P82347 (SGCD_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Delta-sarcoglycan
Short name=Delta-SG

Alternative name(s):
35 kDa dystrophin-associated glycoprotein
Short name=35DAG

Gene names

Name:

Sgcd

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	289 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
Subunit structure	Interacts with FLNC By similarity. Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans. Interacts with DAG1. Ref.2
Subcellular location	Cell membrane › sarcolemma; Single-pass type II membrane protein. Cytoplasm › cytoskeleton Ref.2.
Tissue specificity	Most strongly expressed in skeletal and heart muscle. Also detected in proliferating myoblasts.
Post-translational modification	Disulfide bonds are present.
Sequence similarities	Belongs to the sarcoglycan beta/delta/gamma/zeta family.

Ontologies

Keywords
Cellular component	Cell membrane Cytoplasm Cytoskeleton Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular membrane organization Traceable author statement PubMed 12189167. Source: MGI cytoskeleton organization Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell integral to plasma membrane Traceable author statement Ref.1. Source: MGI sarcoglycan complex Inferred from direct assay PubMed 12189167. Source: MGI sarcolemma Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 289	289	Delta-sarcoglycan		PRO_0000175247
Regions
	Topological domain	1 – 37	37	Cytoplasmic Potential
	Transmembrane	38 – 56	19	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	57 – 289	233	Extracellular Potential
Amino acid modifications
	Glycosylation	60	1	N-linked (GlcNAc...) Potential
	Glycosylation	108	1	N-linked (GlcNAc...) Potential
	Glycosylation	284	1	N-linked (GlcNAc...) Potential
	Disulfide bond	263 ↔ 288		Potential
	Disulfide bond	265 ↔ 281		Potential

Sequences

	Sequence		Length	Mass (Da)
	P82347 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: C44D7D9B511B3409	FASTA	289	32,133
	10 20 30 40 50 60 MPQEQYSHHR STMPSSEGPH IYKVGIYGWR KRCLYFFVLL LMILILVNLA MTIWILKVMN 70 80 90 100 110 120 FTIDGMGNLR ITEKGLKLEG DSEFLQPLYA KEIKSRPGNA LYFKSARNVT VNILNDQTKV 130 140 150 160 170 180 LTQLVTGPKA VEAYGKRFEV KTVSGKLLFS ADDSEVVVGA ERLRVLGAEG TVFPKSIETP 190 200 210 220 230 240 NVRADPFKEL RLESPTRSLV MEAPKGVEIN AEAGNMEAIC RSELRLESKD GEIKLDAAKI 250 260 270 280 KLPRLPRGSY TPTGTRQKVF EVCVCANGRL FLSQAGTGST CQINTSVCL

References

[1]	"Developmental expression of sarcoglycan gene products in cultured myocytes." Noguchi S., Wakabayashi E., Imamura M., Yoshida M., Ozawa E. Biochem. Biophys. Res. Commun. 262:88-93(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Skeletal muscle.
[2]	"Molecular organization of sarcoglycan complex in mouse myotubes in culture." Chan Y.-M., Boennemann C.G., Lidov H.G.W., Kunkel L.M. J. Cell Biol. 143:2033-2044(1998) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, SUBUNIT, DISULFIDE BONDS, INTERACTION WITH DAG1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB024923 mRNA. Translation: BAA83494.1.
IPI	IPI00124831.
RefSeq	NP_036021.1. NM_011891.4.
UniGene	Mm.338890.
3D structure databases
ProteinModelPortal	P82347.
ModBase	Search...
PTM databases
PhosphoSite	P82347.
Proteomic databases
PaxDb	P82347.
PRIDE	P82347.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000077221; ENSMUSP00000076459; ENSMUSG00000020354.
GeneID	24052.
KEGG	mmu:24052.
UCSC	uc007ioz.1. mouse.
Organism-specific databases
CTD	6444.
MGI	MGI:1346525. Sgcd.
Phylogenomic databases
eggNOG	NOG318936.
HOGENOM	HOG000007853.
HOVERGEN	HBG008669.
InParanoid	P82347.
KO	K12563.
OMA	IRSRPGN.
OrthoDB	EOG4GXFNC.
Gene expression databases
ArrayExpress	P82347.
Bgee	P82347.
Genevestigator	P82347.
GermOnline	ENSMUSG00000020354. Mus musculus.
Family and domain databases
InterPro	IPR006875. Sarcoglycan. [Graphical view]
Pfam	PF04790. Sarcoglycan_1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	303991.
SOURCE	Search...

Entry information

Entry name

SGCD_MOUSE

Accession

Primary (citable) accession number: P82347

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	May 1, 2000
Last modified:	May 29, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program