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P82602

- FOLKP_CHLMU

UniProt

P82602 - FOLKP_CHLMU

Protein

Folate synthesis bifunctional protein

Gene

folKP

Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate.
    (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.

    Pathwayi

    GO - Molecular functioni

    1. 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW
    3. dihydropteroate synthase activity Source: UniProtKB-EC
    4. kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. folic acid biosynthetic process Source: UniProtKB-KW
    2. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Folate biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCMUR243161:GHYU-934-MONOMER.
    UniPathwayiUPA00077; UER00155.
    UPA00077; UER00156.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Folate synthesis bifunctional protein
    Including the following 2 domains:
    2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC:2.7.6.3)
    Alternative name(s):
    6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
    Short name:
    PPPK
    7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
    Short name:
    HPPK
    Dihydropteroate synthase (EC:2.5.1.15)
    Short name:
    DHPS
    Alternative name(s):
    Dihydropteroate pyrophosphorylase
    Gene namesi
    Name:folKP
    Ordered Locus Names:TC_0903
    OrganismiChlamydia muridarum (strain MoPn / Nigg)
    Taxonomic identifieri243161 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000800: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 450450Folate synthesis bifunctional proteinPRO_0000168239Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243161.TC0903.

    Structurei

    3D structure databases

    ProteinModelPortaliP82602.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini180 – 441262Pterin-bindingPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 166166HPPKAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the HPPK family.Curated
    Contains 1 pterin-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0294.
    KOiK13941.
    OMAiSERCIIP.
    OrthoDBiEOG67T5P5.

    Family and domain databases

    Gene3Di3.20.20.20. 1 hit.
    3.30.70.560. 1 hit.
    InterProiIPR006390. DHP_synth.
    IPR011005. Dihydropteroate_synth-like.
    IPR000550. Hppk.
    IPR000489. Pterin-binding.
    [Graphical view]
    PfamiPF01288. HPPK. 1 hit.
    PF00809. Pterin_bind. 1 hit.
    [Graphical view]
    SUPFAMiSSF51717. SSF51717. 1 hit.
    SSF55083. SSF55083. 1 hit.
    TIGRFAMsiTIGR01496. DHPS. 1 hit.
    TIGR01498. folK. 1 hit.
    PROSITEiPS00792. DHPS_1. 1 hit.
    PS00793. DHPS_2. 1 hit.
    PS00794. HPPK. 1 hit.
    PS50972. PTERIN_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P82602-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTWNFVCLG LGSNLGNRHE YIKRAYESLK KAGIRNLKSS VILETKALLL    50
    EGSPKEWDLP YFNCVAIGET QLSPDELVKE IKMIENRLSR DSSLKWGPRS 100
    IDIDVLLYGD ESYSCCSERC IIPHPRLLER PFLLSMMASL CPYRYFRLRG 150
    SPYDGKTFAE LAAIYPLTEK DVLGSFAPTT QIMGIVNVTD DSISDTGLFL 200
    EAKRAAAHAE RLFAEGASII DLGAQATNPR VRDLGSVEQE WERLEPVLQI 250
    LAESWKDAKQ YPDVSIDTFR PEVIRRAIQV FPIRWINDVS GGSLEMAHLA 300
    KDLGLRLLIN HSCSLPPRPD CVLSYEESPV TQMLRWGESQ LETFAQIGLD 350
    TSWQVVFDPG IGFGKTPVQS MQLMEGVAKF KHILKCPVLI GHSRKSCLSL 400
    LGRFSSQDRD WETIGCSVAL HNQGVDYLRV HQVEGNRRVL AAAAWSGMPV 450
    Length:450
    Mass (Da):50,448
    Last modified:October 1, 2000 - v1
    Checksum:i068BE8D2DCEE4A2E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE002160 Genomic DNA. Translation: AAF39696.1.
    PIRiG81652.
    RefSeqiNP_297276.1. NC_002620.2.

    Genome annotation databases

    EnsemblBacteriaiAAF39696; AAF39696; TC_0903.
    GeneIDi1246272.
    KEGGicmu:TC_0903.
    PATRICi20373332. VBIChlMur19118_0969.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE002160 Genomic DNA. Translation: AAF39696.1 .
    PIRi G81652.
    RefSeqi NP_297276.1. NC_002620.2.

    3D structure databases

    ProteinModelPortali P82602.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243161.TC0903.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF39696 ; AAF39696 ; TC_0903 .
    GeneIDi 1246272.
    KEGGi cmu:TC_0903.
    PATRICi 20373332. VBIChlMur19118_0969.

    Phylogenomic databases

    eggNOGi COG0294.
    KOi K13941.
    OMAi SERCIIP.
    OrthoDBi EOG67T5P5.

    Enzyme and pathway databases

    UniPathwayi UPA00077 ; UER00155 .
    UPA00077 ; UER00156 .
    BioCyci CMUR243161:GHYU-934-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.20. 1 hit.
    3.30.70.560. 1 hit.
    InterProi IPR006390. DHP_synth.
    IPR011005. Dihydropteroate_synth-like.
    IPR000550. Hppk.
    IPR000489. Pterin-binding.
    [Graphical view ]
    Pfami PF01288. HPPK. 1 hit.
    PF00809. Pterin_bind. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51717. SSF51717. 1 hit.
    SSF55083. SSF55083. 1 hit.
    TIGRFAMsi TIGR01496. DHPS. 1 hit.
    TIGR01498. folK. 1 hit.
    PROSITEi PS00792. DHPS_1. 1 hit.
    PS00793. DHPS_2. 1 hit.
    PS00794. HPPK. 1 hit.
    PS50972. PTERIN_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MoPn / Nigg.

    Entry informationi

    Entry nameiFOLKP_CHLMU
    AccessioniPrimary (citable) accession number: P82602
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3