SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P82850

- KKX11_HETFU

UniProt

P82850 - KKX11_HETFU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Potassium channel toxin kappa-KTx 1.1
Gene
N/A
Organism
Heterometrus fulvipes (Indian black scorpion)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Slows the activation kinetics of Kv1.3/KCNA3 currents, and blocks Kv1.3/KCNA3 and Kv1.2/KCNA2 potassium channels. This block is dose-dependent, voltage-independent, and reversible.1 Publication

GO - Biological processi

  1. pathogenesis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Protein family/group databases

TCDBi8.B.2.1.1. the short scorpion toxin (sst) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin kappa-KTx 1.1
Alternative name(s):
Kappa-hefutoxin-1
Short name:
Kappa-HfTx1
OrganismiHeterometrus fulvipes (Indian black scorpion)
Taxonomic identifieri141248 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesIuridaScorpionoideaScorpionidaeScorpioninaeHeterometrus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi5 – 51Y → A: Loss of channels blocking. Same effect observed; when associated with A-19. 1 Publication
Mutagenesisi19 – 191K → A: Loss of channels blocking. Same effect observed; when associated with A-5. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 2222Potassium channel toxin kappa-KTx 1.1
PRO_0000044544Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi4 ↔ 221 Publication
Disulfide bondi8 ↔ 181 Publication
Modified residuei22 – 221Cysteine amide

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni4 – 63
Helixi7 – 126
Helixi17 – 215

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HP9NMR-A1-22[»]

Miscellaneous databases

EvolutionaryTraceiP82850.

Family & Domainsi

Domaini

Has the structural arrangement of two alpha-helices stabilized by two disulfide bonds (CSalpha/alpha).

Sequence similaritiesi

Family and domain databases

InterProiIPR012630. Toxin_25.
[Graphical view]
PfamiPF08095. Toxin_25. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P82850-1 [UniParc]FASTAAdd to Basket

« Hide

GHACYRNCWR EGNDEETCKE RC                                 22
Length:22
Mass (Da):2,660
Last modified:March 1, 2001 - v1
Checksum:i8FB555EB877C6E98
GO

Mass spectrometryi

Molecular mass is 2655.4±0.2 Da from positions 1 - 22. Determined by ESI. 1 Publication

Cross-referencesi

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1HP9 NMR - A 1-22 [» ]
ModBasei Search...
MobiDBi Search...

Protein family/group databases

TCDBi 8.B.2.1.1. the short scorpion toxin (sst) superfamily.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P82850.

Family and domain databases

InterProi IPR012630. Toxin_25.
[Graphical view ]
Pfami PF08095. Toxin_25. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Kappa-hefutoxin1, a novel toxin from the scorpion Heterometrus fulvipes with unique structure and function. Importance of the functional diad in potassium channel selectivity."
    Srinivasan K.N., Sivaraja V., Huys I., Sasaki T., Cheng B., Kumar T.K.S., Sato K., Tytgat J., Yu C., San B.C.C., Ranganathan S., Bowie H.J., Kini R.M., Gopalakrishnakone P.
    J. Biol. Chem. 277:30040-30047(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, FUNCTION, AMIDATION, STRUCTURE BY NMR, DISULFIDE BONDS, MASS SPECTROMETRY, MUTAGENESIS OF TYR-5; LYS-19 AND 5-TYR--LYS-19.
    Tissue: Venom.

Entry informationi

Entry nameiKKX11_HETFU
AccessioniPrimary (citable) accession number: P82850
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: March 1, 2001
Last modified: October 16, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Miscellaneous

This toxin does not have effect on Kv1.1/KCNA1 currents (1 Publication).

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi