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Protein

Folate synthesis bifunctional protein

Gene

folKP

Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 6-hydroxymethyl-7,8-dihydropterin = AMP + 6-hydroxymethyl-7,8-dihydropterin diphosphate.
6-hydroxymethyl-7,8-dihydropterin diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.

Cofactori

Mg2+By similarity

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Probable dihydroneopterin aldolase (folB)
  4. Folate synthesis bifunctional protein (folKP)
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Folate synthesis bifunctional protein (folKP)
  2. no protein annotated in this organism
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi187MagnesiumBy similarity1
Binding sitei2276-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei2676-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei2876-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei3586-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei3956-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Multifunctional enzyme, Transferase
Biological processFolate biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00077; UER00155
UPA00077; UER00156

Names & Taxonomyi

Protein namesi
Recommended name:
Folate synthesis bifunctional protein
Including the following 2 domains:
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (EC:2.7.6.3)
Short name:
HPPK
Alternative name(s):
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
Short name:
PPPK
Dihydropteroate synthase (EC:2.5.1.15)
Short name:
DHPS
Alternative name(s):
Dihydropteroate pyrophosphorylase
Gene namesi
Name:folKP
Ordered Locus Names:TC_0903
OrganismiChlamydia muridarum (strain MoPn / Nigg)
Taxonomic identifieri243161 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000800 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001682391 – 450Folate synthesis bifunctional proteinAdd BLAST450

Proteomic databases

PRIDEiP82602

Interactioni

Protein-protein interaction databases

STRINGi243161.CmurN_010100004658

Structurei

3D structure databases

ProteinModelPortaliP82602
SMRiP82602
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini180 – 441Pterin-bindingPROSITE-ProRule annotationAdd BLAST262

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 166HPPKAdd BLAST166
Regioni182 – 450DHPSAdd BLAST269
Regioni429 – 4316-hydroxymethyl-7,8-dihydropterin diphosphate bindingBy similarity3

Sequence similaritiesi

In the C-terminal section; belongs to the DHPS family.Curated
In the N-terminal section; belongs to the HPPK family.Curated

Phylogenomic databases

eggNOGiENOG4105EEI Bacteria
COG0294 LUCA
COG0801 LUCA
KOiK13941
OMAiSLWETEP

Family and domain databases

CDDicd00739 DHPS, 1 hit
cd00483 HPPK, 1 hit
Gene3Di3.20.20.20, 1 hit
3.30.70.560, 1 hit
InterProiView protein in InterPro
IPR006390 DHP_synth
IPR011005 Dihydropteroate_synth-like
IPR000550 Hppk
IPR035907 Hppk_sf
IPR000489 Pterin-binding_dom
PfamiView protein in Pfam
PF01288 HPPK, 1 hit
PF00809 Pterin_bind, 1 hit
SUPFAMiSSF51717 SSF51717, 1 hit
SSF55083 SSF55083, 1 hit
TIGRFAMsiTIGR01496 DHPS, 1 hit
TIGR01498 folK, 1 hit
PROSITEiView protein in PROSITE
PS00792 DHPS_1, 1 hit
PS00793 DHPS_2, 1 hit
PS00794 HPPK, 1 hit
PS50972 PTERIN_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

P82602-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTWNFVCLG LGSNLGNRHE YIKRAYESLK KAGIRNLKSS VILETKALLL
60 70 80 90 100
EGSPKEWDLP YFNCVAIGET QLSPDELVKE IKMIENRLSR DSSLKWGPRS
110 120 130 140 150
IDIDVLLYGD ESYSCCSERC IIPHPRLLER PFLLSMMASL CPYRYFRLRG
160 170 180 190 200
SPYDGKTFAE LAAIYPLTEK DVLGSFAPTT QIMGIVNVTD DSISDTGLFL
210 220 230 240 250
EAKRAAAHAE RLFAEGASII DLGAQATNPR VRDLGSVEQE WERLEPVLQI
260 270 280 290 300
LAESWKDAKQ YPDVSIDTFR PEVIRRAIQV FPIRWINDVS GGSLEMAHLA
310 320 330 340 350
KDLGLRLLIN HSCSLPPRPD CVLSYEESPV TQMLRWGESQ LETFAQIGLD
360 370 380 390 400
TSWQVVFDPG IGFGKTPVQS MQLMEGVAKF KHILKCPVLI GHSRKSCLSL
410 420 430 440 450
LGRFSSQDRD WETIGCSVAL HNQGVDYLRV HQVEGNRRVL AAAAWSGMPV
Length:450
Mass (Da):50,448
Last modified:October 1, 2000 - v1
Checksum:i068BE8D2DCEE4A2E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE002160 Genomic DNA Translation: AAF39696.1
PIRiG81652
RefSeqiWP_010231893.1, NZ_ACOV01000004.1

Genome annotation databases

EnsemblBacteriaiAAF39696; AAF39696; TC_0903
GeneIDi1246272
KEGGicmu:TC_0903

Similar proteinsi

Entry informationi

Entry nameiFOLKP_CHLMU
AccessioniPrimary (citable) accession number: P82602
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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