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Protein

Glucomannokinase

Gene
N/A
Organism
Prevotella bryantii
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

The enzyme has great affinity for glucose and mannose.

Catalytic activityi

ATP + D-glucose = ADP + D-glucose 6-phosphate.
ATP + D-mannose = ADP + D-mannose 6-phosphate.

Enzyme regulationi

Competitively inhibited by 2-deoxy-glucose.

Pathway:iglycolysis

This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Glucomannokinase
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Pathway:imannose metabolism

This protein is involved in the pathway mannose metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway mannose metabolism and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00180.
UPA00339.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucomannokinase
Including the following 2 domains:
Glucokinase (EC:2.7.1.2)
Mannokinase (EC:2.7.1.7)
OrganismiPrevotella bryantii
Taxonomic identifieri77095 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPrevotellaceaePrevotella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›25›25GlucomannokinasePRO_0000095680Add
BLAST

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi752555.PBR_0624.

Family & Domainsi

Sequence similaritiesi

Belongs to the ROK (NagC/XylR) family.Curated

Sequencei

Sequence statusi: Fragment.

P82680-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
MNEQSMKPYV IGLDLGGTNS VFGIV
Length:25
Mass (Da):2,670
Last modified:October 1, 2000 - v1
Checksum:i3D56E14510A22558
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei25 – 251

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi752555.PBR_0624.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00109; UER00180.
UPA00339.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "The glucomannokinase of Prevotella bryantii B14 and its potential role in regulating beta-glucanase expression."
    Fields M.W., Russell J.B.
    Microbiology 147:1035-1043(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, CHARACTERIZATION.
    Strain: B14.

Entry informationi

Entry nameiGLMK_PREBR
AccessioniPrimary (citable) accession number: P82680
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 1, 2000
Last modified: June 24, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.