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P82673 (RT35_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
28S ribosomal protein S35, mitochondrial

Short name=MRP-S35
Short name=S35mt
Alternative name(s):
28S ribosomal protein S28, mitochondrial
Short name=MRP-S28
Short name=S28mt
Gene names
Name:MRPS35
Synonyms:MRPS28
ORF Names:HDCMD11P, MDS023, PSEC0213
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length323 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins By similarity. UniProtKB Q2YDF6

Subcellular location

Mitochondrion By similarity UniProtKB Q2YDF6.

Sequence caution

The sequence AAG14958.1 differs from that shown. Reason: Frameshift at position 97. UniProtKB Q2YDF6

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 UniProtKB Q2YDF6 (identifier: P82673-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 UniProtKB Q2YDF6 (identifier: P82673-2)

The sequence of this isoform differs from the canonical sequence as follows:
     176-194: KLSSLNLDDHAKKKLIKLV → PFKEAELRLCSVSTNSVIP
     195-323: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential UniProtKB Q2YDF6
Chain? – 32328S ribosomal protein S35, mitochondrial UniProtKB Q2YDF6PRO_0000046055

Regions

Coiled coil257 – 32165 Potential

Natural variations

Alternative sequence176 – 19419KLSSL…LIKLV → PFKEAELRLCSVSTNSVIP in isoform 2.
VSP_054096
Alternative sequence195 – 323129Missing in isoform 2.
VSP_054097
Natural variant61L → I.
Corresponds to variant rs35475802 [ dbSNP | Ensembl ].
VAR_052051

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: B29F819E914F2B49

FASTA32336,844
        10         20         30         40         50         60 
MAAAALPAWL SLQSRARTLR AFSTAVYSAT PVPTPSLPER TPGNERPPRR KALPPRTEKM 

        70         80         90        100        110        120 
AVDQDWPSVY PVAAPFKPSA VPLPVRMGYP VKKGVPMAKE GNLELLKIPN FLHLTPVAIK 

       130        140        150        160        170        180 
KHCEALKDFC TEWPAALDSD EKCEKHFPIE IDSTDYVSSG PSVRNPRARV VVLRVKLSSL 

       190        200        210        220        230        240 
NLDDHAKKKL IKLVGERYCK TTDVLTIKTD RCPLRRQNYD YAVYLLTVLY HESWNTEEWE 

       250        260        270        280        290        300 
KSKTEADMEE YIWENSSSER NILETLLQMK AAEKNMEINK EELLGTKEIE EYKKSVVSLK 

       310        320 
NEEENENSIS QYKESVKRLL NVT 

« Hide

Isoform 2 [UniParc].

Checksum: 69648AE388E7995A
Show »

FASTA19421,390

References

« Hide 'large scale' references
[1]"Novel genes expressed in hematopoietic stem/progenitor cells from myelodysplastic syndrome patients."
Huang C., Qian B., Tu Y., Gu W., Wang Y., Han Z., Chen Z.
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Hematopoietic stem cell.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Teratocarcinoma.
[3]"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. expand/collapse author list , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Embryo.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Colon, Lung and Pancreas.
[5]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 47-323 (ISOFORM 1).
Tissue: Melanoma.
[6]"A novel gene from human dendritic cells."
Zhao Z., Huang X., Li N., Zhu X., Cao X.
Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 180-323 (ISOFORM 1).
Tissue: Dendritic cell.
[7]"Identification of four proteins from the small subunit of the mammalian mitochondrial ribosome using a proteomics approach."
Koc E.C., Burkhart W., Blackburn K., Koc H., Moseley A., Spremulli L.L.
Protein Sci. 10:471-481(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF182422 mRNA. Translation: AAG14958.1. Frameshift.
AK075378 mRNA. Translation: BAC11579.1.
AK075515 mRNA. Translation: BAC11664.1.
BC015862 mRNA. Translation: AAH15862.2.
BC017086 mRNA. Translation: AAH17086.1.
BC028346 mRNA. Translation: AAH28346.2.
BC063515 mRNA. Translation: AAH63515.1.
BC109372 mRNA. Translation: AAI09373.1.
AL512733 mRNA. Translation: CAC21665.1.
AF068296 mRNA. Translation: AAF65185.1.
CCDSCCDS8714.1. [P82673-1]
RefSeqNP_001177793.1. NM_001190864.1. [P82673-2]
NP_068593.2. NM_021821.3. [P82673-1]
UniGeneHs.714076.

3D structure databases

ProteinModelPortalP82673.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121919. 22 interactions.
IntActP82673. 6 interactions.
MINTMINT-6773400.

PTM databases

PhosphoSiteP82673.

Polymorphism databases

DMDM74708095.

Proteomic databases

MaxQBP82673.
PaxDbP82673.
PRIDEP82673.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000081029; ENSP00000081029; ENSG00000061794. [P82673-1]
ENST00000538315; ENSP00000445390; ENSG00000061794.
GeneID60488.
KEGGhsa:60488.
UCSCuc001rih.3. human. [P82673-1]

Organism-specific databases

CTD60488.
GeneCardsGC12P027863.
HGNCHGNC:16635. MRPS35.
HPAHPA038513.
MIM611995. gene.
neXtProtNX_P82673.
PharmGKBPA31022.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG267668.
HOVERGENHBG082941.
InParanoidP82673.
KOK17413.
OMATEWPSAL.
OrthoDBEOG7QG44D.
PhylomeDBP82673.
TreeFamTF318686.

Gene expression databases

ArrayExpressP82673.
BgeeP82673.
CleanExHS_MRPS28.
HS_MRPS35.
GenevestigatorP82673.

Family and domain databases

InterProIPR019349. Ribosomal_S24/S35_mit.
[Graphical view]
PfamPF10213. MRP-S28. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiMRPS35.
GenomeRNAi60488.
NextBio65371.
PROP82673.
SOURCESearch...

Entry information

Entry nameRT35_HUMAN
AccessionPrimary (citable) accession number: P82673
Secondary accession number(s): Q32LZ1 expand/collapse secondary AC list , Q6P4C6, Q7L1M6, Q8NBP4, Q96AI0, Q9H044, Q9HC14, Q9P1R5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM