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Protein

28S ribosomal protein S5, mitochondrial

Gene

MRPS5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S5, mitochondrial
Short name:
MRP-S5
Short name:
S5mt
Gene namesi
Name:MRPS5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:14498. MRPS5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31024.

Polymorphism and mutation databases

BioMutaiMRPS5.
DMDMi24212347.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 43043028S ribosomal protein S5, mitochondrialPRO_0000131685Add
BLAST

Proteomic databases

EPDiP82675.
MaxQBiP82675.
PaxDbiP82675.
PeptideAtlasiP82675.
PRIDEiP82675.

PTM databases

iPTMnetiP82675.
PhosphoSiteiP82675.

Expressioni

Gene expression databases

BgeeiENSG00000144029.
CleanExiHS_MRPS5.
GenevisibleiP82675. HS.

Organism-specific databases

HPAiHPA055765.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

Protein-protein interaction databases

BioGridi122362. 66 interactions.
IntActiP82675. 8 interactions.
MINTiMINT-4825030.
STRINGi9606.ENSP00000272418.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AD1-430[»]
ProteinModelPortaliP82675.
SMRiP82675. Positions 89-430.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini218 – 28265S5 DRBMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ribosomal protein S5P family.Curated
Contains 1 S5 DRBM domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2646. Eukaryota.
COG0098. LUCA.
GeneTreeiENSGT00390000001878.
HOGENOMiHOG000231482.
HOVERGENiHBG030178.
InParanoidiP82675.
KOiK02988.
OMAiIRMKKQN.
OrthoDBiEOG091G09JG.
PhylomeDBiP82675.
TreeFamiTF313823.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
3.30.230.10. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR000851. Ribosomal_S5.
IPR005324. Ribosomal_S5_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR013810. Ribosomal_S5_N.
IPR018192. Ribosomal_S5_N_CS.
[Graphical view]
PANTHERiPTHR13718. PTHR13718. 1 hit.
PfamiPF00333. Ribosomal_S5. 1 hit.
PF03719. Ribosomal_S5_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
PROSITEiPS00585. RIBOSOMAL_S5. 1 hit.
PS50881. S5_DSRBD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P82675-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATAVRAVGC LPVLCSGTAG HLLGRQCSLN TLPAASILAW KSVLGNGHLS
60 70 80 90 100
SLGTRDTHPY ASLSRALQTQ CCISSPSHLM SQQYRPYSFF TKLTADELWK
110 120 130 140 150
GALAETGAGA KKGRGKRTKK KKRKDLNRGQ IIGEGRYGFL WPGLNVPLMK
160 170 180 190 200
NGAVQTIAQR SKEEQEKVEA DMIQQREEWD RKKKMKVKRE RGWSGNSWGG
210 220 230 240 250
ISLGPPDPGP CGETYEDFDT RILEVRNVFT MTAKEGRKKS IRVLVAVGNG
260 270 280 290 300
KGAAGFSIGK ATDRMDAFRK AKNRAVHHLH YIERYEDHTI FHDISLRFKR
310 320 330 340 350
THIKMKKQPK GYGLRCHRAI ITICRLIGIK DMYAKVSGSI NMLSLTQGLF
360 370 380 390 400
RGLSRQETHQ QLADKKGLHV VEIREECGPL PIVVASPRGP LRKDPEPEDE
410 420 430
VPDVKLDWED VKTAQGMKRS VWSNLKRAAT
Length:430
Mass (Da):48,006
Last modified:October 19, 2002 - v2
Checksum:i80588064E2AB3E97
GO
Isoform 2 (identifier: P82675-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     226-251: RNVFTMTAKEGRKKSIRVLVAVGNGK → FLLGKLLIGWMLSGKQRTEQFTICII
     252-430: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:251
Mass (Da):27,767
Checksum:i4AFFA624301469B1
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei226 – 25126RNVFT…VGNGK → FLLGKLLIGWMLSGKQRTEQ FTICII in isoform 2. 1 PublicationVSP_005725Add
BLAST
Alternative sequencei252 – 430179Missing in isoform 2. 1 PublicationVSP_005726Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049940 mRNA. Translation: BAB40993.1.
AK058160 mRNA. Translation: BAB71695.1.
AC092835 Genomic DNA. Translation: AAX88980.1.
CH471219 Genomic DNA. Translation: EAX10712.1.
BC000219 mRNA. Translation: AAH00219.2.
BC014172 mRNA. Translation: AAH14172.1.
CCDSiCCDS2010.1. [P82675-1]
RefSeqiNP_114108.1. NM_031902.4. [P82675-1]
UniGeneiHs.655259.

Genome annotation databases

EnsembliENST00000272418; ENSP00000272418; ENSG00000144029. [P82675-1]
ENST00000345084; ENSP00000341660; ENSG00000144029. [P82675-2]
GeneIDi64969.
KEGGihsa:64969.
UCSCiuc002sub.4. human. [P82675-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049940 mRNA. Translation: BAB40993.1.
AK058160 mRNA. Translation: BAB71695.1.
AC092835 Genomic DNA. Translation: AAX88980.1.
CH471219 Genomic DNA. Translation: EAX10712.1.
BC000219 mRNA. Translation: AAH00219.2.
BC014172 mRNA. Translation: AAH14172.1.
CCDSiCCDS2010.1. [P82675-1]
RefSeqiNP_114108.1. NM_031902.4. [P82675-1]
UniGeneiHs.655259.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AD1-430[»]
ProteinModelPortaliP82675.
SMRiP82675. Positions 89-430.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122362. 66 interactions.
IntActiP82675. 8 interactions.
MINTiMINT-4825030.
STRINGi9606.ENSP00000272418.

PTM databases

iPTMnetiP82675.
PhosphoSiteiP82675.

Polymorphism and mutation databases

BioMutaiMRPS5.
DMDMi24212347.

Proteomic databases

EPDiP82675.
MaxQBiP82675.
PaxDbiP82675.
PeptideAtlasiP82675.
PRIDEiP82675.

Protocols and materials databases

DNASUi64969.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272418; ENSP00000272418; ENSG00000144029. [P82675-1]
ENST00000345084; ENSP00000341660; ENSG00000144029. [P82675-2]
GeneIDi64969.
KEGGihsa:64969.
UCSCiuc002sub.4. human. [P82675-1]

Organism-specific databases

CTDi64969.
GeneCardsiMRPS5.
HGNCiHGNC:14498. MRPS5.
HPAiHPA055765.
MIMi611972. gene.
neXtProtiNX_P82675.
PharmGKBiPA31024.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2646. Eukaryota.
COG0098. LUCA.
GeneTreeiENSGT00390000001878.
HOGENOMiHOG000231482.
HOVERGENiHBG030178.
InParanoidiP82675.
KOiK02988.
OMAiIRMKKQN.
OrthoDBiEOG091G09JG.
PhylomeDBiP82675.
TreeFamiTF313823.

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiMRPS5. human.
GeneWikiiMRPS5.
GenomeRNAii64969.
PROiP82675.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000144029.
CleanExiHS_MRPS5.
GenevisibleiP82675. HS.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
3.30.230.10. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR000851. Ribosomal_S5.
IPR005324. Ribosomal_S5_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR013810. Ribosomal_S5_N.
IPR018192. Ribosomal_S5_N_CS.
[Graphical view]
PANTHERiPTHR13718. PTHR13718. 1 hit.
PfamiPF00333. Ribosomal_S5. 1 hit.
PF03719. Ribosomal_S5_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
PROSITEiPS00585. RIBOSOMAL_S5. 1 hit.
PS50881. S5_DSRBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRT05_HUMAN
AccessioniPrimary (citable) accession number: P82675
Secondary accession number(s): Q4ZFY5
, Q96LJ6, Q9BWI4, Q9BYC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: September 7, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.