Potassium channel toxin kappa-KTx 1.1

Functionⁱ

Slows the activation kinetics of Kv1.3/KCNA3 currents, and blocks Kv1.3/KCNA3 and Kv1.2/KCNA2 potassium channels. This block is dose-dependent, voltage-independent, and reversible.1 Publication

Miscellaneous

This toxin does not have effect on Kv1.1/KCNA1 currents.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	5	Aromatic residue of the functional dyad1 Publication		1
Siteⁱ	19	Basic residue of the functional dyad1 Publication		1

GO - Biological processⁱ

pathogenesis Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Molecular function

Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Protein family/group databases

TCDBⁱ	8.B.2.1.1. the short scorpion toxin (s-st) superfamily.

TCDBⁱ

8.B.2.1.1. the short scorpion toxin (s-st) superfamily.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Potassium channel toxin kappa-KTx 1.11 Publication Alternative name(s): Kappa-hefutoxin-11 Publication Short name: Kappa-HfTx11 Publication
Organismⁱ	Heterometrus fulvipes (Indian black scorpion)
Taxonomic identifierⁱ	141248 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Scorpiones › Iurida › Scorpionoidea › Scorpionidae › Scorpioninae › Heterometrus

Subcellular locationⁱ

Secreted
1 Publication
Manual assertion based on experiment inⁱ
- Ref.1
  "Kappa-hefutoxin1, a novel toxin from the scorpion Heterometrus fulvipes with unique structure and function. Importance of the functional diad in potassium channel selectivity."
  Srinivasan K.N., Sivaraja V., Huys I., Sasaki T., Cheng B., Kumar T.K.S., Sato K., Tytgat J., Yu C., San B.C.C., Ranganathan S., Bowie H.J., Kini R.M., Gopalakrishnakone P.
  J. Biol. Chem. 277:30040-30047(2002) [PubMed] [Europe PMC] [Abstract]
  Cited for: PROTEIN SEQUENCE, FUNCTION, AMIDATION AT CYS-22, STRUCTURE BY NMR, DISULFIDE BONDS, SUBCELLULAR LOCATION, MASS SPECTROMETRY, MUTAGENESIS OF TYR-5; LYS-19 AND 5-TYR--LYS-19, SITES TYR-5 AND LYS-19 (FUNCTIONAL DYAD).

GO - Cellular componentⁱ

extracellular region Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	5	Y → A: Loss of ability to block potassium channels. Same effect observed; when associated with A-19. 1 Publication		1
Mutagenesisⁱ	19	K → A: Loss of ability to block potassium channels. Same effect observed; when associated with A-5. 1 Publication		1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
PeptideⁱPRO_0000044544	1 – 22	Potassium channel toxin kappa-KTx 1.11 PublicationAdd BLAST		22

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	4 ↔ 22	1 Publication
Disulfide bondⁱ	8 ↔ 18	1 Publication
Modified residueⁱ	22	Cysteine amide1 Publication	1

Keywords - PTMⁱ

Amidation, Disulfide bond

Expressionⁱ

Tissue specificityⁱ

Expressed by the venom gland.1 Publication

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	4 – 6	Combined sources	3
Helixⁱ	7 – 12	Combined sources	6
Helixⁱ	17 – 21	Combined sources	5

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1HP9	NMR	-	A	1-22	[»]
SMRⁱ	P82850.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P82850.

EvolutionaryTraceⁱ

P82850.

Family & Domainsⁱ

Domainⁱ

Has the structural arrangement of two alpha-helices stabilized by two disulfide bonds (CSalpha/alpha 2(S-S)).1 Publication

Sequence similaritiesⁱ

Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor kappa-KTx family. Kappa-KTx 1 subfamily.Curated

Family and domain databases

InterProⁱ	View protein in InterPro IPR012630. Toxin_25.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08095. Toxin_25. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

P82850-1 [UniParc]FASTA Add to basket

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        10         20 
GHACYRNCWR EGNDEETCKE RC

Length:22

Mass (Da):2,660

Last modified:March 1, 2001 - v1

Checksum:ⁱ8FB555EB877C6E98

GO

Mass spectrometryⁱ

Molecular mass is 2655.4±0.2 Da from positions 1 - 22. Determined by ESI. 1 Publication

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1HP9	NMR	-	A	1-22	[»]
SMRⁱ	P82850.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein family/group databases

TCDBⁱ	8.B.2.1.1. the short scorpion toxin (s-st) superfamily.

TCDBⁱ

8.B.2.1.1. the short scorpion toxin (s-st) superfamily.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P82850.

EvolutionaryTraceⁱ

P82850.

Family and domain databases

InterProⁱ	View protein in InterPro IPR012630. Toxin_25.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08095. Toxin_25. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KKX11_HETFU
Accessionⁱ	P82850Primary (citable) accession number: P82850
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 4, 2001
	Last sequence update:	March 1, 2001
	Last modified:	July 5, 2017
	This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Animal Toxin Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Direct protein sequencing

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Scorpion potassium channel toxins
Nomenclature of scorpion potassium channel toxins and list of entries
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P82850 (KKX11_HETFU)

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Protein family/group databases

Protocols and materials databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Documents

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Mass spectrometryⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ