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Protein

28S ribosomal protein S10, mitochondrial

Gene

MRPS10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S10, mitochondrial
Short name:
MRP-S10
Short name:
S10mt
Alternative name(s):
Mitochondrial small ribosomal subunit protein uS10m1 Publication
Gene namesi
Name:MRPS10
ORF Names:MSTP040
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000048544.5.
HGNCiHGNC:14502. MRPS10.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000048544.
PharmGKBiPA30993.

Polymorphism and mutation databases

BioMutaiMRPS10.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001466751 – 20128S ribosomal protein S10, mitochondrialAdd BLAST201

Proteomic databases

EPDiP82664.
MaxQBiP82664.
PaxDbiP82664.
PeptideAtlasiP82664.
PRIDEiP82664.
TopDownProteomicsiP82664.

PTM databases

iPTMnetiP82664.
PhosphoSitePlusiP82664.

Expressioni

Gene expression databases

BgeeiENSG00000048544.
CleanExiHS_MRPS10.
ExpressionAtlasiP82664. baseline and differential.
GenevisibleiP82664. HS.

Organism-specific databases

HPAiHPA029133.
HPA029134.

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.1 Publication

Protein-protein interaction databases

BioGridi120472. 55 interactors.
CORUMiP82664.
DIPiDIP-50902N.
IntActiP82664. 9 interactors.
MINTiMINT-8052140.
STRINGi9606.ENSP00000053468.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AH1-201[»]
ProteinModelPortaliP82664.
SMRiP82664.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3321. Eukaryota.
COG0051. LUCA.
GeneTreeiENSGT00390000009045.
HOGENOMiHOG000012920.
HOVERGENiHBG023133.
InParanoidiP82664.
KOiK02946.
OMAiCWSPRKA.
OrthoDBiEOG091G0QZ2.
PhylomeDBiP82664.
TreeFamiTF315130.

Family and domain databases

Gene3Di3.30.70.600. 1 hit.
InterProiView protein in InterPro
IPR027486. Ribosomal_S10_dom.
IPR036838. Ribosomal_S10_dom_sf.
PfamiView protein in Pfam
PF00338. Ribosomal_S10. 1 hit.
SMARTiView protein in SMART
SM01403. Ribosomal_S10. 1 hit.
SUPFAMiSSF54999. SSF54999. 1 hit.

Sequencei

Sequence statusi: Complete.

P82664-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARTAFGAV CRRLWQGLGN FSVNTSKGNT AKNGGLLLST NMKWVQFSNL
60 70 80 90 100
HVDVPKDLTK PVVTISDEPD ILYKRLSVLV KGHDKAVLDS YEYFAVLAAK
110 120 130 140 150
ELGISIKVHE PPRKIERFTL LQSVHIYKKH RVQYEMRTLY RCLELEHLTG
160 170 180 190 200
STADVYLEYI QRNLPEGVAM EVTKTQLEQL PEHIKEPIWE TLSEEKEESK

S
Length:201
Mass (Da):22,999
Last modified:January 23, 2002 - v2
Checksum:iB89E13504CC4F92B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti63V → A in BAA91686 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF113220 mRNA. Translation: AAG39291.1.
AK001429 mRNA. Translation: BAA91686.1.
AK316599 mRNA. Translation: BAG38186.1.
AL096814 Genomic DNA. No translation available.
CH471081 Genomic DNA. Translation: EAX04086.1.
BC012560 mRNA. Translation: AAH12560.1.
CCDSiCCDS4866.1.
RefSeqiNP_060611.2. NM_018141.3.
UniGeneiHs.380887.
Hs.669022.

Genome annotation databases

EnsembliENST00000053468; ENSP00000053468; ENSG00000048544.
GeneIDi55173.
KEGGihsa:55173.
UCSCiuc003osa.5. human.

Similar proteinsi

Entry informationi

Entry nameiRT10_HUMAN
AccessioniPrimary (citable) accession number: P82664
Secondary accession number(s): B2RE89, Q9H3E5, Q9NVR3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 13, 2001
Last sequence update: January 23, 2002
Last modified: October 25, 2017
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families