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P82349

- SGCB_MOUSE

UniProt

P82349 - SGCB_MOUSE

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Protein

Beta-sarcoglycan

Gene

Sgcb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

GO - Biological processi

  1. cardiac muscle cell development Source: MGI
  2. membrane organization Source: MGI
  3. muscle fiber development Source: MGI
  4. muscle organ development Source: InterPro
  5. vascular smooth muscle cell development Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-sarcoglycan
Short name:
Beta-SG
Alternative name(s):
43 kDa dystrophin-associated glycoprotein
Short name:
43DAG
Gene namesi
Name:Sgcb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1346523. Sgcb.

Subcellular locationi

Cell membranesarcolemma 1 Publication; Single-pass type II membrane protein 1 Publication. Cytoplasmcytoskeleton 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-KW
  3. dystroglycan complex Source: MGI
  4. integral component of plasma membrane Source: MGI
  5. sarcoglycan complex Source: InterPro
  6. sarcolemma Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320Beta-sarcoglycanPRO_0000175244Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi260 – 2601N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi290 ↔ 316Sequence Analysis
Disulfide bondi292 ↔ 309Sequence Analysis

Post-translational modificationi

Disulfide bonds are present.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP82349.
PaxDbiP82349.
PRIDEiP82349.

PTM databases

PhosphoSiteiP82349.

Expressioni

Tissue specificityi

Most strongly expressed in skeletal and heart muscle. Also detected in proliferating myoblasts.

Gene expression databases

BgeeiP82349.
GenevestigatoriP82349.

Interactioni

Subunit structurei

Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans.1 Publication

Protein-protein interaction databases

BioGridi204864. 7 interactions.
IntActiP82349. 1 interaction.
MINTiMINT-4134438.

Structurei

3D structure databases

ProteinModelPortaliP82349.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6767CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini89 – 320232ExtracellularSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei68 – 8821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG84633.
GeneTreeiENSGT00390000008110.
HOGENOMiHOG000133159.
HOVERGENiHBG004508.
InParanoidiP82349.
KOiK12566.
OMAiNMGCQTS.
OrthoDBiEOG74R1R4.
PhylomeDBiP82349.
TreeFamiTF313538.

Family and domain databases

InterProiIPR006875. Sarcoglycan.
IPR027659. Sgcb.
[Graphical view]
PANTHERiPTHR21142. PTHR21142. 1 hit.
PfamiPF04790. Sarcoglycan_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P82349-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAAAAAAAA TEQQGSNGPV KKSMREKAVE RRNVNKEHNS NFKAGYIPID
60 70 80 90 100
EDRLHKTGLR GRKGNLAICV IVLLFILAVI NLLITLVIWA VIRIGPNGCD
110 120 130 140 150
SMEFHESGLL RFKQVSDMGV IHPLYKSTVG GRRNENLVIT GNNQPIVFQQ
160 170 180 190 200
GTTKLSVEKN KTSITSDIGM QFFDPRTHNI LFSTDYETHE FHLPSGVKSL
210 220 230 240 250
NVQKASTERI TSNATSDLNI KVDGRAIVRG NEGVFIMGKT IEFHMGGDVE
260 270 280 290 300
LKAENSIILN GTVMVSPTRL PSSSSGDQSG SGDWVRYKLC MCADGTLFKV
310 320
QVTGHNMGCQ VSDNPCGNTH
Length:320
Mass (Da):34,873
Last modified:May 1, 2000 - v1
Checksum:iAFA5E28496003618
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF169288 Genomic DNA. Translation: AAF28458.1.
AB024921 mRNA. Translation: BAA83492.1.
AK014381 mRNA. Translation: BAB29310.1.
AK132306 mRNA. Translation: BAE21093.1.
AK169403 mRNA. Translation: BAE41149.1.
BC052349 mRNA. Translation: AAH52349.1.
CCDSiCCDS19344.1.
RefSeqiNP_036020.1. NM_011890.4.
UniGeneiMm.89310.

Genome annotation databases

EnsembliENSMUST00000081170; ENSMUSP00000079937; ENSMUSG00000029156.
GeneIDi24051.
KEGGimmu:24051.
UCSCiuc008xtb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF169288 Genomic DNA. Translation: AAF28458.1 .
AB024921 mRNA. Translation: BAA83492.1 .
AK014381 mRNA. Translation: BAB29310.1 .
AK132306 mRNA. Translation: BAE21093.1 .
AK169403 mRNA. Translation: BAE41149.1 .
BC052349 mRNA. Translation: AAH52349.1 .
CCDSi CCDS19344.1.
RefSeqi NP_036020.1. NM_011890.4.
UniGenei Mm.89310.

3D structure databases

ProteinModelPortali P82349.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204864. 7 interactions.
IntActi P82349. 1 interaction.
MINTi MINT-4134438.

PTM databases

PhosphoSitei P82349.

Proteomic databases

MaxQBi P82349.
PaxDbi P82349.
PRIDEi P82349.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000081170 ; ENSMUSP00000079937 ; ENSMUSG00000029156 .
GeneIDi 24051.
KEGGi mmu:24051.
UCSCi uc008xtb.1. mouse.

Organism-specific databases

CTDi 6443.
MGIi MGI:1346523. Sgcb.

Phylogenomic databases

eggNOGi NOG84633.
GeneTreei ENSGT00390000008110.
HOGENOMi HOG000133159.
HOVERGENi HBG004508.
InParanoidi P82349.
KOi K12566.
OMAi NMGCQTS.
OrthoDBi EOG74R1R4.
PhylomeDBi P82349.
TreeFami TF313538.

Miscellaneous databases

NextBioi 303987.
PROi P82349.
SOURCEi Search...

Gene expression databases

Bgeei P82349.
Genevestigatori P82349.

Family and domain databases

InterProi IPR006875. Sarcoglycan.
IPR027659. Sgcb.
[Graphical view ]
PANTHERi PTHR21142. PTHR21142. 1 hit.
Pfami PF04790. Sarcoglycan_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Disruption of the beta-sarcoglycan gene reveals pathogenetic complexity of limb-girdle muscular dystrophy type 2E."
    Durbeej M., Campbell K.P.
    Mol. Cell 5:141-151(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Developmental expression of sarcoglycan gene products in cultured myocytes."
    Noguchi S., Wakabayashi E., Imamura M., Yoshida M., Ozawa E.
    Biochem. Biophys. Res. Commun. 262:88-93(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.
  4. "Molecular organization of sarcoglycan complex in mouse myotubes in culture."
    Chan Y.-M., Boennemann C.G., Lidov H.G.W., Kunkel L.M.
    J. Cell Biol. 143:2033-2044(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, SUBUNIT, DISULFIDE BONDS.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiSGCB_MOUSE
AccessioniPrimary (citable) accession number: P82349
Secondary accession number(s): Q3TEU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3