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Protein

Potassium channel toxin kappa-KTx 1.1

Gene
N/A
Organism
Heterometrus fulvipes (Indian black scorpion)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Slows the activation kinetics of Kv1.3/KCNA3 currents, and blocks Kv1.3/KCNA3 and Kv1.2/KCNA2 potassium channels. This block is dose-dependent, voltage-independent, and reversible.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Protein family/group databases

TCDBi8.B.2.1.1. the short scorpion toxin (s-st) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin kappa-KTx 1.1
Alternative name(s):
Kappa-hefutoxin-1
Short name:
Kappa-HfTx1
OrganismiHeterometrus fulvipes (Indian black scorpion)
Taxonomic identifieri141248 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesIuridaScorpionoideaScorpionidaeScorpioninaeHeterometrus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi5Y → A: Loss of channels blocking. Same effect observed; when associated with A-19. 1 Publication1
Mutagenesisi19K → A: Loss of channels blocking. Same effect observed; when associated with A-5. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000445441 – 22Potassium channel toxin kappa-KTx 1.1Add BLAST22

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi4 ↔ 221 Publication
Disulfide bondi8 ↔ 181 Publication
Modified residuei22Cysteine amide1 Publication1

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

Secondary structure

122
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni4 – 6Combined sources3
Helixi7 – 12Combined sources6
Helixi17 – 21Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HP9NMR-A1-22[»]
SMRiP82850.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP82850.

Family & Domainsi

Domaini

Has the structural arrangement of two alpha-helices stabilized by two disulfide bonds (CSalpha/alpha 2(S-S)).

Sequence similaritiesi

Family and domain databases

InterProiIPR012630. Toxin_25.
[Graphical view]
PfamiPF08095. Toxin_25. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P82850-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
GHACYRNCWR EGNDEETCKE RC
Length:22
Mass (Da):2,660
Last modified:March 1, 2001 - v1
Checksum:i8FB555EB877C6E98
GO

Mass spectrometryi

Molecular mass is 2655.4±0.2 Da from positions 1 - 22. Determined by ESI. 1 Publication

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HP9NMR-A1-22[»]
SMRiP82850.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi8.B.2.1.1. the short scorpion toxin (s-st) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP82850.

Family and domain databases

InterProiIPR012630. Toxin_25.
[Graphical view]
PfamiPF08095. Toxin_25. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKKX11_HETFU
AccessioniPrimary (citable) accession number: P82850
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Miscellaneous

This toxin does not have effect on Kv1.1/KCNA1 currents.1 Publication

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.