Reviewed, UniProtKB/Swiss-Prot P82385 (SOR_PYRFU)

Names and origin

Protein names

Recommended name:
    Superoxide reductase
      Short name=SOR
    EC=1.15.1.2

Gene names

Name:	sorA
Ordered Locus Names:	PF1281

Organism

Pyrococcus furiosus [Complete proteome] [HAMAP]

Taxonomic identifier

2261 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	124 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Uses electrons from reduced NADP, by way of rubredoxin and an oxidoreductase, to catalyze the reduction of superoxide to hydrogen peroxide.
Catalytic activity	Reduced rubredoxin + superoxide + 2 H+ = rubredoxin + H2O2.
Cofactor	Iron.
Subunit structure	Homotetramer.
Sequence similarities	Belongs to the desulfoferrodoxin family.

Ontologies

Keywords
Biological process	Electron transport Transport
Ligand	Iron Metal-binding
Molecular function	Oxidoreductase
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW superoxide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 124

124

Superoxide reductase

PRO_0000140873

Sites

Metal binding

14

1

Iron

Metal binding

16

1

Iron

Metal binding

41

1

Iron

Metal binding

47

1

Iron

Metal binding

111

1

Iron

Metal binding

114

1

Iron

Secondary structure

1

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124

Helix Strand Turn

Details...

Helix

2 – 5

4

Beta strand

19 – 25

7

Beta strand

28 – 35

8

Beta strand

37 – 39

3

Beta strand

44 – 47

4

Beta strand

49 – 58

10

Beta strand

65 – 72

8

Beta strand

91 – 98

8

Beta strand

103 – 111

9

Turn

112 – 114

3

Beta strand

115 – 123

9

Sequences

	Sequence		Length	Mass (Da)
	P82385-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: EDD92C7E501C8048	FASTA	124	14,324
	10 20 30 40 50 60 MISETIRSGD WKGEKHVPVI EYEREGELVK VKVQVGKEIP HPNTTEHHIR YIELYFLPEG 70 80 90 100 110 120 ENFVYQVGRV EFTAHGESVN GPNTSDVYTE PIAYFVLKTK KKGKLYALSY CNIHGLWENE VTLE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Anaerobic microbes: oxygen detoxification without superoxide dismutase." Jenney F.E. Jr., Verhagen M.F.J.M., Cui X., Adams M.W.W. Science 286:306-309(1999) [PubMed: 10514376] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
[2]	"The complete sequence of the Pyrococcus furiosus genome." Weiss R.B., Dunn D.M., Robb F.T., Brown J.R. Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1.
[3]	"Structures of the superoxide reductase from Pyrococcus furiosus in the oxidized and reduced states." Yeh A.P., Hu Y., Jenney F.E. Jr., Adams M.W.W., Rees D.C. Biochemistry 39:2499-2508(2000) [PubMed: 10704199] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS).

Cross-references

Sequence databases

EMBLGenBankDDBJ

AF156097 Genomic DNA. Translation: AAF03229.1.
AE009950 Genomic DNA. Translation: AAL81405.1.

PIR

T44571.

RefSeq

NP_579010.1.

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1DO6	X-ray	2.00	A/B	1-124	[»]
1DQI	X-ray	1.70	A/B/C/D	1-124	[»]
1DQK	X-ray	2.00	A/B/C/D	1-124	[»]

ModBase

Search...

Genome annotation databases

GeneID

1469154.

GenomeReviews

Gene locus PF1281 in contig AE009950_GR.

KEGG

pfu:PF1281.

NMPDR

fig|186497.1.peg.1325.

Organism-specific databases

CMR

Search...

Phylogenomic databases

HOGENOM

HBG541098.

OMA

EHHIAWI.

Enzyme and pathway databases

BRENDA

1.15.1.2. 321.

Family and domain databases

InterPro

IPR002742. Desulfoferrodoxin_Fe-bd.
[Graphical view]

Pfam

PF01880. Desulfoferrodox. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

SOR_PYRFU

Accession

Primary (citable) accession number: P82385

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	May 1, 2000
Last modified:	December 15, 2009
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)