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Protein

28S ribosomal protein S22, mitochondrial

Gene

MRPS22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: MGI

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S22, mitochondrial
Short name:
MRP-S22
Short name:
S22mt
Alternative name(s):
Mitochondrial small ribosomal subunit protein mS221 Publication
Gene namesi
Name:MRPS22
Synonyms:C3orf5, RPMS22
ORF Names:GK002
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:14508. MRPS22.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: Reactome
  • mitochondrial ribosome Source: UniProtKB
  • mitochondrial small ribosomal subunit Source: MGI
  • mitochondrion Source: HPA

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Involvement in diseasei

Combined oxidative phosphorylation deficiency 5 (COXPD5)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA mitochondrial disease resulting in severe metabolic acidosis, edema, hypertrophic cardiomyopathy, tubulopathy, and hypotonia.
See also OMIM:611719
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042733170R → H in COXPD5. 1 PublicationCorresponds to variant dbSNP:rs119478059Ensembl.1

Keywords - Diseasei

Disease mutation, Primary mitochondrial disease

Organism-specific databases

DisGeNETi56945.
MalaCardsiMRPS22.
MIMi611719. phenotype.
OpenTargetsiENSG00000175110.
Orphaneti137908. Hypotonia with lactic acidemia and hyperammonemia.
PharmGKBiPA31010.

Polymorphism and mutation databases

BioMutaiMRPS22.
DMDMi13633893.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000877031 – 36028S ribosomal protein S22, mitochondrialAdd BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei54PhosphoserineCombined sources1
Modified residuei211N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP82650.
MaxQBiP82650.
PaxDbiP82650.
PeptideAtlasiP82650.
PRIDEiP82650.
TopDownProteomicsiP82650-1. [P82650-1]

PTM databases

iPTMnetiP82650.
PhosphoSitePlusiP82650.

Expressioni

Gene expression databases

BgeeiENSG00000175110.
CleanExiHS_MRPS22.
ExpressionAtlasiP82650. baseline and differential.
GenevisibleiP82650. HS.

Organism-specific databases

HPAiHPA006083.
HPA007830.

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.1 Publication

Protein-protein interaction databases

BioGridi121269. 70 interactors.
IntActiP82650. 26 interactors.
STRINGi9606.ENSP00000310785.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AR1-360[»]
ProteinModelPortaliP82650.
SMRiP82650.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3890. Eukaryota.
ENOG4111I44. LUCA.
GeneTreeiENSGT00390000006095.
HOGENOMiHOG000154215.
HOVERGENiHBG017759.
InParanoidiP82650.
KOiK17401.
OMAiMAFFYAW.
OrthoDBiEOG091G0H6J.
PhylomeDBiP82650.
TreeFamiTF312882.

Family and domain databases

InterProiView protein in InterPro
IPR019374. Ribosomal_S22_mit.
PANTHERiPTHR13071. PTHR13071. 1 hit.
PfamiView protein in Pfam
PF10245. MRP-S22. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P82650-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPLGTTVLL WSLLRSSPGV ERVCFRARIQ PWHGGLLQPL PCSFEMGLPR
60 70 80 90 100
RRFSSEAAES GSPETKKPTF MDEEVQSILT KMTGLNLQKT FKPAIQELKP
110 120 130 140 150
PTYKLMTQAQ LEEATRQAVE AAKVRLKMPP VLEERVPIND VLAEDKILEG
160 170 180 190 200
TETTKYVFTD ISYSIPHRER FIVVREPSGT LRKASWEERD RMIQVYFPKE
210 220 230 240 250
GRKILTPIIF KEENLRTMYS QDRHVDVLNL CFAQFEPDST EYIKVHHKTY
260 270 280 290 300
EDIDKRGKYD LLRSTRYFGG MVWYFVNNKK IDGLLIDQIQ RDLIDDATNL
310 320 330 340 350
VQLYHVLHPD GQSAQGAKDQ AAEGINLIKV FAKTEAQKGA YIELTLQTYQ
360
EALSRHSAAS
Length:360
Mass (Da):41,280
Last modified:October 1, 2000 - v1
Checksum:i2DB50257C222D706
GO
Isoform 2 (identifier: P82650-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     57-57: Missing.
     169-169: E → C
     170-360: Missing.

Show »
Length:168
Mass (Da):18,972
Checksum:i4680BF691DD7538E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042733170R → H in COXPD5. 1 PublicationCorresponds to variant dbSNP:rs119478059Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05663457Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_056635169E → C in isoform 2. 1 Publication1
Alternative sequenceiVSP_056636170 – 360Missing in isoform 2. 1 PublicationAdd BLAST191

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321613 mRNA. Translation: AAK01406.1.
AF063603 mRNA. Translation: AAG43162.1.
AF226045 mRNA. Translation: AAF86945.1.
AC024933 Genomic DNA. No translation available.
AC069525 Genomic DNA. No translation available.
AC119740 Genomic DNA. No translation available.
AC130416 Genomic DNA. No translation available.
BC009296 mRNA. Translation: AAH09296.1.
CCDSiCCDS3107.1. [P82650-1]
RefSeqiNP_064576.1. NM_020191.2. [P82650-1]
UniGeneiHs.745001.

Genome annotation databases

EnsembliENST00000310776; ENSP00000310785; ENSG00000175110. [P82650-1]
ENST00000495075; ENSP00000418008; ENSG00000175110. [P82650-1]
ENST00000498505; ENSP00000420482; ENSG00000175110. [P82650-2]
GeneIDi56945.
KEGGihsa:56945.
UCSCiuc003etb.4. human. [P82650-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRT22_HUMAN
AccessioniPrimary (citable) accession number: P82650
Secondary accession number(s): Q9H3I1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: August 30, 2017
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families