P82680 (GLMK_PREBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Glucomannokinase Including the following 2 domains: Glucokinase EC=2.7.1.2 Mannokinase EC=2.7.1.7
Organism	Prevotella bryantii
Taxonomic identifier	77095 [NCBI]
Taxonomic lineage	cellular organisms › Bacteria › Bacteroidetes/Chlorobi group › Bacteroidetes › Bacteroidia › Bacteroidales › Prevotellaceae › Prevotella

Protein attributes

Sequence length	25 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	The enzyme has great affinity for glucose and mannose.
Catalytic activity	ATP + D-glucose = ADP + D-glucose 6-phosphate. ATP + D-mannose = ADP + D-mannose 6-phosphate.
Enzyme regulation	Competitively inhibited by 2-deoxy-glucose.
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4. Carbohydrate metabolism; mannose metabolism.
Subunit structure	Homodimer.
Sequence similarities	Belongs to the ROK (NagC/XylR) family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Direct protein sequencing Multifunctional enzyme
Gene Ontology (GO)
Biological_process	glucose 6-phosphate metabolic process Inferred from electronic annotation. Source: GOC glycolysis Inferred from electronic annotation. Source: UniProtKB-UniPathway mannose metabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glucokinase activity Inferred from electronic annotation. Source: EC mannokinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›25	›25	Glucomannokinase		PRO_0000095680
Experimental info
	Non-terminal residue	25	1

Sequences

	Sequence		Length	Mass (Da)
	P82680 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 3D56E14510A22558	FASTA	25	2,670
	10 20 MNEQSMKPYV IGLDLGGTNS VFGIV

References

[1]	"The glucomannokinase of Prevotella bryantii B14 and its potential role in regulating beta-glucanase expression." Fields M.W., Russell J.B. Microbiology 147:1035-1043(2001) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE, CHARACTERIZATION. Strain: B14.

Cross-references

3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00109; UER00180. UPA00339.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

GLMK_PREBR

Accession

Primary (citable) accession number: P82680

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	October 1, 2000
Last modified:	April 3, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program