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P82385

- SOR_PYRFU

UniProt

P82385 - SOR_PYRFU

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Protein

Superoxide reductase

Gene

sorA

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Uses electrons from reduced NADP, by way of rubredoxin and an oxidoreductase, to catalyze the reduction of superoxide to hydrogen peroxide.1 Publication

Catalytic activityi

Reduced rubredoxin + superoxide + 2 H+ = oxidized rubredoxin + H2O2.1 Publication

Cofactori

Iron.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi14 – 141Iron
Metal bindingi16 – 161Iron
Metal bindingi41 – 411Iron
Metal bindingi47 – 471Iron
Metal bindingi111 – 1111Iron
Metal bindingi114 – 1141Iron

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. superoxide reductase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide reductase (EC:1.15.1.2)
Short name:
SOR
Gene namesi
Name:sorA
Ordered Locus Names:PF1281
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000001013: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 124124Superoxide reductasePRO_0000140873Add
BLAST

Proteomic databases

PRIDEiP82385.

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

STRINGi186497.PF1281.

Structurei

Secondary structure

1
124
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 54
Turni11 – 133
Beta strandi19 – 257
Beta strandi28 – 358
Beta strandi37 – 393
Beta strandi44 – 474
Beta strandi49 – 5810
Beta strandi65 – 728
Beta strandi91 – 988
Beta strandi103 – 1119
Turni112 – 1143
Beta strandi115 – 1239

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DO6X-ray2.00A/B1-124[»]
1DQIX-ray1.70A/B/C/D1-124[»]
1DQKX-ray2.00A/B/C/D1-124[»]
ProteinModelPortaliP82385.
SMRiP82385. Positions 1-124.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP82385.

Family & Domainsi

Sequence similaritiesi

Belongs to the desulfoferrodoxin family.Curated

Phylogenomic databases

eggNOGiCOG2033.
HOGENOMiHOG000008862.
KOiK05919.
OMAiNHSDPLT.

Family and domain databases

InterProiIPR002742. Desulfoferrodoxin_Fe-bd_dom.
[Graphical view]
PfamiPF01880. Desulfoferrodox. 1 hit.
[Graphical view]
SUPFAMiSSF49367. SSF49367. 1 hit.
TIGRFAMsiTIGR00332. neela_ferrous. 1 hit.

Sequencei

Sequence statusi: Complete.

P82385-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MISETIRSGD WKGEKHVPVI EYEREGELVK VKVQVGKEIP HPNTTEHHIR
60 70 80 90 100
YIELYFLPEG ENFVYQVGRV EFTAHGESVN GPNTSDVYTE PIAYFVLKTK
110 120
KKGKLYALSY CNIHGLWENE VTLE
Length:124
Mass (Da):14,324
Last modified:May 1, 2000 - v1
Checksum:iEDD92C7E501C8048
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF156097 Genomic DNA. Translation: AAF03229.1.
AE009950 Genomic DNA. Translation: AAL81405.1.
PIRiT44571.
RefSeqiNP_579010.1. NC_003413.1.
WP_011012425.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL81405; AAL81405; PF1281.
GeneIDi1469154.
KEGGipfu:PF1281.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF156097 Genomic DNA. Translation: AAF03229.1 .
AE009950 Genomic DNA. Translation: AAL81405.1 .
PIRi T44571.
RefSeqi NP_579010.1. NC_003413.1.
WP_011012425.1. NC_003413.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1DO6 X-ray 2.00 A/B 1-124 [» ]
1DQI X-ray 1.70 A/B/C/D 1-124 [» ]
1DQK X-ray 2.00 A/B/C/D 1-124 [» ]
ProteinModelPortali P82385.
SMRi P82385. Positions 1-124.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 186497.PF1281.

Proteomic databases

PRIDEi P82385.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL81405 ; AAL81405 ; PF1281 .
GeneIDi 1469154.
KEGGi pfu:PF1281.

Phylogenomic databases

eggNOGi COG2033.
HOGENOMi HOG000008862.
KOi K05919.
OMAi NHSDPLT.

Miscellaneous databases

EvolutionaryTracei P82385.

Family and domain databases

InterProi IPR002742. Desulfoferrodoxin_Fe-bd_dom.
[Graphical view ]
Pfami PF01880. Desulfoferrodox. 1 hit.
[Graphical view ]
SUPFAMi SSF49367. SSF49367. 1 hit.
TIGRFAMsi TIGR00332. neela_ferrous. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Anaerobic microbes: oxygen detoxification without superoxide dismutase."
    Jenney F.E. Jr., Verhagen M.F.J.M., Cui X., Adams M.W.W.
    Science 286:306-309(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF N-TERMINUS, FUNCTION, CATALYTIC ACTIVITY, COFACTOR.
    Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
  2. "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
    Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
    Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
  3. "Structures of the superoxide reductase from Pyrococcus furiosus in the oxidized and reduced states."
    Yeh A.P., Hu Y., Jenney F.E. Jr., Adams M.W.W., Rees D.C.
    Biochemistry 39:2499-2508(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS).

Entry informationi

Entry nameiSOR_PYRFU
AccessioniPrimary (citable) accession number: P82385
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3