SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P82387

- AUR12_LITRA

UniProt

P82387 - AUR12_LITRA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Aurein-1.2
Gene
N/A
Organism
Litoria raniformis (Southern bell frog)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Antimicrobial activity against B.cereus, L.lactis, L.innocua, M.luteus, P.multocida, S.aureus, S.epidermidis and S.uberis. Probably acts by disturbing membrane functions with its amphipathic structure. Shows anticancer activity.1 Publication

GO - Biological processi

  1. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Amphibian defense peptide, Antibiotic, Antimicrobial

Names & Taxonomyi

Protein namesi
Recommended name:
Aurein-1.2
OrganismiLitoria raniformis (Southern bell frog)
Taxonomic identifieri116057 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaHyloideaHylidaePelodryadinaeLitoria

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 1313Aurein-1.2
PRO_0000043719Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei13 – 131Phenylalanine amide1 Publication

Keywords - PTMi

Amidation

Expressioni

Tissue specificityi

Expressed by the skin dorsal glands.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 1210

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VM5NMR-A1-13[»]

Miscellaneous databases

EvolutionaryTraceiP82387.

Family & Domainsi

Family and domain databases

InterProiIPR013157. Aurein_antimicrobial_peptide.
[Graphical view]
PfamiPF08256. Antimicrobial20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P82387-1 [UniParc]FASTAAdd to Basket

« Hide

GLFDIIKKIA ESF                                           13
Length:13
Mass (Da):1,481
Last modified:May 1, 2000 - v1
Checksum:i1EACB99DFBC83330
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1VM5 NMR - A 1-13 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P82387.

Family and domain databases

InterProi IPR013157. Aurein_antimicrobial_peptide.
[Graphical view ]
Pfami PF08256. Antimicrobial20. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The antibiotic and anticancer active aurein peptides from the australian bell frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2."
    Rozek T., Wegener K.L., Bowie J.H., Olver I.N., Carver J.A., Wallace J.C., Tyler M.J.
    Eur. J. Biochem. 267:5330-5341(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, AMIDATION AT PHE-13, FUNCTION, STRUCTURE BY NMR.
    Tissue: Skin secretion.

Entry informationi

Entry nameiAUR12_LITRA
AccessioniPrimary (citable) accession number: P82387
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 1, 2000
Last modified: October 16, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3

Similar proteinsi