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Protein

28S ribosomal protein S10, mitochondrial

Gene

MRPS10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_267602. Mitochondrial translation termination.
REACT_267677. Mitochondrial translation elongation.
REACT_267680. Mitochondrial translation initiation.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S10, mitochondrial
Short name:
MRP-S10
Short name:
S10mt
Gene namesi
Name:MRPS10
ORF Names:MSTP040
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:14502. MRPS10.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
  2. ribosome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30993.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20120128S ribosomal protein S10, mitochondrialPRO_0000146675Add
BLAST

Proteomic databases

MaxQBiP82664.
PaxDbiP82664.
PeptideAtlasiP82664.
PRIDEiP82664.

PTM databases

PhosphoSiteiP82664.

Expressioni

Gene expression databases

BgeeiP82664.
CleanExiHS_MRPS10.
ExpressionAtlasiP82664. baseline and differential.
GenevestigatoriP82664.

Organism-specific databases

HPAiHPA029133.
HPA029134.

Interactioni

Protein-protein interaction databases

BioGridi120472. 23 interactions.
DIPiDIP-50902N.
IntActiP82664. 2 interactions.
MINTiMINT-8052140.
STRINGi9606.ENSP00000053468.

Structurei

3D structure databases

ProteinModelPortaliP82664.
SMRiP82664. Positions 1-201.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S10P family.Curated

Phylogenomic databases

eggNOGiNOG264717.
GeneTreeiENSGT00390000009045.
HOGENOMiHOG000012920.
HOVERGENiHBG023133.
InParanoidiP82664.
KOiK02946.
OMAiSMKWVQF.
OrthoDBiEOG74R1S4.
PhylomeDBiP82664.
TreeFamiTF315130.

Family and domain databases

Gene3Di3.30.70.600. 1 hit.
InterProiIPR027486. Ribosomal_S10_dom.
[Graphical view]
PfamiPF00338. Ribosomal_S10. 1 hit.
[Graphical view]
SUPFAMiSSF54999. SSF54999. 1 hit.

Sequencei

Sequence statusi: Complete.

P82664-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAARTAFGAV CRRLWQGLGN FSVNTSKGNT AKNGGLLLST NMKWVQFSNL
60 70 80 90 100
HVDVPKDLTK PVVTISDEPD ILYKRLSVLV KGHDKAVLDS YEYFAVLAAK
110 120 130 140 150
ELGISIKVHE PPRKIERFTL LQSVHIYKKH RVQYEMRTLY RCLELEHLTG
160 170 180 190 200
STADVYLEYI QRNLPEGVAM EVTKTQLEQL PEHIKEPIWE TLSEEKEESK

S
Length:201
Mass (Da):22,999
Last modified:January 23, 2002 - v2
Checksum:iB89E13504CC4F92B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti63 – 631V → A in BAA91686. (PubMed:14702039)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF113220 mRNA. Translation: AAG39291.1.
AK001429 mRNA. Translation: BAA91686.1.
AK316599 mRNA. Translation: BAG38186.1.
AL096814 Genomic DNA. Translation: CAD92529.1.
CH471081 Genomic DNA. Translation: EAX04086.1.
BC012560 mRNA. Translation: AAH12560.1.
CCDSiCCDS4866.1.
RefSeqiNP_060611.2. NM_018141.3.
UniGeneiHs.380887.
Hs.669022.

Genome annotation databases

EnsembliENST00000053468; ENSP00000053468; ENSG00000048544.
GeneIDi55173.
KEGGihsa:55173.
UCSCiuc003osa.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF113220 mRNA. Translation: AAG39291.1.
AK001429 mRNA. Translation: BAA91686.1.
AK316599 mRNA. Translation: BAG38186.1.
AL096814 Genomic DNA. Translation: CAD92529.1.
CH471081 Genomic DNA. Translation: EAX04086.1.
BC012560 mRNA. Translation: AAH12560.1.
CCDSiCCDS4866.1.
RefSeqiNP_060611.2. NM_018141.3.
UniGeneiHs.380887.
Hs.669022.

3D structure databases

ProteinModelPortaliP82664.
SMRiP82664. Positions 1-201.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120472. 23 interactions.
DIPiDIP-50902N.
IntActiP82664. 2 interactions.
MINTiMINT-8052140.
STRINGi9606.ENSP00000053468.

PTM databases

PhosphoSiteiP82664.

Proteomic databases

MaxQBiP82664.
PaxDbiP82664.
PeptideAtlasiP82664.
PRIDEiP82664.

Protocols and materials databases

DNASUi55173.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000053468; ENSP00000053468; ENSG00000048544.
GeneIDi55173.
KEGGihsa:55173.
UCSCiuc003osa.4. human.

Organism-specific databases

CTDi55173.
GeneCardsiGC06M042174.
HGNCiHGNC:14502. MRPS10.
HPAiHPA029133.
HPA029134.
MIMi611976. gene.
neXtProtiNX_P82664.
PharmGKBiPA30993.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG264717.
GeneTreeiENSGT00390000009045.
HOGENOMiHOG000012920.
HOVERGENiHBG023133.
InParanoidiP82664.
KOiK02946.
OMAiSMKWVQF.
OrthoDBiEOG74R1S4.
PhylomeDBiP82664.
TreeFamiTF315130.

Enzyme and pathway databases

ReactomeiREACT_267602. Mitochondrial translation termination.
REACT_267677. Mitochondrial translation elongation.
REACT_267680. Mitochondrial translation initiation.

Miscellaneous databases

ChiTaRSiMRPS10. human.
GenomeRNAii55173.
NextBioi58963.
PROiP82664.
SOURCEiSearch...

Gene expression databases

BgeeiP82664.
CleanExiHS_MRPS10.
ExpressionAtlasiP82664. baseline and differential.
GenevestigatoriP82664.

Family and domain databases

Gene3Di3.30.70.600. 1 hit.
InterProiIPR027486. Ribosomal_S10_dom.
[Graphical view]
PfamiPF00338. Ribosomal_S10. 1 hit.
[Graphical view]
SUPFAMiSSF54999. SSF54999. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. "A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins."
    Koc E.C., Burkhart W., Blackburn K., Moseley A., Koc H., Spremulli L.L.
    J. Biol. Chem. 275:32585-32591(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRT10_HUMAN
AccessioniPrimary (citable) accession number: P82664
Secondary accession number(s): B2RE89, Q9H3E5, Q9NVR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2001
Last sequence update: January 23, 2002
Last modified: January 7, 2015
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.