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P82387

- AUR12_LITRA

UniProt

P82387 - AUR12_LITRA

Protein

Aurein-1.2

Gene
N/A
Organism
Litoria raniformis (Southern bell frog)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Antimicrobial activity against B.cereus, L.lactis, L.innocua, M.luteus, P.multocida, S.aureus, S.epidermidis and S.uberis. Probably acts by disturbing membrane functions with its amphipathic structure. Shows anticancer activity.1 Publication

    GO - Biological processi

    1. defense response to bacterium Source: UniProtKB-KW

    Keywords - Molecular functioni

    Amphibian defense peptide, Antibiotic, Antimicrobial

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aurein-1.2
    OrganismiLitoria raniformis (Southern bell frog)
    Taxonomic identifieri116057 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaHyloideaHylidaePelodryadinaeLitoria

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Peptidei1 – 1313Aurein-1.2PRO_0000043719Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei13 – 131Phenylalanine amide1 Publication

    Keywords - PTMi

    Amidation

    Expressioni

    Tissue specificityi

    Expressed by the skin dorsal glands.

    Structurei

    Secondary structure

    1
    13
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi3 – 1210

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1VM5NMR-A1-13[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP82387.

    Family & Domainsi

    Family and domain databases

    InterProiIPR013157. Aurein_antimicrobial_peptide.
    [Graphical view]
    PfamiPF08256. Antimicrobial20. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P82387-1 [UniParc]FASTAAdd to Basket

    « Hide

    GLFDIIKKIA ESF                                           13
    Length:13
    Mass (Da):1,481
    Last modified:May 1, 2000 - v1
    Checksum:i1EACB99DFBC83330
    GO

    Cross-referencesi

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1VM5 NMR - A 1-13 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P82387.

    Family and domain databases

    InterProi IPR013157. Aurein_antimicrobial_peptide.
    [Graphical view ]
    Pfami PF08256. Antimicrobial20. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The antibiotic and anticancer active aurein peptides from the australian bell frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2."
      Rozek T., Wegener K.L., Bowie J.H., Olver I.N., Carver J.A., Wallace J.C., Tyler M.J.
      Eur. J. Biochem. 267:5330-5341(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, AMIDATION AT PHE-13, FUNCTION, STRUCTURE BY NMR.
      Tissue: Skin secretion.

    Entry informationi

    Entry nameiAUR12_LITRA
    AccessioniPrimary (citable) accession number: P82387
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references

    External Data

    Dasty 3