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Protein

Gamma-sarcoglycan

Gene

Sgcg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-sarcoglycan
Short name:
Gamma-SG
Alternative name(s):
35 kDa dystrophin-associated glycoprotein
Short name:
35DAG
Gene namesi
Name:Sgcg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1346524. Sgcg.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei38 – 5821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini59 – 291233ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • cytoskeleton Source: UniProtKB-SubCell
  • dystroglycan complex Source: MGI
  • integral component of plasma membrane Source: MGI
  • sarcoglycan complex Source: MGI
  • sarcolemma Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 291291Gamma-sarcoglycanPRO_0000175250Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi265 ↔ 290Sequence Analysis
Disulfide bondi267 ↔ 283Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP82348.
PRIDEiP82348.

Expressioni

Tissue specificityi

Most strongly expressed in skeletal and heart muscle. Also detected in proliferating myoblasts.

Gene expression databases

BgeeiP82348.
ExpressionAtlasiP82348. baseline and differential.
GenevestigatoriP82348.

Interactioni

Subunit structurei

Interacts with the syntrophin SNTA1 and FLNC. Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans.2 Publications

Protein-protein interaction databases

BioGridi204866. 2 interactions.
STRINGi10090.ENSMUSP00000077106.

Structurei

3D structure databases

ProteinModelPortaliP82348.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG318936.
HOGENOMiHOG000007853.
HOVERGENiHBG008669.
InParanoidiP82348.
KOiK12564.
OMAiVQGTWGP.
OrthoDBiEOG7SN8DC.
PhylomeDBiP82348.
TreeFamiTF313538.

Family and domain databases

InterProiIPR006875. Sarcoglycan.
IPR027660. SGCG.
[Graphical view]
PANTHERiPTHR12939:SF4. PTHR12939:SF4. 1 hit.
PfamiPF04790. Sarcoglycan_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P82348-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVREQYTTVT EGTHIERPEN QHIYKIGIYG WRKRCLYLFV LLLLAILVVN
60 70 80 90 100
LALTIWILKV MWFSPIGMGH LHVTADGLRL EGESEFLFPL YAKEIRSRVD
110 120 130 140 150
SSLLLQSTQN VTVSARNSEG EVTGRVKVGA QMVEVQSQHF QINSEDGKPL
160 170 180 190 200
FSAEEQDVVV GTGRLRVTGP EGALFEHSVE TPLVRADPFQ DLRLESPTRS
210 220 230 240 250
LSMDAPRGVH VKANAGKLEA LSQMDIILQS SEGVLVLDAE TVGLTKLKQG
260 270 280 290
TQGPAGSSNG FYEICACPDG KLYLSMAGEV TTCEEHSHVC L
Length:291
Mass (Da):32,082
Last modified:January 23, 2007 - v2
Checksum:iD61C53F08F241140
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024922 mRNA. Translation: BAA83493.1.
CCDSiCCDS27181.1.
RefSeqiNP_036022.1. NM_011892.3.
XP_006519075.1. XM_006519012.2.
UniGeneiMm.72173.

Genome annotation databases

EnsembliENSMUST00000077954; ENSMUSP00000077106; ENSMUSG00000035296.
ENSMUST00000121148; ENSMUSP00000112576; ENSMUSG00000035296.
GeneIDi24053.
KEGGimmu:24053.
UCSCiuc007ufs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024922 mRNA. Translation: BAA83493.1.
CCDSiCCDS27181.1.
RefSeqiNP_036022.1. NM_011892.3.
XP_006519075.1. XM_006519012.2.
UniGeneiMm.72173.

3D structure databases

ProteinModelPortaliP82348.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204866. 2 interactions.
STRINGi10090.ENSMUSP00000077106.

Proteomic databases

PaxDbiP82348.
PRIDEiP82348.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077954; ENSMUSP00000077106; ENSMUSG00000035296.
ENSMUST00000121148; ENSMUSP00000112576; ENSMUSG00000035296.
GeneIDi24053.
KEGGimmu:24053.
UCSCiuc007ufs.1. mouse.

Organism-specific databases

CTDi6445.
MGIiMGI:1346524. Sgcg.

Phylogenomic databases

eggNOGiNOG318936.
HOGENOMiHOG000007853.
HOVERGENiHBG008669.
InParanoidiP82348.
KOiK12564.
OMAiVQGTWGP.
OrthoDBiEOG7SN8DC.
PhylomeDBiP82348.
TreeFamiTF313538.

Miscellaneous databases

NextBioi303995.
PROiP82348.
SOURCEiSearch...

Gene expression databases

BgeeiP82348.
ExpressionAtlasiP82348. baseline and differential.
GenevestigatoriP82348.

Family and domain databases

InterProiIPR006875. Sarcoglycan.
IPR027660. SGCG.
[Graphical view]
PANTHERiPTHR12939:SF4. PTHR12939:SF4. 1 hit.
PfamiPF04790. Sarcoglycan_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Developmental expression of sarcoglycan gene products in cultured myocytes."
    Noguchi S., Wakabayashi E., Imamura M., Yoshida M., Ozawa E.
    Biochem. Biophys. Res. Commun. 262:88-93(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.
  2. "Interactions between dystrophin glycoprotein complex proteins."
    Madhavan R., Jarrett H.W.
    Biochemistry 34:12204-12209(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SNTA1.
  3. "Molecular organization of sarcoglycan complex in mouse myotubes in culture."
    Chan Y.-M., Boennemann C.G., Lidov H.G.W., Kunkel L.M.
    J. Cell Biol. 143:2033-2044(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, SUBUNIT, DISULFIDE BONDS.

Entry informationi

Entry nameiSGCG_MOUSE
AccessioniPrimary (citable) accession number: P82348
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 23, 2007
Last modified: April 1, 2015
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.