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P82348 (SGCG_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gamma-sarcoglycan

Short name=Gamma-SG
Alternative name(s):
35 kDa dystrophin-associated glycoprotein
Short name=35DAG
Gene names
Name:Sgcg
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length291 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

Subunit structure

Interacts with the syntrophin SNTA1 and FLNC. Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans. Ref.2 Ref.3

Subcellular location

Cell membranesarcolemma; Single-pass type II membrane protein. Cytoplasmcytoskeleton Ref.3.

Tissue specificity

Most strongly expressed in skeletal and heart muscle. Also detected in proliferating myoblasts.

Sequence similarities

Belongs to the sarcoglycan beta/delta/gamma/zeta family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 291291Gamma-sarcoglycan
PRO_0000175250

Regions

Topological domain1 – 3737Cytoplasmic Potential
Transmembrane38 – 5821Helical; Signal-anchor for type II membrane protein; Potential
Topological domain59 – 291233Extracellular Potential

Amino acid modifications

Glycosylation1101N-linked (GlcNAc...) Potential
Disulfide bond265 ↔ 290 Potential
Disulfide bond267 ↔ 283 Potential

Sequences

Sequence LengthMass (Da)Tools
P82348 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: D61C53F08F241140

FASTA29132,082
        10         20         30         40         50         60 
MVREQYTTVT EGTHIERPEN QHIYKIGIYG WRKRCLYLFV LLLLAILVVN LALTIWILKV 

        70         80         90        100        110        120 
MWFSPIGMGH LHVTADGLRL EGESEFLFPL YAKEIRSRVD SSLLLQSTQN VTVSARNSEG 

       130        140        150        160        170        180 
EVTGRVKVGA QMVEVQSQHF QINSEDGKPL FSAEEQDVVV GTGRLRVTGP EGALFEHSVE 

       190        200        210        220        230        240 
TPLVRADPFQ DLRLESPTRS LSMDAPRGVH VKANAGKLEA LSQMDIILQS SEGVLVLDAE 

       250        260        270        280        290 
TVGLTKLKQG TQGPAGSSNG FYEICACPDG KLYLSMAGEV TTCEEHSHVC L 

« Hide

References

[1]"Developmental expression of sarcoglycan gene products in cultured myocytes."
Noguchi S., Wakabayashi E., Imamura M., Yoshida M., Ozawa E.
Biochem. Biophys. Res. Commun. 262:88-93(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Skeletal muscle.
[2]"Interactions between dystrophin glycoprotein complex proteins."
Madhavan R., Jarrett H.W.
Biochemistry 34:12204-12209(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SNTA1.
[3]"Molecular organization of sarcoglycan complex in mouse myotubes in culture."
Chan Y.-M., Boennemann C.G., Lidov H.G.W., Kunkel L.M.
J. Cell Biol. 143:2033-2044(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, SUBUNIT, DISULFIDE BONDS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB024922 mRNA. Translation: BAA83493.1.
RefSeqNP_036022.1. NM_011892.3.
XP_006519075.1. XM_006519012.1.
UniGeneMm.72173.

3D structure databases

ProteinModelPortalP82348.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid204866. 2 interactions.
STRING10090.ENSMUSP00000077106.

Proteomic databases

PaxDbP82348.
PRIDEP82348.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000077954; ENSMUSP00000077106; ENSMUSG00000035296.
ENSMUST00000121148; ENSMUSP00000112576; ENSMUSG00000035296.
GeneID24053.
KEGGmmu:24053.
UCSCuc007ufs.1. mouse.

Organism-specific databases

CTD6445.
MGIMGI:1346524. Sgcg.

Phylogenomic databases

eggNOGNOG318936.
HOGENOMHOG000007853.
HOVERGENHBG008669.
InParanoidP82348.
KOK12564.
OMAVNARNSE.
OrthoDBEOG7SN8DC.
TreeFamTF313538.

Gene expression databases

ArrayExpressP82348.
BgeeP82348.
GenevestigatorP82348.

Family and domain databases

InterProIPR006875. Sarcoglycan.
IPR027660. SGCG.
[Graphical view]
PANTHERPTHR12939:SF4. PTHR12939:SF4. 1 hit.
PfamPF04790. Sarcoglycan_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio303995.
PROP82348.
SOURCESearch...

Entry information

Entry nameSGCG_MOUSE
AccessionPrimary (citable) accession number: P82348
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 23, 2007
Last modified: March 19, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot