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Protein

Aurein-1.2

Gene
N/A
Organism
Litoria raniformis (Southern bell frog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Antimicrobial activity against B.cereus, L.lactis, L.innocua, M.luteus, P.multocida, S.aureus, S.epidermidis and S.uberis. Probably acts by disturbing membrane functions with its amphipathic structure. Shows anticancer activity.1 Publication

GO - Biological processi

  1. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Amphibian defense peptide, Antibiotic, Antimicrobial

Names & Taxonomyi

Protein namesi
Recommended name:
Aurein-1.2
OrganismiLitoria raniformis (Southern bell frog)
Taxonomic identifieri116057 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaHyloideaHylidaePelodryadinaeLitoria

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 1313Aurein-1.2PRO_0000043719Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei13 – 131Phenylalanine amide1 Publication

Keywords - PTMi

Amidation

Expressioni

Tissue specificityi

Expressed by the skin dorsal glands.

Structurei

Secondary structure

1
13
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 1210Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VM5NMR-A1-13[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP82387.

Family & Domainsi

Family and domain databases

InterProiIPR013157. Aurein_antimicrobial_peptide.
[Graphical view]
PfamiPF08256. Antimicrobial20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P82387-1 [UniParc]FASTAAdd to Basket

« Hide

        10 
GLFDIIKKIA ESF
Length:13
Mass (Da):1,481
Last modified:May 1, 2000 - v1
Checksum:i1EACB99DFBC83330
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VM5NMR-A1-13[»]
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP82387.

Family and domain databases

InterProiIPR013157. Aurein_antimicrobial_peptide.
[Graphical view]
PfamiPF08256. Antimicrobial20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The antibiotic and anticancer active aurein peptides from the australian bell frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2."
    Rozek T., Wegener K.L., Bowie J.H., Olver I.N., Carver J.A., Wallace J.C., Tyler M.J.
    Eur. J. Biochem. 267:5330-5341(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, AMIDATION AT PHE-13, FUNCTION, STRUCTURE BY NMR.
    Tissue: Skin secretion.

Entry informationi

Entry nameiAUR12_LITRA
AccessioniPrimary (citable) accession number: P82387
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 1, 2000
Last modified: January 7, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.