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P82543 (COXA_THET8) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase polypeptide 2A

EC=1.9.3.1
Alternative name(s):
Cytochrome c ba(3) subunit IIA
Cytochrome c oxidase polypeptide IIA
Cytochrome cba3 subunit 2A
Gene names
Name:cbaD
Ordered Locus Names:TTHA1133
OrganismThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) [Reference proteome] [HAMAP]
Taxonomic identifier300852 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Protein attributes

Sequence length34 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subcellular location

Cell membrane; Single-pass membrane protein.

Mass spectrometry

Molecular mass is 3794.6 Da from positions 1 - 34. Determined by MALDI. Ref.1

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3434Cytochrome c oxidase polypeptide 2A
PRO_0000183934

Regions

Transmembrane4 – 3431Helical

Amino acid modifications

Modified residue11N-formylmethionine

Secondary structure

... 34
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P82543 [UniParc].

Last modified March 1, 2001. Version 2.
Checksum: F473EB7D0B179FBB

FASTA343,767
        10         20         30 
MEEKPKGALA VILVLTLTIL VFWLGVYAVF FARG 

« Hide

References

« Hide 'large scale' references
[1]"Primary structure of a novel subunit in ba3-cytochrome oxidase from Thermus thermophilus."
Soulimane T., Than M.E., Dewor M., Huber R., Buse G.
Protein Sci. 9:2068-2073(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, FORMYLATION AT MET-1, MASS SPECTROMETRY.
[2]"Complete genome sequence of Thermus thermophilus HB8."
Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HB8 / ATCC 27634 / DSM 579.
[3]"Structure and mechanism of the aberrant ba3-cytochrome c oxidase from Thermus thermophilus."
Soulimane T., Buse G., Bourenkov G.P., Bartunik H.D., Huber R., Than M.E.
EMBO J. 19:1766-1776(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP008226 Genomic DNA. Translation: BAD70956.1.
RefSeqYP_144399.1. NC_006461.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1EHKX-ray2.40C2-34[»]
1XMEX-ray2.30C1-34[»]
2QPDX-ray3.25C1-34[»]
2QPEX-ray2.90C1-34[»]
3BVDX-ray3.37C1-34[»]
3EH3X-ray3.10C2-34[»]
3EH4X-ray2.90C2-34[»]
3EH5X-ray2.80C2-34[»]
3QJQX-ray2.90C1-34[»]
3QJRX-ray3.20C1-34[»]
3QJSX-ray2.80C1-34[»]
3QJTX-ray2.95C1-34[»]
3QJUX-ray2.90C1-34[»]
3QJVX-ray2.80C1-34[»]
3S33X-ray4.45C2-34[»]
3S38X-ray4.20C2-34[»]
3S39X-ray4.80C2-34[»]
3S3AX-ray4.25C2-34[»]
3S3BX-ray3.30C2-34[»]
3S3CX-ray4.00C2-34[»]
3S3DX-ray3.75C2-34[»]
3S8FX-ray1.80C1-34[»]
3S8GX-ray1.80C1-34[»]
4FA7X-ray2.50C1-34[»]
4FAAX-ray2.80C1-34[»]
4G70X-ray2.60C1-34[»]
4G71X-ray2.90C1-34[»]
4G72X-ray3.19C1-34[»]
4G7QX-ray2.60C1-34[»]
4G7RX-ray3.05C1-34[»]
4G7SX-ray2.00C1-34[»]
4GP4X-ray2.80C1-34[»]
4GP5X-ray2.70C1-34[»]
4GP8X-ray2.80C1-34[»]
ProteinModelPortalP82543.
SMRP82543. Positions 2-34.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP82543. 1 interaction.
STRING300852.TTHA1133.

Protein family/group databases

TCDB3.D.4.2.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD70956; BAD70956; BAD70956.
GeneID3168186.
KEGGttj:TTHA1133.
PATRIC23957225. VBITheThe93045_1112.

Phylogenomic databases

OrthoDBEOG6G20Z3.

Enzyme and pathway databases

BioCycTTHE300852:GH8R-1165-MONOMER.

Family and domain databases

InterProIPR012538. Cyt_c_oxidase_su2a.
[Graphical view]
PfamPF08113. CoxIIa. 1 hit.
[Graphical view]
SUPFAMSSF81473. SSF81473. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP82543.

Entry information

Entry nameCOXA_THET8
AccessionPrimary (citable) accession number: P82543
Secondary accession number(s): Q5SJ81
Entry history
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references