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P82602

- FOLKP_CHLMU

UniProt

P82602 - FOLKP_CHLMU

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Protein
Folate synthesis bifunctional protein
Gene
folKP, TC_0903
Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate.
(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.

Pathwayi

GO - Molecular functioni

  1. 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
  3. dihydropteroate synthase activity Source: UniProtKB-EC
  4. kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. folic acid biosynthetic process Source: UniProtKB-KW
  2. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Folate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCMUR243161:GHYU-934-MONOMER.
UniPathwayiUPA00077; UER00155.
UPA00077; UER00156.

Names & Taxonomyi

Protein namesi
Recommended name:
Folate synthesis bifunctional protein
Including the following 2 domains:
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC:2.7.6.3)
Alternative name(s):
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
Short name:
PPPK
7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
Short name:
HPPK
Dihydropteroate synthase (EC:2.5.1.15)
Short name:
DHPS
Alternative name(s):
Dihydropteroate pyrophosphorylase
Gene namesi
Name:folKP
Ordered Locus Names:TC_0903
OrganismiChlamydia muridarum (strain MoPn / Nigg)
Taxonomic identifieri243161 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000800: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 450450Folate synthesis bifunctional protein
PRO_0000168239Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243161.TC0903.

Structurei

3D structure databases

ProteinModelPortaliP82602.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini180 – 441262Pterin-binding
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 166166HPPK
Add
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the HPPK family.

Phylogenomic databases

eggNOGiCOG0294.
KOiK13941.
OMAiSERCIIP.
OrthoDBiEOG67T5P5.

Family and domain databases

Gene3Di3.20.20.20. 1 hit.
3.30.70.560. 1 hit.
InterProiIPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000550. Hppk.
IPR000489. Pterin-binding.
[Graphical view]
PfamiPF01288. HPPK. 1 hit.
PF00809. Pterin_bind. 1 hit.
[Graphical view]
SUPFAMiSSF51717. SSF51717. 1 hit.
SSF55083. SSF55083. 1 hit.
TIGRFAMsiTIGR01496. DHPS. 1 hit.
TIGR01498. folK. 1 hit.
PROSITEiPS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS00794. HPPK. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P82602-1 [UniParc]FASTAAdd to Basket

« Hide

MTTWNFVCLG LGSNLGNRHE YIKRAYESLK KAGIRNLKSS VILETKALLL    50
EGSPKEWDLP YFNCVAIGET QLSPDELVKE IKMIENRLSR DSSLKWGPRS 100
IDIDVLLYGD ESYSCCSERC IIPHPRLLER PFLLSMMASL CPYRYFRLRG 150
SPYDGKTFAE LAAIYPLTEK DVLGSFAPTT QIMGIVNVTD DSISDTGLFL 200
EAKRAAAHAE RLFAEGASII DLGAQATNPR VRDLGSVEQE WERLEPVLQI 250
LAESWKDAKQ YPDVSIDTFR PEVIRRAIQV FPIRWINDVS GGSLEMAHLA 300
KDLGLRLLIN HSCSLPPRPD CVLSYEESPV TQMLRWGESQ LETFAQIGLD 350
TSWQVVFDPG IGFGKTPVQS MQLMEGVAKF KHILKCPVLI GHSRKSCLSL 400
LGRFSSQDRD WETIGCSVAL HNQGVDYLRV HQVEGNRRVL AAAAWSGMPV 450
Length:450
Mass (Da):50,448
Last modified:October 1, 2000 - v1
Checksum:i068BE8D2DCEE4A2E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002160 Genomic DNA. Translation: AAF39696.1.
PIRiG81652.
RefSeqiNP_297276.1. NC_002620.2.

Genome annotation databases

EnsemblBacteriaiAAF39696; AAF39696; TC_0903.
GeneIDi1246272.
KEGGicmu:TC_0903.
PATRICi20373332. VBIChlMur19118_0969.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002160 Genomic DNA. Translation: AAF39696.1 .
PIRi G81652.
RefSeqi NP_297276.1. NC_002620.2.

3D structure databases

ProteinModelPortali P82602.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243161.TC0903.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF39696 ; AAF39696 ; TC_0903 .
GeneIDi 1246272.
KEGGi cmu:TC_0903.
PATRICi 20373332. VBIChlMur19118_0969.

Phylogenomic databases

eggNOGi COG0294.
KOi K13941.
OMAi SERCIIP.
OrthoDBi EOG67T5P5.

Enzyme and pathway databases

UniPathwayi UPA00077 ; UER00155 .
UPA00077 ; UER00156 .
BioCyci CMUR243161:GHYU-934-MONOMER.

Family and domain databases

Gene3Di 3.20.20.20. 1 hit.
3.30.70.560. 1 hit.
InterProi IPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000550. Hppk.
IPR000489. Pterin-binding.
[Graphical view ]
Pfami PF01288. HPPK. 1 hit.
PF00809. Pterin_bind. 1 hit.
[Graphical view ]
SUPFAMi SSF51717. SSF51717. 1 hit.
SSF55083. SSF55083. 1 hit.
TIGRFAMsi TIGR01496. DHPS. 1 hit.
TIGR01498. folK. 1 hit.
PROSITEi PS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS00794. HPPK. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MoPn / Nigg.

Entry informationi

Entry nameiFOLKP_CHLMU
AccessioniPrimary (citable) accession number: P82602
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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