Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P82349

- SGCB_MOUSE

UniProt

P82349 - SGCB_MOUSE

Protein

Beta-sarcoglycan

Gene

Sgcb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

    GO - Biological processi

    1. cardiac muscle cell development Source: MGI
    2. membrane organization Source: MGI
    3. muscle fiber development Source: MGI
    4. muscle organ development Source: InterPro
    5. vascular smooth muscle cell development Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-sarcoglycan
    Short name:
    Beta-SG
    Alternative name(s):
    43 kDa dystrophin-associated glycoprotein
    Short name:
    43DAG
    Gene namesi
    Name:Sgcb
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1346523. Sgcb.

    Subcellular locationi

    Cell membranesarcolemma 1 Publication; Single-pass type II membrane protein 1 Publication. Cytoplasmcytoskeleton 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. cytoskeleton Source: UniProtKB-SubCell
    3. dystroglycan complex Source: MGI
    4. integral component of plasma membrane Source: MGI
    5. sarcoglycan complex Source: InterPro
    6. sarcolemma Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Cytoskeleton, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 320320Beta-sarcoglycanPRO_0000175244Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi260 – 2601N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi290 ↔ 316Sequence Analysis
    Disulfide bondi292 ↔ 309Sequence Analysis

    Post-translational modificationi

    Disulfide bonds are present.

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP82349.
    PaxDbiP82349.
    PRIDEiP82349.

    PTM databases

    PhosphoSiteiP82349.

    Expressioni

    Tissue specificityi

    Most strongly expressed in skeletal and heart muscle. Also detected in proliferating myoblasts.

    Gene expression databases

    BgeeiP82349.
    GenevestigatoriP82349.

    Interactioni

    Subunit structurei

    Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans.1 Publication

    Protein-protein interaction databases

    BioGridi204864. 7 interactions.
    IntActiP82349. 1 interaction.
    MINTiMINT-4134438.

    Structurei

    3D structure databases

    ProteinModelPortaliP82349.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6767CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini89 – 320232ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei68 – 8821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG84633.
    GeneTreeiENSGT00390000008110.
    HOGENOMiHOG000133159.
    HOVERGENiHBG004508.
    KOiK12566.
    OMAiNMGCQTS.
    OrthoDBiEOG74R1R4.
    PhylomeDBiP82349.
    TreeFamiTF313538.

    Family and domain databases

    InterProiIPR006875. Sarcoglycan.
    IPR027659. Sgcb.
    [Graphical view]
    PANTHERiPTHR21142. PTHR21142. 1 hit.
    PfamiPF04790. Sarcoglycan_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P82349-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAAAAAAAA TEQQGSNGPV KKSMREKAVE RRNVNKEHNS NFKAGYIPID    50
    EDRLHKTGLR GRKGNLAICV IVLLFILAVI NLLITLVIWA VIRIGPNGCD 100
    SMEFHESGLL RFKQVSDMGV IHPLYKSTVG GRRNENLVIT GNNQPIVFQQ 150
    GTTKLSVEKN KTSITSDIGM QFFDPRTHNI LFSTDYETHE FHLPSGVKSL 200
    NVQKASTERI TSNATSDLNI KVDGRAIVRG NEGVFIMGKT IEFHMGGDVE 250
    LKAENSIILN GTVMVSPTRL PSSSSGDQSG SGDWVRYKLC MCADGTLFKV 300
    QVTGHNMGCQ VSDNPCGNTH 320
    Length:320
    Mass (Da):34,873
    Last modified:May 1, 2000 - v1
    Checksum:iAFA5E28496003618
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF169288 Genomic DNA. Translation: AAF28458.1.
    AB024921 mRNA. Translation: BAA83492.1.
    AK014381 mRNA. Translation: BAB29310.1.
    AK132306 mRNA. Translation: BAE21093.1.
    AK169403 mRNA. Translation: BAE41149.1.
    BC052349 mRNA. Translation: AAH52349.1.
    CCDSiCCDS19344.1.
    RefSeqiNP_036020.1. NM_011890.4.
    UniGeneiMm.89310.

    Genome annotation databases

    EnsembliENSMUST00000081170; ENSMUSP00000079937; ENSMUSG00000029156.
    GeneIDi24051.
    KEGGimmu:24051.
    UCSCiuc008xtb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF169288 Genomic DNA. Translation: AAF28458.1 .
    AB024921 mRNA. Translation: BAA83492.1 .
    AK014381 mRNA. Translation: BAB29310.1 .
    AK132306 mRNA. Translation: BAE21093.1 .
    AK169403 mRNA. Translation: BAE41149.1 .
    BC052349 mRNA. Translation: AAH52349.1 .
    CCDSi CCDS19344.1.
    RefSeqi NP_036020.1. NM_011890.4.
    UniGenei Mm.89310.

    3D structure databases

    ProteinModelPortali P82349.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204864. 7 interactions.
    IntActi P82349. 1 interaction.
    MINTi MINT-4134438.

    PTM databases

    PhosphoSitei P82349.

    Proteomic databases

    MaxQBi P82349.
    PaxDbi P82349.
    PRIDEi P82349.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000081170 ; ENSMUSP00000079937 ; ENSMUSG00000029156 .
    GeneIDi 24051.
    KEGGi mmu:24051.
    UCSCi uc008xtb.1. mouse.

    Organism-specific databases

    CTDi 6443.
    MGIi MGI:1346523. Sgcb.

    Phylogenomic databases

    eggNOGi NOG84633.
    GeneTreei ENSGT00390000008110.
    HOGENOMi HOG000133159.
    HOVERGENi HBG004508.
    KOi K12566.
    OMAi NMGCQTS.
    OrthoDBi EOG74R1R4.
    PhylomeDBi P82349.
    TreeFami TF313538.

    Miscellaneous databases

    NextBioi 303987.
    PROi P82349.
    SOURCEi Search...

    Gene expression databases

    Bgeei P82349.
    Genevestigatori P82349.

    Family and domain databases

    InterProi IPR006875. Sarcoglycan.
    IPR027659. Sgcb.
    [Graphical view ]
    PANTHERi PTHR21142. PTHR21142. 1 hit.
    Pfami PF04790. Sarcoglycan_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Disruption of the beta-sarcoglycan gene reveals pathogenetic complexity of limb-girdle muscular dystrophy type 2E."
      Durbeej M., Campbell K.P.
      Mol. Cell 5:141-151(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Developmental expression of sarcoglycan gene products in cultured myocytes."
      Noguchi S., Wakabayashi E., Imamura M., Yoshida M., Ozawa E.
      Biochem. Biophys. Res. Commun. 262:88-93(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Skeletal muscle.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Head.
    4. "Molecular organization of sarcoglycan complex in mouse myotubes in culture."
      Chan Y.-M., Boennemann C.G., Lidov H.G.W., Kunkel L.M.
      J. Cell Biol. 143:2033-2044(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, SUBUNIT, DISULFIDE BONDS.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiSGCB_MOUSE
    AccessioniPrimary (citable) accession number: P82349
    Secondary accession number(s): Q3TEU9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3