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Protein

28S ribosomal protein S35, mitochondrial

Gene

MRPS35

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S35, mitochondrial
Short name:
MRP-S35
Short name:
S35mt
Alternative name(s):
28S ribosomal protein S28, mitochondrial
Short name:
MRP-S28
Short name:
S28mt
Gene namesi
Name:MRPS35Imported
Synonyms:MRPS281 Publication
ORF Names:HDCMD11P, MDS023, PSEC0213
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:16635. MRPS35.

Subcellular locationi

  • Mitochondrion By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31022.

Polymorphism and mutation databases

BioMutaiMRPS35.
DMDMi74708095.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 32328S ribosomal protein S35, mitochondrialPRO_0000046055
Transit peptidei1 – ?MitochondrionCurated

Proteomic databases

EPDiP82673.
MaxQBiP82673.
PaxDbiP82673.
PeptideAtlasiP82673.
PRIDEiP82673.

PTM databases

iPTMnetiP82673.
PhosphoSiteiP82673.

Expressioni

Gene expression databases

BgeeiENSG00000061794.
CleanExiHS_MRPS28.
HS_MRPS35.
ExpressionAtlasiP82673. baseline and differential.
GenevisibleiP82673. HS.

Organism-specific databases

HPAiHPA038513.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.By similarity

Protein-protein interaction databases

BioGridi121919. 81 interactions.
IntActiP82673. 20 interactions.
MINTiMINT-6773400.
STRINGi9606.ENSP00000081029.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50A11-323[»]
ProteinModelPortaliP82673.
SMRiP82673. Positions 49-322.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili257 – 32165Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil, Transit peptide

Phylogenomic databases

eggNOGiKOG3933. Eukaryota.
ENOG410ZX0Y. LUCA.
GeneTreeiENSGT00390000003443.
HOVERGENiHBG082941.
InParanoidiP82673.
KOiK17413.
OMAiTEWPSAL.
OrthoDBiEOG091G0ELS.
PhylomeDBiP82673.
TreeFamiTF318686.

Family and domain databases

InterProiIPR019349. Ribosomal_S24/S35_mit.
[Graphical view]
PfamiPF10213. MRP-S28. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1Curated (identifier: P82673-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAALPAWL SLQSRARTLR AFSTAVYSAT PVPTPSLPER TPGNERPPRR
60 70 80 90 100
KALPPRTEKM AVDQDWPSVY PVAAPFKPSA VPLPVRMGYP VKKGVPMAKE
110 120 130 140 150
GNLELLKIPN FLHLTPVAIK KHCEALKDFC TEWPAALDSD EKCEKHFPIE
160 170 180 190 200
IDSTDYVSSG PSVRNPRARV VVLRVKLSSL NLDDHAKKKL IKLVGERYCK
210 220 230 240 250
TTDVLTIKTD RCPLRRQNYD YAVYLLTVLY HESWNTEEWE KSKTEADMEE
260 270 280 290 300
YIWENSSSER NILETLLQMK AAEKNMEINK EELLGTKEIE EYKKSVVSLK
310 320
NEEENENSIS QYKESVKRLL NVT
Length:323
Mass (Da):36,844
Last modified:October 1, 2000 - v1
Checksum:iB29F819E914F2B49
GO
Isoform 2Curated (identifier: P82673-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     176-194: KLSSLNLDDHAKKKLIKLV → PFKEAELRLCSVSTNSVIP
     195-323: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:194
Mass (Da):21,390
Checksum:i69648AE388E7995A
GO

Sequence cautioni

The sequence AAG14958 differs from that shown. Reason: Frameshift at position 97. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61L → I.
Corresponds to variant rs35475802 [ dbSNP | Ensembl ].
VAR_052051

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei176 – 19419KLSSL…LIKLV → PFKEAELRLCSVSTNSVIP in isoform 2. 1 PublicationVSP_054096Add
BLAST
Alternative sequencei195 – 323129Missing in isoform 2. 1 PublicationVSP_054097Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182422 mRNA. Translation: AAG14958.1. Frameshift.
AK075378 mRNA. Translation: BAC11579.1.
AK075515 mRNA. Translation: BAC11664.1.
BC015862 mRNA. Translation: AAH15862.2.
BC017086 mRNA. Translation: AAH17086.1.
BC028346 mRNA. Translation: AAH28346.2.
BC063515 mRNA. Translation: AAH63515.1.
BC109372 mRNA. Translation: AAI09373.1.
AL512733 mRNA. Translation: CAC21665.1.
AF068296 mRNA. Translation: AAF65185.1.
CCDSiCCDS53769.1. [P82673-2]
CCDS8714.1. [P82673-1]
RefSeqiNP_001177793.1. NM_001190864.1. [P82673-2]
NP_068593.2. NM_021821.3. [P82673-1]
UniGeneiHs.714076.

Genome annotation databases

EnsembliENST00000081029; ENSP00000081029; ENSG00000061794. [P82673-1]
ENST00000538315; ENSP00000445390; ENSG00000061794. [P82673-2]
GeneIDi60488.
KEGGihsa:60488.
UCSCiuc001rih.4. human. [P82673-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182422 mRNA. Translation: AAG14958.1. Frameshift.
AK075378 mRNA. Translation: BAC11579.1.
AK075515 mRNA. Translation: BAC11664.1.
BC015862 mRNA. Translation: AAH15862.2.
BC017086 mRNA. Translation: AAH17086.1.
BC028346 mRNA. Translation: AAH28346.2.
BC063515 mRNA. Translation: AAH63515.1.
BC109372 mRNA. Translation: AAI09373.1.
AL512733 mRNA. Translation: CAC21665.1.
AF068296 mRNA. Translation: AAF65185.1.
CCDSiCCDS53769.1. [P82673-2]
CCDS8714.1. [P82673-1]
RefSeqiNP_001177793.1. NM_001190864.1. [P82673-2]
NP_068593.2. NM_021821.3. [P82673-1]
UniGeneiHs.714076.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50A11-323[»]
ProteinModelPortaliP82673.
SMRiP82673. Positions 49-322.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121919. 81 interactions.
IntActiP82673. 20 interactions.
MINTiMINT-6773400.
STRINGi9606.ENSP00000081029.

PTM databases

iPTMnetiP82673.
PhosphoSiteiP82673.

Polymorphism and mutation databases

BioMutaiMRPS35.
DMDMi74708095.

Proteomic databases

EPDiP82673.
MaxQBiP82673.
PaxDbiP82673.
PeptideAtlasiP82673.
PRIDEiP82673.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000081029; ENSP00000081029; ENSG00000061794. [P82673-1]
ENST00000538315; ENSP00000445390; ENSG00000061794. [P82673-2]
GeneIDi60488.
KEGGihsa:60488.
UCSCiuc001rih.4. human. [P82673-1]

Organism-specific databases

CTDi60488.
GeneCardsiMRPS35.
HGNCiHGNC:16635. MRPS35.
HPAiHPA038513.
MIMi611995. gene.
neXtProtiNX_P82673.
PharmGKBiPA31022.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3933. Eukaryota.
ENOG410ZX0Y. LUCA.
GeneTreeiENSGT00390000003443.
HOVERGENiHBG082941.
InParanoidiP82673.
KOiK17413.
OMAiTEWPSAL.
OrthoDBiEOG091G0ELS.
PhylomeDBiP82673.
TreeFamiTF318686.

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiMRPS35. human.
GeneWikiiMRPS35.
GenomeRNAii60488.
PROiP82673.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000061794.
CleanExiHS_MRPS28.
HS_MRPS35.
ExpressionAtlasiP82673. baseline and differential.
GenevisibleiP82673. HS.

Family and domain databases

InterProiIPR019349. Ribosomal_S24/S35_mit.
[Graphical view]
PfamiPF10213. MRP-S28. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRT35_HUMAN
AccessioniPrimary (citable) accession number: P82673
Secondary accession number(s): Q32LZ1
, Q6P4C6, Q7L1M6, Q8NBP4, Q96AI0, Q9H044, Q9HC14, Q9P1R5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.