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P82850

- KKX11_HETFU

UniProt

P82850 - KKX11_HETFU

Protein

Potassium channel toxin kappa-KTx 1.1

Gene
N/A
Organism
Heterometrus fulvipes (Indian black scorpion)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Slows the activation kinetics of Kv1.3/KCNA3 currents, and blocks Kv1.3/KCNA3 and Kv1.2/KCNA2 potassium channels. This block is dose-dependent, voltage-independent, and reversible.1 Publication

    GO - Biological processi

    1. pathogenesis Source: InterPro

    Keywords - Molecular functioni

    Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

    Protein family/group databases

    TCDBi8.B.2.1.1. the short scorpion toxin (sst) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium channel toxin kappa-KTx 1.1
    Alternative name(s):
    Kappa-hefutoxin-1
    Short name:
    Kappa-HfTx1
    OrganismiHeterometrus fulvipes (Indian black scorpion)
    Taxonomic identifieri141248 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesIuridaScorpionoideaScorpionidaeScorpioninaeHeterometrus

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi5 – 51Y → A: Loss of channels blocking. Same effect observed; when associated with A-19. 1 Publication
    Mutagenesisi19 – 191K → A: Loss of channels blocking. Same effect observed; when associated with A-5. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Peptidei1 – 2222Potassium channel toxin kappa-KTx 1.1PRO_0000044544Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi4 ↔ 221 Publication
    Disulfide bondi8 ↔ 181 Publication
    Modified residuei22 – 221Cysteine amide1 Publication

    Keywords - PTMi

    Amidation, Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Structurei

    Secondary structure

    1
    22
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni4 – 63
    Helixi7 – 126
    Helixi17 – 215

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1HP9NMR-A1-22[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP82850.

    Family & Domainsi

    Domaini

    Has the structural arrangement of two alpha-helices stabilized by two disulfide bonds (CSalpha/alpha).

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR012630. Toxin_25.
    [Graphical view]
    PfamiPF08095. Toxin_25. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P82850-1 [UniParc]FASTAAdd to Basket

    « Hide

    GHACYRNCWR EGNDEETCKE RC                                 22
    Length:22
    Mass (Da):2,660
    Last modified:March 1, 2001 - v1
    Checksum:i8FB555EB877C6E98
    GO

    Mass spectrometryi

    Molecular mass is 2655.4±0.2 Da from positions 1 - 22. Determined by ESI. 1 Publication

    Cross-referencesi

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1HP9 NMR - A 1-22 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    TCDBi 8.B.2.1.1. the short scorpion toxin (sst) superfamily.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P82850.

    Family and domain databases

    InterProi IPR012630. Toxin_25.
    [Graphical view ]
    Pfami PF08095. Toxin_25. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Kappa-hefutoxin1, a novel toxin from the scorpion Heterometrus fulvipes with unique structure and function. Importance of the functional diad in potassium channel selectivity."
      Srinivasan K.N., Sivaraja V., Huys I., Sasaki T., Cheng B., Kumar T.K.S., Sato K., Tytgat J., Yu C., San B.C.C., Ranganathan S., Bowie H.J., Kini R.M., Gopalakrishnakone P.
      J. Biol. Chem. 277:30040-30047(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, FUNCTION, AMIDATION, STRUCTURE BY NMR, DISULFIDE BONDS, MASS SPECTROMETRY, MUTAGENESIS OF TYR-5; LYS-19 AND 5-TYR--LYS-19.
      Tissue: Venom.

    Entry informationi

    Entry nameiKKX11_HETFU
    AccessioniPrimary (citable) accession number: P82850
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 4, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Miscellaneous

    This toxin does not have effect on Kv1.1/KCNA1 currents.1 Publication

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Scorpion potassium channel toxins
      Nomenclature of scorpion potassium channel toxins and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3