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Protein

ATP-binding cassette sub-family C member 9

Gene

ABCC9

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi705 – 7128ATP 1PROSITE-ProRule annotation
Nucleotide bindingi1346 – 13538ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family C member 9
Alternative name(s):
Sulfonylurea receptor 2
Gene namesi
Name:ABCC9
Synonyms:SUR2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

  • Membrane PROSITE-ProRule annotation; Multi-pass membrane protein PROSITE-ProRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030ExtracellularSequence analysisAdd
BLAST
Transmembranei31 – 5121Helical; Name=1PROSITE-ProRule annotationAdd
BLAST
Topological domaini52 – 7221CytoplasmicSequence analysisAdd
BLAST
Transmembranei73 – 9321Helical; Name=2PROSITE-ProRule annotationAdd
BLAST
Topological domaini94 – 1018ExtracellularSequence analysis
Transmembranei102 – 12221Helical; Name=3PROSITE-ProRule annotationAdd
BLAST
Topological domaini123 – 13210CytoplasmicSequence analysis
Transmembranei133 – 15321Helical; Name=4PROSITE-ProRule annotationAdd
BLAST
Topological domaini154 – 16714ExtracellularSequence analysisAdd
BLAST
Transmembranei168 – 18821Helical; Name=5PROSITE-ProRule annotationAdd
BLAST
Topological domaini189 – 301113CytoplasmicSequence analysisAdd
BLAST
Transmembranei302 – 32221Helical; Name=6PROSITE-ProRule annotationAdd
BLAST
Topological domaini323 – 35028ExtracellularSequence analysisAdd
BLAST
Transmembranei351 – 37121Helical; Name=7PROSITE-ProRule annotationAdd
BLAST
Topological domaini372 – 42352CytoplasmicSequence analysisAdd
BLAST
Transmembranei424 – 44421Helical; Name=8PROSITE-ProRule annotationAdd
BLAST
Topological domaini445 – 45511ExtracellularSequence analysisAdd
BLAST
Transmembranei456 – 47621Helical; Name=9PROSITE-ProRule annotationAdd
BLAST
Topological domaini477 – 53155CytoplasmicSequence analysisAdd
BLAST
Transmembranei532 – 55221Helical; Name=10PROSITE-ProRule annotationAdd
BLAST
Topological domaini553 – 57119ExtracellularSequence analysisAdd
BLAST
Transmembranei572 – 59221Helical; Name=11PROSITE-ProRule annotationAdd
BLAST
Topological domaini593 – 990398CytoplasmicSequence analysisAdd
BLAST
Transmembranei991 – 101121Helical; Name=12PROSITE-ProRule annotationAdd
BLAST
Topological domaini1012 – 103423ExtracellularSequence analysisAdd
BLAST
Transmembranei1035 – 105521Helical; Name=13PROSITE-ProRule annotationAdd
BLAST
Topological domaini1056 – 112772CytoplasmicSequence analysisAdd
BLAST
Transmembranei1128 – 114821Helical; Name=14PROSITE-ProRule annotationAdd
BLAST
Topological domaini1149 – 124597ExtracellularSequence analysisAdd
BLAST
Transmembranei1246 – 126621Helical; Name=15PROSITE-ProRule annotationAdd
BLAST
Topological domaini1267 – 1549283CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15491549ATP-binding cassette sub-family C member 9PRO_0000093404Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi9 – 91N-linked (GlcNAc...)Sequence analysis
Glycosylationi326 – 3261N-linked (GlcNAc...)Sequence analysis
Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence analysis
Glycosylationi333 – 3331N-linked (GlcNAc...)Sequence analysis
Glycosylationi334 – 3341N-linked (GlcNAc...)Sequence analysis
Glycosylationi1025 – 10251N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Interacts with KCNJ11.

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000024233.

Structurei

3D structure databases

ProteinModelPortaliP82451.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini297 – 597301ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini665 – 912248ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini994 – 1274281ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini1312 – 1546235ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
HOVERGENiHBG101342.
InParanoidiP82451.
KOiK05033.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001475. ABCC9.
IPR027417. P-loop_NTPase.
IPR000388. Sulphorea_rcpt.
[Graphical view]
PANTHERiPTHR24223:SF173. PTHR24223:SF173. 4 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
PRINTSiPR01094. SULFNYLUR2.
PR01092. SULFNYLUREAR.
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P82451-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSFCGNNI SSYNIYDGVL QNPCFVDALN LVPHVFLLFI TFPILFIGWG
60 70 80 90 100
SQSSKVQIHH NTWLHFPGHN LRWILTFALL FVHVCEIAEG IVSDSRRESR
110 120 130 140 150
HLHLFMPAVM GFVATTTSIV YYHNIETSNF PKLLLALFLY WVMAFITKTI
160 170 180 190 200
KLVKYWQSGW GVSDLRFCIT GIMVILNGLL MAVEINVIRI RRYVFFMNPQ
210 220 230 240 250
KVKPPEDLQD LGVRFLQPFV NLLSKATYWW MNTLIISAHK KPIDLKAIGK
260 270 280 290 300
LPIAMRAVTN YVCLKDAYEE QKKKAADHPN RTPSIWLAMY RAFGRPILLS
310 320 330 340 350
STFRYLADLL GFAGPLCISG IVQRVNETQN GTNNTTGISE ILSSKEFLEN
360 370 380 390 400
AYVLAVLLFL ALILQRTFLQ ASYYVTIETG INLRGALLAM IYNKILRLST
410 420 430 440 450
SNLSMGEMTL GQINNLVAIE TNQLMWFLFL CPNLWAMPVQ IIMGVILLYN
460 470 480 490 500
LLGSSALVGA AVIVLLAPMQ YFIATKLAEA QKSTLDYSTE RLKKTNEILK
510 520 530 540 550
GIKLLKLYAW EHIFCKSVEE TRVKELSSLK AFALYTSLSI FMNAAIPIAA
560 570 580 590 600
VLATFVTHAY ASGNNLQPAE AFASLSLFHI LVTPLFLLST VVRFAVKAII
610 620 630 640 650
SVQKLNEFLL SDEIGDDSWR TGEASLPFES CKKHTGVQPK TINRKQPGRY
660 670 680 690 700
HLDSYEQSTR RLRPMETEDI AIKVTNGCFS WGSGAATLSN IDIRIPTGQL
710 720 730 740 750
TMIVGQVGCG KSSLLLAILG EMQTLDGKVH WSNVNESEPS FEATRSRNRY
760 770 780 790 800
SVAYAAQKPW LLNATVEENI TFGSPFNKQR YKAVTDACSL QPDIDLLPFG
810 820 830 840 850
DQTEIGERGI NLSGGQTERI CVARALYQNT NIVFLDDPFS ALDIHLSDHL
860 870 880 890 900
MQEGILKFLQ DDKRTLVLVT HKLQYLTHAD WIIAMKDGSV LREGTLKDIQ
910 920 930 940 950
TKDVELYEHW KTLMNRQDQE LEKDMEADQT TLERKTLRRA MYSREAKAQM
960 970 980 990 1000
EDEDEEEEEE EDEDDNMSTV MRLRTKMPWK TCWRYLTSGG FFLLFLMIFS
1010 1020 1030 1040 1050
KLLKHSVIVA IDYWLATWTS EYSINNTGKA DQTYYVAGFS ILCGAGIFLC
1060 1070 1080 1090 1100
LVTSLTVEWM GLTAAKNLHH NLLNKIILGP IRFFDTTPLG LILNRFSADT
1110 1120 1130 1140 1150
NIIDQHIPPT LESLTRSTLL CLSAIGMISY ATPVFLVALV PLGVAFYFIQ
1160 1170 1180 1190 1200
KYFRVASKDL QELDDSTQLP LLCHFSETAE GLTTIRAFRH EARFKQRMLE
1210 1220 1230 1240 1250
LTDTNNIAYL FLSAANRWLE VRTDYLGACI VLTASIASIS GSSNSGLVGL
1260 1270 1280 1290 1300
GLLYALTITN YLNWVVRNLA DLEVQMGAVK KVNSFLTMES ENYEGTMDPS
1310 1320 1330 1340 1350
QVPEHWPQEG EIKIHDLCVR YENNLKPVLK HVKAYIKPGQ KVGICGRTGS
1360 1370 1380 1390 1400
GKSSLSLAFF RMVDIFDGKI VIDGIDISKL PLHTLRSRLS IILQDPILFS
1410 1420 1430 1440 1450
GSIRFNLDPE CKCTDDRLWE ALEIAQLKNM VKSLSGGLDA VVTEGGENFS
1460 1470 1480 1490 1500
VGQRQLFCLA RAFVRKSSIL IMDEATASID MATENILQKV VMTAFADRTV
1510 1520 1530 1540
VTIAHRVSSI VDADLVLVFS EGILVECDTG PNLLTHKNGL FSTLVMTNK
Length:1,549
Mass (Da):174,171
Last modified:June 1, 2000 - v1
Checksum:iD00DF9ACEEEC0075
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087468 mRNA. Translation: AAD52090.1.
AF417510 mRNA. Translation: AAL07505.1.
RefSeqiNP_001075513.1. NM_001082044.1.
UniGeneiOcu.2375.

Genome annotation databases

GeneIDi100008700.
KEGGiocu:100008700.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087468 mRNA. Translation: AAD52090.1.
AF417510 mRNA. Translation: AAL07505.1.
RefSeqiNP_001075513.1. NM_001082044.1.
UniGeneiOcu.2375.

3D structure databases

ProteinModelPortaliP82451.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000024233.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100008700.
KEGGiocu:100008700.

Organism-specific databases

CTDi10060.

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
HOVERGENiHBG101342.
InParanoidiP82451.
KOiK05033.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001475. ABCC9.
IPR027417. P-loop_NTPase.
IPR000388. Sulphorea_rcpt.
[Graphical view]
PANTHERiPTHR24223:SF173. PTHR24223:SF173. 4 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
PRINTSiPR01094. SULFNYLUR2.
PR01092. SULFNYLUREAR.
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiABCC9_RABIT
AccessioniPrimary (citable) accession number: P82451
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2000
Last modified: November 11, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.