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P82543

- COXA_THET8

UniProt

P82543 - COXA_THET8

Protein

Cytochrome c oxidase polypeptide 2A

Gene

cbaD

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Hydrogen ion transport, Ion transport, Respiratory chain, Transport

    Enzyme and pathway databases

    BioCyciTTHE300852:GH8R-1165-MONOMER.

    Protein family/group databases

    TCDBi3.D.4.2.1. the proton-translocating cytochrome oxidase (cox) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase polypeptide 2A (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c ba(3) subunit IIA
    Cytochrome c oxidase polypeptide IIA
    Cytochrome cba3 subunit 2A
    Gene namesi
    Name:cbaD
    Ordered Locus Names:TTHA1133
    OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
    Taxonomic identifieri300852 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
    ProteomesiUP000000532: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3434Cytochrome c oxidase polypeptide 2APRO_0000183934Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-formylmethionine1 Publication

    Keywords - PTMi

    Formylation

    Interactioni

    Protein-protein interaction databases

    IntActiP82543. 1 interaction.
    STRINGi300852.TTHA1133.

    Structurei

    Secondary structure

    1
    34
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi6 – 3227

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1EHKX-ray2.40C2-34[»]
    1XMEX-ray2.30C1-34[»]
    2QPDX-ray3.25C1-34[»]
    2QPEX-ray2.90C1-34[»]
    3BVDX-ray3.37C1-34[»]
    3EH3X-ray3.10C2-34[»]
    3EH4X-ray2.90C2-34[»]
    3EH5X-ray2.80C2-34[»]
    3QJQX-ray2.90C1-34[»]
    3QJRX-ray3.20C1-34[»]
    3QJSX-ray2.80C1-34[»]
    3QJTX-ray2.95C1-34[»]
    3QJUX-ray2.90C1-34[»]
    3QJVX-ray2.80C1-34[»]
    3S33X-ray4.45C2-34[»]
    3S38X-ray4.20C2-34[»]
    3S39X-ray4.80C2-34[»]
    3S3AX-ray4.25C2-34[»]
    3S3BX-ray3.30C2-34[»]
    3S3CX-ray4.00C2-34[»]
    3S3DX-ray3.75C2-34[»]
    3S8FX-ray1.80C1-34[»]
    3S8GX-ray1.80C1-34[»]
    4FA7X-ray2.50C1-34[»]
    4FAAX-ray2.80C1-34[»]
    4G70X-ray2.60C1-34[»]
    4G71X-ray2.90C1-34[»]
    4G72X-ray3.19C1-34[»]
    4G7QX-ray2.60C1-34[»]
    4G7RX-ray3.05C1-34[»]
    4G7SX-ray2.00C1-34[»]
    4GP4X-ray2.80C1-34[»]
    4GP5X-ray2.70C1-34[»]
    4GP8X-ray2.80C1-34[»]
    ProteinModelPortaliP82543.
    SMRiP82543. Positions 2-34.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP82543.

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 3431HelicalAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    OrthoDBiEOG6G20Z3.

    Family and domain databases

    InterProiIPR012538. Cyt_c_oxidase_su2a.
    [Graphical view]
    PfamiPF08113. CoxIIa. 1 hit.
    [Graphical view]
    SUPFAMiSSF81473. SSF81473. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P82543-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEKPKGALA VILVLTLTIL VFWLGVYAVF FARG                    34
    Length:34
    Mass (Da):3,767
    Last modified:March 1, 2001 - v2
    Checksum:iF473EB7D0B179FBB
    GO

    Mass spectrometryi

    Molecular mass is 3794.6 Da from positions 1 - 34. Determined by MALDI. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008226 Genomic DNA. Translation: BAD70956.1.
    RefSeqiYP_144399.1. NC_006461.1.

    Genome annotation databases

    EnsemblBacteriaiBAD70956; BAD70956; BAD70956.
    GeneIDi3168186.
    KEGGittj:TTHA1133.
    PATRICi23957225. VBITheThe93045_1112.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP008226 Genomic DNA. Translation: BAD70956.1 .
    RefSeqi YP_144399.1. NC_006461.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1EHK X-ray 2.40 C 2-34 [» ]
    1XME X-ray 2.30 C 1-34 [» ]
    2QPD X-ray 3.25 C 1-34 [» ]
    2QPE X-ray 2.90 C 1-34 [» ]
    3BVD X-ray 3.37 C 1-34 [» ]
    3EH3 X-ray 3.10 C 2-34 [» ]
    3EH4 X-ray 2.90 C 2-34 [» ]
    3EH5 X-ray 2.80 C 2-34 [» ]
    3QJQ X-ray 2.90 C 1-34 [» ]
    3QJR X-ray 3.20 C 1-34 [» ]
    3QJS X-ray 2.80 C 1-34 [» ]
    3QJT X-ray 2.95 C 1-34 [» ]
    3QJU X-ray 2.90 C 1-34 [» ]
    3QJV X-ray 2.80 C 1-34 [» ]
    3S33 X-ray 4.45 C 2-34 [» ]
    3S38 X-ray 4.20 C 2-34 [» ]
    3S39 X-ray 4.80 C 2-34 [» ]
    3S3A X-ray 4.25 C 2-34 [» ]
    3S3B X-ray 3.30 C 2-34 [» ]
    3S3C X-ray 4.00 C 2-34 [» ]
    3S3D X-ray 3.75 C 2-34 [» ]
    3S8F X-ray 1.80 C 1-34 [» ]
    3S8G X-ray 1.80 C 1-34 [» ]
    4FA7 X-ray 2.50 C 1-34 [» ]
    4FAA X-ray 2.80 C 1-34 [» ]
    4G70 X-ray 2.60 C 1-34 [» ]
    4G71 X-ray 2.90 C 1-34 [» ]
    4G72 X-ray 3.19 C 1-34 [» ]
    4G7Q X-ray 2.60 C 1-34 [» ]
    4G7R X-ray 3.05 C 1-34 [» ]
    4G7S X-ray 2.00 C 1-34 [» ]
    4GP4 X-ray 2.80 C 1-34 [» ]
    4GP5 X-ray 2.70 C 1-34 [» ]
    4GP8 X-ray 2.80 C 1-34 [» ]
    ProteinModelPortali P82543.
    SMRi P82543. Positions 2-34.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P82543. 1 interaction.
    STRINGi 300852.TTHA1133.

    Protein family/group databases

    TCDBi 3.D.4.2.1. the proton-translocating cytochrome oxidase (cox) superfamily.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD70956 ; BAD70956 ; BAD70956 .
    GeneIDi 3168186.
    KEGGi ttj:TTHA1133.
    PATRICi 23957225. VBITheThe93045_1112.

    Phylogenomic databases

    OrthoDBi EOG6G20Z3.

    Enzyme and pathway databases

    BioCyci TTHE300852:GH8R-1165-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P82543.

    Family and domain databases

    InterProi IPR012538. Cyt_c_oxidase_su2a.
    [Graphical view ]
    Pfami PF08113. CoxIIa. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81473. SSF81473. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure of a novel subunit in ba3-cytochrome oxidase from Thermus thermophilus."
      Soulimane T., Than M.E., Dewor M., Huber R., Buse G.
      Protein Sci. 9:2068-2073(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, FORMYLATION AT MET-1, MASS SPECTROMETRY.
    2. "Complete genome sequence of Thermus thermophilus HB8."
      Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HB8 / ATCC 27634 / DSM 579.
    3. "Structure and mechanism of the aberrant ba3-cytochrome c oxidase from Thermus thermophilus."
      Soulimane T., Buse G., Bourenkov G.P., Bartunik H.D., Huber R., Than M.E.
      EMBO J. 19:1766-1776(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).

    Entry informationi

    Entry nameiCOXA_THET8
    AccessioniPrimary (citable) accession number: P82543
    Secondary accession number(s): Q5SJ81
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 4, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references

    External Data

    Dasty 3