Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alpha-sarcoglycan

Gene

Sgca

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

GO - Molecular functioni

GO - Biological processi

  • membrane organization Source: MGI
  • muscle system process Source: GO_Central
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-sarcoglycan
Short name:
Alpha-SG
Alternative name(s):
50 kDa dystrophin-associated glycoprotein
Short name:
50DAG
Adhalin
Gene namesi
Name:Sgca
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:894698. Sgca.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 293ExtracellularSequence analysisAdd BLAST270
Transmembranei294 – 314HelicalSequence analysisAdd BLAST21
Topological domaini315 – 387CytoplasmicSequence analysisAdd BLAST73

GO - Cellular componenti

  • cell-cell junction Source: MGI
  • cytoplasm Source: UniProtKB-KW
  • cytoskeleton Source: UniProtKB-SubCell
  • dystroglycan complex Source: MGI
  • integral component of plasma membrane Source: MGI
  • membrane raft Source: MGI
  • sarcoglycan complex Source: GO_Central
  • sarcolemma Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000003167524 – 387Alpha-sarcoglycanAdd BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi174N-linked (GlcNAc...)Sequence analysis1
Glycosylationi246N-linked (GlcNAc...)Sequence analysis1
Modified residuei377PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP82350.
PeptideAtlasiP82350.
PRIDEiP82350.

PTM databases

iPTMnetiP82350.
PhosphoSitePlusiP82350.

Expressioni

Tissue specificityi

Striated muscle, both skeletal and cardiac.1 Publication

Developmental stagei

In the embryo, expression begins at day 14 and coincides with the onset of primary myogenesis.1 Publication

Gene expression databases

BgeeiENSMUSG00000001508.
ExpressionAtlasiP82350. baseline and differential.
GenevisibleiP82350. MM.

Interactioni

Subunit structurei

Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans. Interacts with the syntrophin SNTA1.2 Publications

Protein-protein interaction databases

BioGridi203195. 6 interactors.
STRINGi10090.ENSMUSP00000098118.

Structurei

3D structure databases

ProteinModelPortaliP82350.
SMRiP82350.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sarcoglycan alpha/epsilon family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4482. Eukaryota.
ENOG4110FPC. LUCA.
GeneTreeiENSGT00390000005672.
HOGENOMiHOG000074154.
HOVERGENiHBG006891.
InParanoidiP82350.
KOiK12565.
OMAiTEAQQTT.
OrthoDBiEOG091G07H7.
PhylomeDBiP82350.
TreeFamiTF314655.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR028658. Alpha-SG.
IPR006644. Cadg.
IPR015919. Cadherin-like.
IPR013783. Ig-like_fold.
IPR008908. Sarcoglycan_alpha/epsilon.
[Graphical view]
PANTHERiPTHR10132. PTHR10132. 1 hit.
PTHR10132:SF16. PTHR10132:SF16. 1 hit.
PfamiPF05510. Sarcoglycan_2. 1 hit.
[Graphical view]
SMARTiSM00736. CADG. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P82350-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAVTWIPL LAGLLAGLRD TKAQQTTLHL LVGRVFVHPL EHATFLRLPE
60 70 80 90 100
HVAVPPTVRL TYHAHLQGHP DLPRWLHYTQ RSPYNPGFLY GSPTPEDRGY
110 120 130 140 150
QVIEVTAYNR DSFDTTRQRL LLLIGDPEGP RLPYQAEFLV RSHDVEEVLP
160 170 180 190 200
TTPANRFLTA LGGLWEPGEL QLLNITSALD RGGRVPLPIE GRKEGVYIKV
210 220 230 240 250
GSATPFSTCL KMVASPDSYA RCAQGQPPLL SCYDTLAPHF RVDWCNVSLV
260 270 280 290 300
DKSVPEPLDE VPTPGDGILE HDPFFCPPTE ATDRDFLTDA LVTLLVPLLV
310 320 330 340 350
ALLLTLLLAY IMCFRREGRL KRDMATSDIQ MFHHCSIHGN TEELRQMAAS
360 370 380
REVPRPLSTL PMFNVRTGER LPPRVDSAQM PLILDQH
Length:387
Mass (Da):43,287
Last modified:May 1, 2000 - v1
Checksum:i7C3D98A853D04591
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19R → K in AAB70754 (PubMed:9196068).Curated1
Sequence conflicti76L → V in AAB70754 (PubMed:9196068).Curated1
Sequence conflicti149 – 150LP → VS in AAB70754 (PubMed:9196068).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019564 mRNA. Translation: AAB70754.1.
AB024920 mRNA. Translation: BAA83491.1.
AF064081 Genomic DNA. Translation: AAC33447.1.
AK075915 mRNA. Translation: BAC36051.1.
CCDSiCCDS25266.1.
PIRiJC5556.
RefSeqiNP_033187.1. NM_009161.4.
XP_011247138.1. XM_011248836.2.
UniGeneiMm.18709.

Genome annotation databases

EnsembliENSMUST00000100551; ENSMUSP00000098118; ENSMUSG00000001508.
ENSMUST00000103162; ENSMUSP00000099451; ENSMUSG00000001508.
ENSMUST00000166320; ENSMUSP00000130617; ENSMUSG00000001508.
GeneIDi20391.
KEGGimmu:20391.
UCSCiuc007kzo.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019564 mRNA. Translation: AAB70754.1.
AB024920 mRNA. Translation: BAA83491.1.
AF064081 Genomic DNA. Translation: AAC33447.1.
AK075915 mRNA. Translation: BAC36051.1.
CCDSiCCDS25266.1.
PIRiJC5556.
RefSeqiNP_033187.1. NM_009161.4.
XP_011247138.1. XM_011248836.2.
UniGeneiMm.18709.

3D structure databases

ProteinModelPortaliP82350.
SMRiP82350.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203195. 6 interactors.
STRINGi10090.ENSMUSP00000098118.

PTM databases

iPTMnetiP82350.
PhosphoSitePlusiP82350.

Proteomic databases

PaxDbiP82350.
PeptideAtlasiP82350.
PRIDEiP82350.

Protocols and materials databases

DNASUi20391.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000100551; ENSMUSP00000098118; ENSMUSG00000001508.
ENSMUST00000103162; ENSMUSP00000099451; ENSMUSG00000001508.
ENSMUST00000166320; ENSMUSP00000130617; ENSMUSG00000001508.
GeneIDi20391.
KEGGimmu:20391.
UCSCiuc007kzo.3. mouse.

Organism-specific databases

CTDi6442.
MGIiMGI:894698. Sgca.

Phylogenomic databases

eggNOGiKOG4482. Eukaryota.
ENOG4110FPC. LUCA.
GeneTreeiENSGT00390000005672.
HOGENOMiHOG000074154.
HOVERGENiHBG006891.
InParanoidiP82350.
KOiK12565.
OMAiTEAQQTT.
OrthoDBiEOG091G07H7.
PhylomeDBiP82350.
TreeFamiTF314655.

Miscellaneous databases

PROiP82350.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001508.
ExpressionAtlasiP82350. baseline and differential.
GenevisibleiP82350. MM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR028658. Alpha-SG.
IPR006644. Cadg.
IPR015919. Cadherin-like.
IPR013783. Ig-like_fold.
IPR008908. Sarcoglycan_alpha/epsilon.
[Graphical view]
PANTHERiPTHR10132. PTHR10132. 1 hit.
PTHR10132:SF16. PTHR10132:SF16. 1 hit.
PfamiPF05510. Sarcoglycan_2. 1 hit.
[Graphical view]
SMARTiSM00736. CADG. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSGCA_MOUSE
AccessioniPrimary (citable) accession number: P82350
Secondary accession number(s): O35311, O88490
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.