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P82476 (CDA_CRYNV) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length410 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Hydrolyzes the N-acetamido groups of N-acetyl-D-glucosamine residues in chitin.

Catalytic activity

Chitin + H2O = chitosan + acetate.

Sequence similarities

Belongs to the polysaccharide deacetylase family.

Caution

The protein characterized in Ref.2 is not a chitin deacetylase, the peptides sequenced being copurified contaminants of the protein under study.

Ontologies

Keywords
   Biological processLipid degradation
   DomainSignal
   Molecular functionHydrolase
   PTMCleavage on pair of basic residues
Glycoprotein
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological processcarbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

lipid catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionchitin deacetylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Propeptide19 – 3921
PRO_0000024830
Chain40 – 410371Chitin deacetylase
PRO_0000024831

Amino acid modifications

Glycosylation611N-linked (GlcNAc...) Potential
Glycosylation1491N-linked (GlcNAc...) Potential
Glycosylation2791N-linked (GlcNAc...) Potential
Glycosylation2931N-linked (GlcNAc...) Potential
Glycosylation3521N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict54 – 574PGPG → SSPP AA sequence Ref.2
Sequence conflict911P → R AA sequence Ref.2
Sequence conflict3101G → K AA sequence Ref.2

Sequences

Sequence LengthMass (Da)Tools
P82476 [UniParc].

Last modified June 21, 2005. Version 2.
Checksum: 112FD9CC1647C1D5

FASTA41043,974
        10         20         30         40         50         60 
MYGHLSLSAL SLFAVVAAAP FRESWLQPRD SPVSQLFRRT APDPNSNDYM SYYPGPGSTP 

        70         80         90        100        110        120 
NVSTIPQAWL DKLATVNLPN VPVATPDGGR PTYPNNEDDG DSTICSFTDQ CRVEDDLYSP 

       130        140        150        160        170        180 
PGEKIWALSF DDGPTDVSPA LYDYLAQNNI SSSATHFMIG GNVITSPQSV LVAVKAGGHL 

       190        200        210        220        230        240 
AVHTWSHPYM TTLTNEQVVG ELGWTMQALS DLNGGRIPMY WRPPYGDVDN RVRAIAKEVF 

       250        260        270        280        290        300 
GLVTVLWDSD TNDWAITDEP GQYSVASVEA YFDTLVTGNR TQGLLLLEHE LDNNTVEVFE 

       310        320        330        340        350        360 
TEYPKAVGNG WTVKNVADAF NMEWYLNSGK GNNDVVTTMS VAGTLTTATP TNTSTYVASS 

       370        380        390        400        410 
TAASSASVTD SAGVSIASAA SSEASSSWAI ANRPSHFVIA CGLALAAIMV

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of Cryptococcus neoformans serotype A."
Birren B.W., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-Zahra M., Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.M., Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T., Blitshteyn B. expand/collapse author list , Bloom T., Boguslavkiy L., Borowsky M., Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S.E., Camarata J., Campo K., Chang J., Choepel Y., Collymore A., Cook A., Cooke P., Corum B., DeArellano K., Diaz J.S., Dodge S., Dooley K., Dorris L., Elkins T., Engels R., Erickson J., Faro S., Ferreira P., FitzGerald M., Gage D., Galagan J.E., Gardyna S., Gnerre S., Graham L., Grand-Pierre N., Hafez N., Hagopian D., Hagos B., Hall J., Horton L., Hulme W., Iliev I., Jaffe D., Johnson R., Jones C., Kamal M., Kamat A., Karatas A., Kells C., Landers T., Levine R., Lindblad-Toh K., Liu G., Lui A., Ma L.-J., Mabbitt R., MacLean C., Macdonald P., Major J., Manning J., Matthews C., Mauceli E., McCarthy M., Meldrim J., Meneus L., Mihova T., Mlenga V., Murphy T., Naylor J., Nguyen C., Nicol R., Nielsen C.B., Norbu C., O'Connor T., O'Donnell P., O'Neil D., Oliver J., Peterson K., Phunkhang P., Pierre N., Purcell S., Rachupka A., Ramasamy U., Raymond C., Retta R., Rise C., Rogov P., Roman J., Schauer S., Schupback R., Seaman S., Severy P., Smirnov S., Smith C., Spencer B., Stange-Thomann N., Stojanovic N., Stubbs M., Talamas J., Tesfaye S., Theodore J., Topham K., Travers M., Vassiliev H., Venkataraman V.S., Viel R., Vo A., Wang S., Wilson B., Wu X., Wyman D., Young G., Zainoun J., Zembek L., Zimmer A., Zody M., Lander E.S.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: H99.
[2]"Purification and characterization of secretory phospholipase B, lysophospholipase and lysophospholipase/transacylase from a virulent strain of the pathogenic fungus Cryptococcus neoformans."
Chen S.C.A., Wright L.C., Golding J.C., Sorrell T.C.
Biochem. J. 347:431-439(2000) [PubMed: 10749672] [Abstract]
Cited for: PROTEIN SEQUENCE OF 40-58; 73-91; 305-310 AND 315-330.
Strain: BL-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AACO02000025 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalP82476.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR002509. Polysac_deacetylase.
[Graphical view]
Gene3DG3DSA:3.20.20.370. Polysac_deacetylase. 1 hit.
PfamPF01522. Polysacc_deac_1. 1 hit.
[Graphical view]
SUPFAMSSF88713. Glyco_hydro/deAcase_b/a-brl. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCDA_CRYNV
AccessionPrimary (citable) accession number: P82476
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 21, 2005
Last modified: September 21, 2011
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents