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P82543

- COXA_THET8

UniProt

P82543 - COXA_THET8

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Protein

Cytochrome c oxidase polypeptide 2A

Gene

cbaD

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Hydrogen ion transport, Ion transport, Respiratory chain, Transport

Enzyme and pathway databases

BioCyciTTHE300852:GH8R-1165-MONOMER.

Protein family/group databases

TCDBi3.D.4.2.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase polypeptide 2A (EC:1.9.3.1)
Alternative name(s):
Cytochrome c ba(3) subunit IIA
Cytochrome c oxidase polypeptide IIA
Cytochrome cba3 subunit 2A
Gene namesi
Name:cbaD
Ordered Locus Names:TTHA1133
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000532: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3434Cytochrome c oxidase polypeptide 2APRO_0000183934Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-formylmethionine1 Publication

Keywords - PTMi

Formylation

Interactioni

Protein-protein interaction databases

IntActiP82543. 1 interaction.
STRINGi300852.TTHA1133.

Structurei

Secondary structure

1
34
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 3227

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EHKX-ray2.40C2-34[»]
1XMEX-ray2.30C1-34[»]
2QPDX-ray3.25C1-34[»]
2QPEX-ray2.90C1-34[»]
3BVDX-ray3.37C1-34[»]
3EH3X-ray3.10C2-34[»]
3EH4X-ray2.90C2-34[»]
3EH5X-ray2.80C2-34[»]
3QJQX-ray2.90C1-34[»]
3QJRX-ray3.20C1-34[»]
3QJSX-ray2.80C1-34[»]
3QJTX-ray2.95C1-34[»]
3QJUX-ray2.90C1-34[»]
3QJVX-ray2.80C1-34[»]
3S33X-ray4.45C2-34[»]
3S38X-ray4.20C2-34[»]
3S39X-ray4.80C2-34[»]
3S3AX-ray4.25C2-34[»]
3S3BX-ray3.30C2-34[»]
3S3CX-ray4.00C2-34[»]
3S3DX-ray3.75C2-34[»]
3S8FX-ray1.80C1-34[»]
3S8GX-ray1.80C1-34[»]
4FA7X-ray2.50C1-34[»]
4FAAX-ray2.80C1-34[»]
4G70X-ray2.60C1-34[»]
4G71X-ray2.90C1-34[»]
4G72X-ray3.19C1-34[»]
4G7QX-ray2.60C1-34[»]
4G7RX-ray3.05C1-34[»]
4G7SX-ray2.00C1-34[»]
4GP4X-ray2.80C1-34[»]
4GP5X-ray2.70C1-34[»]
4GP8X-ray2.80C1-34[»]
ProteinModelPortaliP82543.
SMRiP82543. Positions 2-34.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP82543.

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 3431HelicalAdd
BLAST

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG6G20Z3.

Family and domain databases

InterProiIPR012538. Cyt_c_oxidase_su2a.
[Graphical view]
PfamiPF08113. CoxIIa. 1 hit.
[Graphical view]
SUPFAMiSSF81473. SSF81473. 1 hit.

Sequencei

Sequence statusi: Complete.

P82543-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30
MEEKPKGALA VILVLTLTIL VFWLGVYAVF FARG
Length:34
Mass (Da):3,767
Last modified:March 1, 2001 - v2
Checksum:iF473EB7D0B179FBB
GO

Mass spectrometryi

Molecular mass is 3794.6 Da from positions 1 - 34. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008226 Genomic DNA. Translation: BAD70956.1.
RefSeqiYP_144399.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD70956; BAD70956; BAD70956.
GeneIDi3168186.
KEGGittj:TTHA1133.
PATRICi23957225. VBITheThe93045_1112.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP008226 Genomic DNA. Translation: BAD70956.1 .
RefSeqi YP_144399.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1EHK X-ray 2.40 C 2-34 [» ]
1XME X-ray 2.30 C 1-34 [» ]
2QPD X-ray 3.25 C 1-34 [» ]
2QPE X-ray 2.90 C 1-34 [» ]
3BVD X-ray 3.37 C 1-34 [» ]
3EH3 X-ray 3.10 C 2-34 [» ]
3EH4 X-ray 2.90 C 2-34 [» ]
3EH5 X-ray 2.80 C 2-34 [» ]
3QJQ X-ray 2.90 C 1-34 [» ]
3QJR X-ray 3.20 C 1-34 [» ]
3QJS X-ray 2.80 C 1-34 [» ]
3QJT X-ray 2.95 C 1-34 [» ]
3QJU X-ray 2.90 C 1-34 [» ]
3QJV X-ray 2.80 C 1-34 [» ]
3S33 X-ray 4.45 C 2-34 [» ]
3S38 X-ray 4.20 C 2-34 [» ]
3S39 X-ray 4.80 C 2-34 [» ]
3S3A X-ray 4.25 C 2-34 [» ]
3S3B X-ray 3.30 C 2-34 [» ]
3S3C X-ray 4.00 C 2-34 [» ]
3S3D X-ray 3.75 C 2-34 [» ]
3S8F X-ray 1.80 C 1-34 [» ]
3S8G X-ray 1.80 C 1-34 [» ]
4FA7 X-ray 2.50 C 1-34 [» ]
4FAA X-ray 2.80 C 1-34 [» ]
4G70 X-ray 2.60 C 1-34 [» ]
4G71 X-ray 2.90 C 1-34 [» ]
4G72 X-ray 3.19 C 1-34 [» ]
4G7Q X-ray 2.60 C 1-34 [» ]
4G7R X-ray 3.05 C 1-34 [» ]
4G7S X-ray 2.00 C 1-34 [» ]
4GP4 X-ray 2.80 C 1-34 [» ]
4GP5 X-ray 2.70 C 1-34 [» ]
4GP8 X-ray 2.80 C 1-34 [» ]
ProteinModelPortali P82543.
SMRi P82543. Positions 2-34.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P82543. 1 interaction.
STRINGi 300852.TTHA1133.

Protein family/group databases

TCDBi 3.D.4.2.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD70956 ; BAD70956 ; BAD70956 .
GeneIDi 3168186.
KEGGi ttj:TTHA1133.
PATRICi 23957225. VBITheThe93045_1112.

Phylogenomic databases

OrthoDBi EOG6G20Z3.

Enzyme and pathway databases

BioCyci TTHE300852:GH8R-1165-MONOMER.

Miscellaneous databases

EvolutionaryTracei P82543.

Family and domain databases

InterProi IPR012538. Cyt_c_oxidase_su2a.
[Graphical view ]
Pfami PF08113. CoxIIa. 1 hit.
[Graphical view ]
SUPFAMi SSF81473. SSF81473. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure of a novel subunit in ba3-cytochrome oxidase from Thermus thermophilus."
    Soulimane T., Than M.E., Dewor M., Huber R., Buse G.
    Protein Sci. 9:2068-2073(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, FORMYLATION AT MET-1, MASS SPECTROMETRY.
  2. "Complete genome sequence of Thermus thermophilus HB8."
    Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB8 / ATCC 27634 / DSM 579.
  3. "Structure and mechanism of the aberrant ba3-cytochrome c oxidase from Thermus thermophilus."
    Soulimane T., Buse G., Bourenkov G.P., Bartunik H.D., Huber R., Than M.E.
    EMBO J. 19:1766-1776(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).

Entry informationi

Entry nameiCOXA_THET8
AccessioniPrimary (citable) accession number: P82543
Secondary accession number(s): Q5SJ81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3