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P82347

- SGCD_MOUSE

UniProt

P82347 - SGCD_MOUSE

Protein

Delta-sarcoglycan

Gene

Sgcd

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. membrane organization Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Delta-sarcoglycan
    Short name:
    Delta-SG
    Alternative name(s):
    35 kDa dystrophin-associated glycoprotein
    Short name:
    35DAG
    Gene namesi
    Name:Sgcd
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1346525. Sgcd.

    Subcellular locationi

    Cell membranesarcolemma 1 Publication; Single-pass type II membrane protein 1 Publication. Cytoplasmcytoskeleton 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. cytoskeleton Source: UniProtKB-SubCell
    3. dystroglycan complex Source: MGI
    4. integral component of plasma membrane Source: MGI
    5. sarcoglycan complex Source: MGI
    6. sarcolemma Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Cytoskeleton, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 289289Delta-sarcoglycanPRO_0000175247Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi60 – 601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi108 – 1081N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi263 ↔ 288Sequence Analysis
    Disulfide bondi265 ↔ 281Sequence Analysis
    Glycosylationi284 – 2841N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Disulfide bonds are present.

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP82347.
    PaxDbiP82347.
    PRIDEiP82347.

    PTM databases

    PhosphoSiteiP82347.

    Expressioni

    Tissue specificityi

    Most strongly expressed in skeletal and heart muscle. Also detected in proliferating myoblasts.

    Gene expression databases

    BgeeiP82347.
    GenevestigatoriP82347.

    Interactioni

    Subunit structurei

    Interacts with FLNC By similarity. Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans. Interacts with DAG1.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi204865. 5 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP82347.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3737CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini57 – 289233ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei38 – 5619Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG318936.
    HOGENOMiHOG000007853.
    HOVERGENiHBG008669.
    InParanoidiP82347.
    KOiK12563.
    OMAiIRSRPGN.
    PhylomeDBiP82347.
    TreeFamiTF313538.

    Family and domain databases

    InterProiIPR006875. Sarcoglycan.
    IPR027661. SGCD.
    [Graphical view]
    PANTHERiPTHR12939:SF6. PTHR12939:SF6. 1 hit.
    PfamiPF04790. Sarcoglycan_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P82347-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPQEQYSHHR STMPSSEGPH IYKVGIYGWR KRCLYFFVLL LMILILVNLA    50
    MTIWILKVMN FTIDGMGNLR ITEKGLKLEG DSEFLQPLYA KEIKSRPGNA 100
    LYFKSARNVT VNILNDQTKV LTQLVTGPKA VEAYGKRFEV KTVSGKLLFS 150
    ADDSEVVVGA ERLRVLGAEG TVFPKSIETP NVRADPFKEL RLESPTRSLV 200
    MEAPKGVEIN AEAGNMEAIC RSELRLESKD GEIKLDAAKI KLPRLPRGSY 250
    TPTGTRQKVF EVCVCANGRL FLSQAGTGST CQINTSVCL 289
    Length:289
    Mass (Da):32,133
    Last modified:May 1, 2000 - v1
    Checksum:iC44D7D9B511B3409
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB024923 mRNA. Translation: BAA83494.1.
    CCDSiCCDS24584.1.
    RefSeqiNP_036021.1. NM_011891.4.
    XP_006533369.1. XM_006533306.1.
    XP_006533370.1. XM_006533307.1.
    UniGeneiMm.338890.

    Genome annotation databases

    EnsembliENSMUST00000077221; ENSMUSP00000076459; ENSMUSG00000020354.
    GeneIDi24052.
    KEGGimmu:24052.
    UCSCiuc007ioz.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB024923 mRNA. Translation: BAA83494.1 .
    CCDSi CCDS24584.1.
    RefSeqi NP_036021.1. NM_011891.4.
    XP_006533369.1. XM_006533306.1.
    XP_006533370.1. XM_006533307.1.
    UniGenei Mm.338890.

    3D structure databases

    ProteinModelPortali P82347.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204865. 5 interactions.

    PTM databases

    PhosphoSitei P82347.

    Proteomic databases

    MaxQBi P82347.
    PaxDbi P82347.
    PRIDEi P82347.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000077221 ; ENSMUSP00000076459 ; ENSMUSG00000020354 .
    GeneIDi 24052.
    KEGGi mmu:24052.
    UCSCi uc007ioz.1. mouse.

    Organism-specific databases

    CTDi 6444.
    MGIi MGI:1346525. Sgcd.

    Phylogenomic databases

    eggNOGi NOG318936.
    HOGENOMi HOG000007853.
    HOVERGENi HBG008669.
    InParanoidi P82347.
    KOi K12563.
    OMAi IRSRPGN.
    PhylomeDBi P82347.
    TreeFami TF313538.

    Miscellaneous databases

    NextBioi 303991.
    PROi P82347.
    SOURCEi Search...

    Gene expression databases

    Bgeei P82347.
    Genevestigatori P82347.

    Family and domain databases

    InterProi IPR006875. Sarcoglycan.
    IPR027661. SGCD.
    [Graphical view ]
    PANTHERi PTHR12939:SF6. PTHR12939:SF6. 1 hit.
    Pfami PF04790. Sarcoglycan_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Developmental expression of sarcoglycan gene products in cultured myocytes."
      Noguchi S., Wakabayashi E., Imamura M., Yoshida M., Ozawa E.
      Biochem. Biophys. Res. Commun. 262:88-93(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Skeletal muscle.
    2. "Molecular organization of sarcoglycan complex in mouse myotubes in culture."
      Chan Y.-M., Boennemann C.G., Lidov H.G.W., Kunkel L.M.
      J. Cell Biol. 143:2033-2044(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, SUBUNIT, DISULFIDE BONDS, INTERACTION WITH DAG1.

    Entry informationi

    Entry nameiSGCD_MOUSE
    AccessioniPrimary (citable) accession number: P82347
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3