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P82611 (ACON_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Aconitate hydratase, mitochondrial
Short name=Aconitase
EC=4.2.1.3
Alternative name(s):
Citrate hydro-lyase
Gene names
Name:ACO1
ORF Names:CaO19.13742, CaO19.6385
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida ›

Protein attributes

Sequence length777 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the isomerization of citrate to isocitrate via cis-aconitate By similarity.

Catalytic activity

Citrate = isocitrate.

Cofactor

Binds 1 4Fe-4S cluster per subunit By similarity.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.

Subunit structure

Monomer By similarity.

Subcellular location

Mitochondrion.

Sequence similarities

Belongs to the aconitase/IPM isomerase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 777Aconitate hydratase, mitochondrialPRO_0000076648

Regions

Region189 – 1913Substrate binding By similarity
Region668 – 6692Substrate binding By similarity

Sites

Metal binding3831Iron-sulfur (4Fe-4S) By similarity
Metal binding4461Iron-sulfur (4Fe-4S) By similarity
Metal binding4491Iron-sulfur (4Fe-4S) By similarity
Binding site961Substrate By similarity
Binding site4721Substrate By similarity
Binding site4771Substrate By similarity
Binding site6051Substrate By similarity

Experimental info

Sequence conflict419 – 4213EQV → VQQ AA sequence Ref.2

Sequences

Sequence LengthMass (Da)Tools
P82611 [UniParc].

Last modified March 3, 2009. Version 2.
Checksum: B854CDE375844793

FASTA77784,221
        10         20         30         40         50         60 
MLSASRTALR APRSVRGLAT ASLTKDSQVN QNLLESHSFI NYKKHLENVE IVKSRLNRPL 

        70         80         90        100        110        120 
TYAEKLLYGH LDDPHNQEIE RGVSYLKLRP DRVACQDATA QMAILQFMSA GIPQVATPST 

       130        140        150        160        170        180 
VHCDHLIQAQ VGGPKDLARA IDLNKEVYDF LSTACAKYNL GFWKPGSGII HQIVLENYAF 

       190        200        210        220        230        240 
PGALLIGTDS HTPNAGGLGQ LAIGVGGADA VDVMSGLPWE LKAPKIIGVK LTGKMSGWTS 

       250        260        270        280        290        300 
PKDIILKLAG ITTVKGGTGS IVEYFGSGVD TFSCTGMGTI CNMGAEIGAT TSVFPFNDSM 

       310        320        330        340        350        360 
VDYLNATGRS EIAQFAQVYK KDFLSADEGA EYDQVIEIDL NTLEPHINGP FTPDLATPVS 

       370        380        390        400        410        420 
KMKETAIANG WPLEVKVGLI GSCTNSSYED MTRAASIIKD AGAHGLKSKA LYTVSPGSEQ 

       430        440        450        460        470        480 
VRATIARDGQ LKTFEDFGGV VMANACGPCI GQWDRQDIKK GDKNTIVSSF NRNFTARNDG 

       490        500        510        520        530        540 
NPATHAFVAS PEMATVYAIS GDLGFNPITD TLVGADGKEF KLKEPQGVGL PPDGYDPGEN 

       550        560        570        580        590        600 
TYQAPPEDRA SVEVVISPTS DRLQKLSPFK PWDGKDAERL PILIKAVGKT TTDHISMAGP 

       610        620        630        640        650        660 
WLKYRGHLEN ISNNYMIGAI NAENGKANEV RNHYTGKYDG VPQTAAAYRD AGHKWVVIGD 

       670        680        690        700        710        720 
ENFGEGSSRE HAALEPRFLG GFAIITKSFA RIHETNLKKQ GLLPLNFKNP ADYDKINFDD 

       730        740        750        760        770 
EVDLIGLTTL APGKDVILRV HPKEGEAWEA VLTHTFNSEQ LEWFKHGSAL NFIKSKY

« Hide

References

« Hide 'large scale' references
[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.
[2]"Cross-species identification of novel Candida albicans immunogenic proteins by combination of two-dimensional polyacrylamide gel electrophoresis and mass spectrometry."
Pardo M., Ward M., Pitarch A., Sanchez M., Nombela C., Blackstock W., Gil C.
Electrophoresis 21:2651-2659(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 377-393 AND 412-422, MASS SPECTROMETRY.
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AACQ01000073 Genomic DNA. Translation: EAK97138.1.
AACQ01000072 Genomic DNA. Translation: EAK97226.1.
RefSeqXP_716141.1. XM_711048.1.
XP_716225.1. XM_711132.1.

3D structure databases

ProteinModelPortalP82611.
SMRP82611. Positions 27-774.
ModBaseSearch...

Protein-protein interaction databases

STRING5476.CAL0001406.

2D gel databases

COMPLUYEAST-2DPAGEP82611.

Proteomic databases

PRIDEP82611.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3642090.
3642201.
KEGGcal:CaO19.13742.
cal:CaO19.6385.

Organism-specific databases

CGDCAL0001406. ACO1.

Phylogenomic databases

eggNOGCOG1048.
KOK01681.

Enzyme and pathway databases

UniPathwayUPA00223; UER00718.

Family and domain databases

Gene3D3.20.19.10. 1 hit.
3.30.499.10. 2 hits.
3.40.1060.10. 1 hit.
InterProIPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
IPR015937. Acoase/IPM_deHydtase.
IPR001030. Acoase/IPM_deHydtase_lsu_aba.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
IPR018136. Aconitase_4Fe-4S_BS.
IPR006248. Aconitase_mito-like.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
[Graphical view]
PANTHERPTHR11670. PTHR11670. 1 hit.
PTHR11670:SF5. PTHR11670:SF5. 1 hit.
PfamPF00330. Aconitase. 1 hit.
PF00694. Aconitase_C. 1 hit.
[Graphical view]
PRINTSPR00415. ACONITASE.
SUPFAMSSF52016. Aconitase/3IPM_dehydase_swvl. 1 hit.
SSF53732. Aconitase_N. 1 hit.
TIGRFAMsTIGR01340. aconitase_mito. 1 hit.
PROSITEPS00450. ACONITASE_1. 1 hit.
PS01244. ACONITASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACON_CANAL
AccessionPrimary (citable) accession number: P82611
Secondary accession number(s): Q5A380
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: March 3, 2009
Last modified: April 3, 2013
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Candida albicans

Candida albicans: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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