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P82350

- SGCA_MOUSE

UniProt

P82350 - SGCA_MOUSE

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Protein
Alpha-sarcoglycan
Gene
Sgca
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. membrane organization Source: MGI
  2. muscle contraction Source: InterPro
  3. muscle organ development Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-sarcoglycan
Short name:
Alpha-SG
Alternative name(s):
50 kDa dystrophin-associated glycoprotein
Short name:
50DAG
Adhalin
Gene namesi
Name:Sgca
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:894698. Sgca.

Subcellular locationi

Cell membranesarcolemma; Single-pass type I membrane protein. Cytoplasmcytoskeleton 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 293270Extracellular Reviewed prediction
Add
BLAST
Transmembranei294 – 31421Helical; Reviewed prediction
Add
BLAST
Topological domaini315 – 38773Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell-cell junction Source: MGI
  2. cytoplasm Source: UniProtKB-KW
  3. cytoskeleton Source: UniProtKB-SubCell
  4. dystroglycan complex Source: MGI
  5. integral component of plasma membrane Source: MGI
  6. membrane raft Source: MGI
  7. sarcoglycan complex Source: InterPro
  8. sarcolemma Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 387364Alpha-sarcoglycan
PRO_0000031675Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi174 – 1741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi246 – 2461N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP82350.

PTM databases

PhosphoSiteiP82350.

Expressioni

Tissue specificityi

Striated muscle, both skeletal and cardiac.1 Publication

Developmental stagei

In the embryo, expression begins at day 14 and coincides with the onset of primary myogenesis.1 Publication

Gene expression databases

ArrayExpressiP82350.
BgeeiP82350.
GenevestigatoriP82350.

Interactioni

Subunit structurei

Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans. Interacts with the syntrophin SNTA1.2 Publications

Protein-protein interaction databases

BioGridi203195. 6 interactions.

Structurei

3D structure databases

ProteinModelPortaliP82350.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG323743.
GeneTreeiENSGT00390000005672.
HOGENOMiHOG000074154.
HOVERGENiHBG006891.
InParanoidiP82350.
KOiK12565.
OMAiHTLDHET.
OrthoDBiEOG7MD4PV.
PhylomeDBiP82350.
TreeFamiTF314655.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR028658. Alpha-SG.
IPR006644. Cadg.
IPR015919. Cadherin-like.
IPR013783. Ig-like_fold.
IPR008908. Sarcoglycan_2.
[Graphical view]
PANTHERiPTHR10132. PTHR10132. 1 hit.
PTHR10132:SF1. PTHR10132:SF1. 1 hit.
PfamiPF05510. Sarcoglycan_2. 1 hit.
[Graphical view]
SMARTiSM00736. CADG. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P82350-1 [UniParc]FASTAAdd to Basket

« Hide

MAAAVTWIPL LAGLLAGLRD TKAQQTTLHL LVGRVFVHPL EHATFLRLPE    50
HVAVPPTVRL TYHAHLQGHP DLPRWLHYTQ RSPYNPGFLY GSPTPEDRGY 100
QVIEVTAYNR DSFDTTRQRL LLLIGDPEGP RLPYQAEFLV RSHDVEEVLP 150
TTPANRFLTA LGGLWEPGEL QLLNITSALD RGGRVPLPIE GRKEGVYIKV 200
GSATPFSTCL KMVASPDSYA RCAQGQPPLL SCYDTLAPHF RVDWCNVSLV 250
DKSVPEPLDE VPTPGDGILE HDPFFCPPTE ATDRDFLTDA LVTLLVPLLV 300
ALLLTLLLAY IMCFRREGRL KRDMATSDIQ MFHHCSIHGN TEELRQMAAS 350
REVPRPLSTL PMFNVRTGER LPPRVDSAQM PLILDQH 387
Length:387
Mass (Da):43,287
Last modified:May 1, 2000 - v1
Checksum:i7C3D98A853D04591
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191R → K in AAB70754. 1 Publication
Sequence conflicti76 – 761L → V in AAB70754. 1 Publication
Sequence conflicti149 – 1502LP → VS in AAB70754. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF019564 mRNA. Translation: AAB70754.1.
AB024920 mRNA. Translation: BAA83491.1.
AF064081 Genomic DNA. Translation: AAC33447.1.
AK075915 mRNA. Translation: BAC36051.1.
CCDSiCCDS25266.1.
PIRiJC5556.
RefSeqiNP_033187.1. NM_009161.4.
UniGeneiMm.18709.

Genome annotation databases

EnsembliENSMUST00000100551; ENSMUSP00000098118; ENSMUSG00000001508.
ENSMUST00000103162; ENSMUSP00000099451; ENSMUSG00000001508.
ENSMUST00000166320; ENSMUSP00000130617; ENSMUSG00000001508.
GeneIDi20391.
KEGGimmu:20391.
UCSCiuc007kzo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF019564 mRNA. Translation: AAB70754.1 .
AB024920 mRNA. Translation: BAA83491.1 .
AF064081 Genomic DNA. Translation: AAC33447.1 .
AK075915 mRNA. Translation: BAC36051.1 .
CCDSi CCDS25266.1.
PIRi JC5556.
RefSeqi NP_033187.1. NM_009161.4.
UniGenei Mm.18709.

3D structure databases

ProteinModelPortali P82350.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203195. 6 interactions.

PTM databases

PhosphoSitei P82350.

Proteomic databases

PRIDEi P82350.

Protocols and materials databases

DNASUi 20391.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000100551 ; ENSMUSP00000098118 ; ENSMUSG00000001508 .
ENSMUST00000103162 ; ENSMUSP00000099451 ; ENSMUSG00000001508 .
ENSMUST00000166320 ; ENSMUSP00000130617 ; ENSMUSG00000001508 .
GeneIDi 20391.
KEGGi mmu:20391.
UCSCi uc007kzo.2. mouse.

Organism-specific databases

CTDi 6442.
MGIi MGI:894698. Sgca.

Phylogenomic databases

eggNOGi NOG323743.
GeneTreei ENSGT00390000005672.
HOGENOMi HOG000074154.
HOVERGENi HBG006891.
InParanoidi P82350.
KOi K12565.
OMAi HTLDHET.
OrthoDBi EOG7MD4PV.
PhylomeDBi P82350.
TreeFami TF314655.

Miscellaneous databases

NextBioi 298330.
PROi P82350.
SOURCEi Search...

Gene expression databases

ArrayExpressi P82350.
Bgeei P82350.
Genevestigatori P82350.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR028658. Alpha-SG.
IPR006644. Cadg.
IPR015919. Cadherin-like.
IPR013783. Ig-like_fold.
IPR008908. Sarcoglycan_2.
[Graphical view ]
PANTHERi PTHR10132. PTHR10132. 1 hit.
PTHR10132:SF1. PTHR10132:SF1. 1 hit.
Pfami PF05510. Sarcoglycan_2. 1 hit.
[Graphical view ]
SMARTi SM00736. CADG. 1 hit.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse adhalin: primary structure and expression during late stages of muscle differentiation in vitro."
    Liu L., Vachon P.H., Kuang W., Xu H., Wewer U.M., Kylsten P., Engvall E.
    Biochem. Biophys. Res. Commun. 235:227-235(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: FVB/N.
    Tissue: Myoblast.
  2. "Developmental expression of sarcoglycan gene products in cultured myocytes."
    Noguchi S., Wakabayashi E., Imamura M., Yoshida M., Ozawa E.
    Biochem. Biophys. Res. Commun. 262:88-93(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.
  3. "Alpha-sarcoglycan-deficient mice as an animal model for autosomal recessive limb-girdle muscular dystrophy."
    Duclos F., Straub V., Moore S., Hrstka R., Crosbie R.H., Durbeej M., Lebakken C.S., Holt K.H., Lim L.E., Ettinger A., Sanes J.R., Davidson B.L., Williamson R., Campbell K.P.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/Sv.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Tongue.
  5. "Interactions between dystrophin glycoprotein complex proteins."
    Madhavan R., Jarrett H.W.
    Biochemistry 34:12204-12209(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SNTA1.
  6. "Molecular organization of sarcoglycan complex in mouse myotubes in culture."
    Chan Y.-M., Boennemann C.G., Lidov H.G.W., Kunkel L.M.
    J. Cell Biol. 143:2033-2044(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, SUBUNIT.

Entry informationi

Entry nameiSGCA_MOUSE
AccessioniPrimary (citable) accession number: P82350
Secondary accession number(s): O35311, O88490
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi