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P82385 (SOR_PYRFU) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Superoxide reductase

Short name=SOR
EC=1.15.1.2
Gene names
Name:sorA
Ordered Locus Names:PF1281
OrganismPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) [Reference proteome] [HAMAP]
Taxonomic identifier186497 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus

Protein attributes

Sequence length124 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Uses electrons from reduced NADP, by way of rubredoxin and an oxidoreductase, to catalyze the reduction of superoxide to hydrogen peroxide.

Catalytic activity

Reduced rubredoxin + superoxide + 2 H+ = rubredoxin + H2O2.

Cofactor

Iron.

Subunit structure

Homotetramer.

Sequence similarities

Belongs to the desulfoferrodoxin family.

Ontologies

Keywords
   Biological processElectron transport
Transport
   LigandIron
Metal-binding
   Molecular functionOxidoreductase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functioniron ion binding

Inferred from electronic annotation. Source: InterPro

superoxide reductase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 124124Superoxide reductase
PRO_0000140873

Sites

Metal binding141Iron
Metal binding161Iron
Metal binding411Iron
Metal binding471Iron
Metal binding1111Iron
Metal binding1141Iron

Secondary structure

....................... 124
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P82385 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: EDD92C7E501C8048

FASTA12414,324
        10         20         30         40         50         60 
MISETIRSGD WKGEKHVPVI EYEREGELVK VKVQVGKEIP HPNTTEHHIR YIELYFLPEG 

        70         80         90        100        110        120 
ENFVYQVGRV EFTAHGESVN GPNTSDVYTE PIAYFVLKTK KKGKLYALSY CNIHGLWENE 


VTLE 

« Hide

References

« Hide 'large scale' references
[1]"Anaerobic microbes: oxygen detoxification without superoxide dismutase."
Jenney F.E. Jr., Verhagen M.F.J.M., Cui X., Adams M.W.W.
Science 286:306-309(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
[2]"Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
[3]"Structures of the superoxide reductase from Pyrococcus furiosus in the oxidized and reduced states."
Yeh A.P., Hu Y., Jenney F.E. Jr., Adams M.W.W., Rees D.C.
Biochemistry 39:2499-2508(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF156097 Genomic DNA. Translation: AAF03229.1.
AE009950 Genomic DNA. Translation: AAL81405.1.
PIRT44571.
RefSeqNP_579010.1. NC_003413.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1DO6X-ray2.00A/B1-124[»]
1DQIX-ray1.70A/B/C/D1-124[»]
1DQKX-ray2.00A/B/C/D1-124[»]
ProteinModelPortalP82385.
SMRP82385. Positions 1-124.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING186497.PF1281.

Proteomic databases

PRIDEP82385.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL81405; AAL81405; PF1281.
GeneID1469154.
KEGGpfu:PF1281.

Phylogenomic databases

eggNOGCOG2033.
HOGENOMHOG000008862.
KOK05919.
OMAHVPVIEY.
ProtClustDBCLSK2518683.

Family and domain databases

InterProIPR002742. Desulfoferrodoxin_Fe-bd_dom.
[Graphical view]
PfamPF01880. Desulfoferrodox. 1 hit.
[Graphical view]
SUPFAMSSF49367. SSF49367. 1 hit.
TIGRFAMsTIGR00332. neela_ferrous. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP82385.

Entry information

Entry nameSOR_PYRFU
AccessionPrimary (citable) accession number: P82385
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: October 16, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references