni
Voltage-gated potassium channel blocker.By similarity
Sites
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Sitei | 5 | Aromatic residue of the functional dyadBy similarity | 1 | |
| Sitei | 19 | Basic residue of the functional dyadBy similarity | 1 |
GO - Biological processi
- pathogenesis Source: InterPro
Keywordsi
| Molecular function | Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin |
Names & Taxonomyi
| Protein namesi | Recommended name: Potassium channel toxin kappa-KTx 1.21 PublicationAlternative name(s): Kappa-hefutoxin-21 Publication Short name: Kappa-HfTx21 Publication |
| Organismi | Heterometrus fulvipes (Indian black scorpion) |
| Taxonomic identifieri | 141248 [NCBI] |
| Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Iurida › Scorpionoidea › Scorpionidae › Scorpioninae › Heterometrus |
Subcellular locationi
- Secreted 1 Publication
GO - Cellular componenti
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| PeptideiPRO_0000044545 | 1 – 23 | Potassium channel toxin kappa-KTx 1.21 PublicationAdd BLAST | 23 |
Amino acid modifications
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Disulfide bondi | 4 ↔ 22 | By similarity | ||
| Disulfide bondi | 8 ↔ 18 | By similarity |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.1 Publication
Family & Domainsi
Domaini
Has the structural arrangement of two alpha-helices stabilized by two disulfide bonds (CSalpha/alpha 2(S-S)).By similarity
Sequence similaritiesi
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor kappa-KTx family. Kappa-KTx 1 subfamily.Curated
Family and domain databases
| InterProi | View protein in InterPro IPR012630. Toxin_25. |
| Pfami | View protein in Pfam PF08095. Toxin_25. 1 hit. |
Sequencei
Sequence statusi: Complete.
Mass spectrometryi
Similar proteinsi
Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:| 100% | UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry. |
| 90% | UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence). |
| 50% | UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster. |
Entry informationi
| Entry namei | KKX12_HETFU | |
| Accessioni | P82851Primary (citable) accession number: P82851 | |
| Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 4, 2001 |
| Last sequence update: | March 1, 2001 | |
| Last modified: | July 5, 2017 | |
| This is version 58 of the entry and version 1 of the sequence. See complete history. | ||
| Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
| Annotation program | Animal Toxin Annotation Program | |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- Scorpion potassium channel toxins
Nomenclature of scorpion potassium channel toxins and list of entries - SIMILARITY comments
Index of protein domains and families
