Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Latherin

Gene

LATH

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Major protein in sweat, has surfactant properties. Has a role in temperature regulation by having a capacity to make hydrophobic surfaces wettable and so can function in promoting spreading and evaporation of sweat.1 Publication

GO - Molecular functioni

GO - Biological processi

  • regulation of liquid surface tension Source: CACAO
  • temperature homeostasis Source: CACAO
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Latherin
Alternative name(s):
Dander allergen Equ c 4/Equ c 5
Allergen: Equ c 4
Gene namesi
Name:LATH
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Allergen of horse dander.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3303. Equ c 4.0101.
336. Equ c 4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001719021 – 228LatherinAdd BLAST208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi153 ↔ 1961 Publication

Post-translational modificationi

No sign of N-X-[ST] acceptor site even though reported as N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP82615.
PeptideAtlasiP82615.

Expressioni

Tissue specificityi

Found in sweat (at protein level).1 Publication

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

STRINGi9796.ENSECAP00000007784.

Structurei

Secondary structure

1228
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi25 – 41Combined sources17
Helixi44 – 50Combined sources7
Helixi54 – 64Combined sources11
Turni65 – 67Combined sources3
Turni69 – 71Combined sources3
Beta strandi81 – 85Combined sources5
Beta strandi94 – 97Combined sources4
Beta strandi99 – 121Combined sources23
Beta strandi124 – 140Combined sources17
Beta strandi146 – 164Combined sources19
Beta strandi167 – 170Combined sources4
Helixi171 – 174Combined sources4
Helixi177 – 188Combined sources12
Helixi191 – 194Combined sources4
Helixi196 – 202Combined sources7
Turni203 – 205Combined sources3
Helixi208 – 223Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZPMNMR-A21-228[»]
SMRiP82615.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi35 – 219Leu-richAdd BLAST185

Sequence similaritiesi

Belongs to the BPI/LBP/Plunc superfamily. Plunc family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J27D. Eukaryota.
ENOG41115PY. LUCA.
HOGENOMiHOG000169393.
HOVERGENiHBG079669.
InParanoidiP82615.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR032942. BPI/LBP/Plunc.
IPR032953. BPIFA1/Latherin.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PANTHERiPTHR10504. PTHR10504. 1 hit.
PTHR10504:SF70. PTHR10504:SF70. 1 hit.
PfamiPF01273. LBP_BPI_CETP. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P82615-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKVSCLFVL LCGLLVPSSA QQIPPEVSSQ ITDALTQGLL DGNFLSLLNA
60 70 80 90 100
INLEGLLNTI LDQVTGLLNI LVGPLLGPSD AEIKLQDTRL LQLSLEFSPD
110 120 130 140 150
SKGIDIWIPL ELSVYLKLLI LEPLTLYVRT DIRVQLRLES DEDGKYRLAF
160 170 180 190 200
GHCSLLPRAI ELQSGNPLSL PVNAVLGTIE NALGNFITED LGAGLCPTLN
210 220
SLVSNLDLQL VNNLINLILD RANVDLSV
Length:228
Mass (Da):24,701
Last modified:July 10, 2007 - v3
Checksum:i544088871FBEFF92
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti88T → A AA sequence (PubMed:11358533).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF491288 mRNA. Translation: AAM09530.3.
RefSeqiNP_001075328.2. NM_001081859.2.
UniGeneiEca.12955.

Genome annotation databases

GeneIDi100033921.
KEGGiecb:100033921.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF491288 mRNA. Translation: AAM09530.3.
RefSeqiNP_001075328.2. NM_001081859.2.
UniGeneiEca.12955.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZPMNMR-A21-228[»]
SMRiP82615.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9796.ENSECAP00000007784.

Protein family/group databases

Allergomei3303. Equ c 4.0101.
336. Equ c 4.

Proteomic databases

PaxDbiP82615.
PeptideAtlasiP82615.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100033921.
KEGGiecb:100033921.

Organism-specific databases

CTDi100033921.

Phylogenomic databases

eggNOGiENOG410J27D. Eukaryota.
ENOG41115PY. LUCA.
HOGENOMiHOG000169393.
HOVERGENiHBG079669.
InParanoidiP82615.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR032942. BPI/LBP/Plunc.
IPR032953. BPIFA1/Latherin.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PANTHERiPTHR10504. PTHR10504. 1 hit.
PTHR10504:SF70. PTHR10504:SF70. 1 hit.
PfamiPF01273. LBP_BPI_CETP. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLATH_HORSE
AccessioniPrimary (citable) accession number: P82615
Secondary accession number(s): P82616, Q8SPI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: July 10, 2007
Last modified: November 2, 2016
This is version 75 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.