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P82602 (FOLKP_CHLMU) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Folate synthesis bifunctional protein

Including the following 2 domains:

  1. 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
    EC=2.7.6.3
    Alternative name(s):
    6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
    Short name=PPPK
    7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
    Short name=HPPK
  2. Dihydropteroate synthase
    Short name=DHPS
    EC=2.5.1.15
    Alternative name(s):
    Dihydropteroate pyrophosphorylase
Gene names
Name:folKP
Ordered Locus Names:TC_0903
OrganismChlamydia muridarum (strain MoPn / Nigg) [Complete proteome] [HAMAP]
Taxonomic identifier243161 [NCBI]
Taxonomic lineageBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia

Protein attributes

Sequence length450 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate.

(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.

Sequence similarities

In the N-terminal section; belongs to the HPPK family.

Contains 1 pterin-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 450450Folate synthesis bifunctional protein
PRO_0000168239

Regions

Domain180 – 441262Pterin-binding
Region1 – 166166HPPK

Sequences

Sequence LengthMass (Da)Tools
P82602 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 068BE8D2DCEE4A2E

FASTA45050,448
        10         20         30         40         50         60 
MTTWNFVCLG LGSNLGNRHE YIKRAYESLK KAGIRNLKSS VILETKALLL EGSPKEWDLP 

        70         80         90        100        110        120 
YFNCVAIGET QLSPDELVKE IKMIENRLSR DSSLKWGPRS IDIDVLLYGD ESYSCCSERC 

       130        140        150        160        170        180 
IIPHPRLLER PFLLSMMASL CPYRYFRLRG SPYDGKTFAE LAAIYPLTEK DVLGSFAPTT 

       190        200        210        220        230        240 
QIMGIVNVTD DSISDTGLFL EAKRAAAHAE RLFAEGASII DLGAQATNPR VRDLGSVEQE 

       250        260        270        280        290        300 
WERLEPVLQI LAESWKDAKQ YPDVSIDTFR PEVIRRAIQV FPIRWINDVS GGSLEMAHLA 

       310        320        330        340        350        360 
KDLGLRLLIN HSCSLPPRPD CVLSYEESPV TQMLRWGESQ LETFAQIGLD TSWQVVFDPG 

       370        380        390        400        410        420 
IGFGKTPVQS MQLMEGVAKF KHILKCPVLI GHSRKSCLSL LGRFSSQDRD WETIGCSVAL 

       430        440        450 
HNQGVDYLRV HQVEGNRRVL AAAAWSGMPV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE002160 Genomic DNA. Translation: AAF39696.1.
PIRG81652.
RefSeqNP_297276.1. NC_002620.2.

3D structure databases

ProteinModelPortalP82602.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243161.TC0903.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF39696; AAF39696; TC_0903.
GeneID1246272.
KEGGcmu:TC_0903.
PATRIC20373332. VBIChlMur19118_0969.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0294.
KOK13941.
OMAMYVLDQD.
OrthoDBEOG67T5P5.
ProtClustDBCLSK871487.

Enzyme and pathway databases

BioCycCMUR243161:GHYU-934-MONOMER.
UniPathwayUPA00077; UER00155.
UPA00077; UER00156.

Family and domain databases

Gene3D3.20.20.20. 1 hit.
3.30.70.560. 1 hit.
InterProIPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000550. Hppk.
IPR000489. Pterin-binding.
[Graphical view]
PfamPF01288. HPPK. 1 hit.
PF00809. Pterin_bind. 1 hit.
[Graphical view]
SUPFAMSSF51717. SSF51717. 1 hit.
SSF55083. SSF55083. 1 hit.
TIGRFAMsTIGR01496. DHPS. 1 hit.
TIGR01498. folK. 1 hit.
PROSITEPS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS00794. HPPK. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFOLKP_CHLMU
AccessionPrimary (citable) accession number: P82602
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 1, 2000
Last modified: December 11, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways