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P82347

- SGCD_MOUSE

UniProt

P82347 - SGCD_MOUSE

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Protein

Delta-sarcoglycan

Gene

Sgcd

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

GO - Biological processi

  1. membrane organization Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-sarcoglycan
Short name:
Delta-SG
Alternative name(s):
35 kDa dystrophin-associated glycoprotein
Short name:
35DAG
Gene namesi
Name:Sgcd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1346525. Sgcd.

Subcellular locationi

Cell membranesarcolemma 1 Publication; Single-pass type II membrane protein 1 Publication. Cytoplasmcytoskeleton 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-KW
  3. dystroglycan complex Source: MGI
  4. integral component of plasma membrane Source: MGI
  5. sarcoglycan complex Source: MGI
  6. sarcolemma Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Delta-sarcoglycanPRO_0000175247Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi60 – 601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi108 – 1081N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi263 ↔ 288Sequence Analysis
Disulfide bondi265 ↔ 281Sequence Analysis
Glycosylationi284 – 2841N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Disulfide bonds are present.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP82347.
PaxDbiP82347.
PRIDEiP82347.

PTM databases

PhosphoSiteiP82347.

Expressioni

Tissue specificityi

Most strongly expressed in skeletal and heart muscle. Also detected in proliferating myoblasts.

Gene expression databases

BgeeiP82347.
ExpressionAtlasiP82347. baseline.
GenevestigatoriP82347.

Interactioni

Subunit structurei

Interacts with FLNC (By similarity). Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans. Interacts with DAG1.By similarity1 Publication

Protein-protein interaction databases

BioGridi204865. 5 interactions.

Structurei

3D structure databases

ProteinModelPortaliP82347.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini57 – 289233ExtracellularSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei38 – 5619Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG318936.
HOGENOMiHOG000007853.
HOVERGENiHBG008669.
InParanoidiP82347.
KOiK12563.
OMAiIRSRPGN.
PhylomeDBiP82347.
TreeFamiTF313538.

Family and domain databases

InterProiIPR006875. Sarcoglycan.
IPR027661. SGCD.
[Graphical view]
PANTHERiPTHR12939:SF6. PTHR12939:SF6. 1 hit.
PfamiPF04790. Sarcoglycan_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P82347-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPQEQYSHHR STMPSSEGPH IYKVGIYGWR KRCLYFFVLL LMILILVNLA
60 70 80 90 100
MTIWILKVMN FTIDGMGNLR ITEKGLKLEG DSEFLQPLYA KEIKSRPGNA
110 120 130 140 150
LYFKSARNVT VNILNDQTKV LTQLVTGPKA VEAYGKRFEV KTVSGKLLFS
160 170 180 190 200
ADDSEVVVGA ERLRVLGAEG TVFPKSIETP NVRADPFKEL RLESPTRSLV
210 220 230 240 250
MEAPKGVEIN AEAGNMEAIC RSELRLESKD GEIKLDAAKI KLPRLPRGSY
260 270 280
TPTGTRQKVF EVCVCANGRL FLSQAGTGST CQINTSVCL
Length:289
Mass (Da):32,133
Last modified:May 1, 2000 - v1
Checksum:iC44D7D9B511B3409
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB024923 mRNA. Translation: BAA83494.1.
CCDSiCCDS24584.1.
RefSeqiNP_036021.1. NM_011891.4.
XP_006533369.1. XM_006533306.1.
XP_006533370.1. XM_006533307.1.
UniGeneiMm.338890.

Genome annotation databases

EnsembliENSMUST00000077221; ENSMUSP00000076459; ENSMUSG00000020354.
GeneIDi24052.
KEGGimmu:24052.
UCSCiuc007ioz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB024923 mRNA. Translation: BAA83494.1 .
CCDSi CCDS24584.1.
RefSeqi NP_036021.1. NM_011891.4.
XP_006533369.1. XM_006533306.1.
XP_006533370.1. XM_006533307.1.
UniGenei Mm.338890.

3D structure databases

ProteinModelPortali P82347.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204865. 5 interactions.

PTM databases

PhosphoSitei P82347.

Proteomic databases

MaxQBi P82347.
PaxDbi P82347.
PRIDEi P82347.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000077221 ; ENSMUSP00000076459 ; ENSMUSG00000020354 .
GeneIDi 24052.
KEGGi mmu:24052.
UCSCi uc007ioz.1. mouse.

Organism-specific databases

CTDi 6444.
MGIi MGI:1346525. Sgcd.

Phylogenomic databases

eggNOGi NOG318936.
HOGENOMi HOG000007853.
HOVERGENi HBG008669.
InParanoidi P82347.
KOi K12563.
OMAi IRSRPGN.
PhylomeDBi P82347.
TreeFami TF313538.

Miscellaneous databases

NextBioi 303991.
PROi P82347.
SOURCEi Search...

Gene expression databases

Bgeei P82347.
ExpressionAtlasi P82347. baseline.
Genevestigatori P82347.

Family and domain databases

InterProi IPR006875. Sarcoglycan.
IPR027661. SGCD.
[Graphical view ]
PANTHERi PTHR12939:SF6. PTHR12939:SF6. 1 hit.
Pfami PF04790. Sarcoglycan_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Developmental expression of sarcoglycan gene products in cultured myocytes."
    Noguchi S., Wakabayashi E., Imamura M., Yoshida M., Ozawa E.
    Biochem. Biophys. Res. Commun. 262:88-93(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.
  2. "Molecular organization of sarcoglycan complex in mouse myotubes in culture."
    Chan Y.-M., Boennemann C.G., Lidov H.G.W., Kunkel L.M.
    J. Cell Biol. 143:2033-2044(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, SUBUNIT, DISULFIDE BONDS, INTERACTION WITH DAG1.

Entry informationi

Entry nameiSGCD_MOUSE
AccessioniPrimary (citable) accession number: P82347
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3