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Protein

Beta-sarcoglycan

Gene

Sgcb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

GO - Biological processi

  • cardiac muscle cell development Source: MGI
  • membrane organization Source: MGI
  • muscle fiber development Source: MGI
  • muscle organ development Source: InterPro
  • vascular smooth muscle cell development Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-sarcoglycan
Short name:
Beta-SG
Alternative name(s):
43 kDa dystrophin-associated glycoprotein
Short name:
43DAG
Gene namesi
Name:Sgcb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1346523. Sgcb.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 67CytoplasmicSequence analysisAdd BLAST67
Transmembranei68 – 88Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini89 – 320ExtracellularSequence analysisAdd BLAST232

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • cytoskeleton Source: UniProtKB-SubCell
  • dystroglycan complex Source: MGI
  • dystrophin-associated glycoprotein complex Source: MGI
  • integral component of plasma membrane Source: MGI
  • sarcoglycan complex Source: GO_Central
  • sarcolemma Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001752441 – 320Beta-sarcoglycanAdd BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi160N-linked (GlcNAc...)Sequence analysis1
Glycosylationi213N-linked (GlcNAc...)Sequence analysis1
Glycosylationi260N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi290 ↔ 316Sequence analysis
Disulfide bondi292 ↔ 309Sequence analysis

Post-translational modificationi

Disulfide bonds are present.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP82349.
PaxDbiP82349.
PeptideAtlasiP82349.
PRIDEiP82349.

PTM databases

iPTMnetiP82349.
PhosphoSitePlusiP82349.

Expressioni

Tissue specificityi

Most strongly expressed in skeletal and heart muscle. Also detected in proliferating myoblasts.

Gene expression databases

BgeeiENSMUSG00000029156.
GenevisibleiP82349. MM.

Interactioni

Subunit structurei

Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans.1 Publication

Protein-protein interaction databases

BioGridi204864. 7 interactors.
IntActiP82349. 1 interactor.
MINTiMINT-4134438.
STRINGi10090.ENSMUSP00000079937.

Structurei

3D structure databases

ProteinModelPortaliP82349.
SMRiP82349.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEAC. Eukaryota.
ENOG4111F15. LUCA.
GeneTreeiENSGT00390000008110.
HOGENOMiHOG000133159.
HOVERGENiHBG004508.
InParanoidiP82349.
KOiK12566.
OMAiSVQYKIC.
OrthoDBiEOG091G0OE4.
PhylomeDBiP82349.
TreeFamiTF313538.

Family and domain databases

InterProiIPR006875. Sarcoglycan.
IPR027659. Sgcb.
[Graphical view]
PANTHERiPTHR21142. PTHR21142. 1 hit.
PfamiPF04790. Sarcoglycan_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P82349-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAAAAAA TEQQGSNGPV KKSMREKAVE RRNVNKEHNS NFKAGYIPID
60 70 80 90 100
EDRLHKTGLR GRKGNLAICV IVLLFILAVI NLLITLVIWA VIRIGPNGCD
110 120 130 140 150
SMEFHESGLL RFKQVSDMGV IHPLYKSTVG GRRNENLVIT GNNQPIVFQQ
160 170 180 190 200
GTTKLSVEKN KTSITSDIGM QFFDPRTHNI LFSTDYETHE FHLPSGVKSL
210 220 230 240 250
NVQKASTERI TSNATSDLNI KVDGRAIVRG NEGVFIMGKT IEFHMGGDVE
260 270 280 290 300
LKAENSIILN GTVMVSPTRL PSSSSGDQSG SGDWVRYKLC MCADGTLFKV
310 320
QVTGHNMGCQ VSDNPCGNTH
Length:320
Mass (Da):34,873
Last modified:May 1, 2000 - v1
Checksum:iAFA5E28496003618
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169288 Genomic DNA. Translation: AAF28458.1.
AB024921 mRNA. Translation: BAA83492.1.
AK014381 mRNA. Translation: BAB29310.1.
AK132306 mRNA. Translation: BAE21093.1.
AK169403 mRNA. Translation: BAE41149.1.
BC052349 mRNA. Translation: AAH52349.1.
CCDSiCCDS19344.1.
RefSeqiNP_036020.1. NM_011890.4.
UniGeneiMm.89310.

Genome annotation databases

EnsembliENSMUST00000081170; ENSMUSP00000079937; ENSMUSG00000029156.
GeneIDi24051.
KEGGimmu:24051.
UCSCiuc008xtb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169288 Genomic DNA. Translation: AAF28458.1.
AB024921 mRNA. Translation: BAA83492.1.
AK014381 mRNA. Translation: BAB29310.1.
AK132306 mRNA. Translation: BAE21093.1.
AK169403 mRNA. Translation: BAE41149.1.
BC052349 mRNA. Translation: AAH52349.1.
CCDSiCCDS19344.1.
RefSeqiNP_036020.1. NM_011890.4.
UniGeneiMm.89310.

3D structure databases

ProteinModelPortaliP82349.
SMRiP82349.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204864. 7 interactors.
IntActiP82349. 1 interactor.
MINTiMINT-4134438.
STRINGi10090.ENSMUSP00000079937.

PTM databases

iPTMnetiP82349.
PhosphoSitePlusiP82349.

Proteomic databases

MaxQBiP82349.
PaxDbiP82349.
PeptideAtlasiP82349.
PRIDEiP82349.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000081170; ENSMUSP00000079937; ENSMUSG00000029156.
GeneIDi24051.
KEGGimmu:24051.
UCSCiuc008xtb.1. mouse.

Organism-specific databases

CTDi6443.
MGIiMGI:1346523. Sgcb.

Phylogenomic databases

eggNOGiENOG410IEAC. Eukaryota.
ENOG4111F15. LUCA.
GeneTreeiENSGT00390000008110.
HOGENOMiHOG000133159.
HOVERGENiHBG004508.
InParanoidiP82349.
KOiK12566.
OMAiSVQYKIC.
OrthoDBiEOG091G0OE4.
PhylomeDBiP82349.
TreeFamiTF313538.

Miscellaneous databases

PROiP82349.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029156.
GenevisibleiP82349. MM.

Family and domain databases

InterProiIPR006875. Sarcoglycan.
IPR027659. Sgcb.
[Graphical view]
PANTHERiPTHR21142. PTHR21142. 1 hit.
PfamiPF04790. Sarcoglycan_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSGCB_MOUSE
AccessioniPrimary (citable) accession number: P82349
Secondary accession number(s): Q3TEU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.