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P82673

- RT35_HUMAN

UniProt

P82673 - RT35_HUMAN

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Protein

28S ribosomal protein S35, mitochondrial

Gene

MRPS35

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  1. DNA damage response, detection of DNA damage Source: UniProtKB
  2. peptide biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S35, mitochondrial
Short name:
MRP-S35
Short name:
S35mt
Alternative name(s):
28S ribosomal protein S28, mitochondrial
Short name:
MRP-S28
Short name:
S28mt
Gene namesi
Name:MRPS35Imported
Synonyms:MRPS281 Publication
ORF Names:HDCMD11P, MDS023, PSEC0213
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:16635. MRPS35.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. mitochondrial small ribosomal subunit Source: UniProtKB
  3. mitochondrion Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31022.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 32328S ribosomal protein S35, mitochondrialPRO_0000046055
Transit peptidei1 – ?MitochondrionCurated

Proteomic databases

MaxQBiP82673.
PaxDbiP82673.
PRIDEiP82673.

PTM databases

PhosphoSiteiP82673.

Expressioni

Gene expression databases

BgeeiP82673.
CleanExiHS_MRPS28.
HS_MRPS35.
ExpressionAtlasiP82673. baseline and differential.
GenevestigatoriP82673.

Organism-specific databases

HPAiHPA038513.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.By similarity

Protein-protein interaction databases

BioGridi121919. 31 interactions.
IntActiP82673. 6 interactions.
MINTiMINT-6773400.

Structurei

3D structure databases

ProteinModelPortaliP82673.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili257 – 32165Sequence AnalysisAdd
BLAST

Keywords - Domaini

Coiled coil, Transit peptide

Phylogenomic databases

eggNOGiNOG267668.
GeneTreeiENSGT00390000003443.
HOVERGENiHBG082941.
InParanoidiP82673.
KOiK17413.
OMAiTEWPSAL.
OrthoDBiEOG7QG44D.
PhylomeDBiP82673.
TreeFamiTF318686.

Family and domain databases

InterProiIPR019349. Ribosomal_S24/S35_mit.
[Graphical view]
PfamiPF10213. MRP-S28. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1Curated (identifier: P82673-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAALPAWL SLQSRARTLR AFSTAVYSAT PVPTPSLPER TPGNERPPRR
60 70 80 90 100
KALPPRTEKM AVDQDWPSVY PVAAPFKPSA VPLPVRMGYP VKKGVPMAKE
110 120 130 140 150
GNLELLKIPN FLHLTPVAIK KHCEALKDFC TEWPAALDSD EKCEKHFPIE
160 170 180 190 200
IDSTDYVSSG PSVRNPRARV VVLRVKLSSL NLDDHAKKKL IKLVGERYCK
210 220 230 240 250
TTDVLTIKTD RCPLRRQNYD YAVYLLTVLY HESWNTEEWE KSKTEADMEE
260 270 280 290 300
YIWENSSSER NILETLLQMK AAEKNMEINK EELLGTKEIE EYKKSVVSLK
310 320
NEEENENSIS QYKESVKRLL NVT
Length:323
Mass (Da):36,844
Last modified:October 1, 2000 - v1
Checksum:iB29F819E914F2B49
GO
Isoform 2Curated (identifier: P82673-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     176-194: KLSSLNLDDHAKKKLIKLV → PFKEAELRLCSVSTNSVIP
     195-323: Missing.

Note: No experimental confirmation available.Curated

Show »
Length:194
Mass (Da):21,390
Checksum:i69648AE388E7995A
GO

Sequence cautioni

The sequence AAG14958.1 differs from that shown. Reason: Frameshift at position 97.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61L → I.
Corresponds to variant rs35475802 [ dbSNP | Ensembl ].
VAR_052051

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei176 – 19419KLSSL…LIKLV → PFKEAELRLCSVSTNSVIP in isoform 2. 1 PublicationVSP_054096Add
BLAST
Alternative sequencei195 – 323129Missing in isoform 2. 1 PublicationVSP_054097Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF182422 mRNA. Translation: AAG14958.1. Frameshift.
AK075378 mRNA. Translation: BAC11579.1.
AK075515 mRNA. Translation: BAC11664.1.
BC015862 mRNA. Translation: AAH15862.2.
BC017086 mRNA. Translation: AAH17086.1.
BC028346 mRNA. Translation: AAH28346.2.
BC063515 mRNA. Translation: AAH63515.1.
BC109372 mRNA. Translation: AAI09373.1.
AL512733 mRNA. Translation: CAC21665.1.
AF068296 mRNA. Translation: AAF65185.1.
CCDSiCCDS53769.1. [P82673-2]
CCDS8714.1. [P82673-1]
RefSeqiNP_001177793.1. NM_001190864.1. [P82673-2]
NP_068593.2. NM_021821.3. [P82673-1]
UniGeneiHs.714076.

Genome annotation databases

EnsembliENST00000081029; ENSP00000081029; ENSG00000061794. [P82673-1]
ENST00000538315; ENSP00000445390; ENSG00000061794. [P82673-2]
GeneIDi60488.
KEGGihsa:60488.
UCSCiuc001rih.3. human. [P82673-1]

Polymorphism databases

DMDMi74708095.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF182422 mRNA. Translation: AAG14958.1 . Frameshift.
AK075378 mRNA. Translation: BAC11579.1 .
AK075515 mRNA. Translation: BAC11664.1 .
BC015862 mRNA. Translation: AAH15862.2 .
BC017086 mRNA. Translation: AAH17086.1 .
BC028346 mRNA. Translation: AAH28346.2 .
BC063515 mRNA. Translation: AAH63515.1 .
BC109372 mRNA. Translation: AAI09373.1 .
AL512733 mRNA. Translation: CAC21665.1 .
AF068296 mRNA. Translation: AAF65185.1 .
CCDSi CCDS53769.1. [P82673-2 ]
CCDS8714.1. [P82673-1 ]
RefSeqi NP_001177793.1. NM_001190864.1. [P82673-2 ]
NP_068593.2. NM_021821.3. [P82673-1 ]
UniGenei Hs.714076.

3D structure databases

ProteinModelPortali P82673.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121919. 31 interactions.
IntActi P82673. 6 interactions.
MINTi MINT-6773400.

PTM databases

PhosphoSitei P82673.

Polymorphism databases

DMDMi 74708095.

Proteomic databases

MaxQBi P82673.
PaxDbi P82673.
PRIDEi P82673.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000081029 ; ENSP00000081029 ; ENSG00000061794 . [P82673-1 ]
ENST00000538315 ; ENSP00000445390 ; ENSG00000061794 . [P82673-2 ]
GeneIDi 60488.
KEGGi hsa:60488.
UCSCi uc001rih.3. human. [P82673-1 ]

Organism-specific databases

CTDi 60488.
GeneCardsi GC12P027863.
HGNCi HGNC:16635. MRPS35.
HPAi HPA038513.
MIMi 611995. gene.
neXtProti NX_P82673.
PharmGKBi PA31022.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG267668.
GeneTreei ENSGT00390000003443.
HOVERGENi HBG082941.
InParanoidi P82673.
KOi K17413.
OMAi TEWPSAL.
OrthoDBi EOG7QG44D.
PhylomeDBi P82673.
TreeFami TF318686.

Miscellaneous databases

GeneWikii MRPS35.
GenomeRNAii 60488.
NextBioi 65371.
PROi P82673.
SOURCEi Search...

Gene expression databases

Bgeei P82673.
CleanExi HS_MRPS28.
HS_MRPS35.
ExpressionAtlasi P82673. baseline and differential.
Genevestigatori P82673.

Family and domain databases

InterProi IPR019349. Ribosomal_S24/S35_mit.
[Graphical view ]
Pfami PF10213. MRP-S28. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Novel genes expressed in hematopoietic stem/progenitor cells from myelodysplastic syndrome patients."
    Huang C., Qian B., Tu Y., Gu W., Wang Y., Han Z., Chen Z.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Hematopoietic stem cell.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Teratocarcinoma.
  3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Embryo.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: ColonImported, LungImported and PancreasImported.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 47-323 (ISOFORM 1).
    Tissue: Melanoma.
  6. "A novel gene from human dendritic cells."
    Zhao Z., Huang X., Li N., Zhu X., Cao X.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 180-323 (ISOFORM 1).
    Tissue: Dendritic cellImported.
  7. "Identification of four proteins from the small subunit of the mammalian mitochondrial ribosome using a proteomics approach."
    Koc E.C., Burkhart W., Blackburn K., Koc H., Moseley A., Spremulli L.L.
    Protein Sci. 10:471-481(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRT35_HUMAN
AccessioniPrimary (citable) accession number: P82673
Secondary accession number(s): Q32LZ1
, Q6P4C6, Q7L1M6, Q8NBP4, Q96AI0, Q9H044, Q9HC14, Q9P1R5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3