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P82385

- SOR_PYRFU

UniProt

P82385 - SOR_PYRFU

Protein

Superoxide reductase

Gene

sorA

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Uses electrons from reduced NADP, by way of rubredoxin and an oxidoreductase, to catalyze the reduction of superoxide to hydrogen peroxide.

    Catalytic activityi

    Reduced rubredoxin + superoxide + 2 H+ = rubredoxin + H2O2.

    Cofactori

    Iron.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi14 – 141Iron
    Metal bindingi16 – 161Iron
    Metal bindingi41 – 411Iron
    Metal bindingi47 – 471Iron
    Metal bindingi111 – 1111Iron
    Metal bindingi114 – 1141Iron

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. superoxide reductase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Transport

    Keywords - Ligandi

    Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Superoxide reductase (EC:1.15.1.2)
    Short name:
    SOR
    Gene namesi
    Name:sorA
    Ordered Locus Names:PF1281
    OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
    Taxonomic identifieri186497 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
    ProteomesiUP000001013: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 124124Superoxide reductasePRO_0000140873Add
    BLAST

    Proteomic databases

    PRIDEiP82385.

    Interactioni

    Subunit structurei

    Homotetramer.

    Protein-protein interaction databases

    STRINGi186497.PF1281.

    Structurei

    Secondary structure

    1
    124
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi2 – 54
    Turni11 – 133
    Beta strandi19 – 257
    Beta strandi28 – 358
    Beta strandi37 – 393
    Beta strandi44 – 474
    Beta strandi49 – 5810
    Beta strandi65 – 728
    Beta strandi91 – 988
    Beta strandi103 – 1119
    Turni112 – 1143
    Beta strandi115 – 1239

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1DO6X-ray2.00A/B1-124[»]
    1DQIX-ray1.70A/B/C/D1-124[»]
    1DQKX-ray2.00A/B/C/D1-124[»]
    ProteinModelPortaliP82385.
    SMRiP82385. Positions 1-124.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP82385.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the desulfoferrodoxin family.Curated

    Phylogenomic databases

    eggNOGiCOG2033.
    HOGENOMiHOG000008862.
    KOiK05919.
    OMAiNHSDPLT.

    Family and domain databases

    InterProiIPR002742. Desulfoferrodoxin_Fe-bd_dom.
    [Graphical view]
    PfamiPF01880. Desulfoferrodox. 1 hit.
    [Graphical view]
    SUPFAMiSSF49367. SSF49367. 1 hit.
    TIGRFAMsiTIGR00332. neela_ferrous. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P82385-1 [UniParc]FASTAAdd to Basket

    « Hide

    MISETIRSGD WKGEKHVPVI EYEREGELVK VKVQVGKEIP HPNTTEHHIR    50
    YIELYFLPEG ENFVYQVGRV EFTAHGESVN GPNTSDVYTE PIAYFVLKTK 100
    KKGKLYALSY CNIHGLWENE VTLE 124
    Length:124
    Mass (Da):14,324
    Last modified:May 1, 2000 - v1
    Checksum:iEDD92C7E501C8048
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF156097 Genomic DNA. Translation: AAF03229.1.
    AE009950 Genomic DNA. Translation: AAL81405.1.
    PIRiT44571.
    RefSeqiNP_579010.1. NC_003413.1.
    WP_011012425.1. NC_003413.1.

    Genome annotation databases

    EnsemblBacteriaiAAL81405; AAL81405; PF1281.
    GeneIDi1469154.
    KEGGipfu:PF1281.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF156097 Genomic DNA. Translation: AAF03229.1 .
    AE009950 Genomic DNA. Translation: AAL81405.1 .
    PIRi T44571.
    RefSeqi NP_579010.1. NC_003413.1.
    WP_011012425.1. NC_003413.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1DO6 X-ray 2.00 A/B 1-124 [» ]
    1DQI X-ray 1.70 A/B/C/D 1-124 [» ]
    1DQK X-ray 2.00 A/B/C/D 1-124 [» ]
    ProteinModelPortali P82385.
    SMRi P82385. Positions 1-124.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 186497.PF1281.

    Proteomic databases

    PRIDEi P82385.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL81405 ; AAL81405 ; PF1281 .
    GeneIDi 1469154.
    KEGGi pfu:PF1281.

    Phylogenomic databases

    eggNOGi COG2033.
    HOGENOMi HOG000008862.
    KOi K05919.
    OMAi NHSDPLT.

    Miscellaneous databases

    EvolutionaryTracei P82385.

    Family and domain databases

    InterProi IPR002742. Desulfoferrodoxin_Fe-bd_dom.
    [Graphical view ]
    Pfami PF01880. Desulfoferrodox. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49367. SSF49367. 1 hit.
    TIGRFAMsi TIGR00332. neela_ferrous. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Anaerobic microbes: oxygen detoxification without superoxide dismutase."
      Jenney F.E. Jr., Verhagen M.F.J.M., Cui X., Adams M.W.W.
      Science 286:306-309(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
    2. "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences."
      Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M., DiRuggiero J., Robb F.T.
      Genetics 152:1299-1305(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
    3. "Structures of the superoxide reductase from Pyrococcus furiosus in the oxidized and reduced states."
      Yeh A.P., Hu Y., Jenney F.E. Jr., Adams M.W.W., Rees D.C.
      Biochemistry 39:2499-2508(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS).

    Entry informationi

    Entry nameiSOR_PYRFU
    AccessioniPrimary (citable) accession number: P82385
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3