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Protein

Beta-sarcoglycan

Gene

Sgcb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

GO - Biological processi

  • cardiac muscle cell development Source: MGI
  • membrane organization Source: MGI
  • muscle fiber development Source: MGI
  • muscle organ development Source: InterPro
  • vascular smooth muscle cell development Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-sarcoglycan
Short name:
Beta-SG
Alternative name(s):
43 kDa dystrophin-associated glycoprotein
Short name:
43DAG
Gene namesi
Name:Sgcb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1346523 Sgcb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 67CytoplasmicSequence analysisAdd BLAST67
Transmembranei68 – 88Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini89 – 320ExtracellularSequence analysisAdd BLAST232

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001752441 – 320Beta-sarcoglycanAdd BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi160N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi213N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi260N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi290 ↔ 316Sequence analysis
Disulfide bondi292 ↔ 309Sequence analysis

Post-translational modificationi

Disulfide bonds are present.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP82349
PaxDbiP82349
PeptideAtlasiP82349
PRIDEiP82349

PTM databases

iPTMnetiP82349
PhosphoSitePlusiP82349

Expressioni

Tissue specificityi

Most strongly expressed in skeletal and heart muscle. Also detected in proliferating myoblasts.

Gene expression databases

BgeeiENSMUSG00000029156
GenevisibleiP82349 MM

Interactioni

Subunit structurei

Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans.1 Publication

Protein-protein interaction databases

BioGridi204864, 7 interactors
CORUMiP82349
IntActiP82349, 1 interactor
MINTiP82349
STRINGi10090.ENSMUSP00000079937

Structurei

3D structure databases

ProteinModelPortaliP82349
SMRiP82349
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEAC Eukaryota
ENOG4111F15 LUCA
GeneTreeiENSGT00390000008110
HOGENOMiHOG000133159
HOVERGENiHBG004508
InParanoidiP82349
KOiK12566
OMAiNMGCQTS
OrthoDBiEOG091G0OE4
PhylomeDBiP82349
TreeFamiTF313538

Family and domain databases

InterProiView protein in InterPro
IPR006875 Sarcoglycan
IPR027659 Sgcb
PANTHERiPTHR21142 PTHR21142, 1 hit
PfamiView protein in Pfam
PF04790 Sarcoglycan_1, 1 hit

Sequencei

Sequence statusi: Complete.

P82349-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAAAAAA TEQQGSNGPV KKSMREKAVE RRNVNKEHNS NFKAGYIPID
60 70 80 90 100
EDRLHKTGLR GRKGNLAICV IVLLFILAVI NLLITLVIWA VIRIGPNGCD
110 120 130 140 150
SMEFHESGLL RFKQVSDMGV IHPLYKSTVG GRRNENLVIT GNNQPIVFQQ
160 170 180 190 200
GTTKLSVEKN KTSITSDIGM QFFDPRTHNI LFSTDYETHE FHLPSGVKSL
210 220 230 240 250
NVQKASTERI TSNATSDLNI KVDGRAIVRG NEGVFIMGKT IEFHMGGDVE
260 270 280 290 300
LKAENSIILN GTVMVSPTRL PSSSSGDQSG SGDWVRYKLC MCADGTLFKV
310 320
QVTGHNMGCQ VSDNPCGNTH
Length:320
Mass (Da):34,873
Last modified:May 1, 2000 - v1
Checksum:iAFA5E28496003618
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169288 Genomic DNA Translation: AAF28458.1
AB024921 mRNA Translation: BAA83492.1
AK014381 mRNA Translation: BAB29310.1
AK132306 mRNA Translation: BAE21093.1
AK169403 mRNA Translation: BAE41149.1
BC052349 mRNA Translation: AAH52349.1
CCDSiCCDS19344.1
RefSeqiNP_036020.1, NM_011890.4
UniGeneiMm.89310

Genome annotation databases

EnsembliENSMUST00000081170; ENSMUSP00000079937; ENSMUSG00000029156
GeneIDi24051
KEGGimmu:24051
UCSCiuc008xtb.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSGCB_MOUSE
AccessioniPrimary (citable) accession number: P82349
Secondary accession number(s): Q3TEU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: February 28, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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