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P82347 (SGCD_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Delta-sarcoglycan

Short name=Delta-SG
Alternative name(s):
35 kDa dystrophin-associated glycoprotein
Short name=35DAG
Gene names
Name:Sgcd
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

Subunit structure

Interacts with FLNC By similarity. Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans. Interacts with DAG1. Ref.2

Subcellular location

Cell membranesarcolemma; Single-pass type II membrane protein. Cytoplasmcytoskeleton Ref.2.

Tissue specificity

Most strongly expressed in skeletal and heart muscle. Also detected in proliferating myoblasts.

Post-translational modification

Disulfide bonds are present.

Sequence similarities

Belongs to the sarcoglycan beta/delta/gamma/zeta family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 289289Delta-sarcoglycan
PRO_0000175247

Regions

Topological domain1 – 3737Cytoplasmic Potential
Transmembrane38 – 5619Helical; Signal-anchor for type II membrane protein; Potential
Topological domain57 – 289233Extracellular Potential

Amino acid modifications

Glycosylation601N-linked (GlcNAc...) Potential
Glycosylation1081N-linked (GlcNAc...) Potential
Glycosylation2841N-linked (GlcNAc...) Potential
Disulfide bond263 ↔ 288 Potential
Disulfide bond265 ↔ 281 Potential

Sequences

Sequence LengthMass (Da)Tools
P82347 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: C44D7D9B511B3409

FASTA28932,133
        10         20         30         40         50         60 
MPQEQYSHHR STMPSSEGPH IYKVGIYGWR KRCLYFFVLL LMILILVNLA MTIWILKVMN 

        70         80         90        100        110        120 
FTIDGMGNLR ITEKGLKLEG DSEFLQPLYA KEIKSRPGNA LYFKSARNVT VNILNDQTKV 

       130        140        150        160        170        180 
LTQLVTGPKA VEAYGKRFEV KTVSGKLLFS ADDSEVVVGA ERLRVLGAEG TVFPKSIETP 

       190        200        210        220        230        240 
NVRADPFKEL RLESPTRSLV MEAPKGVEIN AEAGNMEAIC RSELRLESKD GEIKLDAAKI 

       250        260        270        280 
KLPRLPRGSY TPTGTRQKVF EVCVCANGRL FLSQAGTGST CQINTSVCL 

« Hide

References

[1]"Developmental expression of sarcoglycan gene products in cultured myocytes."
Noguchi S., Wakabayashi E., Imamura M., Yoshida M., Ozawa E.
Biochem. Biophys. Res. Commun. 262:88-93(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Skeletal muscle.
[2]"Molecular organization of sarcoglycan complex in mouse myotubes in culture."
Chan Y.-M., Boennemann C.G., Lidov H.G.W., Kunkel L.M.
J. Cell Biol. 143:2033-2044(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, SUBUNIT, DISULFIDE BONDS, INTERACTION WITH DAG1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB024923 mRNA. Translation: BAA83494.1.
RefSeqNP_036021.1. NM_011891.4.
XP_006533369.1. XM_006533306.1.
XP_006533370.1. XM_006533307.1.
UniGeneMm.338890.

3D structure databases

ProteinModelPortalP82347.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid204865. 5 interactions.

PTM databases

PhosphoSiteP82347.

Proteomic databases

PaxDbP82347.
PRIDEP82347.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000077221; ENSMUSP00000076459; ENSMUSG00000020354.
GeneID24052.
KEGGmmu:24052.
UCSCuc007ioz.1. mouse.

Organism-specific databases

CTD6444.
MGIMGI:1346525. Sgcd.

Phylogenomic databases

eggNOGNOG318936.
HOGENOMHOG000007853.
HOVERGENHBG008669.
InParanoidP82347.
KOK12563.
OMARVMGAEG.
PhylomeDBP82347.
TreeFamTF313538.

Gene expression databases

BgeeP82347.
GenevestigatorP82347.

Family and domain databases

InterProIPR006875. Sarcoglycan.
IPR027661. SGCD.
[Graphical view]
PANTHERPTHR12939:SF6. PTHR12939:SF6. 1 hit.
PfamPF04790. Sarcoglycan_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio303991.
PROP82347.
SOURCESearch...

Entry information

Entry nameSGCD_MOUSE
AccessionPrimary (citable) accession number: P82347
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot