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Protein

Zingipain-2

Gene
N/A
Organism
Zingiber officinale (Ginger) (Amomum zingiber)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Preferential cleavage of peptides with a proline residue at the P2 position.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei27By similarity1
Active sitei161By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Enzyme and pathway databases

BRENDAi3.4.22.67. 6754.

Protein family/group databases

MEROPSiC01.017.

Names & Taxonomyi

Protein namesi
Recommended name:
Zingipain-2 (EC:3.4.22.67)
Alternative name(s):
Cysteine proteinase GP-II
OrganismiZingiber officinale (Ginger) (Amomum zingiber)
Taxonomic identifieri94328 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaZingiberalesZingiberaceaeZingiber

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000505691 – 221Zingipain-2Add BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 651 Publication
Disulfide bondi58 ↔ 981 Publication
GlycosylationiCAR_00019099N-linked (GlcNAc...)1 Publication1
Disulfide bondi155 ↔ 2061 Publication
GlycosylationiCAR_000200156N-linked (GlcNAc...)1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

PTM databases

UniCarbKBiP82474.

Structurei

Secondary structure

1221
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni9 – 13Combined sources5
Helixi27 – 44Combined sources18
Helixi52 – 58Combined sources7
Helixi70 – 80Combined sources11
Turni86 – 88Combined sources3
Beta strandi100 – 102Combined sources3
Beta strandi110 – 114Combined sources5
Helixi120 – 127Combined sources8
Beta strandi132 – 136Combined sources5
Helixi141 – 144Combined sources4
Beta strandi148 – 151Combined sources4
Beta strandi161 – 171Combined sources11
Beta strandi174 – 180Combined sources7
Beta strandi192 – 196Combined sources5
Helixi205 – 207Combined sources3
Beta strandi213 – 216Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CQDX-ray2.10A/B/C/D1-221[»]
ProteinModelPortaliP82474.
SMRiP82474.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP82474.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P82474-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
DDLPDSIDWR ENGAVVPVKN QGGCGSCWAF STVAAVEGIN QIVTGDLISL
60 70 80 90 100
SEQQLVDCTT ANHGCRGGWM NPAFQFIVNN GGINSEETYP YRGQDGICNS
110 120 130 140 150
TVNAPVVSID SYENVPSHNE QSLQKAVANQ PVSVTMDAAG RDFQLYRSGI
160 170 180 190 200
FTGSCNISAN HALTVVGYGT ENDKDFWIVK NSWGKNWGES GYIRAERNIE
210 220
NPDGKCGITR FASYPVKKGT N
Length:221
Mass (Da):23,922
Last modified:May 30, 2000 - v1
Checksum:i909A312BD8632D42
GO

Sequence databases

PIRiA59041.

Cross-referencesi

Sequence databases

PIRiA59041.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CQDX-ray2.10A/B/C/D1-221[»]
ProteinModelPortaliP82474.
SMRiP82474.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiC01.017.

PTM databases

UniCarbKBiP82474.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi3.4.22.67. 6754.

Miscellaneous databases

EvolutionaryTraceiP82474.

Family and domain databases

InterProiIPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCPGP2_ZINOF
AccessioniPrimary (citable) accession number: P82474
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 2, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.