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Protein

Disintegrin EC6 subunit beta

Gene
N/A
Organism
Echis carinatus sochureki (Saw-scaled viper)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Potently inhibits adhesion of alpha-4/beta-1 (ITGA4/ITGB1) and alpha-9/beta-1 (ITGA9/ITGB1) integrins to VCAM1, and adhesion of alpha-5/beta-1 (ITGA5/ITGB1) integrin to fibronectin. Has a much less effect on alpha-IIb/beta-3 (ITGA2B/ITGB3) integrin. Also potently inhibits neutrophil migration across TNF-alpha-activated human umbilical endothelial cells.1 Publication

Miscellaneous

The disintegrin belongs to the dimeric disintegrin subfamily.

GO - Molecular functioni

Keywordsi

Molecular functionCell adhesion impairing toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin EC6 subunit beta
Short name:
EC6B
OrganismiEchis carinatus sochureki (Saw-scaled viper)
Taxonomic identifieri124223 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeViperinaeEchis

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001018021 – 69Disintegrin EC6 subunit betaAdd BLAST69

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi6 ↔ 29PROSITE-ProRule annotation
Disulfide bondi7Interchain (with C-59 in subunit alpha)PROSITE-ProRule annotation
Disulfide bondi12Interchain (with C-54 in subunit alpha)PROSITE-ProRule annotation
Disulfide bondi20 ↔ 26PROSITE-ProRule annotation
Disulfide bondi25 ↔ 50PROSITE-ProRule annotation
Disulfide bondi38 ↔ 57PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Heterodimer with subunit alpha; disulfide-linked.

Structurei

3D structure databases

ProteinModelPortaliP82466.
SMRiP82466.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 65DisintegrinPROSITE-ProRule annotationAdd BLAST65

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 44Cell attachment site3

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG005487.

Family and domain databases

Gene3Di4.10.70.10. 1 hit.
InterProiView protein in InterPro
IPR018358. Disintegrin_CS.
IPR001762. Disintegrin_dom.
IPR036436. Disintegrin_dom_sf.
PfamiView protein in Pfam
PF00200. Disintegrin. 1 hit.
PRINTSiPR00289. DISINTEGRIN.
SMARTiView protein in SMART
SM00050. DISIN. 1 hit.
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiView protein in PROSITE
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P82466-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
NSVHPCCDPV TCKPKRGKHC ASGPCCENCY IVGVGTVCNP ARGDWNDDNC
60
TGVSSDCPPN PWNGKPSDN
Length:69
Mass (Da):7,279
Last modified:June 1, 2000 - v1
Checksum:i6916F2CA0821E1E8
GO

Entry informationi

Entry nameiVM26B_ECHCS
AccessioniPrimary (citable) accession number: P82466
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2000
Last modified: November 22, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families