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P82348

- SGCG_MOUSE

UniProt

P82348 - SGCG_MOUSE

Protein

Gamma-sarcoglycan

Gene

Sgcg

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. membrane organization Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gamma-sarcoglycan
    Short name:
    Gamma-SG
    Alternative name(s):
    35 kDa dystrophin-associated glycoprotein
    Short name:
    35DAG
    Gene namesi
    Name:Sgcg
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1346524. Sgcg.

    Subcellular locationi

    Cell membranesarcolemma 1 Publication; Single-pass type II membrane protein 1 Publication. Cytoplasmcytoskeleton 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. cytoskeleton Source: UniProtKB-SubCell
    3. dystroglycan complex Source: MGI
    4. integral component of plasma membrane Source: MGI
    5. sarcoglycan complex Source: MGI
    6. sarcolemma Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Cytoskeleton, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 291291Gamma-sarcoglycanPRO_0000175250Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi265 ↔ 290Sequence Analysis
    Disulfide bondi267 ↔ 283Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP82348.
    PRIDEiP82348.

    Expressioni

    Tissue specificityi

    Most strongly expressed in skeletal and heart muscle. Also detected in proliferating myoblasts.

    Gene expression databases

    BgeeiP82348.
    GenevestigatoriP82348.

    Interactioni

    Subunit structurei

    Interacts with the syntrophin SNTA1 and FLNC. Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans.2 Publications

    Protein-protein interaction databases

    BioGridi204866. 2 interactions.
    STRINGi10090.ENSMUSP00000077106.

    Structurei

    3D structure databases

    ProteinModelPortaliP82348.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3737CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini59 – 291233ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei38 – 5821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG318936.
    HOGENOMiHOG000007853.
    HOVERGENiHBG008669.
    InParanoidiP82348.
    KOiK12564.
    OMAiVNARNSE.
    OrthoDBiEOG7SN8DC.
    PhylomeDBiP82348.
    TreeFamiTF313538.

    Family and domain databases

    InterProiIPR006875. Sarcoglycan.
    IPR027660. SGCG.
    [Graphical view]
    PANTHERiPTHR12939:SF4. PTHR12939:SF4. 1 hit.
    PfamiPF04790. Sarcoglycan_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P82348-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVREQYTTVT EGTHIERPEN QHIYKIGIYG WRKRCLYLFV LLLLAILVVN    50
    LALTIWILKV MWFSPIGMGH LHVTADGLRL EGESEFLFPL YAKEIRSRVD 100
    SSLLLQSTQN VTVSARNSEG EVTGRVKVGA QMVEVQSQHF QINSEDGKPL 150
    FSAEEQDVVV GTGRLRVTGP EGALFEHSVE TPLVRADPFQ DLRLESPTRS 200
    LSMDAPRGVH VKANAGKLEA LSQMDIILQS SEGVLVLDAE TVGLTKLKQG 250
    TQGPAGSSNG FYEICACPDG KLYLSMAGEV TTCEEHSHVC L 291
    Length:291
    Mass (Da):32,082
    Last modified:January 23, 2007 - v2
    Checksum:iD61C53F08F241140
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB024922 mRNA. Translation: BAA83493.1.
    CCDSiCCDS27181.1.
    RefSeqiNP_036022.1. NM_011892.3.
    XP_006519075.1. XM_006519012.1.
    UniGeneiMm.72173.

    Genome annotation databases

    EnsembliENSMUST00000077954; ENSMUSP00000077106; ENSMUSG00000035296.
    ENSMUST00000121148; ENSMUSP00000112576; ENSMUSG00000035296.
    GeneIDi24053.
    KEGGimmu:24053.
    UCSCiuc007ufs.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB024922 mRNA. Translation: BAA83493.1 .
    CCDSi CCDS27181.1.
    RefSeqi NP_036022.1. NM_011892.3.
    XP_006519075.1. XM_006519012.1.
    UniGenei Mm.72173.

    3D structure databases

    ProteinModelPortali P82348.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204866. 2 interactions.
    STRINGi 10090.ENSMUSP00000077106.

    Proteomic databases

    PaxDbi P82348.
    PRIDEi P82348.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000077954 ; ENSMUSP00000077106 ; ENSMUSG00000035296 .
    ENSMUST00000121148 ; ENSMUSP00000112576 ; ENSMUSG00000035296 .
    GeneIDi 24053.
    KEGGi mmu:24053.
    UCSCi uc007ufs.1. mouse.

    Organism-specific databases

    CTDi 6445.
    MGIi MGI:1346524. Sgcg.

    Phylogenomic databases

    eggNOGi NOG318936.
    HOGENOMi HOG000007853.
    HOVERGENi HBG008669.
    InParanoidi P82348.
    KOi K12564.
    OMAi VNARNSE.
    OrthoDBi EOG7SN8DC.
    PhylomeDBi P82348.
    TreeFami TF313538.

    Miscellaneous databases

    NextBioi 303995.
    PROi P82348.
    SOURCEi Search...

    Gene expression databases

    Bgeei P82348.
    Genevestigatori P82348.

    Family and domain databases

    InterProi IPR006875. Sarcoglycan.
    IPR027660. SGCG.
    [Graphical view ]
    PANTHERi PTHR12939:SF4. PTHR12939:SF4. 1 hit.
    Pfami PF04790. Sarcoglycan_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Developmental expression of sarcoglycan gene products in cultured myocytes."
      Noguchi S., Wakabayashi E., Imamura M., Yoshida M., Ozawa E.
      Biochem. Biophys. Res. Commun. 262:88-93(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Skeletal muscle.
    2. "Interactions between dystrophin glycoprotein complex proteins."
      Madhavan R., Jarrett H.W.
      Biochemistry 34:12204-12209(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SNTA1.
    3. "Molecular organization of sarcoglycan complex in mouse myotubes in culture."
      Chan Y.-M., Boennemann C.G., Lidov H.G.W., Kunkel L.M.
      J. Cell Biol. 143:2033-2044(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, SUBUNIT, DISULFIDE BONDS.

    Entry informationi

    Entry nameiSGCG_MOUSE
    AccessioniPrimary (citable) accession number: P82348
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3