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P82673

- RT35_HUMAN

UniProt

P82673 - RT35_HUMAN

Protein

28S ribosomal protein S35, mitochondrial

Gene

MRPS35

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB

    GO - Biological processi

    1. DNA damage response, detection of DNA damage Source: UniProtKB
    2. peptide biosynthetic process Source: UniProtKB

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    28S ribosomal protein S35, mitochondrial
    Short name:
    MRP-S35
    Short name:
    S35mt
    Alternative name(s):
    28S ribosomal protein S28, mitochondrial
    Short name:
    MRP-S28
    Short name:
    S28mt
    Gene namesi
    Name:MRPS35Imported
    Synonyms:MRPS281 Publication
    ORF Names:HDCMD11P, MDS023, PSEC0213
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:16635. MRPS35.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. mitochondrial small ribosomal subunit Source: UniProtKB
    3. mitochondrion Source: HPA

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31022.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 32328S ribosomal protein S35, mitochondrialPRO_0000046055
    Transit peptidei1 – ?MitochondrionCurated

    Proteomic databases

    MaxQBiP82673.
    PaxDbiP82673.
    PRIDEiP82673.

    PTM databases

    PhosphoSiteiP82673.

    Expressioni

    Gene expression databases

    ArrayExpressiP82673.
    BgeeiP82673.
    CleanExiHS_MRPS28.
    HS_MRPS35.
    GenevestigatoriP82673.

    Organism-specific databases

    HPAiHPA038513.

    Interactioni

    Subunit structurei

    Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.By similarity

    Protein-protein interaction databases

    BioGridi121919. 22 interactions.
    IntActiP82673. 6 interactions.
    MINTiMINT-6773400.

    Structurei

    3D structure databases

    ProteinModelPortaliP82673.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili257 – 32165Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Transit peptide

    Phylogenomic databases

    eggNOGiNOG267668.
    HOVERGENiHBG082941.
    InParanoidiP82673.
    KOiK17413.
    OMAiTEWPSAL.
    OrthoDBiEOG7QG44D.
    PhylomeDBiP82673.
    TreeFamiTF318686.

    Family and domain databases

    InterProiIPR019349. Ribosomal_S24/S35_mit.
    [Graphical view]
    PfamiPF10213. MRP-S28. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1Curated (identifier: P82673-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAAALPAWL SLQSRARTLR AFSTAVYSAT PVPTPSLPER TPGNERPPRR    50
    KALPPRTEKM AVDQDWPSVY PVAAPFKPSA VPLPVRMGYP VKKGVPMAKE 100
    GNLELLKIPN FLHLTPVAIK KHCEALKDFC TEWPAALDSD EKCEKHFPIE 150
    IDSTDYVSSG PSVRNPRARV VVLRVKLSSL NLDDHAKKKL IKLVGERYCK 200
    TTDVLTIKTD RCPLRRQNYD YAVYLLTVLY HESWNTEEWE KSKTEADMEE 250
    YIWENSSSER NILETLLQMK AAEKNMEINK EELLGTKEIE EYKKSVVSLK 300
    NEEENENSIS QYKESVKRLL NVT 323
    Length:323
    Mass (Da):36,844
    Last modified:October 1, 2000 - v1
    Checksum:iB29F819E914F2B49
    GO
    Isoform 2Curated (identifier: P82673-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         176-194: KLSSLNLDDHAKKKLIKLV → PFKEAELRLCSVSTNSVIP
         195-323: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:194
    Mass (Da):21,390
    Checksum:i69648AE388E7995A
    GO

    Sequence cautioni

    The sequence AAG14958.1 differs from that shown. Reason: Frameshift at position 97.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti6 – 61L → I.
    Corresponds to variant rs35475802 [ dbSNP | Ensembl ].
    VAR_052051

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei176 – 19419KLSSL…LIKLV → PFKEAELRLCSVSTNSVIP in isoform 2. 1 PublicationVSP_054096Add
    BLAST
    Alternative sequencei195 – 323129Missing in isoform 2. 1 PublicationVSP_054097Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF182422 mRNA. Translation: AAG14958.1. Frameshift.
    AK075378 mRNA. Translation: BAC11579.1.
    AK075515 mRNA. Translation: BAC11664.1.
    BC015862 mRNA. Translation: AAH15862.2.
    BC017086 mRNA. Translation: AAH17086.1.
    BC028346 mRNA. Translation: AAH28346.2.
    BC063515 mRNA. Translation: AAH63515.1.
    BC109372 mRNA. Translation: AAI09373.1.
    AL512733 mRNA. Translation: CAC21665.1.
    AF068296 mRNA. Translation: AAF65185.1.
    CCDSiCCDS53769.1. [P82673-2]
    CCDS8714.1. [P82673-1]
    RefSeqiNP_001177793.1. NM_001190864.1. [P82673-2]
    NP_068593.2. NM_021821.3. [P82673-1]
    UniGeneiHs.714076.

    Genome annotation databases

    EnsembliENST00000081029; ENSP00000081029; ENSG00000061794. [P82673-1]
    ENST00000538315; ENSP00000445390; ENSG00000061794. [P82673-2]
    GeneIDi60488.
    KEGGihsa:60488.
    UCSCiuc001rih.3. human. [P82673-1]

    Polymorphism databases

    DMDMi74708095.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF182422 mRNA. Translation: AAG14958.1 . Frameshift.
    AK075378 mRNA. Translation: BAC11579.1 .
    AK075515 mRNA. Translation: BAC11664.1 .
    BC015862 mRNA. Translation: AAH15862.2 .
    BC017086 mRNA. Translation: AAH17086.1 .
    BC028346 mRNA. Translation: AAH28346.2 .
    BC063515 mRNA. Translation: AAH63515.1 .
    BC109372 mRNA. Translation: AAI09373.1 .
    AL512733 mRNA. Translation: CAC21665.1 .
    AF068296 mRNA. Translation: AAF65185.1 .
    CCDSi CCDS53769.1. [P82673-2 ]
    CCDS8714.1. [P82673-1 ]
    RefSeqi NP_001177793.1. NM_001190864.1. [P82673-2 ]
    NP_068593.2. NM_021821.3. [P82673-1 ]
    UniGenei Hs.714076.

    3D structure databases

    ProteinModelPortali P82673.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121919. 22 interactions.
    IntActi P82673. 6 interactions.
    MINTi MINT-6773400.

    PTM databases

    PhosphoSitei P82673.

    Polymorphism databases

    DMDMi 74708095.

    Proteomic databases

    MaxQBi P82673.
    PaxDbi P82673.
    PRIDEi P82673.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000081029 ; ENSP00000081029 ; ENSG00000061794 . [P82673-1 ]
    ENST00000538315 ; ENSP00000445390 ; ENSG00000061794 . [P82673-2 ]
    GeneIDi 60488.
    KEGGi hsa:60488.
    UCSCi uc001rih.3. human. [P82673-1 ]

    Organism-specific databases

    CTDi 60488.
    GeneCardsi GC12P027863.
    HGNCi HGNC:16635. MRPS35.
    HPAi HPA038513.
    MIMi 611995. gene.
    neXtProti NX_P82673.
    PharmGKBi PA31022.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG267668.
    HOVERGENi HBG082941.
    InParanoidi P82673.
    KOi K17413.
    OMAi TEWPSAL.
    OrthoDBi EOG7QG44D.
    PhylomeDBi P82673.
    TreeFami TF318686.

    Miscellaneous databases

    GeneWikii MRPS35.
    GenomeRNAii 60488.
    NextBioi 65371.
    PROi P82673.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P82673.
    Bgeei P82673.
    CleanExi HS_MRPS28.
    HS_MRPS35.
    Genevestigatori P82673.

    Family and domain databases

    InterProi IPR019349. Ribosomal_S24/S35_mit.
    [Graphical view ]
    Pfami PF10213. MRP-S28. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel genes expressed in hematopoietic stem/progenitor cells from myelodysplastic syndrome patients."
      Huang C., Qian B., Tu Y., Gu W., Wang Y., Han Z., Chen Z.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Hematopoietic stem cell.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Teratocarcinoma.
    3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Embryo.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: ColonImported, LungImported and PancreasImported.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 47-323 (ISOFORM 1).
      Tissue: Melanoma.
    6. "A novel gene from human dendritic cells."
      Zhao Z., Huang X., Li N., Zhu X., Cao X.
      Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 180-323 (ISOFORM 1).
      Tissue: Dendritic cellImported.
    7. "Identification of four proteins from the small subunit of the mammalian mitochondrial ribosome using a proteomics approach."
      Koc E.C., Burkhart W., Blackburn K., Koc H., Moseley A., Spremulli L.L.
      Protein Sci. 10:471-481(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRT35_HUMAN
    AccessioniPrimary (citable) accession number: P82673
    Secondary accession number(s): Q32LZ1
    , Q6P4C6, Q7L1M6, Q8NBP4, Q96AI0, Q9H044, Q9HC14, Q9P1R5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 7, 2006
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3